US08513715B2
According to an embodiment, the present invention provides a semiconductor device that is easily integrated with other electronic circuits and functions as an oscillator with high frequency accuracy. The semiconductor device includes: a semiconductor substrate; an element region; an element isolation region that surrounds the element region; a field effect transistor including a gate electrode that is formed on the element region, source and drain regions, and a channel region that is interposed between the source region and the drain region; gate, source, and drain terminals that are used to apply a voltage to the gate electrode, the source region, and the drain region, respectively; and an output terminal that is electrically connected to the channel region. When the threshold voltage of the field effect transistor is Vth, a gate voltage Vgs applied between the source terminal and the gate terminal and a drain voltage Vds applied between the source terminal and the drain terminal satisfy the following relationship: Vth
US08513712B2
The present disclosure provides an apparatus and method for fabricating a semiconductor gate. The apparatus includes, a substrate having an active region and a dielectric region that forms an interface with the active region; a gate electrode located above a portion of the active region and a portion of the dielectric region; and a dielectric material disposed within the gate electrode, the dielectric material being disposed near the interface between the active region and the dielectric region. The method includes, providing a substrate having an active region and a dielectric region that forms an interface with the active region; forming a gate electrode over the substrate, the gate electrode having an opening near a region of the gate electrode that is above the interface; and filling the opening with a dielectric material.
US08513708B2
The present invention provides an integrated circuit suitable for various packaging modes. This integrated circuit includes: a core circuit, a plurality of pads, and a selection circuit. The selection circuit is coupled between the core circuit and the pads for determining the connection state between the core circuit and the pads based on a control signal. When the control signal provides a first value, the core circuit and the pads will be in a first connection state, and the integrated circuit will be applied with a single-die package. However, when the control signal provides a second value, the core circuit and the pads will be in the second connection state, and the integrated circuit will be applied with a multi-die package.
US08513703B2
The Si substrate of a group III-N HEMT is formed in layers that define a p-n junction which electrically isolates an upper region of the Si substrate from a lower region of the Si substrate. As a result, the upper region of the Si substrate can electrically float, thereby obtaining a full buffer breakdown voltage, while the lower region of the Si substrate can be attached to a package by way of a conductive epoxy, thereby significantly improving the thermal conductivity of the group III-N HEMT and minimizing undesirable floating-voltage regions.
US08513693B2
A package for a light source is disclosed. In particular, a Plastic Leaded Chip Carrier (PLCC) is described which provides many features offered by traditional surface mount technology lamps, but also has a decreased height, increased light output, and enables a smaller viewing angle as compared to traditional surface mount technology lamps.
US08513685B2
Electrically pixelated luminescent devices incorporating optical elements, methods for forming electrically pixelated luminescent devices incorporating optical elements, and systems including electrically pixelated luminescent devices incorporating optical elements are described.
US08513681B2
A light emitting device including a second conductive type semiconductor layer; an active layer over the second conductive type semiconductor layer; a first conductive type semiconductor layer over the active layer; a second electrode in a first region under the second conductive type semiconductor layer; a current blocking layer including a metal; and a first electrode over the first conductive type semiconductor layer. Further, the first electrode has at least one portion that vertically overlaps the current blocking layer.
US08513678B2
A light-emitting device includes a pixel having a transistor provided over a substrate, and a light-emitting element. The transistor includes a single-crystal semiconductor layer which forms a channel formation region, a silicon oxide layer is provided between the substrate and the single-crystal semiconductor layer, a source or a drain of the transistor is electrically connected to an electrode of the light-emitting element, and the transistor is operated in a saturation region when the light-emitting element emits light. Further, in the light-emitting device, a gray scale of the light-emitting element is displayed by changing a potential applied to the gate of the transistor.
US08513677B2
A thin film transistor substrate for a liquid crystal display device includes a substrate, a metal layer on the substrate, and an aluminum complex oxide layer on the metal layer. The aluminum complex oxide layer comprises at least one selected from the group consisting of zirconium, tungsten, chromium and molybdenum. A passivation layer is formed on the aluminum complex oxide layer through a dipping process.
US08513674B2
A method of manufacturing of a semiconductor device (101) includes: a fine pattern forming step of forming p-type impurity regions (3, 4) and surface ohmic contact electrodes (5) using a stepper, after forming an N-type epitaxial layer (2) on a SiC single-crystal substrate (1); a protective film planarizing step of forming a protective film so as to cover the surface ohmic contact electrodes (5) and performing planarization of the protective film; a substrate thinning step of thinning the SiC single-crystal substrate (1); a backside ohmic contact electrode forming step of forming a backside ohmic contact electrode (7) on the SiC single-crystal substrate (1); a surface Schottky contact electrode forming step of forming a Schottky metal portion (8) connected to the p-type impurity regions (3, 4) and the surface ohmic contact electrodes (5); and a step of forming a surface pad electrode (9) that covers the Schottky metal portion (8).
US08513671B2
A display device with the substrate divided into three areas. A semiconductor layer is formed in the first second areas and includes a channel area and source/drain areas; a gate insulating layer formed on the semiconductor layer in an area corresponding to the channel area; and a gate electrode formed on the gate insulating layer. The source/drain electrodes contact the source/drain areas, respectively; a pixel electrode is formed in the same layer but in a third area; an interlayer insulating layer is formed on a whole surface of the substrate including the formed structures; and a gate line is formed on the interlayer insulating layer and is electrically connected to a gate electrode of the first area through a via contact hole of the interlayer insulating layer.
US08513656B2
According to one embodiment, an organic EL device includes a first organic EL element, a second organic EL element and a third organic EL element. The first organic EL element has a first electrode, a second electrode, and a first emitting layer. The second organic EL element has a third electrode, a fourth electrode, and a second emitting layer. At least a part of the first emitting layer extends on the second emitting layer. A third organic EL element has a fifth electrode, a sixth electrode, and a third emitting layer. At least a part of the first and the second emitting layers extends on the third emitting layer. A thickness of the first emitting layer between the first and the second electrodes is thicker than a thickness of the first emitting layer extending on the second and the third emitting layers.
US08513655B2
An organic light emitting diode (OLED) and a method for manufacturing the same are provided. In the OLED, patterned metal electrodes are positioned on one or more of upper and lower portions of a light emission layer to allow light generated from the light emission layer to emit to an area between the patterned metal electrodes.
US08513650B2
A dielectric layer for an electronic device, such as a thin-film transistor, is provided. The dielectric layer comprises a molecular glass. The resulting dielectric layer is very thin, pure, and stable. Processes and compositions for fabricating such a dielectric layer are also disclosed.
US08513647B1
A quantum computational (QC) device includes a multi-qubit (MQ) structure and another MQ structure coupled to the MQ structure. The MQ structure is arranged to provide an adiabatic quantum computation by application of an initial Hamiltonian operator. The other MQ structure is arranged to provide another adiabatic quantum computation by application of another Hamiltonian operator that is spatially different than the initial Hamiltonian operator.
US08513637B2
Arrays of memory cells are described along with devices thereof and method for manufacturing. Memory cells described herein include memory elements comprising programmable resistive material and self-aligned bottom electrodes. In preferred embodiments the area of the memory cell is 4F2, F being the feature size for a lithographic process used to manufacture the memory cell, and more preferably F being equal to a minimum feature size. Arrays of memory cells described herein include memory cells arranged in a cross point array, the array having a plurality of word lines and source lines arranged in parallel in a first direction and having a plurality of bit lines arranged in parallel in a second direction perpendicular to the first direction.
US08513636B2
A steering device. The steering device includes an n-type impurity region comprising a zinc oxide material and a p-type impurity region comprising a silicon germanium material. A pn junction region formed from the zinc oxide material and the silicon germanium material. The steering device is a serially coupled to a resistive switching device to provide rectification for the resistive switching device to form a non-volatile memory device.
US08513631B2
A light processing apparatus irradiates an ultra violet light through a square or a rectangular light transmitting window onto a work piece that has a square or rectangular pattern formation portion. The apparatus includes a light emitting unit that comprises a casing, an ultraviolet irradiance lamp arranged inside the casing and the light transmitting window member provided in one face of the casing. One side of the light transmitting window and one side of the pattern formation portion are not parallel to each other.
US08513613B2
The invention relates to a radiation detector (100), particularly for X-rays (X) and for γ-rays, which comprises a combination of (a) at least one primary conversion layer (101a-101f) with a low attenuation coefficient for the photons and (b) at least one secondary conversion layer (102) with a high attenuation coefficient for the photons. In preferred embodiments, the primary conversion layer (101a-101f) may be realized by a silicon layer coupled to associated energy-resolving counting electronics (111a-111f, 121). The secondary conversion layer (102) may be realized for example by CZT or GOS coupled to energy-resolving counting electronics or integrating electronics. Using primary conversion layers with low stopping power allows to build a stacked radiation detector (100) for spectral CT in which the counting rates of the layers are limited to feasible values without requiring unrealistic thin layers.
US08513610B2
Provided is a detector module for measuring one or more types of radiation, in particular X-ray, gamma ray, or nuclear particle radiation, comprising a detection unit, an analog-to-digital converter, an information processing device, and a memory device for storing the position of the detector module. The detector module comprises at least one light-emitting diode (LED), optically connected with the detection unit for stabilizing the detector unit. Further, the invention provides a stanchion, in particular a portable stanchion, whereby the stanchion comprises a inventive detector module. Yet further, a (wireless) network of detector modules is provided, whereby each detector module is mounted within a stanchion.
US08513608B2
The coating film inspection apparatus according to one embodiment of the present invention comprises a terahertz-wave generator that generates a terahertz-wave; an irradiation optical system that irradiates, with the terahertz-wave, a sample with a film formed thereon; a terahertz-wave detector that detects a terahertz-wave reflected at the sample; and a control unit that shows an electric field intensity of the detected terahertz-wave in wave form data on a time axis to detect a plurality of peaks from the wave form data, and also calculates film thickness on the basis of time difference between peaks.
US08513599B2
Charged droplets are guided along a defined path from a droplet source to a droplet sink. A focusing pseudopotential distribution generated by audio frequencies on electrodes of a guiding device guide the charged droplets from the droplet source to the droplet sink with low loss. The droplets can be driven along the droplet guide by a gas flow, an axial electric field or a combination of both. For example, charged droplets from a spray capillary of an electrospray ion source at atmospheric pressure may be introduced into the inlet capillary leading to the vacuum system of ion analyzers, a procedure similar to that used up to now in nanoelectrospraying, but with substantially higher flow rates. In the guiding device, the droplets can be manipulated in different ways, for example evaporated down to a desired size. The introduction of small droplets into gas-aspirating capillaries is of interest because it is possible to keep the droplets on axis by Bernoulli focusing and to guide them in large quantities and with low loss through the capillary. The ability to guide the droplets makes it also possible to install a segmented inlet capillary with intermediate pumping, which allows pumping capacity to be saved. Advantageously, the sensitivity of ion analyzers such as mass spectrometers or ion mobility spectrometers by at least one order of magnitude.
US08513596B2
An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.
US08513591B2
An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. Techniques are disclosed for operating the ion mobility spectrometer to produce highly resolved ion mobility spectra.
US08513589B2
An optical encoder may include an encoder disk, an illumination system, and a detector to detect light diffracted from the encoder disk. The encoder disk may include a signal track comprising a diffraction grating, and an index track comprising a reflective index mark, wherein a width of the index mark is larger than a pitch of the diffraction grating. An indexing method may include providing an encoder disk, providing an illumination system to direct light to the encoder disk, providing a detector structured to detect light diffracted from the encoder disk, calculating an estimated count of quadrature states from a rising edge of an index pulse to a middle of the index interval, and calculating the quadrature state at an approximate center of the index pulse. A dynamic parameter correction method may include calculating a target gain and offset and correcting values based on the target gain and offset.
US08513584B2
Apparatus are provided for use in photovoltaic systems. A photovoltaic array includes a rigid transparent material supporting a flexible material there beneath. Numerous photovoltaic cells are supported by the flexible material and are electrically coupled to circuit pathways borne there on. A positioner operates to shift the flexible material thus adjusting respective angular relationships between the photovoltaic cells and the overlying transparent material. Photovoltaic cells are reoriented in accordance with daily or seasonal variations in the suns position by way of the present teachings.
