81. ANTI-DANDRUFF COMPOSITION COMPRISING AN ANTIFUNGAL POLYPEPTIDE

申请号: EP99972925.4

申请日: 1999-11-26

公开（公告）号: EP1143995A1

公开（公告）日: 2001-10-17

发明人: VIND, Jesper; SORENSEN, Niels Henrik

The present invention relates to an anti-dandruff composition comprising an antifungal polypeptide, to the use of an antifungal polypeptide for the treatment or prophylaxis of dandruff, to a method for the treatment or prophylaxis of dandruff, and to the use of an antifungal polypeptide for the preparation of a composition for the treatment or prophylaxis of dandruff. It has been found that the antifungal polypeptide with the amino acid sequence shown in Fig. 1 efficiently impedes the growth of the yeast P. ovale, even in low concentrations.

82. 머리뿔가위벌 유래 항균 및 항진균 활성을 갖는 신규 폴리펩티드

申请号: KR1020150150975

申请日: 2015-10-29

公开（公告）号: KR1020170049992A

公开（公告）日: 2017-05-11

发明人: 이경용; 윤형주; 이영보; 김남정

본발명은머리뿔가위벌유래항균및 항진균활성을갖는신규폴리펩티드, 이를코딩하는핵산서열, 상기폴리펩티드를유효성분으로함유하는항균및 항진균용조성물에관한것이다. 본발명에따른머리뿔가위벌유래항균및 항진균활성을갖는신규폴리펩티드는키모트립신, 서브틸리신 A, 프로테아제 K에대한저해활성을통해세균, 병원성곰팡이균과같은미생물의성장을효과적으로억제할수 있는바, 의약품, 세정제, 식물병방제제, 코팅제또는화장품과같은다양한분야의소재로서유용하게사용될수 있다.

83. ANTI-DANDRUFF COMPOSITION COMPRISING AN ANTIFUNGAL POLYPEPTIDE

申请号: PCT/DK1999/000659

申请日: 1999-11-26

公开（公告）号: WO00032220A1

公开（公告）日: 2000-06-08

发明人:

The present invention relates to an anti-dandruff composition comprising an antifungal polypeptide, to the use of an antifungal polypeptide for the treatment or prophylaxis of dandruff, to a method for the treatment or prophylaxis of dandruff, and to the use of an antifungal polypeptide for the preparation of a composition for the treatment or prophylaxis of dandruff. It has been found that the antifungal polypeptide with the amino acid sequence shown in Fig. 1 efficiently impedes the growth of the yeast P. ovale, even in low concentrations.

84. Antifungal polypeptide from alfalfa and methods for controlling plant pathogenic fungi

申请号: US09003198

申请日: 1998-01-07

公开（公告）号: US06316407B1

公开（公告）日: 2001-11-13

发明人: Jihong Liang; Dilip Maganlal Shah; Yonnie S. Wu; Cindy A. Rosenberger; Salim Hakimi

Antifungal polypeptides, isolated from Medicago plants, are shown to control fungal damage to plants. The polypeptides can be formulated into compositions useful in controlling undesired fungi.

85. Antifungal polypeptide AlyAFP from Alyssum and methods for controlling plant pathogenic fungi

申请号: US09829381

申请日: 2001-04-09

公开（公告）号: US06653280B2

公开（公告）日: 2003-11-25

发明人: Jihong Liang; Dilip Maganlal Shah; Yonnie Shun Wu; Cindy Annette Rosenberger

An antifungal polypeptide, AlyAFP, that controls fungal damage to plants is provided. DNA encoding this polypeptide can be cloned into vectors for transformation of plant-colonizing microorganisms or plants, thereby providing a method of inhibiting fungal growth on plants. The polypeptide can be formulated into compositions that can be used to control undesired fungi on plants and elsewhere.

