US08319386B2
A motor having a rotor and a stator is disclosed. A motor having a rotor and as stator is disclosed. The rotor is a consequent-pole rotor having a rotor core, a plurality of magnets, and a plurality of salient poles. The stator includes a plurality of teeth. The stator is arranged to be opposite to the rotor with a gap along the radial direction. The gap between the stator and the rotor is set to satisfy an expression 1
US08319377B2
A photovoltaic system includes an inverter, a photovoltaic generator with a plurality of serially connected photovoltaic modules, said photovoltaic generator connected to the inverter by an electrical supply line, a controllable fuse interconnected in the electrical supply line between the inverter and the photovoltaic generator and having a signal input, and a voltage-dependent resistor connected between the signal input of the controllable fuse and the electrical supply line and generating a control signal which triggers the controllable fuse responsive to the control signal and interrupts the electrical supply line. The controllable fuse can be used to disconnect the electrical connection of the photovoltaic system to the inverter when a switch short-circuiting one or more modules of the photovoltaic generator malfunctions. The arrangement permits operation of photovoltaic system at an operating voltage of close to 1000 V, thereby allowing use of thinner cables.
US08319369B2
An aircraft electrical system includes a generator that supplies electrical AC power to a plurality of accessories associated with a gas turbine engine. The generator also supplies power to an aircraft DC bus in parallel to the supply to the accessory bus.
US08319363B2
A wind power generator includes a pillar fixed on a base, a nacelle platform disposed on an upper end portion of the pillar, a service crane provided at a side of the nacelle platform, a generator assembly coupled to the nacelle platform, a rotor hub rotatably coupled to the generator assembly, and a plurality of blades coupled to the rotor hub and rotating the rotor hub. The rotor hub is provided at an outer circumference of a front end thereof with a plurality of first pulleys for guiding a case from a winch installed on the ground.
US08319361B2
The invention relates to a device for monitoring a wind energy installation (1) comprising a tower (2) and a rotor provided with rotor blades (5) and arranged on the tower, in terms of a possible collision of a rotor blade (5) with the tower (2). Said device comprises at least one distance sensor (7a, 7b) which is arranged on the wind energy installation (1) and used for the non-contact measurement of the distance between the rotor blades (5) and a pre-determined point on the wind energy installation (1). The device also comprises an electronic evaluation system in which the distance data measured by the at least one distance sensor (7a, 7b) is evaluated, said system emitting a collision warning in the event of a critical distance not being reached.
US08319360B1
A generator which extracts operating energy from waves of a body of water. A plurality of floats may be suspended beside a rotary power collector. The rotary power collector is arranged to turn unidirectionally as the floats rise and fall vertically on the waves. Rotation of the rotary power collector is transmitted to a rotary generator. The floats may comprise rigid rods each having a finger which engages and rotates the rotary power collector. Alternatively, the floats may be suspended from ropes or the like which are wound around a reel, with the reel driving the rotary power collector in a manner controlled by ratchet action.
US08319354B2
The invention provides a semiconductor chip comprising an interconnecting structure over said passivation layer. The interconnecting structure comprises a first contact pad connected to a second contact pad exposed by an opening in a passivation layer. A metal bump is on the first contact pad and over multiple semiconductor devices, wherein the metal bump has more than 50 percent by weight of gold and has a height of between 8 and 50 microns.
US08319343B2
The present invention provides a solder bump structure. In one aspect, the solder bump structure is utilized in a semiconductor device, such as an integrated circuit. The semiconductor device comprises active devices located over a semiconductor substrate, interconnect layers comprising copper formed over the active devices, and an outermost metallization layer positioned over the interconnect layers. The outermost metallization layer comprises aluminum and includes at least one bond pad and at least one interconnect runner each electrically connected to an interconnect layer. An under bump metallization layer (UBM) is located over the bond pad, and a solder bump is located over the UBM.
US08319339B2
A silicon chip surface mounted via balls attached to its front surface, wherein the front and rear surfaces of the chip are covered with a thermosetting epoxy resin having the following characteristics: the resin contains a proportion ranging from 45 to 60% by weight of a load formed of carbon fiber particles with a maximum size of 20 μm and with its largest portion having a diameter ranging between 2 and 8 μm, on the front surface side, the loaded resin covers from 45 to 60% of the ball height, on the rear surface side, the loaded resin has a thickness ranging between 80 and 150 μm.
US08319323B2
In one embodiment, a leadless package includes down-set conductive leads having base portions. The base portions include stand-offs that attach to electrodes on an electronic chip using, for example, a solder die attach material. An optional encapsulating layer covers portions of the down-set conductive leads and portions of the electronic chip while leaving pad portions of the down-set conductive leads and a surface of the electronic chip exposed. The pad portions and the surface of the electronic chip are oriented to attach to a next level of assembly.
US08319319B2
A semiconductor package and mounting method of improving reliability by strengthening adhesive strength of both a printed circuit board and a surface mounting package, includes a chip pad on which a semiconductor device is disposed, and lead terminals, wherein at least one of the chip pad and the lead terminals have a plurality of grooves. Accordingly, in comparison with a typical package, since a plurality of grooves are formed on both a chip pad and lead terminals of a package adhering to a printed circuit, an adhesive area of both the package and the cream solder is widened so that the shearing strength may be improved and greater solder joint reliability can be acquired.
US08319317B2
Problems with a conventional mesa type semiconductor device, which are deterioration in a withstand voltage and occurrence of a leakage current caused by reduced thickness of an insulation film on an inner wall of a mesa groove corresponding to a PN junction, are solved using an inexpensive material, and a mesa type semiconductor device of high withstand voltage and high reliability is offered together with its manufacturing method. A stable protection film made of a thermal oxide film is formed on the inner wall of the mesa groove in the mesa type semiconductor device to cover and protect the PN junction, and an insulation film having negative electric charges is formed to fill a space in the mesa groove covered with the thermal oxide film so that an electron accumulation layer is not easily formed at an interface between an N− type semiconductor layer and the thermal oxide film. With the structure described above, an influence of the positive electric charges in the thermal oxide film is weakened and an extension of a depletion layer into the N− type semiconductor layer at the interface with the thermal oxide film is secured.
US08319314B2
A semiconductor device comprises a first base layer of a first conductivity type; a plurality of second base layers of a second conductivity type, provided on a part of a first surface of the first base layer; trenches formed on each side of the second base layers, and formed to be deeper than the second base layers; an emitter layer formed along the trench on a surface of the second base layers; a collector layer of the second conductivity type, provided on a second surface of the first base layer opposite to the first surface; an insulating film formed on an inner wall of the trench, the insulating film being thicker on a bottom of the trench than on a side surface of the trench; a gate electrode formed within the trench, and isolated from the second base layers and the emitter layer by the insulating film; and a space section provided between the second base layers adjacent to each other, the space section being deeper than the second base layers and being electrically isolated from the emitter layer and the second base layers.
US08319310B2
A Schottky gate (27′, 27″) of a metal-semiconductor FET (20′, 20″) is formed on a semiconductor comprising substrate (21) by, etching a gate recess (36) so as to expose a slightly depressed surface (362) of the substrate (21), the etching step also producing surface undercut cavities (363) extending laterally under the etch mask (43) from the gate recess (36), then conformally coating the slightly depressed surface (362) with a first Schottky forming conductor (40′) and substantially also coating inner surfaces (366) of the surface undercut cavities (363), and forming a Schottky contact to the semiconductor comprising substrate (21), adapted when biased to control current flow in a channel (22) extending between source (23) and drain (24) of the FET (20′, 20″) under the gate recess (36). In further embodiments, a conformal or non-conformal barrier layer conductor (41′, 41″) may be provided over the Schottky forming conductor (40′) and a thicker overlying gate conductor (442, 272) provided over the barrier layer conductor (41′, 41″).
US08319309B2
The present invention provides a semiconductor device including: a base substrate; a semiconductor layer which is disposed on the base substrate and has a 2-Dimensional Electron Gas (2DEG) formed therewithin; a first ohmic electrode disposed on a central region of the semiconductor layer; a second ohmic electrode which is formed on the edge regions of the semiconductor layer in such a manner to be disposed to be spaced apart from the first ohmic electrodes, and have a ring shape surrounding the first ohmic electrode; and a Schottky electrode part which is formed on the central region to cover the first ohmic electrode and is formed to be spaced apart from the second ohmic electrode.
US08319306B2
A method of fabricating an image sensor and an image sensor thereof are provided. The method comprises: providing a mask; utilizing the mask at a first position to form a first group of micro-lenses having a first height on a first group of color filters of a color filter array on a pixel array; shifting the mask from the first position to a second position, wherein a distance between the first position and the second position is substantially equal to a width of a pixel of the pixel array; and utilizing the mask at the second position to form a second group of micro-lenses having a second height, different from the first height, on a second group of color filters of the color filter array.
US08319305B2
This invention provides a solid-state image sensing apparatus in which a sensor portion that performs photo-electric conversion and plural layers of wiring lines including a signal line for the sensor portion are formed on a semiconductor substrate; which includes an effective pixel portion configured such that light enters the sensor portion, and an optical black portion shielded so that the light does not enter the sensor portion; and which has a light-receiving surface on the back surface side of the semiconductor substrate. The optical black portion includes the sensor portion, a first light-shielding film formed closer to the back surface side of the semiconductor substrate than the sensor portion, and a second light-shielding film formed closer to the front surface side of the semiconductor substrate than the sensor portion.