US08513579B2
A heater assembly for a microwave oven is provided. The heater assembly includes a ceramic heater and a halogen heater that provides heat used to cook food in a cooking chamber provided in a cavity assembly; a heater supporter fixed to a side of the cavity assembly, with the ceramic and halogen heaters fixed to the heater supporter; and a reflection plate provided above the ceramic and halogen heaters to reflect heat of the ceramic and halogen heaters to the cooking chamber, wherein a portion of the reflection plate corresponding to the ceramic heater is open in its longitudinal direction. With this structure, contact between a heating wire of the ceramic heater and the reflection plate is prevented and the heat dissipation of the ceramic and halogen heaters is obtained by means of airflow that is generated by a cooling fan assembly to cool electric parts.
US08513578B2
A processing apparatus using an electromagnetic wave is provided to perform a heat treatment on a target object. The processing apparatus includes a metallic processing chamber; a loading/unloading opening provided in one end of the processing chamber; a closing body capable of closing and opening the loading/unloading opening; a holding unit loaded and unloaded into and from the inside of the processing chamber through the loading/unloading opening, holding target objects at a predetermined interval, the holding unit being made of a material allowing the electromagnetic wave to transmit therethrough; an electromagnetic wave supply unit for introducing the electromagnetic wave into the processing chamber; a gas introducing unit for introducing a gas into the processing chamber; and a gas exhaust unit for exhausting an atmosphere in the processing chamber.
US08513566B2
A laser beam processing machine comprising a laser beam application means for applying a laser beam to a workpiece held on a chuck table and a processing-feed means, wherein the laser beam application means comprises a first pulse laser beam application means and a second pulse laser beam application means; the first pulse laser beam application means comprises an acousto-optic deflection means for deflecting the optical axis of a pulse laser beam oscillated by a first pulse laser beam oscillation means in the processing-feed direction (X direction), and a first condenser lens for converging a pulse laser beam passing through the acousto-optic deflection means; the second pulse laser beam application means comprises a second condenser lens for converging a pulse laser beam oscillated by the second pulse laser beam oscillation means; and an NA value of the first condenser lens is set smaller than the NA value of the second condenser lens.
US08513560B2
A spot welding system including a spot welding gun having a pair of electrodes disposed opposite to each other, and a servo motor for allowing the pair of electrodes to approach each other and separate from each other; a robot for movably holding either a spot welding gun or a workpiece so that a workpiece is disposed between the pair of electrodes of the spot welding gun; a physical quantity detection section for detecting a physical quantity correlative to torque or velocity of the servo motor; a position detection section for detecting positions of the pair of electrodes; a mode switching section for switching, by a switching command, an operation mode of the spot welding system between a spot welding mode for spot-welding the workpiece and a position correction mode for correcting a spot welding position of the workpiece; and a processing section for performing a spot welding process in the spot welding mode and a position correction process in the position correction mode.
US08513557B2
An actuator device including a holder element provided to be fixed against a device operated on by the actuator device. An actuator body is displaceable in a longitudinal direction along the holder element. A guide member is provided so as to guide the actuator body along the holder element. The actuator body includes a first part that is operable from outside the actuator device, and a second part that is movable in the longitudinal direction in relation to the first part. The actuator body is displaceable to a first, non-actuated position, in which the first part and the second part of the body are movable in the longitudinal direction and a second, actuated position, in which the second part is rotationally displaced in relation to the first part and abuts an abutment surface on the holder element such that motion of the second part in the longitudinal direction towards the first position is inhibited. The first part includes a rotational locking member that engages the second part in the second position and locks the second part rotationally in the second position.
US08513552B2
An electrical connector assembly includes a connector, designed to connect to a mating electrical device while maintaining a closed circuit throughout. The electrical device includes conductive contacts. The electrical connector includes an insulating housing with at least a pair of input/output terminals mounted thereon. The terminals include contacts for engaging the electrical device. A switch mechanism, mounted on the housing for movement between connecting and disconnecting positions, includes a latch member and at least one switch terminal. In the connecting position, the latch member engages a latch on the electrical device with the switch terminal out of engagement with the input/output terminals. In the disconnecting position, the latch member disengages from the latch on the electrical device for removal from the assembly with the switch terminal in engagement with the input/output terminals to maintain a closed circuit throughout when the electrical device is removed.
US08513543B1
A cable connector has a hollow housing, an input cap, an output cap, a wire separating base, a cable sealing assembly and a wire sealing assembly. The hollow housing has an input end and an output end. The input cap is mounted on the input end of the housing. The output cap is mounted on the output end of the housing so as to define a sealed space between the housing, the input cap and the output cap to hold the wire separating base, the cable sealing assembly and the wire sealing assembly inside. The wire separating base is mounted in the housing and has a first end and a second end. The cable sealing assembly is connected to the first end of the wire separating base. The wire sealing assembly is connected to the second end of the wire separating base.
US08513541B2
A method of blocking electro-magnetic interference (EMI) in an electric machine having a housing including an interior portion, an opening leading to the interior portion, and an enclosure positioned about the opening, includes positioning an EMI blocking member in the enclosure across the opening. The EMI blocking member includes an insulating layer having a first surface and a second surface. An EMI shield member is positioned on one of the first and second surfaces. The EMI shield member includes a surface formed from an electrically conductive material that substantially covers the one of the first and second surfaces. The EMI shield member is grounded to the housing. The EMI shield member is configured and disposed to block EMI release from the housing via the enclosure.
US08513539B2
A wiring board has a base substrate, a conductive pattern formed on the base substrate, an insulation layer formed on the conductive pattern and the base substrate and including a resin-impregnated inorganic cloth, a conductive pattern formed on the insulating layer, a via formed in the insulation layer and connecting the conductive pattern formed on the base substrate and the conductive pattern formed on the insulating layer, and a through-hole connected to the conductive pattern formed on the base substrate, penetrating through the base substrate and having a hole diameter in a range of 10 μm to 150 μm.
US08513538B2
According to one embodiment, a television apparatus includes a circuit board, a pad, a heat-transfer layer, and a block. The circuit board is mounted with an electronic component. The pad is provided on a surface of the circuit board. The heat-transfer layer is formed on the inner surface of a through hole in the circuit board. The through hole has an opening on the pad. The block contains a resin material and is located inside the heat-transfer layer to block the through hole.
US08513536B2
An electronic circuit module is mounted on an electronic circuit board. The electronic circuit module includes an electronic component that has a first electrode and a second electrode that form a facing surface. The electronic circuit module also includes a coaxial cable with a core wire and a shielded wire being exposed in stages. The core wire and the shielded wire of the coaxial cable are directly connected to the first electrode and the second electrode that are exposed at a predetermined cable connecting surface of the electronic component.
US08513533B2
A multilayer stacked circuit arrangement with localized separation section, has a first flat cable and first signal transmission lines arranged on the first flat cable. A second flat cable is stacked on and bonded to the first flat cable. The second flat cable further has signal transmission lines arranged on it. A bonding substance layer is formed between a first non-separation section of the first flat cable and a second non-separation section of the second flat cable for properly stacking the first and second flat cables where the separation sections are spaced apart from each other. A conductive via extends between the first non-separation section and the second non-separation section. At least some of the second signal transmission lines of the second flat cable are connected through the conductive via to the first signal transmission lines of the first flat cable.
US08513528B2
A cable interconnection structure includes a sheet-metal member including a wall which is bent from and substantially normal to a plate-like base and extends along an end side of the base, and an opening including a first opening region provided in the base and a second opening region provided in the wall in a boundary region between the base and the wall; and a support member blocking a portion of the first opening region and supporting the sheet-metal member, wherein the sheet-metal member is slidable from a first position to a second position on the first surface, the support member includes a cutout, and the sheet-metal member includes a tongue which overlaps with the cutout and presses the support member to the sheet metal member, when the sheet-metal member is located at the second position.
US08513527B2
A superconducting circuit including a superconducting joint that joints a niobium titanium superconducting wire having a structure where a filament made of niobium titanium alloy is arranged in a matrix made of copper or copper alloy and other superconducting wire, in which a volume ratio or a surface density of an α-Ti precipitation in the niobium titanium alloy of the filament in the superconducting joint is smaller than the volume ratio or the surface density of the α-Ti precipitation in the niobium titanium alloy of the filament in the niobium titanium superconducting wire in a portion other than the superconducting joint.
US08513526B2
A wiring harness 1 includes: an electric wire 2; and a connector 3. The electric wire 2 includes: a conductive core wire 21; and an insulating cover 22 for covering the core wire 21. The connector 3 is attached to an end 2a of the electric wire 2, and receives the end 2a of the electric wire 2. A first marker 6 and a second marker 7 are formed on an outer surface 22a of the cover 22 of the electric wire 2. The first marker 6 is formed by coloring a part of the outer surface 22a of the cover 22 of the electric wire 2 received in the connector 3 in a color A. The second marker 7 is formed by coloring a part of the outer surface 22a of the cover 22 of the electric wire 2 exposed to an outside of the connector 3.
US08513521B2
An electronic device enclosure includes a main enclosure, a cable holding device received in the main enclosure, and a cable which held by the cable holding device in different orientations. A first positioning slot and a second positioning slot are defined in the cable holding device. The cable is guided out of the cable holding device in one or more predetermined directions.
US08513520B2
Disclosed is a dye-sensitized photovoltaic device in which a metal complex dye represented by Formula (1), or a salt thereof, is carried on a thin film of oxide semiconductor micrograins disposed on a substrate. (In Formula (1), m1 represents an integer from 1 to 2 and n1 represents an integer from 1 to 3. X1 represents an oxygen atom or sulfur atom. Y1 and Y2 each independently represent a thiocyanate group (—SCN) or isothiocyanate group (—NCS). M1 and M2 represent hydrogen atoms. R1 and R2 represent hydrogen atoms. R3 and R4 each independently represent a straight-chain alkyl group with 1 to 6 carbons. Further, when m1 is 2 and there are multiple of each of R3 and R4, each of R3 and R4 may be the same as or different from one another.)
US08513514B2
An automated method causes a terrestrial solar cell array to track the sun. The solar cell system includes motors that adjust a position of the array along different respective axes with respect to the sun, wherein a first motor adjusts the inclination angle of the array relative to the surface of the earth and a second motor rotates the array about an axis substantially perpendicular to that surface. The method includes (a) using a software algorithm to predict a position of the sun at a future time; (b) using a computer model to determine respective positions for the motors corresponding to the solar cell array being substantially aligned with the sun at the future time; and (c) activating and operating the motors at respective particular speeds so that at the future time the solar cell array is substantially aligned with the sun. The future time may correspond to any time during operation. An initial future time may correspond to a start up time after sunrise at which point the solar cell is to begin tracking the sun.
US08513505B2
A wheat cultivar, designated WB-196, is disclosed. The invention relates to the seeds, plants, and hybrids of wheat cultivar WB-196, and to methods for producing a wheat plant produced by crossing plants from wheat cultivar WB-196 with themselves or with plants from another wheat variety. The invention also relates to methods for producing a wheat plant containing in its genetic material one or more transgenes and to the transgenic wheat plants and plant parts produced by those methods. The invention also relates to wheat varieties or breeding varieties and plant parts derived from wheat cultivar WB-196, to methods for producing other wheat varieties, lines or plant parts derived from wheat cultivar WB-196, and to the wheat plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid wheat seeds and plants produced by crossing wheat cultivar WB-196 with another wheat cultivar.
US08513501B1
A novel maize variety designated PH13HC and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH13HC with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH13HC through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH13HC or a locus conversion of PH13HC with another maize variety.
US08513495B2
In an embodiment, the invention relates to the seeds, plants, and plant parts of canola line SCV291489 and to methods for producing a canola plant produced by crossing canola line SCV291489 with itself or with another canola line. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola lines or breeding lines and plant parts derived from canola line SCV291489, to methods for producing other canola lines, lines or plant parts derived from canola line SCV291489 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the line SCV291489 with another canola line.
US08513489B2
We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.
US08513486B2
The present invention discloses methods for cell nuclear transfer that comprise for example modification of zona pellucida of an oocyte, and/or sectioning of oocytes into several parts. The present invention also discloses methods for producing a genetically modified non-human mammal. Genetically modified non-human mammals obtainable by the disclosed methods are also within the scope of the present invention. Disclosed are also methods for cryopreservation of cells.
US08513484B2
The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplasic transformation, or that modulate sensitivity to chemotherapy or radiation therapy. Immortal tumor cells lines, methods of making immortal tumor cells lines and methods of their use are also provided.
