公开(公告)号：WO2023067002A1

公开(公告)日：2023-04-27

申请号：PCT/EP2022/079103

申请日：2022-10-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： MALZONE, Carmine ,  PANSEGRAU, Werner ,  SANTINI, Laura

IPC: C07K16/12 ,  G01N33/569 ,  G01N33/577

Abstract: The invention uses ELISA or similar assays for analysing a meningococcal vaccine. The assay uses antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which are bactericidal for meningococcus and/or which recognise conformational epitopes within the meningococcal proteins. By performing the assay on a series of dilutions of a test vaccine, and by comparing the results with those obtained using a reference vaccine of known potency, it is possible to determine the relative potency of the test vaccine. This value can be used as a parameter for determining whether a manufactured batch of a vaccine is suitable for release to the public, or whether it has experienced a production failure and so should not be used.

公开(公告)号：WO2023066872A1

公开(公告)日：2023-04-27

申请号：PCT/EP2022/078862

申请日：2022-10-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： BEHNIA, Kamelia ,  SOBOT, Dunja ,  STRODIOT, Laurent

IPC: A61K31/4155 ,  A61K31/4184 ,  A61K39/39 ,  A61K33/06

Abstract: The present application relates to an adjuvant composition comprising: (i) a STING agonist of Formula (I) or a pharmaceutically acceptable salt thereof (I); and (ii) aluminium hydroxide, aluminium phosphate, aluminium oxyhydroxide, or aluminium hydroxyphosphate; immunogenic compositions comprising the adjuvant composition, their use in methods of immunising a subject, and related aspects thereof.

公开(公告)号：WO2023020994A1

公开(公告)日：2023-02-23

申请号：PCT/EP2022/072764

申请日：2022-08-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： DIDIERLAURENT, Arnauld Michel ,  COLLIGNON, Catherine Pascaline Anne Ghislaine ,  GUTZEIT, Cindy ,  COCCIA, Margherita ,  VAN DER MOST, Robbert Gerrit ,  ROUXEL, Ronan ,  TEMMERMAN, Stephane Theophile

IPC: A61K39/08 ,  A61K39/12

Abstract: The present invention relates inter alia to methods for eliciting immune responses involving administration of an adjuvant comprising a saponin, and to related aspects.

公开(公告)号：WO2023274860A1

公开(公告)日：2023-01-05

申请号：PCT/EP2022/067299

申请日：2022-06-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： BLAIS, Normand ,  SACCONNAY, Lionel ,  VASSILEV, Ventzislav Bojidarov

IPC: A61K39/12 ,  A61P31/16 ,  A61K39/00 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N2760/16222 ,  C12N2760/16234

Abstract: Recombinant influenza B strain haemagglutinin antigens, polynucleotides encoding the antigens and immunogenic compositions comprising the antigens and polynucleotides.

公开(公告)号：WO2022248353A1

公开(公告)日：2022-12-01

申请号：PCT/EP2022/063709

申请日：2022-05-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： HANON, Emmanuel Jules

IPC: A61K39/12

Abstract: The present invention relates to immunisation using carrier-formulated mRNA in conjunction with an adjuvant comprising a STING agonist, and to related aspects.

公开(公告)号：WO2022129209A1

公开(公告)日：2022-06-23

申请号：PCT/EP2021/085961

申请日：2021-12-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： BUDRONI, Sonia ,  RONDINI, Simona ,  ROSSI PACCANI, Silvia

IPC: G01N33/50 ,  A61K31/43 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/545 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/04

Abstract: The present invention relates to antibiotic agents for use in the treatment of patients presenting with an exacerbation of chronic obstructive pulmonary disease (COPD). More particularly the present invention relates to antibiotic agents for use in the treatment of COPD exacerbations in patients that, through analysis, have been identified as having an increased concentration of the IL-1α and TNF-α cytokine biomarkers in a biological sample taken from said patient. The present invention is further directed to methods of diagnosing and methods of treating a patient presenting with an exacerbation of COPD, said methods including identifying the patient is suffering from an exacerbation that is associated with a bacterial infection.

公开(公告)号：WO2022122830A2

公开(公告)日：2022-06-16

申请号：PCT/EP2021/084813

申请日：2021-12-08

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： BROWN, Murray ,  CHAPMAN, Edward ,  COLLIS, Andrew ,  FUERST, Douglas ,  HOSFORD, Joseph ,  MACDERMAID, Christopher ,  MORRISON, James

IPC: C12P33/00 ,  C12P19/56 ,  C12P19/14 ,  C07J63/00 ,  A61K39/39 ,  C12N9/42 ,  C12N9/24 ,  C07J63/008 ,  C12N9/2405 ,  C12N9/2445 ,  C12Y302/01021 ,  C12Y302/0104

Abstract: Methods for the enzymatic modification of saponins, products made thereby, uses of said products and also to other associated aspects. The saponins may be extracts of Quillaja species, such as extracts of Quillaja saponaria Molina.

公开(公告)号：WO2022122830A1

公开(公告)日：2022-06-16

申请号：PCT/EP2021/084813

申请日：2021-12-08

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA [BE]/[BE]

Inventor： BROWN, Murray ,  CHAPMAN, Edward ,  COLLIS, Andrew ,  FUERST, Douglas ,  HOSFORD, Joseph ,  MACDERMAID, Christopher ,  MORRISON, James

Abstract: Methods for the enzymatic modification of saponins, products made thereby, uses of said products and also to other associated aspects. The saponins may be extracts of Quillaja species, such as extracts of Quillaja saponaria Molina.

公开(公告)号：WO2022002783A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/067472

申请日：2021-06-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： HANON, Emmanuel Jules

IPC: A61K39/12 ,  A61K39/245 ,  A61K39/39 ,  A61P31/22 ,  A61P37/04 ,  A61K39/00 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N2710/16634

Abstract: The present invention relates to immunisation using carrier-formulated mRNA in conjunction with squalene emulsion adjuvants, and to related aspects.

公开(公告)号：WO2021209970A1

公开(公告)日：2021-10-21

申请号：PCT/IB2021/053161

申请日：2021-04-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： YU, Dong ,  MARUGGI, Giulietta ,  WESTERBECK, Jason W. ,  ULMER, Jeffrey B. ,  LALIBERTE, Jason P. ,  LUISI, Kate ,  QU, Lin

IPC: A61K39/12 ,  A61P31/12

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an antigen, in particular a Coronavirus antigen.