86. ANTIFUNGAL POLYPEPTIDE AND METHODS FOR CONTROLLING PLANT PATHOGENIC FUNGI

申请号: EP97920175.0

申请日: 1997-03-27

公开（公告）号: EP0904375A2

公开（公告）日: 1999-03-31

发明人: LIANG, Jihong; SHAH, Dilip, Maganlal; WU, Yonnie, Shun; ROSENBERGER, Cindy, Annette

An antifungal polypeptide, AlyAFP, that controls fungal damage to plants is provided. DNA encoding this polypeptide can be cloned into vectors for transformation of plant-colonizing microorganisms or plants, thereby providing a method of inhibiting fungal growth on plants. The polypeptide can be formulated into compositions that can be used to control undesired fungi on plants and elsewhere.

87. Immunogenic composition against helicobacter infection, polypeptide for use in the composition, and nucleic acid sequence encoding the polypeptide

申请号: JP2007252748

申请日: 2007-09-27

公开（公告）号: JP2008086316A

公开（公告）日: 2008-04-17

发明人: LABIGNE AGNES; SUERBAUM SEBASTIEN; FERRERO RICHARD; THIBERGE JEAN-MICHEL

<P>PROBLEM TO BE SOLVED: To provide an immunogenic composition inducing a protective antibody against Helicobacter infection. <P>SOLUTION: The immunogenic composition comprises (i) at least one subunit of a urease structural polypeptide derived from Helicobacter pylori or its fragment recognizable by antibodies reacting with Helicobacter felis urease and/or at least one subunit of a urease structural polypeptide derived from Helicobacter felis or its fragment recognizable by antibodies reacting with Helicobacter pylori urease and/or (ii) a heat shock protein (HSP), or chaperonin, derived from Helicobacter or a fragment of the protein. The preparation of such immunogenic composition by recombinant means is also provided. <P>COPYRIGHT: (C)2008,JPO&INPIT

88. Antifungal Plant Proteins, Peptides, And Methods Of Use

申请号: US14888011

申请日: 2014-04-29

公开（公告）号: US20160208278A1

公开（公告）日: 2016-07-21

发明人: Dilip Shah

Provided are transgenic plants expressing MtDef5 antifungal proteins and peptides exhibiting high levels of resistance to susceptible fungi. Such transgenic plants contain a recombinant DNA construct comprising a natural or heterologous signal peptide sequence operably linked to a nucleic acid sequence encoding these molecules. Also provided are methods of producing such plants, methods of protecting plants against susceptible fungal infection and damage, as well as compositions that can be applied to the locus of plants, comprising microorganisms expressing these molecules, or these molecules themselves, as well as pharmaceutical compositions containing these molecules. Human and veterinary therapeutic use of MtDef5 antifungal proteins and peptides to treat susceptible fungal infections are also encompassed by the invention.

89. Nucleotide sequence encoding anti-fungal polypeptide

申请号: EP10154293.4

申请日: 2006-07-13

公开（公告）号: EP2221383B1

公开（公告）日: 2015-03-25

发明人: De Seixas Boavida Ferreira, Ricardo Manuel; Valadas da Silva Monteiro, Sara Alexandra; Nascimento Teixeira, Artur Ricardo; Borges Loureiro, Virgílio

90. Antivirotic or antiviral food containing polymeric immunoglobulin receptor, partial polypeptide thereof or variant of those

申请号: JP2009141236

申请日: 2009-06-12

公开（公告）号: JP2010285382A

公开（公告）日: 2010-12-24

发明人: MATSUDA MIKI; MURAKAMI KOSUKE; SUZUKI SAYAKA; UCHIDA KENJI

<P>PROBLEM TO BE SOLVED: To provide a new antivirotic or new antiviral food, excellent in safety and takable or ingestible everyday over a long period of time. <P>SOLUTION: This antivirotic or antiviral food containing a polymeric immunoglobulin receptor, its partial polypeptide containing at least an amino acid sequence of a free type pIgR (polymeric Immunoglobulin Receptor) or variants thereof as an active ingredient is provided. <P>COPYRIGHT: (C)2011,JPO&INPIT