US08513482B2
The present invention relates to a wound dressing including a first wound pad and a first cover layer covering the first wound pad and extending beyond the first wound pad around the circumference thereof. According to the invention a second wound pad is disposed outside the first cover layer and enclosed in a second cover layer. Furthermore, the first and second wound pads are connected to each other by liquid transferring means.
US08513467B2
Described is a method of making 2,4-diones via acid catalyzed or thermally induced ring-opening of a 4-hydroxy-6-substituted-2-pyrone to yield a 2,4-dione.
US08513466B2
The present invention is directed towards a new class of semi-conducting acene derivatives. These compounds are all soluble species and they all possess superior resistance to photooxidation as compared to their counterparts that lack the substitution patterns disclosed herein.
US08513465B2
Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.
US08513460B2
The invention provides a process for preparing N-(hydrocarbyl)phosphoric or thiophosphoric triamides with substantially improved yields and purity. Two equivalents of hydrocarbylamine are used in the reaction with phosphoryl or thiophosphoryl chloride and then with ammonia in an aromatic solvent. The invention further relates to N-(hydrocarbyl)phosphopric or thiophosphoric triamides having the purity of at least 98% wherein R is a hydrocarbyl group and X is O or S. (RNH)(NH2)2P=X (I).
US08513459B2
Perfluoropolyether carboxylic acid fluoride having the following general formula: F(CF2CF2CF2O)nCF2CF2COF (n: 2-200, preferably 35-70) can be produced by starting fluorination reaction of polyfluoropolyether carboxylic acid having the general formula as a tetrafluorooxetane polymer: F(CH2CF2CF2O)nCH2CF2COF (n: 2-200) in a dispersed state in a perfluoropolyether-based solvent with a fluorine gas at 50°-80° C., then slowly elevating the fluorination reaction temperature, and finally completing the fluorination reaction at 100°-120° C., where even in the case of fluorination reaction of the starting material with a high degree of polymerization the desired product can be produced in high yield, while suppressing the decomposition and keeping the high degree of polymerization substantially.
US08513455B2
The present invention relates to a crystalline oxybutynin base and process for preparing the same. Further, this invention discloses a process for preparing an acid addition salt of oxybutynin employing the crystalline oxybutynin base.
US08513453B2
The invention is directed to a process for preparing aromatic carbamates which comprises the reaction of an aromatic amine with an organic carbonate in the presence of a catalyst characterized in that Zn4O(OAc)6 is used as catalyst.
US08513451B2
Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.
US08513450B2
The invention provides a process for preparing polysilanes of the general formula (1) SinR2n+2 (1), in which silane of the general formula (2) R1mSiH4-m (1a) is converted in the presence of boron compounds of the general formula (3) R23B (3), where R1 is a hydrocarbyl radical having 1 to 18 carbon atoms, R is hydrogen or an R1 radical, R2 is fluorine, chlorine, bromine or a hydrocarbyl radical which has 1 to 18 carbon atoms and may bear substituents selected from fluorine, chlorine, bromine, iodine and NO2, n has integer values from 2 to 100,000, and m is 0, 1 or 2.
US08513439B2
The invention provides a pharmaceutical composition of duloxetine or its pharmaceutically equivalent derivatives like salts, isomers, complexes, polymorphs, hydrates or esters thereof and at least one buffering agent. The duloxetine or its pharmaceutically equivalent derivative is present from about 2 mg to approximately 200 mg; and the buffering agent is present in an amount of approximately 0.1 mEq to approximately 2.5 mEq per mg of duloxetine. Also provided is a method for treating of major depressive disorder and or diabetic peripheral neuropathic pain comprising administering to a mammal in need of such treatment a therapeutically effective amount of a composition.
US08513434B2
This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.
US08513433B2
Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
US08513429B2
The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
US08513419B2
The present invention relates to novel N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
US08513408B2
A low calcium sensitive (calcium stable) high acyl gellan gum is prepared for enhanced colloidal stability in beverages. The low calcium sensitive high acyl gellan gum has superior suspension performance for colloidal stability compared to other high acyl gellan gums. The low calcium sensitive high acyl gellan gum is prepared by adjusting the pH of a gellan fermentation broth (polymer solution) prior to pasteurization and reducing the pasteurization hold time compared to conventional pH levels and hold times.
US08513406B2
The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
US08513405B2
Disclosed are a chaotropic agent; a reagent including a chaotropic agent and a lithium salt; a reagent kit including a chaotropic agent; a chaotropic agent, a reagent, a reagent kit, and a method for isolating a nucleic acid by use of a magnetic cellulose material; a method for binding a nucleic acid to a magnetic cellulose material; a method for isolating a nucleic acid; and a method for purifying a chromosome DNA. It is required that each of the chaotropic agents, the reagents, and the reagent kits works with at least one solid-phase, magnetic cellulose-containing carrier to isolate a nucleic acid from non-nucleic acid substances. In addition, each chaotropic agent includes an alcohol substance and a substrate solution for adjusting the alcohol substance to an appropriate concentration and thereby promoting binding of the nucleic acid in a sample to the magnetic cellulose.
US08513399B2
The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of template DNA and a method for PCR amplification comprising the steps of mixing the composition for PCR amplification comprising the primers with nucleic acid template; and performing PCR with the mixture. The primers for PCR amplification of the present invention contain abasic parts not having specific coding information in their nucleotide sequences, so that they can amplify different templates having mutated sites at the same time.
US08513397B2
Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
US08513388B2
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
US08513379B2
The invention provides a depolymerization method for a polymer containing an ester bond in a main chain, by causing a solid acid catalyst to act on a polymer containing an ester bond in a main chain to depolymerize the polymer, thereby obtaining a re-polymerizable monomer and/or oligomer as a depolymerization product, and a method for producing a polymer containing an ester bond in a main chain, by polymerizing the re-polymerizable monomer and/or oligomer obtained by the depolymerization method.
US08513376B2
The present disclosure provides polyamides and amidoamine curing agents including the reaction product of (1) a modified amine component comprising at least one multifunctional amine of structure 1: wherein R1 is selected from C1-C16 linear, cyclic, and branched alkyl, alkenyl, and alkaryl groups; R2 and R4 are hydrogen, R3 is R1 or hydrogen, X, Y, and Z are independently selected from C2-C10 alkylene, hexylene and cycloalkylene groups, n=0, 1, 2, 3, 4, 5, 6, or 7; and (2) a fatty acid component. Exemplary fatty acid components include at least one of monomer fatty acids, dimer fatty acids, trimer fatty acids, polymer fatty acids, esters of monomer, dimer, trimer, and polymer fatty acids and combinations thereof. The method for making the curing agents and articles formed therefrom are also disclosed.
US08513373B2
A process for the production of non-thermoplastic polyimide film whose precursor solution has high storage stability and which exhibits high adhesiveness even without expensive surface treatment, more specifically, a process for the production of non-thermoplastic polyimide film made of a non-thermoplastic polyimide containing a block resulting from a thermoplastic polyimide which comprises (A) the step of forming a prepolymer having amino or an acid anhydride group at the end in an organic polar solvent (B) the step of synthesizing a polyimide precursor solution by using the obtained prepolymer, an acid anhydride, and a diamine in such a way as to become substantially equimolar over the whole step, and (C) the step of casting a film-forming dope containing the polyimide precursor solution and subjecting the resultant dope to chemical and/or thermal imidization, wherein the diamine and acid dianhydride used in the step (A) are selected so that the reaction of both with each other in equimolar amounts can give a thermoplastic polyimide, and the polyimide precursor obtained in the step (B) is a precursor of a non-thermoplastic polyimide.
US08513372B2
Described herein are photo-patternable sol-gel precursors and their methods of preparation. The sol-gel precursors are thermally stable and form compositions that have high refractive indices and low optical loss values. The precursors can be used to make sol-gel compositions that are ideally suited toward optical waveguide applications in the realm of telecommunications wavelengths.
US08513370B2
A method is described for sealing and assembling, pointing and/or coating a substrate by means of silicon elastomers prepared using silicon compositions that do not contain any metal catalyst such as, for example, tin, and cross-linking by polycondensation reactions in the presence of water (for example, ambient moisture).
US08513367B2
Method of reducing fouling in an elastomer polymerization process that includes providing a reactor capable of housing an industrial-scale elastomer polymerization reaction, and applying a mechanical force to the reactor so as to create a vibration in at least one wall of the reactor, in which fouling is reduced in the reactor. In one embodiment the reaction is an industrial scale butyl polymerization reaction and the reactor is a butyl polymerization reactor.
US08513366B2
Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures.
US08513363B2
An adhesive composition, an optical member, a surface protective film, and an adhesive sheet, the adhesive composition including 100 parts by weight of a (meth)acrylic copolymer having a weight average molecular weight of about 100,000 to about 2,000,000 g/mol; about 0.05 to about 5 parts by weight of a carbodiimide crosslinker, based on 100 parts by weight of the (meth)acrylic copolymer; and about 0.001 to about 5 parts by weight of an imidazole compound represented by Formula 1, based on 100 parts by weight of the (meth)acrylic copolymer: wherein, in Formula 1, R1, R2, and R3 are each independently a hydrogen atom, a halogen atom, or a substituted or unsubstituted C1 to C10 straight or branched alkyl group.
US08513362B2
To provide a polyolefin polymer having a polar group represented by Formula (i) produced by modifying, with a high modification ratio, a double bond in a polymer having the double bond at one terminal, both terminals, or at the inside of a polymer chain thereof that is obtained by a known method; a method for producing the polyolefin polymer; and a water dispersion material and a mold release agent composition each containing the polyolefin polymer, wherein, PO, A, B, D, E, d, e, M, i, j, and n are defined as in the application.
US08513354B2
A thermoplastic polymer material containing starch is shown and described, which can be obtained by homogenizing a mixture containing 40 to 85 wt.-% starch and/or starch derivative, 15 to 55 wt.-% softener, and 0.01 to 7 wt.-% of a polymer which contains an epoxy group, while supplying thermal and/or mechanical energy and setting the water content of the mixture to less than approximately 12 wt.-%. The polymer material according to the invention is characterized by outstanding mechanical properties.
US08513347B2
This invention relates a composition comprising: (i) at least one low molecular weight polyolefin; (ii) a block copolymer obtainable by selectively hydrogenating a block copolymer having terminal polymeric blocks of a vinyl aromatic monomer and a mid-block prepared originally with an olefin and subsequently hydrogenated; and (iii) polypropylene; (iv) with the proviso that when (i) is a PAO having a molecular weight of between about 400 and 1000 g/mole, either: (a) (iii) is a homopolymer characterized by an MFR greater than 2 g/10 min, (b) (iii) is a copolymer; or (c) (iii) is a polymer or copolymer made by a metallocene catalyst; or (d) the composition does not contain calcium carbonate.
US08513343B2
The present invention relates to unsaturated polyester resin composition comprising an unsaturated polyester resin, a manganese compound, a 1,3-dioxo compound and a base; the molar ratio between the dioxo compound and the basic functionality of the base is from 170:1 to 1:30 and the resin composition being curable with a peroxide. The present invention further relates to a process for radically curing such a resin composition wherein a peroxide is added to the resin composition and the curing is effected in the absence of cobalt.
US08513341B2
A polylactic acid resin composition containing 100 parts by weight of a polylactic acid compound (A) having a specific moiety represented by the formula (1): —X1—R1—X2— and having a weight average molecular weight (Mw) of 5,000 to 500,000, 5 to 2,000 parts by weight of a lactic acid resin (B) and 0.1 to 10 parts by weight of at least one kind of a transparent nucleating agent (C) selected from carboxylic acid amides, aliphatic alcohols and aliphatic carboxylic acid esters. In the formula (1), X1, X2 and R1 are defined. The resin composition can exhibit improved heat resistance (high crystallinity) and transparency without impairing the rigidity of the polylactic acid resin. A molded article composed of the resin composition is also provided.
US08513340B2
A method for reducing chatter in an extrusion process, which includes the steps of preparing an extrusion composition by combining a polymer composition with a chatter-reducing formulation, and extruding the extrusion composition to provide a substantially continuous extrudate. The chatter-reducing formulation comprises an alkyltin mercaptide and dibutyltin dilaurate. The resultant extrudate exhibits reduced chatter, which is categorized according to the Reed Scale as less than or equal to 2.
US08513338B2
A binder composition and a mixture of the binder composition and aggregate that are suitably used to prepare pavements are disclosed. The binder composition comprises a resin of vegetable origin, an oil of vegetable and a polymer, and the polymer is functionalised with silane groups.
