公开(公告)号：WO2023006879A1

公开(公告)日：2023-02-02

申请号：PCT/EP2022/071198

申请日：2022-07-28

Applicant: PROKARIUM LIMITED

Inventor： DEBAN, Livija ,  GLANVILLE, Nicholas

IPC: A61K35/74 ,  A61K39/112 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention relates to the field of cancer therapy. In particular, the present invention relates to a first composition comprising a live attenuated bacterium for use in the treatment, prevention, reduction, inhibition, prevention of recurrence, or control of a neoplastic disease in a subject being or intended to be administered a second composition comprising a live attenuated bacterium, said bacterium being the same or different to that of the first composition and methods thereof.

公开(公告)号：WO2023003329A1

公开(公告)日：2023-01-26

申请号：PCT/KR2022/010548

申请日：2022-07-19

Applicant: 에스케이바이오사이언스(주)

Inventor： 양선영 ,  김훈 ,  박용욱 ,  하경호 ,  이민창 ,  정진호

IPC: A61K39/112 ,  A61K39/385 ,  A61K47/64 ,  A61P31/04 ,  A61K39/00

Abstract: 본 발명은 살모넬라 타이피 유래의 피막 다당류-단백질 접합체를 포함하는 백신 조성물에 관한 것으로, 살모넬라 타이피 생장 및 Vi 피막 다당류 발현에 최적인 배양 조건을 확립하고, 정제된 Vi 피막 다당류를 접합 단백질에 접합시켜 특정 평균분자량을 가지는 접합체를 제조하였으며, 본 발명의 Vi 피막 다당류-접합 단백질 접합체의 면역원성이 우수한 것을 확인하였다. 본 발명의 Vi 피막 다당류-접합 단백질 접합체의 제조 방법, 이에 의해 제조된 접합체를 장티푸스 예방에 사용할 수 있다.

公开(公告)号：WO2022174224A2

公开(公告)日：2022-08-18

申请号：PCT/US2022/070578

申请日：2022-02-09

Applicant: UNIVERSITY OF MASSACHUSETTS ,  ERNEST PHARMACEUTICALS, LLC

Inventor： FORBES, Neil S. ,  RAMAN, Vishnu ,  VAN DESSEL, Nele ,  HARDY, Jeanne A.

IPC: A61K48/00 ,  C12N15/74 ,  A61K35/74 ,  C12N15/113 ,  A61K38/00 ,  A61K39/112 ,  C12N1/36 ,  C07K14/255 ,  C12N1/20 ,  C12R2001/42

Abstract: Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

公开(公告)号：WO2022040768A1

公开(公告)日：2022-03-03

申请号：PCT/BR2021/050367

申请日：2021-08-27

Applicant: NOWILL, Alexandre Eduardo

Inventor： NOWILL, Alexandre Eduardo

IPC: A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/04 ,  A61K39/085 ,  A61K39/09 ,  A61K39/108 ,  A61K39/112 ,  A61K39/12 ,  A61K38/43 ,  A61K38/46 ,  A61P31/14 ,  A61P37/02

Abstract: Disclosed herein are immunomodulatory compositions useful for the treatment of SARS-CoV-2 infection and symptoms related to COVID-19, such as the cytokine storm. The immunomodulatory compositions comprise two or more antigenic agents presenting pathogen-associated molecular patterns (PAMPS) and/or danger associated molecular patterns (DAMPS) and physiologically acceptable carriers, excipients, diluents or solvents.

公开(公告)号：WO2021141384A1

公开(公告)日：2021-07-15

申请号：PCT/KR2021/000138

申请日：2021-01-06

Applicant: 전북대학교산학협력단

Inventor： 이존화 ,  박성우

IPC: C12N15/74 ,  A61K39/112 ,  A61K39/116 ,  C07K14/255 ,  C07K14/195 ,  A61P31/04 ,  A61K39/00 ,  C12R1/42 ,  A61K2039/522 ,  A61K2039/542 ,  A61K39/0275 ,  C12R2001/42 ,  A50

Abstract: 본 발명은 로소니아 인트라셀룰라리스( Lawsonia intracellularis)의 오토트랜스포터(LatA) 단백질의 항원 결정기(epitope)를 모아 새롭게 합성한 항원과, 펩티도글리칸과 관련된 지질 단백질(Pal)의 양 말단에 편모 단백질(FliC)을 융합시킨 키메라 항원을 발현하는 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물에 관한 것이다.