US08319304B2
A light detecting apparatus includes an SOI substrate. In the SOI substrate, a semiconductor layer and a silicon substrate are laminated via an insulating layer. The semiconductor layer has a light receiving unit and a circuit unit formed therein. The light detecting apparatus also includes an interlayer insulating film formed on a first main surface of the SOI substrate. The light detecting apparatus also includes a front surface circuit wiring embedded in the interlayer insulating film. The light detecting apparatus also includes a front surface pseudo-wiring having a grid unit. The grid unit has at least one opening allowing passage of a light of a predetermined wavelength range to the light receiving unit. The light detecting apparatus also includes a rear surface circuit wiring and a rear surface pseudo-wiring formed on a second main surface of the SOI substrate. The light detecting apparatus also includes a penetration circuit wiring that connects the front surface circuit wiring to the rear surface circuit wiring. The light detecting apparatus also includes a penetration pseudo-wiring that electrically connects the front surface pseudo-wiring to the rear surface pseudo-wiring. The light receiving unit is surrounded by the front surface pseudo-wiring, the rear surface pseudo-wiring, and the penetration pseudo-wiring.
US08319299B2
A process for forming at least one transistor on a substrate is described. The substrate comprises a polyimide and a nanoscopic filler. The polyimide is derived substantially or wholly from rigid rod monomers and the nanoscopic filler has an aspect ratio of at least 3:1. The substrates of the present disclosure are particularly well suited for thin film transistor applications, due at least in part to high resistance to hygroscopic expansion and relatively high levels of thermal and dimensional stability.
US08319296B2
In a semiconductor device including a carbon-containing electrode and a method for fabricating the same, an electrode has a high work function due to a carbon-containing TiN layer contained therein. It is possible to provide a dielectric layer having a high permittivity and thus to reduce the leakage current by forming an electrode having a high work function. Also, sufficient capacitance of a capacitor can be secured by employing an electrode having a high work function and a dielectric layer having a high permittivity.
US08319294B2
Techniques for providing a source line plane are disclosed. In one particular exemplary embodiment, the techniques may be realized as an apparatus for providing a source line plane. The apparatus may comprise a source line plane coupled to at least one constant voltage source. The apparatus may also comprise a plurality of memory cells arranged in an array of rows and columns, each memory cell including one or more memory transistors. Each of the one or more memory transistors may comprise a first region coupled to the source line plane, a second region coupled to a bit line, a body region disposed between the first region and the second region, wherein the body region may be electrically floating, and a gate coupled to a word line and spaced apart from, and capacitively coupled to, the body region.
US08319286B2
A system and method for electrostatic discharge protection. The system includes a first transistor including a first drain, a second transistor including a second drain, and a resistor including a first terminal and a second terminal. The first terminal is coupled to the first drain and the second drain. Additionally, the system includes a third transistor coupled to the second terminal and a protected system. The third transistor includes a first gate, a first dielectric layer located between the first gate and a first substrate, a first source, and a third drain. The protected system includes a fourth transistor, and the fourth transistor includes a second gate, a second dielectric layer located between the second gate and a second substrate, a second source, and a fourth drain.
US08319274B2
A gate dielectric functioning as a charge-trapping layer of a non-volatile memory cell with a structure of an insulator gate field effect transistor is formed by laminating a first insulator formed of a silicon oxide film, a second insulator formed of a silicon nitride film, a third insulator formed of a silicon nitride film containing oxygen, and a fourth insulator formed of a silicon oxide film in this order on a main surface of a semiconductor substrate. Holes are injected into the charge-trapping layer from a gate electrode side. Accordingly, since the operations can be achieved without the penetration of the holes through the interface in contact to the channel and the first insulator, the deterioration in rewriting endurance and the charge-trapping characteristics due to the deterioration of the first insulator does not occur, and highly efficient rewriting (writing and erasing) characteristics and stable charge-trapping characteristics can be achieved.
US08319263B2
The output voltage of an MRAM is increased by means of an Fe(001)/MgO(001)/Fe(001) MTJ device, which is formed by microfabrication of a sample prepared by the following steps. A single-crystalline MgO (001) substrate 11 is prepared. An epitaxial Fe(001) lower electrode (a first electrode) 17 with the thickness of 50 nm is grown on a MgO(001) seed layer 15 at room temperature, followed by annealing under ultrahigh vacuum (2×10−8 Pa) and at 350° C. A MgO(001) barrier layer 21 with the thickness of 2 nm is epitaxially formed on the Fe(001) lower electrode (the first electrode) at room temperature, using a MgO electron-beam evaporation. A Fe(001) upper electrode (a second electrode) with the thickness of 10 nm is then formed on the MgO(001) barrier layer 21 at room temperature. This is successively followed by the deposition of a Co layer 21 with the thickness of 10 nm on the Fe(001) upper electrode (the second electrode) 23. The Co layer 21 is provided so as to increase the coercive force of the upper electrode 23 in order to realize an antiparallel magnetization alignment.
US08319253B2
The device including an active layer composed of AlGaInP, and an n-type clad layer and a p-type clad layer disposed so as to sandwich the active layer, the n-type clad layer and the p-type clad layer each having a bandgap greater than the bandgap of the active layer. The n-type clad layer includes a first n-type clad layer composed of AlGaInP and a second n-type clad layer composed of AlInP; and the second n-type clad layer has a thickness in the range from 40 nm to 200 nm.
US08319252B2
A light emitting device comprises two light-emitting diode (LED) groups, a group of luminophor layers, and an input terminal. The first LED group includes at least one blue LED emitting light having a dominant wavelength in a range between 400 nm and 480 nm, and the second LED group includes at least one red-orange LED emitting light having a dominant wavelength in a range between 610 nm and 630 nm. The group of luminophor layers, which are selected from one of silicates, nitrides, and nitrogen oxides, are positioned above the first LED group and partially converts the light emitted by the first LED group into light having a dominant wavelength in a range between 500 nm and 555 nm. The input terminal is connected to the two LED groups for providing desired electric energy thereto.
US08319230B1
An optoelectronics chip-to-chip interconnects system is provided, including at least one packaged chip to be connected on the printed-circuit-board with at least one other packaged chip, optical-electrical (O-E) conversion mean, waveguide-board, and (PCB). Single to multiple chips interconnects can be interconnected provided using the technique disclosed in this invention. The packaged chip includes semiconductor die and its package based on the ball-grid array or chip-scale-package. The O-E board includes the optoelectronics components and multiple electrical contacts on both sides of the O-E substrate. The waveguide board includes the electrical conductor transferring the signal from O-E board to PCB and the flex optical waveguide easily stackable onto the PCB to guide optical signal from one chip-to-other chip. Alternatively, the electrode can be directly connected to the PCB instead of including in the waveguide board. The chip-to-chip interconnections system is pin-free and compatible with the PCB. The main advantages of this invention are to use the packaged chip for interconnection and the conventional PCB technology can be used for low speed electrical signal connection. Also, the part of the heat from the packaged chip can be transmitted to the PCB through the conductors, so that complex cooling system can be avoided.
US08319189B2
A radiographic imaging assistance device is provided. An acquisition component acquires position information representing positions of defective pixels of an imaging device, the imaging device being plurally provided with pixels comprising detection elements which detect radiation that has passed through a subject of imaging, and the imaging device carrying out imaging by generating image information which represents a radiographic image in accordance with radiation amounts detected by the detection elements and storing the image information in a pre-specified storage region. A judgment component, based on detection region information, which represents a detection region with a size corresponding to the subject of imaging, and the acquired position information, judges whether or not an influence from the defective pixels in a detection region that is represented by the detection region information is within an acceptable level that accepts imaging a radiographic image.
US08319187B2
Disclosed are a system and method counting photons. Photons are counted through a plurality of counters. Each of the counters generates a flag signal indicating the availability of each counter for an output of a photon detector. The generated flag signal is input into a control unit which controls a switching unit. The control unit allows a signal to be input into a counter, which is not in dead time, based on the received flag signal.
US08319177B2
An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.
US08319172B2
An optoelectronic sensor (10) is provided having a transmitter (12) for operating light, a light receiver (14) for the generation of an electrical received signal from incident light and an evaluation unit (16) which can detect an object in the beam path from the transmitter (12) for operating light to the light receiver (14) from the received light, wherein a first alignment light transmitter (13a) is provided. In this respect, a second alignment transmitter (13b) is provided, with the first alignment light transmitter (13a) and the second alignment light transmitter (13b) being able to be individually activated and the evaluation unit (16) being designed to determine alignment information on the adjustment of the sensor (10) from a received first alignment signal of the light receiver (14) with an activated first alignment light transmitter (13a) and from a received second alignment signal of the light receiver (14) with an activated second alignment light transmitter (13b).
US08319171B2
There is provided an optical scanning type photoelectric switch capable of facilitating control of holding a set detection sensitivity, wherein first and second reflection surfaces with different reflection factors are built as reference objects in the optical scanning type photoelectric switch, and arranged in a measurement invalid range in rotation of a scanning mirror, a light projection path, a light reception path, a laser light source LD and a light receiving element, which are used for scanning in the measurement area, are shared, and when a light reception intensity of the white second reflection surface is smaller than a “reference light reception intensity (white)”, a light projection driving section is controlled to increase the light projection intensity.
US08319164B2
A slow rolling projectile comprises a projectile body has a forward section and a rear section and having a longitudinal axis. Two or more canards in the forward section are capable of being extended from and retracted into the projectile body at predetermined frequencies and/or for predetermined times. Two or more tail fins in the rear section are fixed coextensive to or at an angle to the longitudinal axis, and an actuator extends and retracts the canards. The canards are capable of being extended and retracted at a rate based on the rotation of the projectile sufficient to correct for lateral movement. A GPS or INS navigational system activates an actuator to extend and retract the canards.
US08319163B2
A GNC device for use with a projectile, includes a rotating GNC portion and a non-rotating GNC portion, the rotating GNC portion being fixedly coupled to a projectile body, at least one bearing being interposed between the rotating GNC portion and a non-rotating GNC portion, the at least one bearing permitting the rotating GNC portion to rotate with respect to the non-rotating GNC portion. In a GNC device for use with a projectile, a method is further included.
