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12 条记录 (耗时 0.011 秒)

    1, 3, 4-SELENADIAZOLE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY
    1.
    发明申请
    1, 3, 4-SELENADIAZOLE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY 审中-公开
    具有药理学活性的1,3,4-噻二唑化合物

    公开(公告)号：WO2017101793A1

    公开(公告)日：2017-06-22

    申请号：PCT/CN2016/109975

    申请日：2016-12-14

    申请人： HANGZHOU JENNIFER BIOTECH CO., LTD.

    发明人： JENNIFER JIN, Ruan ,  BENFANG HELEN, Ruan

    IPC分类号： C07D293/06 ,  C07D421/04 ,  C07D421/12 ,  C07D421/06 ,  A61P39/06

    CPC分类号： C07D293/06 ,  C07D421/06 ,  C07D421/12

    摘要： The invention belongs to the field of biomedical research involving the 1, 3, 4- selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.

    摘要翻译： 本发明属于涉及具有细胞保护活性的1,3,4-二硒二重氮衍生物的生物医学研究领域。 由于没有太多杂环硒化合物，我们合成了一种新型的BPTES硒类似物。 作为BPTES的异构体，该化合物具有抗肿瘤活性，抗氧化和保护细胞功能。 目前很多药物都含有thiodiazo基元，因此合成硒代重氮官能团可以进一步优化这些药物，并且在新药开发和应用中具有重要意义。

    PRODRUGS AND CONJUGATES OF THIOL- AND SELENOL- CONTAINING COMPOUNDS AND METHODS OF USE THEREOF
    7.
    发明申请
    PRODRUGS AND CONJUGATES OF THIOL- AND SELENOL- CONTAINING COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
    含硫和含SELENOL的化合物的制备和结合及其使用方法

    公开(公告)号：WO99007719A1

    公开(公告)日：1999-02-18

    申请号：PCT/US1998/016324

    申请日：1998-08-06

    IPC分类号： C07D293/06 ,  C07H5/00 ,  C07H5/10 ,  C07H15/26 ,  C07H17/00 ,  C07H5/04 ,  C07H5/06 ,  C07H15/00

    CPC分类号： C07H5/00 ,  C07D293/06 ,  C07H5/10 ,  C07H15/26 ,  C07H17/00

    摘要： Disclosed is a prodrugs of the formula (I) where A is a sulfur or a selenium, and R is derived from a mono- di- or oligosaccharide. Also disclosed is a prodrug of the formulas (II); where A is sulfur or selenium, R' is derived from a sugar and R' has the formula (CHOH)nCH2OH, where n is 1 to 5, or R' is an alkyl or aryl group, or R' is =O, and the R'' groups may be the same or different and may be hydrogen, alkyl, alkoxy, carboxy. Also disclosed is a conjugate of an antioxidant vitamin and a thiolamine or selenolamine. Also disclosed is a prodrug of the formula (III); where A is sulfur or selenium, and R' is derived from a sugar and R' has the formula (CHOH)nCH2OH, where n is 1 to 5, or R' is also an alkyl or aryl group, or R' is =O, and R is an alkoxy, or an amine group. Also disclosed is a prodrug of the formula (IV) R is COOH or H, and R' is derived from a sugar and R' has the formula (CHOH)nCH2OH, where n is 1 to 5, or R' is an alkyl or aryl group, or R' is =O.

    摘要翻译： 公开了式（I）的前药，其中A是硫或硒，R衍生自单糖或寡糖。 还公开了式（II）的前药; 其中A是硫或硒，R'衍生自糖，R'具有式（CHOH）n CH 2 OH，其中n为1至5，或R'为烷基或芳基或R'为= O，和 R“可以相同或不同，可以是氢，烷基，烷氧基，羧基。 还公开了抗氧化维生素和硫胺或硒胺的缀合物。 还公开了式（III）的前药; 其中A是硫或硒，R'来自糖，R'具有式（CHOH）nCH 2 OH，其中n为1至5，或R'也为烷基或芳基，或R'为= O ，R +是烷氧基或胺基。 还公开了式（IV）的前药：R是COOH或H，R'来自糖，R'具有式（CHOH）n CH 2 OH，其中n为1至5，或R'为烷基或 芳基或R'= O。