公开(公告)号：WO2021074352A1

公开(公告)日：2021-04-22

申请号：PCT/EP2020/079140

申请日：2020-10-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： CITIULO, Francesco ,  MARTIN, Laura Bartle ,  SAUL, Allan James

IPC: A61K39/00 ,  A61P31/04 ,  A61K39/112

Abstract: A Shigella flexneri O-antigen of a first serotype or subserotype are provided for use in raising an immune response against one or more Shigella flexneri O-antigen of a different serotype or subserotype, together with associated binding moieties, pharmaceutical compositions, kits, uses or methods.

公开(公告)号：WO2020212524A1

公开(公告)日：2020-10-22

申请号：PCT/EP2020/060762

申请日：2020-04-16

Applicant: BIOMVIS S.R.L.

Inventor： GRANDI, Guido ,  GRANDI, Alberto ,  FANTAPPIE', Laura ,  ZANELLA, Ilaria ,  KOENIG, Enrico ,  GAGLIARDI, Assunta

IPC: A61P31/00 ,  A61P35/00 ,  C12N15/62 ,  A61K39/108 ,  A61K39/095 ,  A61K39/112 ,  A61K39/104

Abstract: The invention relates to gram-negative bacteria carrying gene-inactivating mutations that cause deletion of proteins belonging to the OMV proteome, to Outer Membrane Vesicles (OMVs) produced by these bacteria and immunogenic compositions thereof.

公开(公告)号：WO2020157203A1

公开(公告)日：2020-08-06

申请号：PCT/EP2020/052298

申请日：2020-01-30

Applicant: PROKARIUM LIMITED

Inventor： CRANENBURGH, Rocky Marc ,  SOULIER, Annelise Juliette

IPC: A61K39/112 ,  C12N15/74 ,  A61K39/00

Abstract: The present invention relates to the modification of a live attenuated strain of Salmonella enterica serovar Typhi, wherein its natural surface-exposed polysaccharide and flagellin antigens may be converted to, or augmented by, those from other strains of Salmonella , including S. enterica serovars Paratyphi, Typhimurium and Enteritidis. The present invention also relates to modified strains of Salmonella enterica serovar Typhi being suitable for use as components of a vaccine for enteric fever and salmonellosis.

公开(公告)号：WO2020095324A1

公开(公告)日：2020-05-14

申请号：PCT/IN2019/050825

申请日：2019-11-07

Applicant: BHARAT BIOTECH INTERNATIONAL LIMITED

Inventor： ELLA, Krishna Murthy ,  RAMASAMY, Venkatesan ,  NAIDU, Mandalapu Gangadhara

IPC: A61K39/112 ,  A61K47/64

Abstract: Disclosed are multivalent conjugate compositions against Salmonella diseases. A combined vaccine composition of glycol-conjugates in tetravalent, trivalent and bivalent combinations are disclosed in the present invention.

公开(公告)号：WO2018096007A3

公开(公告)日：2018-05-31

申请号：PCT/EP2017/080145

申请日：2017-11-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.

Inventor： ALFINI, Renzo ,  MICOLI, Francesca ,  SAUL, Allan James

IPC: A61K39/00 ,  A61K39/095 ,  A61K39/116 ,  A61K39/385 ,  A61K39/108 ,  A61K39/112 ,  A61K39/04 ,  A61K39/05 ,  A61K39/02 ,  A61K39/015

Abstract: The provided technology is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to antigens to form nOMV-antigen conjugates, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates is also provided.