US08319158B2
The present invention relates to a method of manufacturing an electric heating device, comprising a housing in which a heating block is held with the pretensioning force of at least one spring element located approximately at the same level as the heating block in its post assembly position and which defines opposite housing apertures between which the heating block is exposed, wherein the heating block is introduced into a housing part and the heating block is enclosed in the housing by another housing part. The spring element is brought into its assembled position and pretensioned when the housing is being closed to enclose the heating block.
US08319156B2
A vapor cell includes an interrogation cell in a substrate, the interrogation cell having an entrance window and an exit window, and a first transparent thin-film heater in thermal communication with the entrance window. The transparent thin-film heater has a first layer in communication with a first pole contact at a proximal end of the heater and a layer coupler contact at a distal end, a second layer in communication with a second pole contact at the proximal end, and the second layer electrically coupled to the layer coupler contact at the distal end. An insulating layer is sandwiched between the first and second layers. The insulating layer has an opening at the distal end to admit the layer coupler contact and to insulate the remainder of the second layer from the first layer. The first and second pole contacts are available to complete an electric circuit at the proximal end, with magnetic fields for each of the first and second layers oriented in opposing directions when a current is applied through the circuit.
US08319154B2
A self-heating fluid connector comprising a housing in which is provided exothermic phase change material and one or more fluid channels extending from one end of the housing to the other, in thermal communication with the exothermic phase change material, whereby fluid passing through the fluid conduits is heated by the exothermic phase change material. The self-heating connector is particularly suited for use with a fluid container and a fluid delivery port such as a baby's bottle and feeding teat.
US08319143B2
A laser processing apparatus having a holding unit for holding a workpiece to be processed and a processing unit for applying a laser beam to the workpiece held by the holding unit. The processing unit includes an oscillator for oscillating the laser beam, a focusing lens for focusing the laser beam oscillated by the oscillator toward the workpiece, and a focal position adjusting mechanism for adjusting the focal position of the laser beam focused by the focusing lens. The focal position adjusting mechanism includes a movable unit having a permanent magnet and supporting the focusing lens, a fixed portion having a coil for moving the movable unit in a direction perpendicular to the workpiece and a gas bearing for supporting the movable unit by using a gas, and a supporting member for supporting the movable unit from the under side by using a magnetic repulsive action.
US08319133B2
A charging assembly for an electrical switching apparatus includes a cam shaft and including a number of cams. A latch lobe and a charging handle are coupled to opposing ends of the cam shaft. Each stroke of the charging handle pivots the cams a predetermined amount. A rocker arm includes a first portion cooperating with the cams, a second portion translating movement of the cams into movement of a stored energy mechanism, and a third portion cooperating with a close D-shaft having a close latch. A close prop includes a first end cooperating with the close D-shaft, and a second end including a roller that cooperates with the latch lobe. The close D-shaft pivots between latched and unlatched positions. The third portion cooperates with the close D-shaft to hold the close latch in the unlatched position until the charging handle has been pivoted a predetermined number of strokes.
US08319131B2
A device is disclosed for switching an electrical switch on and off, with a drive shaft and an output shaft. The drive shaft and the output shaft run transversely with respect to one another and interact in such that a rotation of the drive shaft entails a rotation of the output shaft, the drive shaft being rotatable between an ON position and an OFF position, and the output shaft being rotatable between a switch-on position and a switch-off position. The output shaft is connected to the switch which can be switched to the switch-on and the switch-off position as a result of the rotation of the output shaft. The drive shaft and the output shaft are connected to one another via a displaceable sliding element which, during the rotation of the drive shaft, is displaced, and the output shaft is rotated by the sliding element in the course of displacement.
US08319130B2
A light emitting key structure is provided. The key structure includes a base, a reflective sheet, a circuit board, an elastic member, a linkage mechanism, and a key cap sequentially disposed one on another in order. The reflective sheet is disposed on the base. The circuit board is made of a light guide material. At least one light source is bonded to a lateral side of the circuit board. The circuit board, together with the light source bonded to the lateral side thereof is disposed on the reflective sheet. The elastic member is directly coupled to the circuit board. The key cap is featured with a light transmission characteristic. Therefore, in operation, the light emitted from the light source can be directly guided into the circuit board, and then outputted from the light transmissive key cap, thus achieving the light emitting effect.
US08319126B2
A dispensing apparatus includes a housing defining a channel, a plunger slidably engaged with an inner surface of the channel, a substrate with one or more passages each having two or more openings, a liquid in each of the one or more passages, at least one fluid, and a force application system. The substrate is disposed in the channel on one side of the plunger. The liquid in each of the one or more passages has a volume which exceeds an internal volume of each the one or more passages and forms a liquid drop around each of the openings. The liquid drops are fluidly connected to one another and each of the liquid drops is individually adjustable between two or more sizes. Each of the sizes and a location of each of the liquid drops define one of two or more switch positions. The fluid is located in the channel on the one side of the plunger and substantially surrounding the liquid drops. The force application system is configured to individually and selectively apply a force on the liquid in each of the one or more passages to control switching between the two or more switch positions of each of the liquid drops. Engaging one or more of the switch positions moves the plunger along the inner surface of the channel away from the substrate.
US08319121B2
A server enclosure includes a bottom wall, two sidewalls extending from opposite sides of the bottom wall, a backboard to electrically connected to a number of hard disk drives, and two fixing elements. The fixing elements are fixed on opposite ends of the backboard. Each fixing element includes a connection board fixed on the backboard, a first fixing portion extending from a bottom of the connection board along a first direction, and a positioning arm extending from a side of the connection board along the first direction. The first fixing portion is fixed on the bottom wall. The positioning arm is slidably positioned on the corresponding sidewall to fix the backboard.
US08319114B2
A dual footprint mounting package for a surface mount power converter modules and its method of manufacture. Castellated regions are formed on the edge of the component package using the appropriate sized drill or milling bit. Edge plating is applied to the castellated surfaces to create edge pads. The edge plating provides electrical continuity between the edge pads and the SMT pads. Solder mask, or other materials, is applied to prevent solder from wicking between each SMT pad and its respective edge pad. Such component may be attached to a larger device PWB using either the edge pads or the SMT pads, or may even be attached using a combination of the two, such as in the event of a pad failure or other defect.
US08319107B2
A circuit board and a heat radiating system of the circuit board. In the circuit board, a plurality of conductive layer regions coated with a conductor are separately formed on both sides of an insulating substrate, the conductive layer region formed on either side of an insulating region on each of the both sides of the insulating substrate, the plurality of the conductive layer regions includes a plurality of through holes which penetrate through the insulating substrate and are coated with a conductor over an inner wall, the conductor in the through hole electrically conducts the coated conductor of the plurality of the conductive layer regions, one of the lead pins is connected to one of the separated conductive layer regions on the both sides based on the insulating region, and the other lead pin is connected to the other conductive layer region. Accordingly, the efficient heat radiation of the circuit board can prevent the component malfunction, the lifespan reduction, the power consumption increase, and the illuminance drop.
US08319084B2
A system, method, and apparatus for learning music through an educational audio track embodied on a computer readable medium are presented. The system can comprise have components including a processor, an input device, a database, a transformation module, an emulation recording module, an integration engine, an output module, and an output device, wherein each component is operable in itself to perform it's function in the system and operable with other system components to provide a system to a user for learning music.
US08319068B2
According to the invention, there is provided seed and plants of the corn variety designated CV951414. The invention thus relates to the plants, seeds and tissue cultures of the variety CV951414, and to methods for producing a corn plant produced by crossing a corn plant of variety CV951414 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV951414 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV951414.
US08319065B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH734952. The invention thus relates to the plants, seeds and tissue cultures of the variety CH734952, and to methods for producing a corn plant produced by crossing a corn plant of variety CH734952 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH734952.
US08319063B2
According to the invention, there is provided seed and plants of the corn variety designated CV493546. The invention thus relates to the plants, seeds and tissue cultures of the variety CV493546, and to methods for producing a corn plant produced by crossing a corn plant of variety CV493546 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV493546 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV493546.
US08319059B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH113132. The invention thus relates to the plants, seeds and tissue cultures of the variety CH113132, and to methods for producing a corn plant produced by crossing a corn plant of variety CH113132 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH113132.
US08319045B1
A novel maize variety designated PHPJA and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHPJA with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHPJA through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PHPJA or a trait conversion of PHPJA with another maize variety. Inbred maize varieties derived from maize variety PHPJA, methods for producing other inbred maize varieties derived from maize variety PHPJA and the inbred maize varieties and their parts derived by the use of those methods.
US08319041B1
A novel soybean variety, designated XBP39008 is provided. Also provided are the seeds of soybean variety XBP39008, cells from soybean variety XBP39008, plants of soybean XBP39008, and plant parts of soybean variety XBP39008. Methods provided include producing a soybean plant by crossing soybean variety XBP39008 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP39008, methods for producing other soybean varieties or plant parts derived from soybean variety XBP39008, and methods of characterizing soybean variety XBP39008. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP39008 are further provided.
US08319040B2
The invention relates to the soybean variety designated A1024255. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024255. Also provided by the invention are tissue cultures of the soybean variety A1024255 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024255 with itself or another soybean variety and plants produced by such methods.
US08319031B2
The invention relates to the soybean variety designated A1016242. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1016242. Also provided by the invention are tissue cultures of the soybean variety A1016242 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1016242 with itself or another soybean variety and plants produced by such methods.