US08513332B2
Disclosed is a color filter ink composition that includes an acrylic-based copolymer resin including repeating units represented by a particular chemical formula, a polymerizable monomer, a pigment, and a solvent. According to the present invention, the color filter ink composition can have excellent ejection properties and ejection stability by using a new acrylic-based copolymer resin as a binder resin, and also can have excellent storage stability, so that it can be used for a long period. In addition, a pattern formed using the color filter ink composition can have improved heat resistance, chemical resistance, and film strength.
US08513326B2
The present invention relates, generally, to monomers containing carbamate-methacrylates or derivatives of carbamate-methacrylates, processes for making the monomers, and compositions comprising the monomers. The present invention also relates to methods of using the monomers, such as in dental applications, and in particular, dental restorative resins.
US08513323B2
Generally silicone materials adapted to releasably adhere to human skin don't attach readily to substrates such as fibrous substrates (e.g., woven and nonwoven webs), films, plastic, etc. Disclosed are inventive blends of low-tack materials, such as a low-tack silicone material, and a high-tack silicone material, such as a high-tack, hot-melt, silicone adhesive, that both releasably adhere to skin and join to various substrates, including fibrous substrates. Furthermore, these same blends may be disposed between, and attached to, a silicone adhesive layer and a substrate. In other words, the disclosed silicone blends may be used to join a silicone adhesive layer to a substrate.
US08513322B2
Polymeric beads and methods of making the polymeric beads are described. The polymeric beads are crosslinked hydrogels or dried hydrogels. The polymeric beads are formed from droplets of a precursor composition that are exposed to radiation. The droplets are totally surrounded by a gas phase. The precursor composition contains a polar solvent and a polymerizable material miscible in the polar solvent. The polymerizable material has an average number of ethylenically unsaturated groups per monomer molecule equal to at least 1.2.
US08513321B2
Disclosed herein are dual cure coating compositions that include (a) a melamine-group containing polyethylenically unsaturated compound and (b) an acrylate-containing compound different from (a), wherein the acrylate-containing compound is present at a level sufficient to provide a cured coating layer having a glass transition temperature of 100° C. or below and a crosslink density of 20.0 mmoles/cc or below. Also disclosed are related multi-component composite coatings, coated substrates, and methods for coating a substrate.
US08513318B2
A method for producing a rigid polyurethane foam, which comprises reacting a polyol with a polyisocyanate in the presence of an amine catalyst and a blowing agent, wherein as the amine catalyst, at least one amine compound having at least one type of substituent selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group in its molecule, or N-(2-dimethylaminoethyl)-N′-methylpiperazine, is used, and as the blowing agent, 1,1,1,3,3-pentafluoropropane (HFC-245fa) and/or 1,1,1,3,3-pentafluorobutane (HFC-365mfc) is used.
US08513316B2
A process for producing Fischer-Tropsch hydrocarbon products onboard a marine vessel from carbonaceous feedstock by gasification in a thermal conversion plant connected to an onboard power plant unit includes the steps of forming Fischer-Tropsch hydrocarbons in a Fischer-Tropsch reactor having a recycle line from the Fischer-Tropsch reactor to the thermal conversion plant and recycling at least one of carbon dioxide and tail gas from the Fischer-Tropsch reactor to the thermal conversion plant during gasification.
US08513314B2
Improved design of a catalytic reactor for the production of methanol at equilibrium conditions whereby methanol as it is formed is separated from the gaseous phase into the liquid phase within the reactor, without reducing the catalytic activity of the methanol catalysts This is achieved by adjusting the boiling point of a liquid cooling agent being in indirect contact with the catalyst particles and by providing a specific ratio of catalyst bed volume to cooling surface area. Thereby, condensation of methanol as it is formed in the gaseous phase takes place at the cooling surface arranged evenly distributed within the reactor and within a very limited region of the catalyst bed.
US08513308B2
The present invention is directed to Pak1 agonists and methods of use.
US08513306B2
A method of treating nocturia in a human individual includes administering dosages of creatine to the individual; and reducing the dosages of creatine to the individual responsive to an increase in difficulty of the individual to initiate urination. Another example method includes reducing the dosages of creatine to the individual responsive to an increase in nocturnal urination frequency of the individual. A dosing system includes doses of creatine for treating nocturia in a human individual and is configured for reduced doses for administration in response to an increase in one or more nocturia symptoms. Various other methods as well as compositions, systems, etc., are also disclosed.
US08513295B2
Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus, and fungal infections such as, for example, candidiasis.
US08513289B2
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
US08513278B2
Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and D50W, which is useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting.
US08513269B2
A compound represented by the formula (I), salt thereof, or hydrate thereof has an excellent anti-pruritic effect and an excellent effect in terms of metabolism. The topical formulation of the present invention has excellent skin absorption properties of the compound represented by the formula (I), salt thereof, or hydrate thereof. Furthermore, the topical formulation of the present invention is excellent in stability because ingredients are hardly bled after long-term storage. wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
US08513268B2
The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
US08513267B2
The present invention relates to the use of 4-anilinoquinazoline derivatives as adenosine-kinase inhibitors. The present invention also relates to a method for protecting tissues and organs like heart, brain and kidneys affected by ischemia, and for treating heart insufficiency, myocardium infarct, arrhythmia, arterial hypertension, atherosclerosis, coronary artery restenosis after angioplasty, chronic renal insufficiency, cerebral vascular accident, and chronic inflanunatory diseases (e.g., rheumatoid arthritis). The present invention also relates to the compound 6,7-dimethoxy-4-(3′-N′,N′-dimethylaminoanilino)quinazoline, or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising it and use of such compound in the manufacture of a medicament for treating or preventing diseases or conditions that are benefited from the adenosine-kinase inhibition.
US08513266B2
The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.(Formula I)
US08513262B2
A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L′ are suitable leaving groups, with a compound of formula (III) UNH2 (III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L′.
US08513259B2
Described herein are injectable compositions containing non-sedating or second and third generation antihistamines such as cetirizine/levocetirizine and methods of use thereof. Specifically, methods of treating acute urticaria or angioedema associated with an acute allergic reaction are disclosed. In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms with the same number of mg of cetirizine.
US08513255B2
The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
US08513254B2
The present invention relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof. Also provided are methods for modulating ventricular and atrial rhythm and rate. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
US08513253B2
There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.
US08513247B2
Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.4% to about 0.6% by weight of brimonidine and a pharmaceutically acceptable carrier.
US08513239B2
There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are herein described. These compounds are useful as anticancer agents.
US08513235B2
The invention provides a homocysteine synthase inhibitor useful for the prophylaxis or treatment of diseases involving homocysteine synthase. The homocysteine synthase inhibitor is a compound of the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof.
US08513232B2
The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
US08513208B2
A method is provided for treating or preventing an undesired immune response in a patient, comprising: administering to said patient, cells that transiently express, and/or that are transfected with mRNA encoding, one or more polypeptides selected from the group consisting of an IL-4 receptor agonist, an IFN-γ receptor antagonist, an IFN-α receptor antagonist, an IL-12 receptor antagonist, an IL-23 receptor antagonist, and a TNF antagonist. Preferably, the cells selectively accumulate in one or more secondary lymphoid tissues at or proximate to the site of the undesired immune response. Related compositions are provided. The methods and compositions are useful for the treatment or prevention of undesired immune responses including, but not limited to, transplant rejection, autoimmune disease, allergy and immune responses directed against therapeutic compositions.
US08513205B2
The present invention relates to compounds, in particular, dual antagonists comprising a nucleoside reverse transcriptase inhibitor (NRTI) or a nucleoside competitive reverse transcriptase inhibitor and a non-nucleoside reverse transcriptase inhibitor (NNRTI), linked together using a chemical linker, which may be used to inhibit HIV (HIV-1) reverse transcriptase and in the treatment of HIV infections, more severe cases of HIV infections, including ARC and AIDS, including reducing the likelihood of these infections and disease states.
US08513204B2
The present invention comprises compositions and formulations comprising amphotericin B, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.
US08513195B2
The invention relates to a selective inhibitor of Elk-1 or MSK-1 activation for use in the prevention and/or treatment of mood and anxiety disorders.
US08513190B2
The present invention provides methods for modification and regulation of type II diabetes by administering to an animal a therapeutically effective amount of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to treat type II diabetes but not sufficient to suppress the immune system of the animal.
US08513189B2
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
US08513183B2
Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and/or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and/or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.
US08513176B2
Source water is treated by mixing a first component selected from the group comprising neutralized phosphonic acid compounds, neutralized phosphonate compounds, neutralized derivatives of phosphorus, neutralized anti-scalent polymers, and mixtures thereof, a second component from the group comprising chlorite salt and chlorate salt is admixed to the mixture of the water and the first component, and water. The water and the first and second components are present in amounts sufficient to form a stable liquid composition in which there is substantially no conversion of the second component to chlorine dioxide.
US08513175B2
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to the parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency and specific activity.
US08513165B2
There is provided a planar lipid bilayer array formed by microfluidic technique and a method of analysis using the planar lipid bilayers, providing the advantages such as portability, decreased analysis time, a smaller amount of required reagents, and parallel automation with high reproducibility. The planar lipid bilayer array formed by microfluidic technique is a planar lipid bilayer array formed by microfluidic technique (PDMS device) 1 saturated with water by preliminarily immersing in water, comprising microchannels 2 connected to an inlet of a microfluidic channel and arranged in parallel, and microchambers 3 having apertures on both sides of the microchannel 2.
US08513163B2
A high-temperature superconducting thin-film strip conductor (HTSL-CC) includes a metal substrate, a buffer layer chemically generated thereon and grown crystallographically unrotated in relation to the metal substrate, and a chemically generated superconducting coating thereon. The HTSL-CC possesses high texturing of the buffer layer since the metal substrate has a surface roughness RMS<50 nm, and since and the buffer layer is grown directly onto its surface, without an intermediate layer, crystallographically unrotated in relation to the crystalline structure of the metal substrate.
US08513156B2
A catalyst for the manufacture of alkylene oxide, for example ethylene oxide, by the vapor-phase epoxidation of alkene containing impregnated silver and at least one efficiency-enhancing promoter on an inert, refractory solid support, said support incorporating a sufficient amount of zirconium component (present and remaining substantially as zirconium silicate) as to enhance at least one of catalyst activity, efficiency and stability as compared to a similar catalyst which does not contain the zirconium component.
US08513154B2
The present invention provides porous body precursors and shaped porous bodies. Also included are catalysts and other end-use products based upon the shaped porous bodies and thus the porous body precursors. Finally, processes for making these are provided. The porous body precursors, comprise one or more topography-enhancing additives, i.e., additives that are capable of at least marginally enhancing one or more of surface area, aspect ratio, pore volume, median pore diameter, surface morphology, etc. Downstream products need not necessarily comprise the topography-enhancing additives in order to exhibit the benefits of their inclusion in the porous body precursors.
US08513141B2
The present invention provides an etching solution for revealing defects in a germanium layer, a method for revealing defects in a germanium layer using such an etching solution and to a method for making such an etching solution. The etching solution according to embodiments of the present invention is able to exhibit an etch rate of between 4 nm·min−1 and 450 nm·min−1, which makes it suitable to be used for revealing defects in a thin layer of germanium, i.e. in a layer of germanium with a thickness of between 20 nm and 10 μm, for example between 20 nm and 2 μm, between 20 nm and 1 μm or between 20 nm and 200 nm.
US08513138B2
A method and system for performing gas cluster ion beam (GCIB) etch processing of Si-containing material and/or Ge-containing material is described. In particular, the GCIB etch processing includes forming a GCIB that contains a halogen element.
US08513135B2
Methods for reducing line roughness of spacers and other features utilizing a non-plasma and non-wet etch fluoride processing technology are provided. Embodiments of the methods can be used for spacer or line reduction and/or smoothing the surfaces along the edges of such features through the reaction and subsequent removal of material.
US08513124B1
Disclosed are methods of depositing a copper seed layer to be used for subsequent electroplating a bulk-layer of copper thereon. A copper seed layer may be deposited with different processes, including CVD, PVD, and electroplating. With electroplating methods for depositing a copper seed layer, disclosed are methods for depositing a copper alloy seed layer, methods for depositing a copper seed layer on the semi-noble metal layer with a non-corrosive electrolyte, methods of treating the semi-noble metal layer that the copper seed layer is deposited on, and methods for promoting a more uniform copper seed layer deposition across a semiconductor wafer.
