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公开(公告)号：WO2023281088A2
公开(公告)日：2023-01-12
申请号：PCT/EP2022/069156
申请日：2022-07-08
申请人： SPCM SA
发明人： FAVERO, Cédrick , KIEFFER, Johann
IPC分类号： C12P7/40 , C12P13/02 , C07C51/08 , C07C57/04 , C07C231/06 , C07C233/09 , C08F20/06 , C08F20/56 , C08F220/56 , C12Y305/01004 , C12Y402/01084
摘要： The present invention relates to a biological method for obtaining an MO monomer comprising an ethylenic unsaturation by bioconversion of a CN compound comprising at least one nitrile function, said CN compound being at least partially renewable and non-fossil, said biological method comprising at least one step of enzymatic bioconversion of the CN compound in the presence of a biocatalyst comprising at least one enzyme.
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公开(公告)号：WO2022202952A1
公开(公告)日：2022-09-29
申请号：PCT/JP2022/013776
申请日：2022-03-24
申请人： 三菱ケミカル株式会社
IPC分类号： C07K19/00 , C12P11/00 , C12P13/02 , C12N15/52 , C12N15/54 , C12N15/62 , C12N9/00 , C12N9/10 , C12N9/12 , C12P21/02
摘要： 本発明は、改変型（変異型）ニコチンアミドホスホリボシルトランスフェラーゼ、及びそれを用いたニコチンアミドモノヌクレオチドの製造方法に関する。本発明の改変型ニコチンアミド・ホスホリボシルトランスフェラーゼ（Ｎａｍｐｔ）は、下記配列番号１に示されるアミノ酸配列及び／又は下記配列番号２に示されるアミノ酸配列を含み、 野生型Ｎａｍｐｔよりも活性が向上している。 （ａ）配列番号１： Ｓ-[Ｖ/Ｉ]-Ｐ-Ａ-Ｘ１-Ｘ２-Ｈ-Ｓ-[Ｔ/Ｖ/Ｉ]-[Ｍ/Ｖ/Ｉ]-Ｘ３ （ｂ）配列番号２： Ｘ４-[Ｓ/Ｉ]-Ｄ-Ｘ５ ［Ｘ１～Ｘ５は明細書内で規定したとおりである］
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公开(公告)号：WO2022005225A1
公开(公告)日：2022-01-06
申请号：PCT/KR2021/008349
申请日：2021-07-01
申请人： 씨제이제일제당 (주)
摘要： 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제 활성을 가지는 폴리펩타이드, 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 상기 폴리펩타이드 및/또는 미생물을 포함하는 판토텐산 및/또는 판토산 생산용 조성물, 및 상기 미생물을 배양하는 단계를 포함하는 판토텐산 및/또는 판토산 제조 방법이 제공된다.
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公开(公告)号：WO2021255618A1
公开(公告)日：2021-12-23
申请号：PCT/IB2021/055213
申请日：2021-06-14
申请人： INDENA S.P.A.
发明人： DONZELLI, Fabio , ALLEGRINI, Pietro , ANDREANI, Alessandro , GAMBINI, Andrea , BERLANDA, Davide
IPC分类号： C12P7/02 , C12P13/02 , C12P15/00 , C12P19/56 , A61P19/06 , A61P29/00 , C07H15/248 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091
摘要： The invention relates to a process for the preparation of colchicine 1 from colchicoside 2 which comprises enzymatic conversion of colchicoside 2 to 3-O- demethylcolchicine 3, wherein the enzyme used is a cellulase. According to another aspect of the invention, 3-O-demethylcolchicine 3 can be converted to colchicine 1 using an alkylating agent. The invention also relates to a process for enriching the colchicine 1 content of extracts from plants belonging to the Colchicaceae family containing colchicine 1, colchicoside 2 and 3 -(9-demethyl colchicine 3, which comprises conversion by means of a colchicoside 2 cellulase to 3-O-demethylcolchicine 3, followed by conversion of 3-O-demethylcolchicine 3 to colchicine 1 using an alkylating agent.