91. Transgenic plants comprising antifungal polypeptides from alfalfa and methods for controlling plant pathogenic fungi

申请号: US10010731

申请日: 2001-11-13

公开（公告）号: US06916970B2

公开（公告）日: 2005-07-12

发明人: Jihong Liang; Dilip Maganlal Shah; Yonnie S. Wu; Cindy A. Rosenberger; Salim Hakimi

Transgenic plants and host cells comprising antifungal polypeptides, isolated from alfalfa plants, are shown to possess antifungal activity. DNA encoding the polypeptides was cloned into vectors for transformation of plant, therby providing a method of inhibiting fungal growth on plants.

92. A NOVEL POLYPEPTIDE-HUMAN ATP-DEPENDENT HELICASE 31 AND THE POLYNUCLEOTIDE ENCODING SAID POLYPEPTIDE

申请号: PCT/CN2001/000069

申请日: 2001-01-21

公开（公告）号: WO01055401A1

公开（公告）日: 2001-08-02

发明人:

The invention discloses a new polypeptide- human ATP-dependent helicase 31, the polynucleotide encoding said polypeptide, and a process for producing the polypeptide by recombinant DNA technology. It also discloses methods of applying the polypeptide for the treatment of various diseases, such as malignancy, hemopathy, HIV infection, immune disorders, and inflammation. This invention also discloses antagonist against said polypeptide and thereof therapy uses. In addition, it refers to the use of said polynucleotide encoding this new human ATP-dependent helicase 31.

93. PROCESS FOR THE PREPARATION OF TRIAZOLE ANTIFUNGAL DRUG, ITS INTERMEDIATES AND POLYMORPHS THEREOF

申请号: PCT/IN2012000618

申请日: 2012-09-17

公开（公告）号: WO2013042138A2

公开（公告）日: 2013-03-28

发明人: SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VISHNUVARDHAN SUNKARA

The present invention relates to a process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl) tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl] phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof.

94. IMMUNOGENIC COMPOSITIONS AGAINST HELICOBACTER INFECTION, POLYPEPTIDES FOR USE IN THE COMPOSITIONS, AND NUCLEIC ACID SEQUENCES ENCODING SAID POLYPEPTIDES

申请号: PCT/EP1996001834

申请日: 1996-05-02

公开（公告）号: WO1996034624A1

公开（公告）日: 1996-11-07

发明人: INSTITUT PASTEUR; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

There is provided an immunogenic composition capabale of inducing protective antibodies against Helicobacter infection characterized in that it comprises: i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter pylori urease; ii) and/or, a heat shock protein (Hsp), or chaperonin, from Helicobacter, or a fragment of said protein. The preparation, by recombinant means, of such immunogenic composition is also provided.

95. RECOMBINANT PLASMID DNAs, CODING FOR SYNTHESIS OF POLYPEPTIDE SUBSTANCES FOR A VACCINE AGAINST HEPATITIS A

申请号: PCT/SU1987000085

申请日: 1987-07-31

公开（公告）号: WO1988000973A1

公开（公告）日: 1988-02-11

发明人: INSTITUT BIOORGANICHESKOI KHIMII IMENI ...; INSTITUT POLIOMIELITA I VIRUSNYKH ENTSEFALITOV ...; VSESOJUZNY NAUCHNO-ISSLEDOVATELSKY INSTITUT ...; MOSKOVSKY NAUCHNO-ISSLEDOVATELSKY INSTITUT ...