US08513119B2
A bump structure that may be used for stacked die configurations is provided. Through-silicon vias are formed in a semiconductor substrate. A backside of the semiconductor substrate is thinned to expose the through-silicon vias. An isolation film is formed over the backside of the semiconductor substrate and the exposed portion of the through-silicon vias. The isolation film is thinned to re-expose the through-silicon vias. Bump pads and redistribution lines are formed on the backside of the semiconductor substrate providing an electrical connection to the through-silicon vias. Another isolation film is deposited and patterned, and a barrier layer is formed to provide contact pads for connecting to an external device, e.g., another die/wafer or circuit board.
US08513118B2
It is intended to provide a production method that enables at least one of improvement in transparency, reduction in sheet resistance, homogenization in planar distribution of sheet resistance, and reduction in contact resistance related to a contact layer regarding a transparent conductive oxide film included in a compound semiconductor light-emitting device. A method for producing a compound semiconductor light-emitting device includes depositing on a substrate a compound semiconductor stacked-layer body including a light-emitting layer, depositing a transparent conductive oxide film on the compound semiconductor stacked-layer body, and annealing the transparent conductive oxide film and thereafter cooling the same in a vacuum atmosphere.
US08513101B2
A method of synthesizing a nanowire. The method includes disposing a first oxide layer including germanium (Ge) on a substrate, forming a second oxide layer including a nucleus by annealing the first oxide layer, and growing a nanowire including Ge from the nucleus by a chemical vapor deposition (“CVD”) method.
US08513100B2
In a semiconductor device manufacturing method, an amorphous or microcrystalline metal oxide film is formed over a first metal film which is preferentially oriented along a predetermined crystal plane. After that, a ferroelectric film is formed by a MOCVD method. When the ferroelectric film is formed, the metal oxide film formed over the first metal film is reduced to a second metal film and the ferroelectric film is formed over the second metal film. When the ferroelectric film is formed, the amorphous or microcrystalline metal oxide film is apt to be reduced uniformly. As a result, the second metal film the orientation of which is good is obtained and the ferroelectric film the orientation of which is good is formed over the second metal film. After the ferroelectric film is formed, an upper electrode is formed over the ferroelectric film.
US08513099B2
A method of forming a self-aligned device is provided and includes depositing carbon nanotubes (CNTs) onto a crystalline dielectric substrate, isolating a portion of the crystalline dielectric substrate encompassing a location of the CNTs, forming gate dielectric and gate electrode gate stacks on the CNTs while maintaining a structural integrity thereof and forming epitaxial source and drain regions in contact with portions of the CNTs on the crystalline dielectric substrate that are exposed from the gate dielectric and gate electrode gate stacks.
US08513097B2
Disclosed is a plasma processing device that provides an object to be treated with plasma treatment. A wafer as an object to be treated, which is attached on the upper surface of adhesive sheet held by a holder frame, is mounted on a stage. In a vacuum chamber that covers the stage therein, plasma is generated, by which the wafer mounted on the stage undergoes plasma treatment. The plasma processing device contains a cover member made of dielectric material. During the plasma treatment on the wafer, the holder frame is covered with a cover member placed at a predetermined position above the stage, at the same time, the wafer is exposed from an opening formed in the center of the cover member.
US08513087B2
Processes for forming isolation structures for semiconductor devices include forming a submerged floor isolation region and a filed trench which together enclose an isolated pocket of the substrate. One process aligns the trench to the floor isolation region. In another process a second, narrower trench is formed in the isolated pocket and filled with a dielectric material while the dielectric material is deposited so as to line the walls and floor of the first trench. The substrate does not contain an epitaxial layer, thereby overcoming the many problems associated with fabricating the same.
US08513086B2
Methods for selectively etching doped oxides in the manufacture of microfeature devices are disclosed herein. An embodiment of one such method for etching material on a microfeature workpiece includes providing a microfeature workpiece including a doped oxide layer and a nitride layer adjacent to the doped oxide layer. The method include selectively etching the doped oxide layer with an etchant comprising DI:HF and an acid to provide a pH of the etchant such that the etchant includes (a) a selectivity of phosphosilicate glass (PSG) to nitride of greater than 250:1, and (b) an etch rate through PSG of greater than 9,000 Å/minute.
US08513081B2
A method includes providing a wafer that has a semiconductor layer having an insulator layer disposed on the semiconductor layer. The insulator layer has openings made therein to expose a surface of the semiconductor layer, where each opening corresponds to a location of what will become a transistor channel in the semiconductor layer disposed beneath a gate stack. The method further includes depositing a high dielectric constant gate insulator layer so as to cover the exposed surface of the semiconductor layer and sidewalls of the insulator layer; depositing a gate metal layer that overlies the high dielectric constant gate insulator layer; and implanting Carbon through the gate metal layer and the underlying high dielectric constant gate insulator layer so as to form in an upper portion of the semiconductor layer a Carbon-implanted region having a concentration of Carbon selected to establish a voltage threshold of the transistor.
US08513073B1
A method of forming a fin field effect transistor (finFET) device includes forming a silicon fin on a substrate; forming an inner spacer adjacent to a first portion of the silicon fin; forming silicon germanium regions adjacent to a second portion of the silicon fin and the inner spacer; and oxidizing the silicon germanium regions, such that the second portion of the silicon fin that is located adjacent to the silicon germanium regions is converted to a silicon germanium channel region during oxidizing of the silicon germanium regions, and such that the first portion of the silicon fin is protected by the inner spacer during oxidation of the silicon germanium regions, wherein the first portion of the silicon fin comprises a silicon buffer region located between the silicon germanium channel region and a source/drain region of the finFET device.
US08513068B2
A method for forming a nanowire field effect transistor (FET) device including forming a first silicon on insulator (SOI) pad region, a second SOI pad region, a third SOI pad region, a first SOI portion connecting the first SOI pad region to the second SOI pad region, and a second SOI portion connecting the second SOI pad region to the third SOI pad region on a substrate, patterning a first hardmask layer over the second SOI portion, forming a first suspended nanowire over the semiconductor substrate, forming a first gate structure around a portion of the first suspended nanowire, patterning a second hardmask layer over the first gate structure and the first suspended nanowire, removing the first hardmask layer, forming a second suspended nanowire over the semiconductor substrate, forming a second gate structure around a portion of the second suspended nanowire, and removing the second hardmask layer.
US08513066B2
A method for creating an inverse T field effect transistor is provided. The method includes creating a horizontal active region and a vertical active region on a substrate. The method further comprises forming a sidewall spacer on a first side of the vertical active region and a second side of the vertical active region. The method further includes removing a portion of the horizontal active region, which is not covered by the sidewall spacer. The method further includes removing the sidewall spacer. The method further includes forming a gate dielectric over at least a first part of the horizontal active region and at least a first part of the vertical active region. The method further includes forming a gate electrode over the gate dielectric. The method further includes forming a source region and a drain region over at least a second part of the horizontal active region and at least a second part of the vertical active region.
US08513062B2
A method includes providing a carrier having a first cavity, providing a dielectric foil with a metal layer attached to the dielectric foil, placing a first semiconductor chip in the first cavity of the carrier, and applying the dielectric foil to the carrier.
US08513060B2
A method for forming a sealing body without cracks in manufacture of a semiconductor device having an external terminal formed through the use of an electrolysis plating method. A front surface of a semiconductor wafer is placed over a front surface of a first support heated to a first temperature. An adhesive sheet is then bonded to a back surface of the semiconductor wafer, after which the semiconductor wafer is subjected to heat treatment at a second temperature higher than the first temperature. After the semiconductor wafer and the adhesive sheet are cut along cutting regions, a plurality of semiconductor chips each having an adhesive patch bonded thereto are obtained. A mother substrate is placed over a front surface of a second support heated to a third temperature and the semiconductor chips are fixed to an upper surface of the mother substrate via the adhesive patch.
US08513049B2
A method for texturing an active surface of a photovoltaic cell in single-crystal silicon or poly-crystal silicon includes depositing a resin on the active surface of the cell, texturing the resin on the active surface with geometric patterns, and texturing the active surface of the cell by eliminating the deposited resin. The depositing of the resin is preceded by pre-texturing the resin on a depositing tool. The texturing step of the resin on the active surface is simultaneous with the depositing of the resin on the active surface.
US08513048B2
An image sensor and a method of manufacturing the same are disclosed. A passivation layer on an interlayer dielectric layer has different thicknesses for neighboring pixels. Consequently, a phase of light incident on a pixel is out of phase with light incident on an adjacent pixel before it reaches a photodiode. As a result, diffraction of the incident light results in destructive interference between the pixels. Thus, cross talk between adjacent pixels can be prevented.
US08513045B1
A laser system with multiple laser pulses for removing material from a solar cell being fabricated. The laser system includes a single pulse laser source and a multi-pulse generator. The multi-pulse generator receives a single pulse laser beam from the single pulse laser source and converts the single pulse laser beam into a multi-pulse laser beam. A laser scanner scans the multi-pulse laser beam onto the solar cell to remove material from the solar cell.
US08513040B2
According to one embodiment, a method is disclosed for manufacturing a display device. A film material layer is formed on a support substrate. A first heating process for the film material layer at a first temperature to form a film layer and a second heating process for a second region surrounding a first region at a second temperature higher than the first temperature are performed. The first region is provided in a central part of the film layer. A display layer is formed in the first region and a peripheral circuit section is formed at least in a part of the second region. A third heating process is performed for at least a part of the film layer at a third temperature higher than the second temperature. In addition, the film layer is peeled off from the support substrate.
US08513034B2
A method of manufacturing a layered chip package that includes a main body, and wiring disposed on a side surface of the main body. The main body includes a plurality of layer portions. The method includes fabricating a plurality of substructures, and completing the layered chip package by fabricating the main body using the plurality of substructures and by forming the wiring on the main body. Each substructure is fabricated through the steps of: fabricating a pre-substructure wafer including a plurality of pre-semiconductor-chip portions aligned; distinguishing between a normally functioning pre-semiconductor-chip portion and a malfunctioning pre-semiconductor-chip portion among the plurality of pre-semiconductor-chip portions included in the pre-substructure wafer; and forming electrodes connected to the normally functioning pre-semiconductor-chip portion and having respective end faces located in the side surface of the main body on which the wiring is disposed, without forming any electrode connected to the malfunctioning pre-semiconductor-chip portion.
US08513025B2
This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry, e.g., tandem mass spectrometry, by derivatizing succinylacetone in a sample by contacting the sample with an extraction solution comprising a C1-3 linear or branched chain monoalcohol and a strong base selected from the group consisting of hydrazine, a modified hydrazine, and hydroxylamine.
US08513024B2
Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized on a sensing element and with a second target substance trapping member immobilized on a gel particle to hold the gel particle on the sensing element; adjusting a magnetic marker precursor including the gel particle and a magnetic material precursor existing in the gel particle by bringing the magnetic material precursor into contact with the gel particle; synthesizing a magnetic material from the magnetic material precursor held on the gel particle, thereby adjusting the magnetic markers; and detecting the magnetic markers with the sensing element.
US08513022B2
A method for determining the amount of a chemical species in a sample, in particular the amount of weak acid dissociable cyanide or total cyanide in a sample, and an apparatus for performing said method. The method comprises the steps of: i) treating the sample to liberate the chemical species into a gaseous stream; ii) directing the gaseous stream to a scrubber; iii) absorbing the chemical species into a scrubber solution; and iv) determining the amount of chemical species absorbed into the scrubber solution, wherein any remaining chemical species not absorbed into the scrubber solution is directed or recirculated to the scrubber in the gaseous stream and step iii) is repeated to increase absorption of the chemical species prior to performing step iv).
US08513016B2
A method of producing a stably transformed corn plant in a single container is demonstrated. This method allows for the automation of the transformation process and reduces labor, material, and ergonomic costs associated with traditional plant tissue culture systems.
US08513011B2
The present invention provides cardiomyocyte-like cells that have been cultured from populations of bone marrow cells. The culture method includes the use of defined media that are free of agents such a 5-azacytidine. The cardiomyocyte-like cells can be engrafted to heart tissue to repair damage resulting from an ischaemic episode.
US08513007B2
A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.
US08513001B2
A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.
US08512999B2
The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided that comprise the use of xylose and depolymerized cellulosic materials for the production of oil-bearing microorgansims.