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公开(公告)号：WO2021253009A2
公开(公告)日：2021-12-16
申请号：PCT/US2021/037274
申请日：2021-06-14
申请人： CORNELL UNIVERSITY
发明人： TSAI, Wen-Chyan , WANG, Yadong
摘要： In various examples, methods of forming a polymer (e.g., a condensation polymer including but not limited to a polyester), include the steps of forming a mixture comprising one or more monomer(s), one or more biocatalyst(s), and carbon dioxide. In various examples, the methods are at least partially carried out in sub critical carbon dioxide or supercritical carbon dioxide. In various examples, a polymer is a condensation polymer. In various examples, a fabricated article, which may be a medical article, includes one or more polymer(s).
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公开(公告)号：WO2021131627A1
公开(公告)日：2021-07-01
申请号：PCT/JP2020/045377
申请日：2020-12-07
申请人： 株式会社ジェヌインＲ＆Ｄ
摘要： グリコシルイノシトールホスホセラミド（ＧＩＰＣ）からフリーセラミド（Ｃｅｒ）を調製する手段が提供される。より具体的には、キノコ自己消化液又はその精製物を含む、フリーセラミド生成のためのグルコシルイノシトールホスホセラミド（ＧＩＰＣ）又はグルコシルセラミド消化用組成物が提供される。
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公开(公告)号：WO2020155690A1
公开(公告)日：2020-08-06
申请号：PCT/CN2019/113301
申请日：2019-10-25
申请人： 大连理工大学
摘要： 提供了一种新型腈水合酶高效催化脂肪二腈水合反应的体系。提供了来自红球菌Rhodococcus erythropolis CCM2595的腈水合酶在催化脂肪族二腈方面的全新应用。尤其该酶可选择性催化己二腈生成5-氰基戊酰胺，反应速率高，反应条件简单温和，为5-氰基戊酰胺的工业生产提供方法。
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公开(公告)号：WO2020126484A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/083541
申请日：2019-12-03
发明人： POECHLAUER, Peter , SELIG, Philipp , ZINGANELL, Christopher , PITZER, Julia , GLIEDER, Anton , KROUTIL, Wolfgang , STEINER, Kerstin
摘要： The present invention relates to a process for biocatalytic amidation of non-protected amino acids comprising the step of contacting a non-protected amino acid with an ammonia source in the presence of an organic solvent and an enzyme.
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公开(公告)号：WO2020079152A1
公开(公告)日：2020-04-23
申请号：PCT/EP2019/078218
申请日：2019-10-17
申请人： BASF SE
发明人： EL-TOUFAILI, Faissal-Ali , LOESCH, Dennis , SCHMIDT, Anna-Corina , ZIMMERMANN, Tobias Joachim , OSTERMAYR, Markus , TINSLEY, Jack , BUSBY, Brent
IPC分类号： C08F20/56 , C08F2/01 , C08F220/56 , C12P13/02 , E21B7/00
摘要： Process for producing aqueous polyacrylamide concentrates by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel, comminuting said aqueous polyacrylamide gel and mixing it with an aqueous liquid, wherein the manufacturing steps areallocated to two different locations A and B and the process comprises the step of transporting an aqueous polyacrylamide concentrate hold in a suitable transport unit from a location A to a location B. Modular, relocatable plant for manufacturing aqueous polyacrylamide, wherein the units of the plant are located at two different locations A and B.
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公开(公告)号：WO2020079124A1
公开(公告)日：2020-04-23
申请号：PCT/EP2019/078166
申请日：2019-10-17
申请人： BASF SE
IPC分类号： C08F20/56 , C08F2/01 , C08F220/56 , C12P13/02 , E21B7/00
摘要： Process for producing aqueous polyacrylamide compositions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel, comminuting said aqueous polyacrylamide gel and mixing it with an aqueous liquid, wherein the polymerization is a continuous process comprising partially polymerizing said aqueous monomer solution in a first reactor device comprising a positive displacement pump and continuing the polymerization in a second reactor device. Modular, relocatable plant for carrying out the described process.
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