US08319028B2
A soybean cultivar designated S080102 is disclosed. The invention relates to the seeds of soybean cultivar S080102, to the plants of soybean S080102, to plant parts of soybean cultivar S080102, and to methods for producing a soybean plant produced by crossing soybean cultivar S080102 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars, or breeding cultivars, and plant parts derived from soybean variety S080102, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar S080102, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing the cultivar S080102 with another soybean cultivar.
US08319022B2
A soybean cultivar designated 8536465 is disclosed. The invention relates to the seeds of soybean cultivar 8536465, to the plants of soybean 8536465, to plant parts of soybean cultivar 8536465, and to methods for producing a soybean plant produced by crossing soybean cultivar 8536465 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars, or breeding cultivars, and plant parts derived from soybean variety 8536465, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 8536465, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing the cultivar 8536465 with another soybean cultivar.
US08319014B1
A novel maize variety designated X08A201 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08A201 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08A201 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08A201, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08A201. This invention further relates to methods for producing maize varieties derived from maize variety X08A201.
US08319013B2
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH626058. The invention thus relates to the plants, seeds and tissue cultures of the variety CH626058, and to methods for producing a corn plant produced by crossing a corn plant of variety CH626058 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH626058.
US08319007B2
Disclosed herein are an α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse of the present invention may be usefully used for development of therapeutic agents for essential tremor because the mouse exhibits essential tremor strong and evident enough to be visually confirmed, compared to an α1 knockout mouse.
US08319004B2
An aid is usable with a wearer's garment, the aid including a structural layer having a skin-facing side, wherein the structural layer is adapted to be positioned within the garment such that the skin-facing side is in at least partial skin contact with the wearer; and a thermal grill disposed on the structural layer. Also, an absorbent article delivers discomfort without causing physiological damage, the article including a bodyside liner; a plurality of warm portions disposed on the bodyside liner; and a plurality of cool portions disposed on the bodyside liner, wherein the warm portions and cool portions are disposed in an alternating pattern.
US08319003B2
An adhesive wafer for an ostomy faceplate or wound dressing comprising a backing layer, said backing layer having one surface facing the skin, said surface comprising a first and a second adhesive zone being separated from each others by a void volume, said void volume being defined by the backing layer, the first and the second adhesive zones and the skin surface and wherein the first and the second adhesive zones are capable of moving independently of each others with respect to the lateral plane of the backing layer.
US08318985B2
The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensively on an industrial scale. The method comprises the following stepsa) catalytic hydrogenation of neral and/or geranial to give citronellal,b) cyclization of citronellal to isopulegol in the presence of an acidic catalyst,c) purification of isopulegol by crystallization andd) catalytic hydrogenation of isopulegol to give menthol.
US08318984B2
This invention provides a method of producing cyathin A3 in a culture of Cyathus helenae. It employs added bacteria to stimulate production of cyathin A3.
US08318981B2
There is provided a compound having an excellent controlling effect on arthropod pests represented by the formula (I-1): wherein Z represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; G represents a -A1-R1 group, etc.; X represents a -A2-R4 group, etc.; X represents a -A2-R4 group, etc.; X0 represents a -A3-R6 group, etc.; or X and X0 are optionally taken together to form a -A2-T0-A3- group; M1 represents a —R8 group, etc.; A1, A2 and A3 independently represent an oxygen atom, etc.; R1 and R8 independently represents an optionally substituted C1-C20 chain hydrocarbon group, etc.; R4 and R6 independently represent an optionally substituted C1-C6 chain hydrocarbon group, etc.; and T0 represents an optionally substituted C2-C6 alkanediyl group.
US08318980B2
The invention relates to new, highly efficient UV-absorbing compounds, a process for their manufacturing and to uses of these UV-absorbing compounds. The UV-absorbing compounds are in particular UV-A-absorbing compounds according to Formula (VI) or (VII): R2CH2—N(R17)—(CR12)m—N(R17)—CH2R2 (VI) N{(R17)3-n[(CR12)m-N(R17)—CH2R2]n} (VII).
US08318979B2
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
US08318968B2
Process for preparing an alkenylphosphonic acid derivative by reacting a phosphonic acid derivative with an alkyne in the presence of a complex catalyst system and a base whose conjugate acid has a pKa in dimethyl sulfoxide (25° C., 1 bar) of at least 6.
US08318964B2
ProblemTo provide an environmentally-friendly method for producing industrially an ester compound.SolutionThe present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.
US08318953B2
Chemically reactive 7-hydroxycoumarin derivatives and their application for analyzing cell function, for example in combination with additional fluorescent labels. The coumarin derivatives exhibit a strong absorption at 405 nm and high fluorescence quantum yields.
US08318948B2
Disclosed is a novel fluorene derivative and an organic electronic device using the same. The organic electronic device has excellent efficiency, driving voltage, and a lifespan.
US08318945B2
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
US08318936B2
Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): wherein X− represents an anion other than the bromide anion, and R represents hydrogen or a leaving group, is dissolved or dispersed in a suitable polar solvent, the solution or dispersion is mixed with a compound containing bromide anions, and the resulting reaction mixture is stirred until N-methylnaltrexone bromide has formed and crystallized, wherein, in the case where R represents a leaving group, that group is removed during or after the reaction.
US08318932B2
A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
US08318931B2
The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
US08318927B2
6-(4-Cyclopropylpiperazin-1-yl)-2′-methyl-[3,4′]bipyridinyl and salts and hydrates thereof interact with the histamine H3 receptor are defined.
US08318922B2
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are disclosed. One aspect provides an antisense oligonucleotide that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication-initiation gene. By administering a therapeutically effective amount of an antisense oligonucleotide or by contacting the hyperproliferating cells with an effective amount of one or more antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also disclosed.
US08318921B2
The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some embodiments, a method of silencing a target gene is provided. The method comprises providing an initiator to a cell comprising a detection target and a silencing target gene, wherein the detection target is different from the silencing target gene; providing a first substrate monomer to the cell, wherein the first substrate monomer comprises a silencing target complement region that is substantially complementary to a portion of the silencing target gene, and an initiator complement region that is substantially complementary to a portion of the initiator; and providing a second substrate monomer to the cell, wherein the second substrate monomer comprises a silencing target region that is substantially complementary to the silencing target complement region; wherein binding of the detection target to the initiator initiates formation of an inactivator double-stranded RNA (inactivator dsRNA) which silences the silencing target gene.
US08318919B2
Disclosed herein are methods of destabilizing double-stranded nucleic acid hybridization using an enzyme comprising DNA N-glycosylase activity. Also disclosed herein is the detection of a double-stranded target DNA wherein the hybridization of duplex strands has been at least partially disrupted thereby permitting invasion of a probe strand. Also disclosed herein are methods of using an enzyme comprising DNA N-glycosylase activity to generate single-stranded circular nucleic acids.
US08318917B2
The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.
US08318909B2
Based on the discovery of the nucleotide and amino acid differences which distinguish the Gova and Govb allelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Gova allelic form has Tyr at amino acid position 703 in the CD109 sequence. The Govb allelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Gova allele to C for the Govb allele, in the CD109 gene.
US08318904B2
The present invention is directed to liquid, aqueous pharmaceutical compositions stabilized against chemical and/or physical degradation containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising at least 0.01 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; and at least one stabilizing agent (iii) comprising a —C(═N—Z1—R1)—NH—Z2—R2 motif, e.g. benzamidine compounds and guanidine compounds such as arginine.
US08318903B2
A benign solvent for dissolving proteins comprises alcohol, salt and water. The ratio by volume of water to alcohol is between about ninety-nine-to-one and about one-to-ninety-nine. A salt concentration is between near zero moles per liter and the maximum salt concentration soluble in water. The amount of protein by weight as compared to the mixture of water and alcohol is between near zero percent and about 25 percent. A method for forming a protein structure from a benign solvent comprises forming a benign solvent from water, alcohol, and salt; and dissolving a protein in the benign solvent to form a protein solution. The method further comprises extracting the protein from the protein solution; and arranging the protein into a protein structure.
US08318892B2
A capped structured organic film comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.
US08318891B2
A copolycarbonate-polyester, comprising units of formula wherein at least 60 percent of the total number of R1 groups are divalent aromatic organic radicals and the balance thereof are divalent aliphatic or alicyclic radicals; units of formula wherein T is a C7-20 divalent alkyl aromatic radical or a C6-20 divalent aromatic radical, and D is a divalent C6-20 aromatic radical; and units of the formula wherein R2 and R3 are each independently a halogen or a C1-6 alkyl group, R4 is a methyl or phenyl group, each c is independently 0 to 4, and T is as described above. A method of making a copolycarbonate-polyester is also disclosed.
US08318883B1
A polymer having a density of from about 0.960 g/cc to about 0.965 g/cc and a melt index of from about 0.2 g/10 min. to about 0.6 g/10 min. wherein an article formed from the polymer has an environmental stress crack resistance of equal to or greater than about 150 hours when measured in accordance with ASTM D 1693 condition B, 100% Igepal. A polymer having a density of from about 0.955 g/cc to about 0.960 g/cc and a melt index of from about 0.2 g/10 min. to about 0.6 g/10 min. wherein an article formed from the polymer has an environmental stress crack resistance of equal to or greater than about 500 hours when measured in accordance with ASTM D 1693 condition B, 100% Igepal.
US08318869B2
A composition useful for imparting durable stain repellence and soil release properties to textile substrates, a method for treating textile substrates using such composition, and the textile substrates obtained therefrom. The composition comprises: (A) at least one fluorinated ionisable polyurethane polymer (PUR) being free from perfluoroalkyl chains and comprising at least one fluorinated block comprising a fluoropolyoxyalkene chain, and at least one functional block comprising an hydrocarbon chain (RHC) having from 2 to 14 carbon atoms, said chain (RHC) comprising at least one ionisable group, said blocks being linked by urethane moieties of formula (I), wherein E is a divalent hydrocarbon carbon group; (B) at least one fluorocarbon polymer (F) comprising at least one perfluoroalkyl chain (Rf) linked by one or more ester moiety of formula (II) and/or urethane moiety of formula (III) and/or urea moiety of formula (IV); and (C) at least one crosslinking agent.