US08512992B2
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
US08512990B2
Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided.
US08512988B2
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
US08512982B2
The present invention relates to cells that have been genetically manipulated to have an altered capacity to express and/or produce proteins of interest. In particular, the present invention relates to modified host cells of Gram-positive microorganisms, such as Bacillus species that are capable of overexpressing ymaH. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode YmaH, and the modified host cells comprising them. In particular, the present invention relates to compositions and methods of overexpressing YmaH for enhancing the expression and production of proteins of interest (e.g., proteases) in Bacillus species.
US08512979B2
A system including an apparatus is presented for treatment of biomass that allows successful biomass treatment at a high solids dry weight of biomass in the biomass mixture. The design of the system provides extensive distribution of a reactant by spreading the reactant over the biomass as the reactant is introduced through an injection lance, while the biomass is rotated using baffles. The apparatus system to provide extensive assimilation of the reactant into biomass using baffles to lift and drop the biomass, as well as attrition media which fall onto the biomass, to enhance the treatment process.
US08512971B2
Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.
US08512967B2
This invention provides methods for determining or predicting response to HER2-directed therapy in an individual.
US08512964B2
In certain embodiments this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of hypercholesterolemia. Methods of treating hypercholesterolemia and methods of screening for agents to treat hypercholesterolemia are provided.
US08512962B2
The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step of the assay drastically increases accuracy of the assay, thus it allows for a more effective, reliable, quick, and cost effective way of identifying and thereby removing infected cattle and/or other animals from an otherwise uninfected herd.
US08512954B2
The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other methicillin-resistant bacteria in a sample.
US08512944B2
Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.
US08512938B2
Methods of forming a pattern in a material and methods of forming openings in a material to be patterned are disclosed, such as a method that includes exposing first portions of a first material to radiation through at least two apertures of a mask arranged over the first material, shifting the mask so that the at least two apertures overlap a portion of the first portions of the first material, and exposing second portions of the first material to radiation through the at least two apertures. The first portions and the second portions will overlap in such a way that non-exposed portions of the first material are arranged between the first portions and second portions. The non-exposed or exposed portions of the first material may then be removed. The remaining first material may be used as a photoresist mask to form vias in an integrated circuit. The pattern of vias produced have the capability to exceed the current imaging resolution of a single exposure treatment.
US08512937B2
A novel approach to dry development of exposed photo resist is described in which a photo resist layer is exposed to a visible light source in order to remove the resist in the areas of exposure. The class of compounds used as the resist material, under the influence of the light source, undergoes a chemical/structural change such that the modified material becomes volatile and is thus removed from the resist surface. The exposure process is carried out for a time sufficient to ablate the exposed resist layer down to the layer below. A group of compounds found to be useful in this process includes aromatic calixarenes.
US08512922B2
Aspects of the present invention provide an electrophotographic photosensitive member in which an intermediate layer contains metal oxide particles, an organic resin, and a specific compound (fluorenone derivative), and a process cartridge and an electrophotographic apparatus including the electrophotographic photosensitive member.
US08512920B2
A color filter substrate includes a transparent substrate, a color photoresist layer and an air guiding layer. The color photoresist layer is disposed on the transparent substrate. The air guiding layer is disposed on the substrate and surrounds the color photoresist layer. The air guiding layer includes a plurality of strip-shaped patterns disposed apart from each other. One end of each of the strip-shaped patterns is connected to the color photoresist layer, and the other end of each of the strip-shaped patterns extends toward a direction far away from the color photoresist layer. An air guiding groove is formed between each two adjacent strip-shaped patterns. A color display apparatus having the color filter substrate is also provided. The color filter substrate can be assembled to the display layer without producing air bubbles, and thereby improves display quality of the color display apparatus.
US08512917B2
A photomask is provided, with which the roundness of a corner portion of a resist mask can be reduced in a photolithography step. Further, a method for manufacturing a semiconductor device with less variation is provided. A photomask includes an auxiliary pattern at a corner portion of a light-blocking portion, and (k+1) sides (k is a natural number of 3 or more) form k obtuse angles in the auxiliary pattern. Alternatively, a photomask includes an auxiliary pattern at a corner portion of a light-blocking portion, and the auxiliary pattern includes a zigzag curve.
US08512885B2
A battery includes a battery case including battery chemistry for supplying electricity, a first end, and a second end opposite the first end; a first positive terminal, a first negative terminal, and a first insulator therebetween at the first end that together form a first positive terminal and negative terminal configuration; a second positive terminal, a second negative terminal, and a second insulator therebetween at the second end that together form a second positive terminal and negative terminal configuration, wherein the second positive terminal and the second negative terminal configuration is a mirror image of the first positive terminal and the first negative terminal configuration.
US08512883B2
A low-emissivity multilayer coating includes, in order outward from the substrate, a first layer including a layer containing titanium oxide, a layer containing silicon nitride, or a sublayer layer containing titanium oxide in combination with a sublayer containing silicon 5 nitride, a second layer including Ag, a third layer including at least one layer selected from titanium oxide layers and silicon nitride layers, a fourth layer including Ag, and a fifth layer including silicon nitride, where the color of the coatings can be varied over a wide range by controlling the thicknesses of the layers of titanium oxide, silicon nitride and Ag.
US08512882B2
Cutting tools and cutting inserts having a wear resistant coating on a substrate comprising a metal carbide particle and a binder. For certain applications, a cutting insert having a wear resistant coating comprising hafnium carbon nitride and a binder comprising ruthenium may provide a greater service life. The wear resistant coating comprising hafnium carbon nitride may have a thickness of from 1 to 10 microns. In another embodiment, the cutting tool comprises a cemented carbide substrate with a binder comprising at least one of iron, nickel and cobalt.
US08512877B2
Naphthylcarbazole derivatives are provided. The naphthylcarbazole derivatives are represented by Formula 1. Further provided are KL host materials, organic electroluminescent devices employing the host materials, and displays and lighting systems comprising the devices.
US08512869B2
A silicon composition with a silicon compound represented by Formula 1 and a silicon compound represented by Formula 2: wherein, R1, R2, R3, R4, R11, R12, R13, R14, R15, R16, R17, R18, and R19 are each independently a C1-C4 alkyl group, R5, R6, R7, R8, R9, and R10 are each independently hydrogen or deuterium, k, m, and n are positive integers, and the ratio of k to the sum of m and n is from about 1:0.001 to about 1:0.2; and an organic light emitting device including the same.
US08512867B2
A very protective coated glass article includes a glass substrate, a bond enhancing layer formed on the glass substrate and a boron carbide layer deposited on the bond enhancing layer. A method of manufacturing the coated glass article is provided.
US08512853B2
A polymer-based composite sandwich includes a core bonded between fiber reinforced resin facesheets. The core includes a truss formed by groups of composite pins held in a low density foam. The pins in each group intersect to form nodes adjacent to one of the facesheets. The ends of the pins extend parallel and are bonded to the facesheets.
US08512847B2
This invention aims to provide a transparent conductive laminate excellent in sliding durability, edge-writing durability, finger writing durability and light resistance and suitable as a movable electrode substrate for a touch panel. Further, it aims to provide a touch panel using the above transparent conductive laminate. This invention is a transparent conductive laminate that is a laminate formed by laminating a polymer film, a cured resin layer-1 and a transparent conductive layer in this order, the cured resin layer-1 having concavoconvex shapes formed by phase separation of two components and containing no fine particles that impart concavoconvex shapes, and the cured resin layer-1 having an arithmetic average roughness (Ra), measured according to JIS B0601-1994, of 0.05 μm or more but less than 0.5 μm and a ten-point average roughness (Rz), measured according to JIS B0601-1982, of 0.5 μm or more but less than 2.0 μm, and a touch panel using the transparent conductive laminate.
US08512845B2
A molded male surface fastener includes resin invasion preventing walls, which prevent an invasion of a molding foamable resin material of a cushion body, on right and left edge portions along a longitudinal direction of a surface of a flat base member made of a thermoplastic resin, a plurality of engaging elements provided between left and right resin invasion preventing walls, and a linear sealing body that is continuously disposed in the longitudinal direction of the base member along a peripheral portion of a top portion of each resin invasion preventing wall. When an engaging element forming surface of the surface fastener is placed on a concavo-convex surface of foaming body molding cavities of a foaming mold, if the mold has the same magnetic force as that in the related art, the linear sealing body is well adhered along the concavo-convex surface.
US08512843B2
Composite and laminated composite padding materials or cushions formed from an elastic foam matrix structurally supporting and encapsulated gel elements are disclosed. Methods of manufacturing such composite and laminated composite padding materials or cushions are also disclosed.
US08512838B2
Disclosed is a laminar shaped article comprising a heterogeneous blend of (a) a composition comprising a vinyl halide or vinylidene halide polymer and optionally an ethylene copolymer containing carboxyl and/or carbon monoxide moieties, and (b) a polyolefin functionalized with a comonomer selected from the group consisting of maleic anhydride, maleic acid diesters, maleic acid monoesters, itaconic anhydride, itaconic acid diesters, itaconic acid monoesters, fumaric acid diesters, fumaric acid monoesters, or combinations thereof as a compatibilizer; and (c) a polyamide wherein the polyamide is present in the vinyl halide or vinylidene halide polymer as a multitude of overlapping layers.
US08512832B2
The invention relates to a method of making a coating composition for coating glass. The method includes the steps of combining an epoxy resin component, a methacrylate component, a silane coupling agent, an epoxy curing agent, and an initiator agent.
US08512828B2
A biaxially oriented white polypropylene film containing a core layer (layer A) and a skin layer (layer B), said layer B is laminated at least on one surface of said layer A, wherein said layer A contains a polypropylene resin having β-crystal activity and 1 to 20 mass % particle (a) having an average dispersed diameter of 60 to 400 nm, and wherein, said layer B contains a polypropylene resin and 0.05 to 5 mass % particle (b) of an average dispersed diameter of 1 to 4 μm. The present invention provides a biaxially oriented white polypropylene film excellent in film quality and productivity and capable of making sensitivity and productivity compatible in a high level when used as a base for a receiving sheet, and a receiving sheet for thermal transfer recording made thereof.
US08512818B1
A highly tensile dielectric layer is generated on a heat sensitive substrate while not exceeding thermal budget constraints. Cascaded ultraviolet (UV) irradiation is used to produce highly tensile films to be used, for example, in strained NMOS transistor architectures. Successive UV radiation of equal or shorter wavelengths with variable intensity and duration selectively breaks bonds in the Si—N matrix and minimizes shrinkage and film relaxation. Higher tensile stress than a non-cascaded approach may be obtained.
US08512816B2
Provided is a method of fabricating, with satisfactory adhesion, a thin film of a metal or a metallic-compound, such as a metal oxide or nitride, on a substrate made of a high-melting-point material such as silicon or ceramics by using a metal or metallic-compound target as the primary raw material so as to eliminate the necessity of using harmful gases such as organometallic gas, and by using an atmospheric-pressure plasma generated under atmospheric pressure as a reaction field and also as a heat source. Additionally provided is an apparatus for fabricating the thin film. The thin-film fabrication method by microplasma processing includes the steps of disposing a raw material for thin-film fabrication in one or more tubes (A) having a uniform inner diameter throughout, introducing an inert gas and applying a high-frequency voltage to the narrow tubes (A) to generate high-frequency plasma in the narrow tubes (A), heating/evaporating the raw material while maintaining the flow rate of the plasma gas in the narrow tubes (A) and maintaining the plasma gas temperature high, ejecting the evaporated material from the narrow tubes (A) to spray it onto the substrate, heating the substrate with the plasma, and depositing the sprayed material on the substrate under atmospheric pressure.
US08512814B2
Sound-dampening material, including a base coat and a top coat, and a method for sound-dampening a surface, are described. The base coat includes about 20-50 percent rubber emulsion, about 10-20 percent carbonate filler, about 3-10 percent fire retardant, about 3-10 percent opacity filler, and about 10-64 percent of other components. The top coat includes about 40-80 percent of a rubber emulsion, about 10-20 percent of a carbonate filler, about 3-10 percent of a fire retardant, about 3-10 percent of an opacity filler, and about 0-44 percent of other components. The method includes applying a base coat to a desired thickness allowing the base coat to dry, then applying a top coat over the base coat to a desired thickness.