Recombinant plasmid DNAs, coding for synthesis of polypeptide substances for a vaccine against hepatitis A, consist of a fragment of the HAV genome and an expressing vector. As the fragment of the HAV genome are used: a fragment of the size 389 b.p., coding for the VP1 protein fragment from 4 to 129 a.a.; a fragment of the size 3372 b.p., coding for all structured VP4 proteins starting with 38 a.a., and for all non-structured HAV proteins; a fragment of the size 1243 b.p., coding for a polypeptide chain containing the VP3 protein fragments from 110 to 233 a.a. and the VP1 protein fragments from 1 to 271 a.a; a fragment of the size 144 b.p., coding for the VP1 protein from 4 to 57 a.a.; a synthetic fragment of DNA, coding for the VP1 protein fragment from 11 to 25 a.a. having the following structure: AATTCACAGTTAGTACTGAACAAAATGTACCAGATCCACAGGTAGGTATTGCGGTGTCAATCATGACTTGTTTTACATGGTCTAGGTGTCCATCCATA or a fragment of the size 4296 b.p. consisting of a fragment of the size 3372 b.p., coding for all the structured and some non-structured HAV proteins, and of a fragment of the size 924 b.p., coding for the viral protease. As the expressing vector are used: plasmid pUR 291, pUR 292, pIFN-fu1, pIFN-fu2 or plasmid pSPVV inserted in vaccinia virus LIVP as vector.

96. 다제내성균에 대한 항균, 항진균, 항염증 활성을 보이는 프로태티아마이신 항생펩타이드 유도체 및 그 용도

申请号: KR1020130121083

申请日: 2013-10-11

公开（公告）号: KR1020150042447A

公开（公告）日: 2015-04-21

发明人: 김양미; 이은정

본발명은흰점박이꽃무지()유충으로부터분리된프로태티아마이신의α-helix영역의 9개잔기서열을바탕으로설계된항생펩타이드를기반으로항균, 항염활성은유지하면서세포독성을감소시키는서열번호 1 내지 7로기재된항생펩타이드 7종과그 용도및 작용기작에관한것이다. 본발명의신규한항균펩타이드 2종은내성균과여드름균에대해탁월한항균활성을나타내고, 동시에항염증활성도나타내며세포독성이없으므로인체에안전한항균제, 항진균제등으로유용하게사용될수 있다.

97. Nucleic acid sequences encoding an antifungal polypeptide, aly AFP from alyssum and methods for their use

申请号: US09103489

申请日: 1998-06-24

公开（公告）号: US06215048B1

公开（公告）日: 2001-04-10

发明人: Jihong Liang; Dilip Maganlal Shah; Yonnie Shun Wu; Cindy Annette Rosenberger

Isolated DNA molecules encoding an AlyAFP antifungal polypeptide from Alyssum are disclosed. The isolated DNA molecules comprise the nucleotide sequence of SEQ ID NO:12 or encode the amino acid sequence of SEQ ID NO:2. Also disclosed are vectors and transgenic plants comprising said DNA molecules and a method for reducing fungal damage in a plant with said DNA molecule. The isolated DNA molecules may be used to prepare transgenic plants that exhibit reduced damage from fungi as compared to non-transgenic plants. The isolated DNA molecules may be used in combination with additional nucleic acid sequences encoding anti-fungal or anti-insect proteins or polypeptides.

98. LAG-3 PROTEIN SOLUBLE POLYPEPTIDE FRACTIONS, METHOD OF PRODUCTION, THERAPEUTIC COMPOSITION AND ANTI-IDIOTYPE ANTIBODY

申请号: PCT/FR9500593

申请日: 1995-05-05

公开（公告）号: WO9530750A3

公开（公告）日: 1995-12-21

发明人: FAURE FLORENCE; HERCEND THIERRY; HUARD BERTRAND; TRIEBEL FREDERIC

Soluble polypeptide fraction consisting of all or part of one at least of the four immunoglobulin-type extracellular LAG-3 protein domains (aminoacid 1-159, 160-239, 240-330 and 331-412 of the SEQ ID N° 1 sequence) or consisting of one peptide sequence derived from these domains by replacement, addition or deletion of one or more aminoacids. The fraction of the invention has a specificity at least equal to that of LAG-3 in relation to its ligand.