US08318847B2
In one embodiment, a plastic composition can comprise: a plastic, a white pigment, and a non-white colorant. The composition can have a whiteness index of greater than or equal to about 50, and a composition yellowness index of less than 10, as measured on a 3 mm thick color chip under D65 illuminant and 2 degree observer. Also disclosed are articles made from the plastic composition.
US08318843B2
Use of thermoplastic molding compositions comprising, as essential components, A) from 29 to 99.95% by weight of a polyester, B) from 0.05 to 2.0% by weight of Na2CO3, K2CO3, NaHCO3, KHCO3, or a mixture of these, based on 100% by weight of A) and B), and also C) from 0 to 70% by weight of further additives, where the total of the % by weight values for A) to C) is 100%, for producing laser-transparent moldings of any type.
US08318841B2
A binder for air drying paint, based on metal oxide-containing nanoparticles with unsaturated organic branches. At least one metal atom of the nanoparticle is chemically bound to an organic branch with at least one unsaturated ethylenic functionality. A process for preparation of the binder.
US08318839B2
The present invention provides a tire puncture sealant which has a reduced viscosity at low temperatures and better injectability at low temperatures while exerting excellent initial sealing performance and storage stability. The present invention also provides a tire puncture sealant which further has better injectability at high temperatures while exerting the seal retention performance. The present invention relates to a tire puncture sealant including: a natural rubber latex; a tackifier; and propylene glycol, wherein the amount of the propylene glycol in 100% by mass of a liquid portion of the puncture sealant is 55% by mass or more, and also relates to a tire puncture sealant including: a natural rubber latex; a tackifier; propylene glycol; and a nonionic surfactant, wherein the nonionic surfactant is a polyoxyalkylene alkyl ether and/or a polyoxyalkylene alkenyl ether.
US08318832B2
The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.
US08318830B2
The present invention provides organometallic latent catalyst compounds, which are suitable as catalysts in polyaddition or polycondensation reactions which are catalysed by a Lewis acid type catalyst, in particular for the crosslinking of a blocked or unblocked isocyanate or isothiocyanate component with a polyol or polythiolto form a polyurethane (PU).
US08318819B2
The disclosure provides a composition as well as a set of compositions and method for producing cellular or foamed or blown fluoropolymers such as perfluoropolymers and other thermoplastics articles allowing for the creation of a lower cost communications cable, conductor separator, conductor support-separator, jacketing, tape, wire insulation and in some cases a conduit tube as individual components or combined configurations that exhibit improved electrical, flammability and optical properties. Specifically, the foamable or blown fluoropolymer such as a perfluoropolymer cellular insulation composition comprises; talc and the selected fluoropolymer such as perfluoropolymers. Compounded pellets or products resulting in cellular or foamable products using these pellets has also been realized by providing the melt combination in the pellets of only talc and a perfluoropolymer.
US08318804B2
Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereo selective nature of the palladium catalyzed transformations.
US08318802B2
This invention relates to a stable epoprostenol composition that can be combined with commercially available IV fluids and can be administered in its reconstituted and/or diluted form under ambient conditions of about 15-30° C. for greater than 24 hours. The composition preferably contains (a) epoprostenol or a salt thereof; (b) a alkalinization agent; and (c) a base, such that when reconstituted or in solution, the solution has a pH>11. Methods for making the lyophilized composition are also disclosed.
US08318797B2
Compositions for treating hair are disclosed. Methods of making and using compositions for treating hair are also disclosed.
US08318794B2
The invention provides method of use of a porphyrin compound as shown below in preparing a medicament for sonodynamic therapy, and a method of sonodynamic therapy using a porphyrin compound. Said therapy comprises administering a porphyrin compound to a patient and applying sonic wave to the patient, wherein each symbol has the meaning as defined in the description.
US08318748B2
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
US08318738B2
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
US08318732B2
The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
US08318726B2
The present invention provides a compound of formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of formula 5a-t.
US08318725B2
The present invention relates to novel aryl indolyl sulfonamide compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein and pharmaceutically acceptable compositions containing them.
US08318719B2
This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-II: wherein, variables Q1, Q2, R, X, Y1, Y2, Y2′, Y3, Y4, Y5, m, and p are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-II and at least one carrier, diluent or excipient.
US08318717B2
The present invention relates to compounds capable of inhibiting binding of the Smac protein to Inhibitors of apoptosis (IAPs). Such compounds are preferably capable of inhibiting IAP and thus may promote apoptosis or sensitize cells for apoptosis. The compounds may be used in the treatment of proliferative diseases, such as cancer.
US08318711B2
The invention relates to the use of 2,5-diacetyl-3a,5,6,6a-tetrahydro-6a-hydroxy-2,3a,5-trimethylfuro[2,3-d]-1,3-dioxole (diacetyl trimer) of the formula in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two or more of the stereoisomers (i) as an odoriferous or aromatic substance, (ii) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (iii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavor, and/or (iv) for masking a bitter flavor. The invention furthermore relates to corresponding aromatic compositions as well as compositions which serve for nutrition, oral hygiene, consumption for pleasure or for oral pharmaceutical use.
US08318710B2
Compositions comprising an LXR activator and retinoic acid and/or a metabolic precursor thereto are useful in reducing the effects of chronoageing and/or photoageing of the skin.
US08318699B2
The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions.
US08318694B2
A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.
US08318690B2
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Hemoglobin (HBF/HBG), in particular, by targeting natural antisense polynucleotides of Hemoglobin (HBF/HBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of HBF/HBG.
US08318689B2
A double-strand oligonucleotide including two complementary oligonucleotide sequences forming a hybrid, each including at one of their 3′ or 5′ ends, one to five unpaired nucleotides forming single-strand ends extending beyond the hybrid, one of the oligonucleotide sequences being substantially complementary to a target sequence belonging to a DNA or RNA molecule to be specifically repressed, the target sequence belonging to a DNA or RNA molecule of a gene coding an angiogenic factor.
US08318686B2
A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.
US08318678B2
The present invention generally features novel cosmetic skin and hair care compositions for enhancing the appearance of eyelashes and eyebrows. Specifically, the topical skin and hair care compositions of the invention contain a concentration of at least one of pentapeptide-17 tetrapeptide-12 that provide for thicker, longer and more voluminous appearing eyelashes and eyebrows. The cosmetic formulations of the invention may further include cosmetically acceptable vehicle(s) and/or other skin and hair conditioning agents.
US08318673B2
An anti-hemorrhage medication pack for administering an anti-hemorrhage drug, in particular for the treatment of hemorrhage caused by trauma in emergency situations comprises an active ingredient selected from the group comprising the 1-24 amino acid sequence of the adrenocorticotropic hormone (ACTH 1-24) and all its fragments and analogues, and analogues of fragments, with agonist activity on the MC4 melanocortin receptors, and all the synthesis agonists, including those with a nonpeptidic structure, of the MC4 melanocortin receptors. An auto-injector (1; 11) includes the drug for automatically injecting a patient with the drug.
US08318671B1
The invention relates to a method for producing biologically active β-NGF from the proform proNGF. After expressing the proform of the β-NGF in a prokaryotic host cell, the recombinant protein is isolated in the form of insoluble inactive aggregates (inclusion bodies). After the solubilization thereof in a strong denaturing agent and the subsequent conversion thereof into the natural conformation, which is determined by the disulfide bridges present in the natural β-NGF, biologically active β-NGF is obtained by subsequently splitting-off the prosequence.
US08318661B2
The present invention relates to the use of plasminogen/plasmin and its derivatives as agents for enhancing host defense against infection or other infectious diseases. The invention also relates to a method for screening of compounds which enhance host defense against infection by evaluating the host defense against bacterial arthritis and spontaneous otitis media in an animal model.
US08318659B2
Peptide-based organic sunscreens, formed by coupling a skin-binding peptide with an organic sunscreen agent, are described. The skin-binding peptide part of the peptide-based organic sunscreen binds strongly to the skin, thus keeping the organic sunscreen agent attached to the skin for long lasting protection. Sunscreen compositions comprising the peptide-based organic sunscreens are also provided.
US08318658B2
This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.
US08318653B2
The present invention relates to amphiphilic water-soluble alkoxylated polyalkyleneimines having an inner polyethylene oxide block comprising 20 to 50 polyethylene oxide units and an outer polypropylene oxide block comprising 10 to 50 polyethylene oxide units and especially to such alkoxylated polyalkyleneimines wherein the ratio of polyethylene oxide units and polypropylene oxide units is proportionally related to the square root of the number of polyalkyleneimine units present in the backbone. The present invention further relates to the use of these alkoxylated polyalkyleneimines as a soil detachment promoting additive to laundry detergents and cleaning compositions and to laundry detergents and cleaning compositions which comprise these alkoxylated mono- or polyalkyleneimines.
US08318648B2
A lubricant base stock is provided. The base stock is a polyether of a plurality of epoxidized olefin monomeric units. The polyether has 30 carbon atoms or more. There is also a process for making a polyether.
US08318638B2
An object of the present invention is to determine novel means of activating plants; more particularly, means of controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C4-C24 ketol fatty acids, in particular, 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid.