US08512813B2
There is provided a coating composition having a good wetting property which is capable of forming a coating film exhibiting a high refractive index, a less discoloration, and excellent transparency and uniformity when polymerized and cured. The present invention relates to a coating composition comprising (A) 100 parts by weight of a thiirane ring-containing compound, (B) 0.0001 to 10 parts by weight of a catalyst for accelerating polymerization of the thiirane ring-containing compound, and (C) 0.005 to 4 parts by weight of a modified silicone oil; a coating film produced from the composition; and an optical product provided with the coating film.
US08512800B2
Methods of reducing phase and amplitude ripples in a BAW resonator frequency response by providing a substrate, fabricating a Bragg mirror having alternate layers of a high acoustic material and a low acoustic material on a first surface of the substrate, fabricating a BAW on the Bragg mirror, and coating a second side of the substrate opposite the first side with a lossy material having an acoustic impedance in the range of 0.01× to 1.0× the acoustic impedance of the layers of high impedance material, the second surface of the substrate being a polished surface. Various embodiments are disclosed.
US08512798B2
The present invention is a high-throughput, ultraviolet (UV) assisted metalorganic chemical vapor deposition (MOCVD) system for the manufacture of HTS-coated tapes. The UV-assisted MOCVD system of the present invention includes a UV source that irradiates the deposition zone and improves the thin film growth rate. The MOCVD system further enhances the excitation of the precursor vapors and utilizes an atmosphere of monatomic oxygen (O) rather than the more conventional diatomic oxygen (O2) in order to optimize reaction kinetics and thereby increase the thin film growth rate. In an alternate embodiment, a microwave plasma injector is substituted for the UV source.
US08512792B2
A method for producing blocks of cheese from curd, wherein a curd mass is deposited in at least one cheese mold provided with a follower and in the at least one cheese mold is subjected to a vacuum treatment and pressing treatment, which pressing treatment is carried out while the at least one cheese mold is situated in a holder in which a vacuum prevails, wherein the vacuum treatment comprises at least a first and a second step, wherein in the first step in the holder with the aid of vacuum pump means a vacuum with a first vacuum pressure is created to draw air and whey entrained with the air from the curd mass, and in the second step the vacuum pressure in the holder is reduced further to a second vacuum pressure, which has a value at which the whey present in the curd mass starts to boil and residual air and free whey are pushed from the curd mass.
US08512783B2
Containers for pressurized filling and pasteurization and methods of reducing creep in a pressurized pasteurizable container. The container is a blow-molded plastic container having a biaxially oriented wall of a structural polymer with a moisture content of no greater than a predetermined value at the start of a pressurized filling, capping, and pasteurization process. Also disclosed are pasteurizable containers having a desired shelf life.
US08512781B2
A fresh fruit preservative and method of using the preservative for fresh cut fruit that significantly extend the shelf life of fresh cut fruit are provided. The fresh fruit preservative preserves the texture, flavor, appearance, and color of the fresh fruit, particularly exposed surfaces of the fresh fruit that have been cut, in particular by reducing oxidation of the exposed cut surfaces of the fruit. The preservative includes the ingredients of ascorbic acid, calcium ascorbate, carbohydrate, sodium chloride, magnesium chloride, potassium bicarbonate and malic acid.
US08512773B2
A method of making bread is provided. The method includes a thermally treated dough making process of forming a thermally treated dough, a sponge making process of forming a sponge, a dough mixing process of mixing the thermally treated dough and the sponge with wheat flour, salt, butter, dried yeast, dried milk, sugar, egg, and water to form a dough mixture and stirring the dough mixture, a division process of dividing the dough mixture into equal-sized dough pieces, a first fermentation process of rolling out and fermenting the divided dough pieces for a predetermined period of time, a molding process of molding the dough pieces to fit a bread pan, a second fermentation process of fermenting the molded dough pieces in the bread pan, and a baking process of heating the fermented dough pieces.
US08512772B1
A dietary supplement which is useful for human hair pigment augmentation is provided. The dietary supplement contains black beans, black seeds, walnuts and flaxseeds, which are arranged in substantially equal amounts. This human hair pigment augmentation is achieved naturally without the use of dyes, colorants, or the like.
US08512765B2
A Salvia hispanica L. derived seed oil extract composition of matter containing from 60-88% PUFAs in a ratio of from 3.1:1-3.3:1 of ALA to LA, 4-10% of C-18 mono-unsaturated fatty acid, 1-5% of C-18 saturated fatty acid and 4-8% of C-16 saturated fatty acid in a mixed triglyceride form stable at room temperature of 12-24 months containing a mixture of selected antioxidants.
US08512762B2
What is described are sporicidal compositions, in which hydrogen peroxide and at least one radical stabilizer are homogeneously dissolved in a methacrylate monomer or a mixture of methacrylate monomers, and the quantitative ratio of radical stabilizer to hydrogen peroxide is larger than or equal to 1 to 1. The sporicidal monomer/monomer mixture is usually used for producing single component bone cement pastes; two-component bone cement pastes or monomer solutions for polymethylmethacrylate bone cements that are based on cement powder and monomer liquid. Moreover, a sporicidal cement paste having the following components is proposed: hydrogen peroxide and/or a hydrogen peroxide-releasing substance or mixture of substances; radical stabilizer; low-molecular liquid methacrylate; linear or branched polymethylmethacrylate or linear or branched methylmethacrylate co-polymer; cross-linked polymethylmethacrylate or cross-linked methylmethacrylate copolymer; as well as at least one component of a radical initiator system.
US08512760B2
A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.
US08512757B2
The invention provides a block copolymer comprising at least a first block and a second block. The first block comprises a plurality of temperature-sensitive monomeric units, a plurality of hydrophilic monomeric units and a plurality of targeting monomeric units, and the second block comprises a plurality of hydrophobic monomeric units. The second block comprises at least one pH-sensitive moiety.
US08512749B2
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
US08512742B2
Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.
US08512738B2
Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
US08512737B1
This application is directed to means for embolic delivery of therapeutic agents to an afflicted organ in the body of a patient.
US08512730B2
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.
US08512725B2
There is provided a method for treating a fluid with an anti-microbial agent comprising the steps of: (a) contacting the fluid with a solid material containing an anti-microbial agent; and, (b) abrading an interface of the solid material and removing particles therefrom and exposing an underlying surface of the solid material to the fluid, thereby facilitating release of the antimicrobial agent of the underlying surface of the solid material and/or the removed particles into the fluid. The solid material comprises an anti-microbial agent dispersed and/or embedded in a solid carrier. Typically, the anti-microbial agent is one or more of a metal, metal oxide, metal compound, metal salt, metal-ligand complex or derivatives thereof based on silver, copper and zinc.
US08512719B2
A simple and efficient method for the production of stable, clear, high-potency oat extracts is disclosed. The method employs the use of differential dissociation constants and ultrafiltration to stabilize extracts, prevent hazing, and prevent the loss of functional activity as an anti-irritant and anti-oxidant. Also disclosed are compositions of oat extracts derived from whole oat grains and oatmeal. Further disclosed are compositions of oat extracts for use in cosmetic, nutraceutical, therapeutic medical and veterinary preparations.
US08512702B2
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also relates to novel pharmaceutical compositions for the treatment of prostate cancer. Furthermore the present invention relates to assay systems and kits for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof.
US08512699B2
Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
US08512693B2
The present invention relates to self-assembling membranes. In particular, the present invention provides self-assembling membranes configured for securing and/or delivering bioactive agents. In some embodiments, the self-assembling membranes are used in the treatment of diseases, and related methods (e.g., diagnostic methods, research methods, drug screening).
US08512691B2
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.
US08512676B1
The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an “unhealthy” state in an organism such as a human. Described herein are methods of determining the state of health of an individual, such as the transition from healthy to infected, by identifying changes in oscillation modes in breath isotope ratio data. Changes in the frequency and/or amplitude of the oscillation modes are correlated with the heath of the individual. The methods can advantageously be used to provide information about the health of an individual in shorter periods of time than previous methods.
US08512670B2
A graphite film having excellent thermal conductivity, surface hardness, surface adhesion and appearance can be obtained. Further, a thick graphite film in which each of such properties is excellent can be obtained. There is provided a process for producing a graphite film in which a polymer film is thermally treated at a temperature of 2,000° C. or more, the process comprising the step of bringing a polymer film into contact with a substance containing a metal during graphitization treatment. When a polymer film having a high plane orientation is used as a raw material and the raw material is brought into contact with a metal to thermally treat the material, a problem of separation of graphite from the surface can be solved which has not been solved by the prior art, and furthermore a graphite can be obtained having excellent thermal conductivity, surface hardness, density and surface adhesion.
US08512666B2
The invention relates to a method for producing neopentasilanes of the general formula (1) Si(SiR3)4 (1), wherein silicon compounds of the general formula (2) R3Si— (SiR2—)xSiR3 (2), where R is selected from Cl, Br, and I, and x is a non-negative whole number up to 5, are converted in the presence of catalytically active compounds (K), wherein the separating of the tetrahalogen silane formed thereby takes place by distilling out in the presence of a compound (L) that is liquid at room temperature having a higher boiling point than the released tetrahalogen silane.
US08512664B1
A method is provided for treating silica sand scrubs (SSS) generated and accumulated as waste in the chloride manufacturing process of titanium dioxide pigment. A hydrothermal process is used to produce sodium silicate solutions of modulus 3.0 to 3.8, and precipitated silicas. In some embodiments, the process uses two specific principal reaction stages. A sodium silicate solution having a low SiO2:Na2O molar ratio, in the range from 2.0 to 2.8, is first produced by reaction of the SSS, as a cost-effective SiO2 source, with aqueous caustic soda. The conversion of this intermediate sodium silicate solution of low modulus to a high SiO2:Na2O molar ratio is made possible by using a SiO2 source that is prepared as precipitated amorphous silica from the intermediate sodium silicate solution produced above.
US08512660B2
The absorptive removal of carbon dioxide from biogas using a scrubbing liquid in which carbon dioxide is chemically bound proceeds by heating the loaded scrubbing liquid, occurring after the absorption, to a temperature at which liberation of CO2 begins. Immediately thereafter, the loaded scrubbing liquid is fed to at least one centrifugal separator for separating off the gas phase from the liquid phase, wherein methane and dissolved fractions of CO2 escape via the gas phase. After separation is complete, the gas phase is passed into the absorber unit and the liquid phase is further heated to the temperature required for desorption and fed to the desorption unit for regeneration.
US08512659B2
There is disclosed iron-containing aluminosilicate zeolites having both framework iron and iron cations on the ion-exchange sites. There is also disclosed a direct synthesis method of making an iron-containing aluminosilicate zeolite, which does not require the use of an intermediate step, such as ion-exchange or impregnation. In addition, there is disclosed a method of using the iron-containing aluminosilicate zeolite disclosed herein in a selective catalytic reduction reaction, typically in the presence of ammonia, to reduce or remove nitric oxides from exhaust emissions.
US08512651B2
An apparatus and method for tagging a specimen slide are described. The apparatus comprises a receiving region for receiving at least one cassette magazine, a reading unit for reading the machine-readable coded information of a cassette identifier of a cassette, and a tagging unit for generating a machine-readable coded information for tagging the specimen slide with a specimen slide identifier that depends on the cassette identifier. Data are transferred from the microtome to the apparatus via the data transfer path as soon as the cassette is inserted into the microtome, and only then can the machine-readable coded information for tagging the specimen slide be applied onto the specimen slide by the tagging unit.
US08512647B2
A support pipette including at least one cylinder with an upper end and a lower end, each cylinder having a movable piston, and an elongate handle (1) with an upper part and a lower part, at which handle the pipette can be manually gripped, wherein the lower part (13.1; 13.2; 13.3) of the handle (1) includes a sideways protruding lower support (10.1; 10.2; 10.3; 10.4; 10.5).
US08512645B2
The present invention describes an exchanger-reactor for carrying out endothermic reactions, comprising a shell inside which a heat transfer fluid moves, said shell enclosing a plurality of tubes inside which the reactant fluid moves, the tubes being of the bayonet type, and the reactor not having a tube plate. This reactor may operate with a pressure difference between the tube side and the shell side which may be up to 100 bars.
