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公开(公告)号：WO2023089343A1
公开(公告)日：2023-05-25
申请号：PCT/GB2022/052957
申请日：2022-11-22
Applicant: IPSEN BIOPHARM LIMITED
Inventor： FONFRIA SUBIROS, Elena , KRUPP, Johannes , MAIGNEL, Jaqueline Caroline , PONS, Laurent , MARTIN, Vincent
Abstract: The present invention is directed inter alia to the treatment of pain. For example, there is provided a chimeric clostridial neurotoxin for use in treating pain by inhibiting release of a pain mediator from a neuron comprising an Aδ nerve fiber or a C nerve fiber, wherein the chimeric clostridial neurotoxin binds to the neuron comprising the Aδ nerve fiber or the C nerve fiber, respectively, and wherein the chimeric clostridial neurotoxin comprises a botulinum neurotoxin A (BoNT/A) light-chain and translocation domain (HN domain), and a BoNT/B receptor binding domain (He domain). Also provided are methods, uses, kits, and unit dosage forms.
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公开(公告)号：WO2023079118A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080881
申请日：2022-11-04
Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
Inventor： DZEKAN, Horst , WITTLICH, Luisa , REUM, Nico
IPC: A61K9/70 , A61K47/22 , A61K31/196 , A61P29/02
Abstract: Die vorliegende Erfindung betrifft ein transdermales therapeutisches System zur Verabreichung von Diclofenac, umfassend eine Rückschicht und eine Matrixschicht, wobei die Matrixschicht Diclofenac, mindestens eine okklusive Klebstoffkomponente und mindestens ein Lösemittel enthält, dadurch gekennzeichnet, dass das mindestens eine Lösemittel Dimethylpropylenharnstoff umfasst, sowie dessen Verwendung als Arzneimittel.
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公开(公告)号：WO2022229446A1
公开(公告)日：2022-11-03
申请号：PCT/EP2022/061597
申请日：2022-04-29
Inventor： RICHARD, Gilles , PISANI, Emilia , BALESTRA, Richard , ARTAUD, Laurent
IPC: A61K9/08 , A61K31/167 , A61K6/00 , A61K47/10 , A61K47/18 , A61K47/22 , A61P23/02 , A61K47/02 , A61K47/20 , A61P29/02
Abstract: The present invention relates to the field of anesthetics. Especially, the present invention refers to an injectable anesthetic solution having a reduced bitterness comprising: - an anesthetic agent; - optionally, a vasoconstrictor; - a pharmaceutically acceptable solvent; and - a bitterness suppressant comprising or consisting of a mixture of at least two among sodium saccharin, sorbitol and an amino acid, wherein the amino acid is selected from: serine, threonine and their mixtures. The present invention also relates to a method for providing said injectable anesthetic solution and its uses in dentistry, oral surgery and/or maxillofacial surgery.
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公开(公告)号：WO2022159480A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/012964
申请日：2022-01-19
Applicant: ROTH, Dr. Ivar Edward
Inventor： ROTH, Dr. Ivar Edward
Abstract: The present invention provides a composition and its use in a unique treatment that provides pain relief for mammals. By treating an unconventional set of terminal nerve endings in an extremity (e.g., nerve endings that are generally found in the third plantar web space of the upper and lower extremities), pain in areas proximal to and/or at the root of the nerve can be treated. In several embodiments, these nerve endings are the terminal ends of nerves that emanate from the spinal cord and interconnect with other nerves to supply pain reception to the extremities. Treatment can occur with a variety of modalities to provide temporary and/or permanent pain relief in the unrelated distant part of the body (e.g., those areas closer to the root of the nerve).
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公开(公告)号：WO2022037641A1
公开(公告)日：2022-02-24
申请号：PCT/CN2021/113504
申请日：2021-08-19
Applicant: 江苏恒瑞医药股份有限公司 , 上海恒瑞医药有限公司
IPC: C07F9/576 , A61K31/675 , A61P29/02
Abstract: 一种选择性Na V抑制剂的前药及其晶型，即通式(A)所示的化合物、式(I)所示化合物的A晶型和B晶型，以及它们的制备方法。
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Patent Agency Ranking
公开(公告)号：WO2021176100A1
公开(公告)日：2021-09-10
申请号：PCT/EP2021/055734
申请日：2021-03-08
Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
Inventor： LINN, Michael , SCHMITZ, Christoph
Abstract: Die vorliegende Erfindung betrifft iontophoretische Zusammensetzungen umfassend ein Ketaminsalz, einen Verdicker in einer Menge, um eine Viskosität von mindestens 500 mPas (bei 20°C) einzustellen, und Wasser sowie deren Verwendung zur Behandlung von Schmerz oder Depressionen. Weiterhin betrifft die vorliegende Erfindung Kits, die entsprechende iontophoretische Zusammensetzungen und eine lontophorese-Vorrichtung umfassen.
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公开(公告)号：WO2021172488A1
公开(公告)日：2021-09-02
申请号：PCT/JP2021/007254
申请日：2021-02-26
Applicant: 東レ株式会社
IPC: C07D401/06 , A61K31/454 , A61P25/04 , A61P29/02
Abstract: 本発明は、痛み、特に神経障害性疼痛に対して鎮痛作用を示す化合物を提供することを目的としている。本発明は、下記の化学式に代表される環状アミン誘導体又はその薬理学的に許容される塩を提供する。
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公开(公告)号：WO2021105461A1
公开(公告)日：2021-06-03
申请号：PCT/EP2020/083782
申请日：2020-11-27
Applicant: NUVAMID SA
Inventor： BERMOND, Guillaume , GARCON, Laurent
IPC: A61K31/706 , A61K45/06 , A61P29/02 , A01K67/027
Abstract: L'invention porte sur un composé de formule (I) et/ou un composé de formule (Ia) pour utilisation dans la prévention et/ou le traitement de la spondylarthrite ankylosante ainsi que les compositions et les préparations sous forme juxtaposées les comprenant.
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公开(公告)号：WO2020053274A1
公开(公告)日：2020-03-19
申请号：PCT/EP2019/074222
申请日：2019-09-11
Applicant: DSM IP ASSETS B.V. , NOVOZYMES A/S
Inventor： LOPEZ-ULIBARRI, Rual , PEREZ CALVO, Estefania
IPC: A23K20/189 , A61K38/47 , A61P29/02 , A61P37/04 , A23K20/174
Abstract: The present invention relates to a method of improving immunity and/or anti-inflammatory ability of a monogastric animal comprising administering to the animal a composition, an animal feed or an animal feed additive comprising one or more microbial muramidases.
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公开(公告)号：WO2020046479A1
公开(公告)日：2020-03-05
申请号：PCT/US2019/041639
申请日：2019-07-12
Applicant: INNOPHOS, INC.
Inventor： RANA, Jatinder , MITCHELL, Kylie
IPC: A61K36/22 , A23L33/105 , A61P29/02
Abstract: A botanical extract that exhibits anti-inflammatory activity, wherein the botanical extract, is at least an extract from the genus Anacardium .
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