US08318632B2
An exhaust gas purification catalyst includes a substrate, and a first catalyst layer formed on the substrate, the first catalyst layer containing palladium and/or platinum and alumina doped with an alkaline-earth metal element. The exhaust gas purification catalyst has a correlation coefficient ρAl,AE given by the following formula of 0.75 or more: ρ Al , AE = C Al , AE σ Al σ AE . ( 1 )
US08318629B2
A catalyzed diesel particulate filter (CDPF) and a method for filtering particulates from diesel engine exhaust are provided, where the catalyzed diesel particulate filter includes a substrate and a catalyst composition, where the catalyst composition contains at least one first component, at least one second component, and at least one third component, where the first component is at least one first component selected from the group consisting of cerium and a lanthanide and mixtures thereof, the at least one second component is selected from the group consisting of cobalt, copper, manganese and mixtures thereof; and the third component comprises strontium, where the first component, the second component, and the third component are in an oxide form after calcination. The catalyst on the catalyzed diesel particulate filter lowers the temperature at which particulates are removed from the CDPF by oxidizing the particulates on the filter. The catalyzed diesel particulate filter may also include a washcoat. Washcoats prepared from colloidal aluminum oxide may have higher surface areas and pore volumes loadings than washcoats containing aluminum oxide prepared from aluminum nitrate.
US08318627B2
This invention relates to catalyst carriers to be used as supports for metal and metal oxide catalyst components of use in a variety of chemical reactions. More specifically, the invention provides a process of formulating a low surface area alpha alumina carrier that is suitable as a support for silver and the use of such catalyst in chemical reactions, especially the epoxidation of ethylene to ethylene oxide. A precursor for a catalyst support comprises an admixture of an alpha alumina and/or a transition alumina; a binder; and either a solid blowing agent which expands, or propels a gas upon the application of sufficient heat, and optionally contains talc and/or water soluble titanium compound.
US08318625B2
A method of scavenging oil from an oil-water mixture includes providing a plurality of functionalized fly ash particles having functionalized surfaces including reactive groups or reactive materials having hydrophobic groups covalently bound to the reactive groups or reactive materials. The oil-water mixture is contacted with the plurality of functionalized fly ash particles. The plurality of functionalized fly ash particles absorb oil from the oil-water mixture to form oil-laden fly ash particles. The oil-laden fly ash particles can be fed into a combustion process to generate heat from oil absorbed thereon, or absorbed oil from the oil-laden fly ash particles can be separated using a desorption process, and the oil recovered after separating.
US08318611B2
Combinatorial plasma enhanced deposition techniques are described, including designating multiple regions of a substrate, providing a precursor to at least a first region of the multiple regions, and providing a plasma to the first region to deposit a first material on the first region formed using the first precursor, wherein the first material is different from a second material formed on a second region of the substrate.
US08318589B2
Embodiments disclosed herein generally relate to a process of depositing a transparent conductive oxide layer over a substrate. The transparent oxide layer is sometimes deposited onto a substrate for later use in a solar cell device. The transparent conductive oxide layer may be deposited by a “cold” sputtering process. In other words, during the sputtering process, a plasma is ignited in the processing chamber which naturally heats the substrate. No additional heat is provided to the substrate during deposition such as from the susceptor. After the transparent conductive oxide layer is deposited, the substrate may be annealed and etched, in either order, to texture the transparent conductive oxide layer. In order to tailor the shape of the texturing, different wet etch chemistries may be utilized. The different etch chemistries may be used to shape the surface of the transparent conductive oxide and the etch rate.
US08318586B2
Two plates, each comprising a thin layer of silicon or silicon oxide at a surface thereof, are bonded by subjecting the thin layer of at least one of the plates to a surface treatment step forming a silicon oxynitride superficial thin film with a thickness of less than 5nm. The thin film is performed with a nitrogen-based plasma generated by an inductively coupled plasma source. Furthermore, a potential difference applied between the plasma and a substrate holder supporting said plate during the surface treatment step is less than 50 V, advantageously less than 15 V and preferably zero. This enables a defect-free bonding interface to be obtained irrespective of a temperature of any heat treatment carried out after a contacting step between the respective thin layers of the two plates.
US08318584B2
The formation of a gap-filling silicon oxide layer with reduced volume fraction of voids is described. The deposition involves the formation of an oxygen-rich less-flowable liner layer before an oxygen-poor more-flowable gapfill layer. However, the liner layer is deposited within the same chamber as the gapfill layer. The liner layer and the gapfill layer may both be formed by combining a radical component with an unexcited silicon-containing precursor (i.e. not directly excited by application of plasma power). The liner layer has more oxygen content than the gapfill layer and deposits more conformally. The deposition rate of the gapfill layer may be increased by the presence of the liner layer. The gapfill layer may contain silicon, oxygen and nitrogen and be converted at elevated temperature to contain more oxygen and less nitrogen. The presence of the gapfill liner provides a source of oxygen underneath the gapfill layer to augment the gas phase oxygen introduced during the conversion.
US08318581B2
Micro-electromechanical system (MEMS) devices and methods of manufacture thereof are disclosed. In one embodiment, a MEMS device includes a semiconductive layer disposed over a substrate. A trench is disposed in the semiconductive layer, the trench with a first sidewall and an opposite second sidewall. A first insulating material layer is disposed over an upper portion of the first sidewall, and a conductive material disposed within the trench. An air gap is disposed between the conductive material and the semiconductive layer.
US08318575B2
In one embodiment a method of forming a compressive polycrystalline semiconductive material layer is disclosed. The method comprises forming a polycrystalline semiconductive seed layer over a substrate and forming a silicon layer by depositing silicon directly on the polycrystalline silicon seed layer under amorphous process conditions at a temperature below 600 C.
US08318568B2
A method for fabricating an FET device characterized as being a tunnel FET (TFET) device is disclosed. The method includes processing a gate-stack, and processing the adjoining source and drain junctions, which are of a first conductivity type. A hardmask is formed covering the gate-stack and the junctions. A tilted angle ion implantation is performed which is received by a first portion of the hardmask, and it is not received by a second portion of the hardmask due to the shadowing of the gate-stack. The implanted portion of the hardmask is removed and one of the junctions is exposed. The junction is etched away, and a new junction, typically in-situ doped to a second conductivity type, is epitaxially grown into its place. A device characterized as being an asymmetrical TFET is also disclosed. The source and drain junctions of the TFET are of different conductivity types, and the TFET also includes spacer formations in a manner that the spacer formation on one side of the gate-stack is thinner than on the other side of the gate-stack.
US08318567B2
The invention provides a method for activating impurity element added to a semiconductor and performing gettering process in shirt time, and a thermal treatment equipment enabling to perform such the heat-treating. The thermal treatment equipment comprises treatment rooms of n pieces (n>2) performing heat-treating, a preparatory heating room, and a cooling room, and heating a substrate using gas heated by heating units of n pieces as a heating source, wherein a gas-supplying unit is connected to a gas charge port of the cooling room, a discharge port of the cooling room is connected to a first gas-heating unit through a heat exchanger, a charge port of an m-th (1≦m≦(n−1)) treatment room is connected to a discharge port of an m-th gas-heating unit, a charge port of an n-th treatment room is connected to a discharge port of an n-th gas-heating unit, a discharge port of the n-th treatment room is connected to the heat exchanger, and discharge port of the heat exchanger is connected to gas charge port of the preparatory heating room.
US08318566B2
Devices and methods for isolating adjacent charge accumulation layers in a semiconductor device are disclosed. In one embodiment, a semiconductor device comprises a bit line formed in a semiconductor substrate, a charge accumulation layer formed on the semiconductor substrate, a word line formed on the charge accumulation layer across the bit line, and a channel region formed in the semiconductor substrate below the word line and between the bit line and its adjacent bit line. For the semiconductor device, the charge accumulation layer is formed above the channel region in a widthwise direction of the word line, and a width of the word line is set to be narrower than a distance between an end of the channel region and a central part of the channel region in a lengthwise direction of the word line.
US08318564B2
In sophisticated transistor elements, integrity of sensitive gate materials may be enhanced while, at the same time, the lateral offset of extension regions may be reduced. To this end, at least a portion of the extension regions may be implanted at an early manufacturing stage, i.e., in the presence of a protective liner material, which may, after forming the extension regions, be patterned into a protective spacer structure used for preserving integrity of the sensitive gate electrode structure.
US08318561B2
According to an aspect of the invention, there is provided a semiconductor device including a plurality of memory cells, comprising a plurality of floating gate electrodes which are formed on a tunnel insulating film formed on a semiconductor substrate and have an upper portion which is narrower in a channel width direction than a lower portion, an interelectrode insulating film formed on the floating gate electrodes, and a control gate electrode which is formed on the interelectrode insulating film formed on the floating gate electrodes and partially buried between the floating gate electrodes opposing each other.
US08318558B2
A semiconductor device and a method for forming the same are disclosed. The semiconductor device includes vertical pillars formed by etching a semiconductor substrate and junction regions which are located among the neighboring vertical pillars and spaced apart from one another in a zigzag pattern. As a result, the semiconductor device easily guarantees an electrical passage between the semiconductor substrate and the vertical pillars, such that it substantially prevents the floating phenomenon from being generated, resulting in the prevention of deterioration of the semiconductor device.
US08318552B2
A process for forming gate structures is described. A web comprises a substrate, a plurality of conductive elements disposed on the substrate, and a conductive anodization bus. The web is moved through an anodization station to form a plurality of gate structures comprising a plurality of gate dielectrics adjacent to a plurality of gate electrodes. A process for forming electronic devices further providing a semiconductor, a source electrode, and a drain electrode is described.
US08318546B2
Thermal management is provided for a device. The device may include a substrate having a mounting area on a first surface of the substrate. The device may also include first thermal vias extending from the mounting area to at least an interior of the substrate. The device may also include at least one thermal plane substantially parallel to the first surface of the substrate, the at least one thermal plane being in thermal contact with at least one of the first thermal vias. The device may also include a heat sink attachment area, and second thermal vias extending from the heat sink attachment area to the interior of the substrate, the at least one thermal plane being in thermal contact with the second thermal vias.
