公开(公告)号：WO2022253950A1

公开(公告)日：2022-12-08

申请号：PCT/EP2022/065036

申请日：2022-06-02

Applicant: TOPAS THERAPEUTICS GMBH

Inventor： POHLNER, Johannes ,  DIGIGOW, Reinaldo ,  METZLER, Barbara ,  FLEISCHER, Sabine

IPC: A61K47/69 ,  A61P37/00 ,  A61P37/08 ,  A61K47/6931 ,  A61K47/6933

Abstract: The present invention provides nanoparticles comprising: (a) an amphiphilic polymer with a number average molecular weight (Mn) of 20,000 g/mol or less; and (b) a peptide that is covalently linked to the polymer, wherein the peptide comprises 8 to 50 amino acids, including an N-terminal linker sequence comprising at least one Arg amino acid residue and a sequence comprising an MHC binding sequence comprising a T cell receptor epitope. The present invention further comprises compositions comprising respective nanoparticles and a liquid or lyophilized carrier as well as nanoparticles and compositions of the invention for use in inducing tolerance to a therapeutic compound (protein, viral vector, lipid vesicle), an allergen or to an autoantigen or for treating an allergy, an autoimmune disease, an exogenous antigen (transplantation antigens, drugs) or a food intolerance.

公开(公告)号：WO2022005590A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/029795

申请日：2021-04-29

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： XU, Peisheng

IPC: A61K47/62 ,  A61K47/69 ,  A61P35/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/55555 ,  A61K39/0011 ,  A61K47/64 ,  A61K47/6903 ,  A61K47/6933 ,  A61K47/6935 ,  A61K9/5146 ,  C08G69/10 ,  C08G69/26 ,  C08G69/48

Abstract: Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application.