公开(公告)号：WO2004000785A3

公开(公告)日：2004-10-14

申请号：PCT/EP0306417

申请日：2003-06-18

Applicant: SMITHKLINE BEECHAM CORP ,  DODIC NERINA ,  DUMAITRE BERNARD ANDRE ,  GELLIBERT FRANCOISE JEANNE ,  SIERRA MICHAEL LAWRENCE

Inventor： DODIC NERINA ,  DUMAITRE BERNARD ANDRE ,  GELLIBERT FRANCOISE JEANNE ,  SIERRA MICHAEL LAWRENCE

IPC: A61K31/415 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/427 ,  A61P1/14 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/50 ,  A61P9/04 ,  A61P9/10 ,  A61P25/00 ,  A61P43/00 ,  C07D231/12 ,  C07D231/38 ,  C07D271/06 ,  C07D277/20 ,  C07D277/28 ,  C07D277/42 ,  C07D409/12 ,  C07D417/12 ,  C07C271/06 ,  A61K31/425 ,  C07C231/12 ,  C07C409/12 ,  C07C231/38 ,  C07C277/28 ,  C07C277/42 ,  C07C417/12

CPC classification number: C07D231/12 ,  C07D231/38 ,  C07D271/06 ,  C07D277/28 ,  C07D277/42 ,  C07D409/12 ,  C07D417/12

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:

Abstract translation: 式（I）化合物或其药学上可接受的盐，溶剂合物或可水解的酯，其中：

公开(公告)号：WO2019073476A1

公开(公告)日：2019-04-18

申请号：PCT/IN2018/050616

申请日：2018-09-21

Applicant: HIKAL LIMITED

Inventor： KUBAVAT, Hitesh Trambak ,  NAMBIAR, Sudhir ,  BHOSALE, Chitrasen ,  SURYAVANSHI, Sandeep Laxman ,  NAVALE, Pravin Mahadu ,  TAPDIYA, Shubham Santosh ,  SANE, Pramodchandra V

IPC: C07C277/42

CPC classification number: C07C227/18 ,  C07C2601/14 ,  C07C229/28

Abstract: The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the Hofmann rearrangement reaction using pinch tube reactor in greener and commercially viable manner with safer conditions in high yield and high chemical purity. wherein X is any alkali metal.