公开(公告)号：WO2021248109A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036095

申请日：2021-06-07

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY OFFICE OF THE GENERAL COUNSEL

Inventor： HEILSHORN, Sarah, C. ,  KRATOCHVIL, Michael, J.

IPC: A61K9/127 ,  A61K31/506 ,  A61K38/20 ,  A61K38/45 ,  A61K39/00 ,  A61K39/12 ,  A61K9/0019 ,  A61K9/1273

Abstract: An injectable hydrogel for drug delivery is provided having a first component of repeating protein domains, and a second component cross-linked with the first component. The protein domain in the repeating protein domains is a WW protein sequence interspersed with hydrophilic protein sequences (repeats ranges from 2 to 10). The second component is an inter-bilayer crosslinked multilamellar vesicle. The vesicle is capable of containing drug cargo and eluting the drug cargo. The vesicle is derived from a first lipid and a second lipid. The surface of the vesicle has tethers, which are cross-linked with protein domains of the first component. Control over elution rate of drug cargo is accomplished through stabilization of the vesicles. Gelation occurs in a simple and rapid mixing of the two components without the necessity of additional crosslinking stimuli. Tuning of elution rate is achieved while not losing injectability. Bioresorbable components are used.

公开(公告)号：WO2022032154A2

公开(公告)日：2022-02-10

申请号：PCT/US2021/045038

申请日：2021-08-06

Applicant: MODERNATX, INC.

Inventor： CADETE PIRES, Ana ,  SUNG, Jean C. ,  CORNEBISE, Mark ,  HRKACH, Jeffrey

IPC: A61K9/127 ,  A61K47/18 ,  A61K47/60 ,  A61K9/51 ,  A61K31/7088 ,  A61K38/00 ,  A61K9/1273 ,  A61K9/5123 ,  C07J9/00

Abstract: The present disclosure provides LNPs comprising payload molecules, e.g., mRNA therapeutics, for the treatment of diseases or disorders, which would benefit from delivery of payload molecules to airway cells.

公开(公告)号：WO2021019102A2

公开(公告)日：2021-02-04

申请号：PCT/EP2020/071809

申请日：2020-08-03

Applicant: ACM BIOLABS PTE LTD

Inventor： NALLANI, Madhavan ,  CORNELL, Thomas Andrew ,  KHAN, Amit Kumar ,  DECAILLOT, Fabien

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K31/74 ,  A61K2039/5152 ,  A61K2039/6093 ,  A61K39/0005 ,  A61K39/0011 ,  A61K9/0019 ,  A61K9/1273 ,  C12N2760/16034 ,  C12N2770/20034

Abstract: The present invention relates to a method of eliciting an immune response in a subject by administration of an antigen and an adjuvant, wherein the antigen is associated with a first population of polymersomes, and wherein the adjuvant is associated with a second population of polymersomes, and wherein the two populations of polymersomes are administered to the subject. The present invention also relates to compositions such as vaccines comprising the two polymersome populations of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.