US08318540B2
A method of manufacturing a semiconductor structure. One embodiment produces a substrate having at least two semiconductor chips embedded in a molded body. A layer is applied over at least one main surface of the substrate by using a jet printing process.
US08318539B2
A method of manufacture of an integrated circuit packaging system includes: providing a carrier having a planar surface and a cavity therein, a first barrier between the planar surface and a first interconnect, and a second barrier between the cavity and a second interconnect; providing a substrate; mounting an integrated circuit over the substrate; mounting the carrier to the substrate with the first interconnect and the second interconnect attached to the substrate and with the planar surface over the integrated circuit; forming an encapsulation between the substrate and the carrier covering the integrated circuit, the encapsulation having an encapsulation recess under the planar surface and over the integrated circuit; and removing a portion of the carrier to expose the encapsulation, a portion of the first barrier to form a first contact pad, and a portion of the second barrier to form a second contact pad.
US08318523B2
A thin film transistor, a method of fabricating the same, and an OLED display device having the same. The thin film transistor includes a substrate, a semiconductor layer disposed on the substrate and having a channel region, source and drain regions, and a body contact region, a gate insulating layer disposed on the semiconductor layer to expose the body contact region, a silicon layer disposed on the gate insulating layer and contacting the body contact region exposed by the gate insulating layer, a gate electrode disposed on the silicon layer, an interlayer insulating layer disposed on the gate electrode, and source and drain electrodes disposed on the interlayer insulating layer and electrically connected with the source and drain regions, wherein the body contact region is formed in an edge region of the semiconductor layer.
US08318521B2
A top emission organic light emitting display and a method of manufacturing the same. The organic light emitting display includes a substrate, a plurality of thin film transistors (TFT) on the substrate, a plurality of first electrodes coupled to the plurality of TFTs, auxiliary electrodes having a mesh structure defining areas where the plurality of first electrodes are located, a pixel defining layer on a substantially entire area of the substrate and patterned to expose the first electrodes and the auxiliary electrodes, an organic light emission layer on the substantially entire area of the substrate including the exposed first electrodes and auxiliary electrodes, and second electrodes on the organic light emission layer. Steps are formed at lower parts of the auxiliary electrodes, and the second electrodes are coupled to the auxiliary electrodes through contact regions in which the auxiliary electrodes are exposed due to the steps.
US08318519B2
Systems and methods for fabricating a light emitting diode include forming a multilayer epitaxial structure above a carrier substrate; depositing at least one metal layer above the multilayer epitaxial structure; removing the carrier substrate.
US08318518B2
A light emitting device including a sapphire layer and a light emitting layer formed on the sapphire layer. The sapphire layer has a polygonal sectional shape whose internal angle is an obtuse angle, such as a regular hexagonal shape. Light emitted from the light emitting layer is totally reflected on one side surface of the sapphire layer and next transmitted through another side surface of the sapphire layer.
US08318511B2
A method for manufacturing an MEMS device is provided. The method includes steps of a) providing a first substrate having a concavity located thereon, b) providing a second substrate having a connecting area and an actuating area respectively located thereon, c) forming plural microstructures in the actuating area, d) mounting a conducting element in the connecting area and the actuating area, e) forming an insulating layer on the conducting element and f) connecting the first substrate to the connecting area to form the MEMS device. The concavity contains the plural microstructures.
US08318501B2
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
US08318497B2
The present invention is related to a reversible, parallel and/or multitask cloning method and kit, which improve the cloning of (preferably multiple) genetic element(s) in a nucleic acid construct such as vector or in chromosome of a cell and the rapid and efficient selection of said construct with a correct integration of said genetic element(s) either in vitro or in vivo.
US08318488B1
Provided are assay systems for determining the therapeutic or toxic effect of a putative drug based on assaying its activity in cells which have been differentiated in vitro from stem cells, and induced to display a phenotype that resembles a disease to be treated.
US08318486B2
A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
US08318472B2
An optimized nucleic acid sequence encoding the immunoconjugate VB4-845 is disclosed. Modifications to the original VB4-845 nucleic acid sequence include optimization of the sequences encoding the VH region, VL region, linkers and pseudomonas exotoxin A. The modifications improved the yield of VB4-845 in an Escherichia coli expression system.
US08318461B2
A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product comprising glucose from a pretreated lignocellulosic feedstock and enzymes for use in the process are provided. The process comprises hydrolyzing an aqueous slurry of a pretreated lignocellulosic feedstock with cellulase enzymes, one or more than one β-glucosidase enzyme and a binding agent for binding the β-glucosidase enzyme to fiber solids present in the aqueous slurry. During the hydrolysis, both the cellulase enzyme and β-glucosidase enzyme bind to the fiber solids. The hydrolysis is performed in a solids-retaining hydrolysis reactor so that unhydrolyzed fiber solids and bound enzyme are retained in the reactor longer than the aqueous phase of the slurry.
US08318459B2
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95 % content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
US08318456B2
Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.
US08318447B2
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
US08318445B2
The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sample mixture is done by immunomagnetic separation. Upon introduction of the sample within an imaging chamber, the capture complex (biological target-magnetic capture agent) will be attracted by the magnetic field and will lay on the surface of the chamber in the focal plane of the imaging system.
US08318432B2
Cross-reacting hybridization probe for detecting HIV-1 and HIV-2 nucleic acids. The probe advantageously exhibited uniformly high signal-to-noise ratios when hybridized to HIV-1 and HIV-2 target nucleic acids. The probe can be used, for example, in screening applications for detecting donated blood contaminated with either of the two analytes.
US08318425B2
Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to the Gag proteolytic cleavage site rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.
US08318424B2
The presently disclosed subject matter relates to technology and methods for analyzing the structure of RNA molecules. More particularly, the presently disclosed subject matter is directed to methods of, compositions for, and computer program products for RNA structure analysis through alkoxide-selective 2′-hydroxyl acylation analyzed by primer extension.
US08318421B2
New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more complete screening of blood samples for HCV, and allow HCV genotyping.
US08318413B2
A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from a target tissue using a tissue harvesting device. A kit for collecting and storing samples of the target tissue.
US08318411B2
Method for fabricating an interposer is provided. A substrate is provided having thereon at least a conductive via and at least a flange. The flange is bonded on the substrate and shades a portion of the via. A photoresist layer is formed on the interior surface of the via, on a contact surface of the flange and on an inner surface of the flange opposite to the contact surface. An opening is formed in the photoresist layer to expose a portion of the contact surface of the flange, while the photoresist layer still covers the interior surface of the via and the inner surface of the flange. A plating layer is formed on the exposed contact surface of the flange. The photoresist layer is then removed.
US08318401B2
Disclosed is a photosensitive resin composition, comprising 0.1 to 20 parts by weight of a polygonal oligomeric silsesquioxane derivative, and 5 to 30 parts by weight of a compound generating acid by light, based on 100 parts by weight of a polyamide derivative.
US08318400B2
A method of preparing a toner, including periodically discharging a toner constituent liquid from plural nozzles having the same aperture diameter with a mechanical oscillator, wherein the toner constituent liquid includes: a binder resin, a colorant, and an organic solvent, wherein the binder resin and the colorant are dissolved or dispersed in the organic solvent; forming a droplet of the toner constituent liquid in a gas phase; and solidifying the droplet, wherein the aperture diameter is from 3 to 30 μm, and the binder resin has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) of THF (tetrahydrofuran)-soluble components therein of from 1.5 to 15 in a molecular weight distribution measured by GPC (gel permeation chromatography), and a ½ flow temperature (Tm) of from 114 to 149° C.
US08318392B2
An alignment method is disclosed, in which a distance between a substrate and a photomask is set at a predetermined exposure gap. The photomask is rectangular, and includes a first side, and a second side opposite to the first side. A distance between a midpoint of the first side and the substrate is matched with the exposure gap. The photomask is rotated about, as an axis, a line that connects the midpoint of the first side and a midpoint of the second side to each other, whereby distances between both ends of the first side and the substrate are individually matched with the exposure gap. The photomask is rotated about the first side taken as an axis, whereby a distance between the midpoint of the second side and the substrate is matched with the exposure gap.
US08318390B2
A halftone mask includes shielding parts partially formed on a transparent substrate; a lower portion halftone transmission pattern partially formed between the shielding parts on the transparent substrate; and an upper potion halftone transmission pattern partially formed on the lower portion halftone transmission layer pattern, where the lower portion halftone transmission pattern is partially exposed in a gap between the shielding parts and the upper portion halftone transmission pattern.
US08318377B2
A membrane-electrode junction agent, a proton conducting membrane having a junction layer, a membrane-electrode assembly, a polymer electrolyte fuel cell, and a manufacturing method of the membrane-electrode assembly, which enhance the power generation performance, realize the high fuel barrier property, and are capable of enhancing the joint strength between the membrane and the electrodes, is provided. A membrane-electrode junction agent that joins a proton conducting membrane and electrodes arranged on both surfaces of the proton conducting membrane to each other, the membrane-electrode junction agent including: a cross-linked compound (X) having a silicon-oxygen bond; a polymer material (Y) containing an acid group; and a hydrophilic resin (Z) containing no acid group.
US08318375B2
A cathode for an electrochemical reactor including a diffusion layer and a catalyst layer. The cathode has bimetallic or multimetallic nanoparticles, dispersed in direct contact with the diffusion layer, at least one of the metals being chromium (Cr) wholly or partly in oxidized form. The cathode is fabricated by depositing the bimetallic or multimetallic nanoparticles on the diffusion layer by DLI-MOCVD in the presence of O2.
US08318357B2
Disclosed is a secondary battery with a non-aqueous electrolyte that has excellent cycle characteristics and output characteristics. Also disclosed is a positive electrode active material for a secondary battery with a non-aqueous electrolyte that includes a powder of a volume resistivity of 20 Ω·cm or more and 100 Ω·cm or less when said powder has a bulk density of 3 g/cm3. The use of the lithium nickel composite oxide as a positive electrode active material can provide a secondary battery with a non-aqueous electrolyte that has excellent cycle characteristics and output characteristics.
US08318336B2
A rechargeable battery includes an electrode assembly having positive and negative electrodes and a separator interposed between the positive and negative electrodes. Each of the positive and negative electrodes has an active material coated part and an active material uncoated part. A case receives the electrode assembly, the case being provided with an opening through which the electrode assembly is inserted therein. A cap plate is coupled to the opening. An electrode terminal is coupled to a through-hole formed on the cap plate and protrudes out of the case. A current collector has a flange part with a cross-sectional area greater than the through-hole and a contacting part which connects the current collector to the active material uncoated part.
US08318333B2
A battery pack includes a battery including a battery element covered with a packaging member, a battery protection circuit board, a covering material, and a rippable portion formed in a part of the covering material. The battery element includes a positive electrode and a negative electrode which are spirally wound or stacked through a separator. The covering material collectively covers the battery and the battery protection circuit board. The rippable portion rips open due to a gas generated from the battery in the event of an abnormal condition to form a gas release hole for releasing the gas outside the battery pack.
US08318330B2
A substrate for a magnetic read/write head is disclosed. The substrate can reduce detachment of crystal grains when the substrate is machined. The substrate may be machined when the substrate is cut into strips or a flow path surface recess is formed to produce the magnetic read/write head. The reduced detachment of crystal grains makes the magnetic read/write head more resilient to chipping, which allows the magnetic read/write head to have a lower and more stable flying height that increases recording density.
US08318328B2
An inventive workpiece features on at least parts of its surface a wear resistant hard coating comprising the following composition Al1-a-b-c-dCraXbSicBdZ, where x is at least one element from Nb, Mo, W or Ta; Z is one element or compound from N, C, CN, NO, CO, CNO; and 0.2<=a<=0.5; 0.01<=b<=0.2; 0<=c<=0.1; 0<=d<=0.1. Further a PVD process for depositing such a wear resistant coating is disclosed whereby at least one workpiece is installed in a vacuum coating system and said system is operated in a low pressure argon atmosphere utilizing at least two metal or metal alloy targets with at least temporarily addition of a reactive gas.
US08318288B2
An optical element includes a top layer which is transmissive for EUV radiation with wavelength λ in the range of 5-20 nm, and a structure of the top layer is a structure having an rms roughness value equal to or larger than λ/10 for spatial periods equal to or smaller than λ/2. The structure promotes transmission through the top layer to the optical element.
US08318285B1
An article for absorbing fluids that includes a backing sheet and an absorption sheet, wherein the absorption sheet is made of a material that is capable of absorbing any oil based liquid, and wherein the backing sheet is at least partly affixed to the absorption sheet; at least one first fastener means, wherein the first fastener means includes an attachment means on the bottom side and a mating attachment means on the top side, and wherein the bottom side of the first fastener means is at least partly affixed to a top side of the absorption sheet; and one or more malleable strips positioned along at least a portion of a length of the article.
US08318280B2
A compressed and re-expandable soft foam sealing tape, which is provided on one side with a self-adhesive layer covered by a cover film, and rolled up into a roll, is provided. A flexible film strip is inserted between the adhesive surface and the cover film at least along its edge on one side of the sealing tape roll and is adhered to the adhesive surface. The remaining film strip is folded over the sealing tape roll and inserted between the soft foam layer, to which the portion of the film strip has been adhered, and the cover film adhering to the adjacent soft foam layer.
US08318277B2
A plastic fuel tank is disclosed including polyethylene layers laminated respectively onto an upper surface and a lower surface of an ethylene/vinyl alcohol layer for preventing fuel seepage. The outermost polyethylene layer laminated onto the upper surface is a high-density polyethylene layer colored black so as to minimize transmission of ultraviolet light.
US08318272B1
A system and method by which new or recycled paper is rolled and assembled to form artwork is herein disclosed. The art form comprises a plurality of pre-rolled or flat pieces of paper that are rolled and formed into tubes. These tubes are then taped to hold them together, and if desired, folded inwardly at end portions for aesthetic purposes. Next, the tubes are arranged in a two-layer matrix forming an initial panel and secured using plastic wire ties. The panels are then layered and joined using the wire ties to form various finished designs. When completed, the art assembly comprises various abstract pieces of art being flat, non-flat, three-dimensional, or the like, that can be hung on a wall, stood upon a floor, or suspended from a ceiling. It is envisioned that the art form may be provided using recycled paper from catalogues and magazines to provide lively colors and brightly colored pattern that is also ecologically friendly. It is envisioned that the art form is to be sold in a kit format with the paper in a flat form to be rolled by the final user. The kit would be packaged with a suitable number of wire ties, common adhesive tape, and instructions for producing one (1) or more pieces of artwork.
US08318267B2
An object to be processed which has silicon on its surface is loaded in a processing chamber. A plasma of a processing gas containing oxygen gas and nitrogen gas is generated in the processing chamber. The silicon on the surface of the object to be processed is oxidized by the plasma, thereby forming a silicon oxide film.
US08318266B2
A method for depositing a refractory metal nitride barrier layer having a thickness of about 20 angstroms or less is provided. In one aspect, the refractory metal nitride layer is formed by introducing a pulse of a metal-containing compound followed by a pulse of a nitrogen-containing compound. The refractory metal nitride barrier layer provides adequate barrier properties and allows the grain growth of the first metal layer to continue across the barrier layer into the second metal layer thereby enhancing the electrical performance of the interconnect.
US08318261B2
The disclosure provides a method of producing thermally sprayed Al2O3 coatings having a high content of corundum without any property-reducing additives. The coatings may be utilized particularly in the field of electrical insulation, as a dielectric, and as protection from wear. The thermally sprayed Al2O3 coatings have a porosity of no more than 19%, and a high content of α-Al2O3 (content of corundum) of at least 72% by volume. The coatings have a specific electrical resistance of >1·1012 Ohms·cm, and a purity of >97%. The production of said coatings is carried out utilizing aqueous or alcoholic suspensions made from substantially pure α-Al2O3, having a grain size of >100 nm by thermal spraying.
US08318257B2
Dispersions and methods for forming dispersions that include a higher crystallinity polyolefin and at least one dispersing agent are disclosed. Various applications for use of the dispersions are also disclosed.
US08318254B2
A copolymer deposited with particles of catalytic metal is disclosed in the present invention, which is formed from an ethylenically unsaturated monomer and a hydrophilic monomer, and the catalytic metal is Au, Ag, Pd, Pt or Ru. The copolymer is hydrophilic when the temperature is lower than a specific temperature, and will become hydrophobic when the temperature is greater than the specific temperature. The present invention also discloses a method for forming a metal layer on a substrate via electroless plating, which includes contacting the substrate with an ink composition, drying the ink composition on the substrate, and contacting the dried ink composition with an electroless plating solution, wherein the ink composition contains the copolymer of the present invention in an aqueous phase. The present invention further discloses a method for forming metal conductors in through holes of a substrate.
US08318247B2
The present invention includes: a first step of discharging a coating solution from a nozzle to a center portion of the substrate to apply the coating solution on a surface of the substrate while rotating the substrate; a second step of decelerating, after the first step, the rotation of the substrate and continuously rotating the substrate; and a third step of accelerating, after the second step, the rotation of the substrate to dry the coating solution on the substrate, wherein: the substrate is rotated at a fixed speed of a first speed immediately before the first step; and in the first step, the rotation of the substrate which is at the first speed before start of the first step is gradually accelerated after the start of the first step so as to make the speed continuously change, and the acceleration of the rotation of the substrate is gradually decreased so as to make the speed of the rotation of the substrate converge in a second speed higher than the first speed at end of the first step.
US08318243B2
Disclosed is a method for manufacturing an optical information recording medium. The method includes laminating plural layers successively on a substrate having a through-hole at its center; and fitting center caps each having a predetermined radius in the through-hole to form at least two of the plural layers by a spin coat method. A radius of a first center cap used for forming an upper layer of the at least two layers is larger than a radius of a second center cap used for forming a lower layer thereof.
US08318242B2
A method in one embodiment includes applying an organic coating to a magnetic head for reducing exposure of the head to oxidation promoting materials; and storing the magnetic head. A method in another embodiment includes applying an organic coating to a magnetic head for reducing exposure of the head to oxidation promoting materials, the organic coating being applied to the magnetic head after the head is installed in the magnetic storage system. Another method includes fabricating a tape having an applicator portion for applying an organic coating to a magnetic head for reducing exposure of the head to oxidation promoting materials; applying the organic coating to the applicator portion of the tape; and applying a lubricant to a data portion of the tape. A method in another embodiment includes fabricating a tape having a data portion, and a cleaning portion for removing an organic coating from a magnetic head.
US08318239B2
The embodiments of the present invention provide a defect detection process and apparatus to detect defects in solar cell structures. During the process, an input signal from a signal source is applied to a top surface of a transparent conductive layer of a solar cell structure. In response to the input signal, an output signal is generated from a predetermined area of the top surface and detected by a defect detector. The output signal carrying the defect position information is transmitted to a computer and registered in a database. With the position information, an injector is driven to the defect location to apply an insulator to passivate the defect. A finger pattern layer may be formed over the predetermined area after completing the defect detection and passivation processes.