US08512642B2
Provided is an apparatus for producing hard polyurethane foam by a froth process having a foaming agent supply means that quantitatively supplies the inert gas as a foaming agent and a foaming means that discharges a hard polyurethane foam obtained by forming a foaming polyol composition, in which the foaming agent supply means has a pressure-reducing valve that reduces and adjusts the pressure of the inert gas and a needle valve that adjusts the flow rate of the inert gas, the foaming means has a compression cylinder for compressing and supplying the polyol composition, a regulation means that regulates the supply of the inert gas to the foaming means is provided between the foaming means and the foaming agent supply means, and a control means that controls the regulation means by sensing the operation of the compression cylinder is connected to the regulation means.
US08512641B2
The present invention is directed to methods and systems of modulating step function phenomena by varying nanoparticle size—particularly wherein a plurality of such nanoparticles are employed, and wherein said nanoparticles comprise a size distribution favorable for collectively smoothing the step function. Such methods and systems are particularly favorable for hydrogen sensors.
US08512640B2
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
US08512629B2
A system for heat treating an alloy steel component includes a first enclosure and a second enclosure opposed to the first enclosure. The first and second enclosures define a chamber around only a portion of the alloy steel component. The system further includes a heating element in the chamber to heat the portion of the alloy steel component. A method for heat treating an alloy steel component includes placing a first enclosure against a first side of the alloy steel component and placing a second enclosure against a second side of the alloy steel component. The method further includes creating a substantially airtight chamber around only a portion of the alloy steel component between the first and second enclosures and heating the portion of the alloy steel component inside the substantially airtight chamber.
US08512627B2
The present invention provides a method for the production of a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) asymmetric hollow fiber membrane. The invention comprises preparing a dope solution of PVDF-HFP with an additive of lithium chloride or glycerol dissolved in a solvent such as N-methylpyrollidone (NMP). The dope solution is spun to form a PVDF-HFP asymmetric hollow fiber membrane.
US08512619B2
Embodiments provide methods and systems for manufacturing a golf ball that precisely control the retraction of mold pins based on feedback sensor data, to avoid the formation of imperfections in the finished golf balls. An embodiment may involve holding a golf ball sub-part within a mold using at least one retractable mold pin; injecting molten molding material into the mold; detecting, during injection, operating conditions within the mold indicative of positions of the molten molding material relative to the at least one mold pin; and based on the detected operating conditions, retracting the at least one mold pin before the molten molding material reaches the at least one mold pin. Other embodiments may retract a mold pin after the molten material contacts the pin but within a duration suitably short enough to avoid undesirable part properties.
US08512618B2
Process for the production of a molding from particulate and/or fibrous substrates based on renewable raw materials and a formaldehyde-free, aqueous binder.
US08512610B2
The nonwoven fabric sheet of the present invention is characterized by a porosity in the range of 0.3 to 0.7 and an average pore size in the range of 0.5 μm to 5.0 μm. The nonwoven fabric sheet of the present invention preferably has a maximum pore size (μm)/average pore size (μm) ratio of 1.30 or lower. The nonwoven fabric sheet of the present invention is obtained by press-molding a nonwoven fabric at a temperature lower than the melting point of the thermoplastic resin which constitutes the nonwoven fabric sheet. According to the present invention, there is provided a nonwoven fabric sheet that has a high porosity, small uniform pore sizes and excellent productivity, which can suitably be used in various applications such as filters, light diffusing material, liquid absorber and heat insulating materials; and a method for producing the nonwoven fabric sheet.
US08512606B2
A procedure for dimensionally accurate sintering of a shaped piece manufactured from a blank of porous ceramic material, in which during the sintering, the shaped piece remains connected via at least one first connection like a rib, with a support that is manufactured from the blank. To ensure with simple procedural steps and simple design measures that the geometry does not change during sintering, the invention provides that the support is manufactured as a section of the blank that at least in sections surrounds the shaped piece by materials removal processing from the blank, and after the manufacture, the support, for one, is connected via the at least one first connection with the shaped piece, and for another, via at least one second connection with the residual blank that in sections is separated from the support.
US08512603B2
This invention relates to a range of compounds, polymeric compounds, and compositions used to prepare semiconductor and optoelectronic materials and devices including thin film and band gap materials for photovoltaic applications including devices and systems for energy conversion and solar cells. In particular, this invention relates to polymeric precursor compounds and precursor materials for preparing photovoltaic layers. A compound may contain repeating units {MA(ER)(ER)} and {MB(ER)(ER)}, wherein each MA is Cu, each MB is In or Ga, each E is S, Se, or Te, and each R is independently selected, for each occurrence, from alkyl, aryl, heteroaryl, alkenyl, amido, silyl, and inorganic and organic ligands.
US08512601B2
It is provided a paste composition for a solar cell electrode containing a conductive powder, a glass frit, and a vehicle, the glass frit being made of glass containing PbO, B2O3, and SiO2 at proportions within ranges of 46 to 57 (mol %), 1 to 7 (mol %), and 38 to 53 (mol %), respectively, in terms of oxide.
US08512600B2
The present invention provides a polycarbonate resin composition comprising a polycarbonate (A), a styrene copolymer resin (B), carbon nano-tubes (C) and a carbon black (D).
US08512593B2
Provided herein are chemical mechanical polishing (CMP) slurries and methods for producing the same.Embodiments of the invention include CMP slurries that include (a) a metal oxide; (b) a pH-adjusting agent; (c) a fluorinated surfactant; and (d) a quaternary ammonium surfactant. In some embodiments, the fluorinated surfactant is a non-ionic perfluoroalkyl sulfonyl compound.Also provided herein are methods of polishing a polycrystalline silicon surface, including providing a slurry composition according to an embodiment of the invention to a polycrystalline silicon surface and performing a CMP process to polish the polycrystalline silicon surface.
US08512587B2
Etch solutions for selectively etching doped oxide materials in the presence of silicon nitride, titanium nitride, and silicon materials, and methods utilizing the etch solutions, for example, in construction of container capacitor constructions are provided. The etch solutions are formulated as a mixture of hydrofluoric acid and an organic acid having a dielectric constant less than water, optionally, with an inorganic acid, and a pH of 1 or less.
US08512586B2
A method and system for performing gas cluster ion beam (GCIB) etch processing of various materials is described. In particular, the GCIB etch processing includes setting one or more GCIB properties of a GCIB process condition for the GCIB to achieve one or more target etch process metrics.
US08512584B2
An etching method that uses an etch reactant retained within at least a semi-solid media (120, 220, 224, 230). The etch reactant media is applied to selectively etch a surface layer (106, 218, 222). The etch reactant media may be applied to remove metal shorts (222), smearing and eaves resulting from CMP or in failure analysis for uniform removal of a metal layer (218) without damaging the vias, contact, or underlying structures.
US08512579B2
The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein.
US08512577B2
Process and apparatus for completely recovering the reusable components of an abrasive slurry used in slicing crystalline materials of silicon, quartz or ceramics when it becomes exhausted and enriched with undesired waste matter. The process consists of an initial centrifuge separation of the exhausted slurry as such and of a wet size-sorting treatment of the fraction containing the abrasive grains obtained from the centrifuge, carried out in a battery of hydrocyclones or centrifuges connected in series. The section for the recovery and purification of the abrasive grains comprises a multifunctional apparatus that performs all the required operations within a single pressure vessel.
US08512571B2
The present invention is a method and system for treating iron-contaminated water (e.g., mine drainage) using an innovative treatment approach identified herein as the Activated Iron Solids (AIS) Process. The AIS process is capable of oxidizing and removing iron as iron oxides from iron-contaminated waters (such as, mining-related discharge, groundwater, surface water and industrial waste streams) producing a clean effluent. The AIS process is performed in a single or multiple tank system in which high concentrations of AIS are suspended through mechanical mixing to maintain a catalytic surface chemistry environment that increases iron removal thousands times faster than would naturally occur and hundreds times faster than existing arts (e.g., aerobic pond passive treatment). The AIS process can utilize inexpensive alkaline material (such as, pulverized limestone) where initial mine drainage alkalinity (mg/L as CaCO3) to ferrous iron (mg/L) ratio is less than approximately 1.7. Excess accumulated activated iron solids are periodically removed from the system using a waste-activated iron solids (WAIS) system and directed to an iron oxide thickener for further concentration.
US08512565B2
A solid-liquid separator prevents wear of a self-priming liquid pump connected to a cyclone mechanism and a solid-liquid mixture can be purified at low cost. The separator separates sludge in the liquid by a cyclone in a separation portion directly or indirectly connected to a suction of the upstream side of the pump. The separation portion has a first and second cyclones with the first cyclone disposed in said second cyclone coaxially. A tank disposed under the cyclones collects separated from the liquid.
US08512554B2
In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.
US08512550B2
A method for the determination of optimal pipestill operation comprising the steps of: feeding a crude oil feedstream into the pipestill wherein the crude oil feedstream is separated into boiling range fractions, performing a virtual assay of the crude oil feedstream to determine predicted boiling range fraction yields, comparing the predicted boiling range fraction yields with the actual boiling range fraction yields from the pipestill to determine differences between these fraction yields, relating the difference between the fraction yields with the operation of the pipestill.
US08512544B2
The method of the present invention includes a step (i) in which a voltage is applied between first and second electrodes 21 and 22 so that the first electrode serves as a cathode, with the first and second electrodes 21 and 22 being placed in contact with a material that allows ions to move therethrough. The material includes an adsorbent (gel 11) containing a macromolecule that has adsorbed a metal ion. The macromolecule contains the same constitutional units as those contained in a macromolecule extracted from Aphanothece sacrum. The first electrode 21 is placed in contact with the adsorbent in step (i). The metal is deposited on a surface of the first electrode 21 by applying the voltage in step (i).
US08512542B2
A method for the electrochemical coating of a substrate uses brush plating. This is to take place with an electrolyte in that particles are dispersed, which are embedded into the developing layer. It is proposed to add the particles to the carrier for the electrolyte by way of a separate conduit system. The electrolyte is added by way of a conduit system. In this way it is achieved that an agglomeration of the particles in the electrolyte can be prevented because only a short time passes between when the particles are fed and the layer is formed. A device for electrochemical coating has two conduit systems provided for this purpose.
US08512539B2
The invention relates to a method (3) of fabricating a mould (39, 39′, 39″) that includes the following steps: a) providing (10) a substrate (9, 9′) that has a top layer (21, 21′) and a bottom layer (23, 23′) made of electrically conductive, micromachinable material, and secured to each other by an electrically insulating, intermediate layer (22, 22′); b) etching (11, 12, 14, 2, 4) at least one pattern (26, 26′, 27) in the top layer (21, 21′) as far as the intermediate layer (22, 22′) to form at least one cavity (25, 25′) in said mould; c) coating (6, 16) the top part of said substrate with an electrically insulating coating (30, 30′); d) directionally etching (8, 18) said coating and said intermediate layer to limit the presence thereof exclusively at each vertical wall (31, 31′, 33) formed in said top layer. The invention concerns the field of micromechanical parts, in particular, for timepiece movements.
US08512527B2
A sputtering apparatus for uniformly eroding a sputtering target is disclosed. The sputtering apparatus includes a substrate, a sputtering target having a first surface facing the substrate, a magnet configured to apply a magnetic field to the sputtering target, and facing a second surface of the sputtering target, a guide rail connected to the magnet configured to support and guide the magnet member, wherein a first portion of the guide rail, corresponding to a central portion of the sputtering target, includes a linear portion in a first direction parallel to the second surface of the sputtering target, and wherein a second portion of the guide rail, corresponding to an edge portion of the sputtering target, includes an inclined portion away from the sputtering target in a second direction perpendicular to the first direction, a screw line formed in the first direction in parallel to the guide rail, and a connector connected to the magnet by an elastic, and configured to move the magnet in the first direction along the screw line.
US08512525B2
The present invention features a coke drum de-heading system that enables the de-heading of a coke drum without having to physically remove the head units. This is essentially accomplished using one of a variety of specially designed de-header valves that may be removably coupled to a coke drum much the same way a conventional head or flange unit would be attached.
US08512515B2
Wiping products are disclosed containing an additive composition that enhances the cleaning properties of the product. The additive composition, for instance, comprises an aqueous dispersion containing an alpha-olefin polymer, an ethylene-carboxylic acid copolymer, or mixtures thereof. The alpha-olefin polymer may comprise an interpolymer of ethylene and octene, while the ethylene-carboxylic acid copolymer may comprise ethylene-acrylic acid copolymer. The additive composition may also contain a dispersing agent, such as a fatty acid.
US08512514B2
A method for generating steam in a digester plant of a chemical pulp mill including: producing black liquor in the digester plant, extracting a first stream of black liquor from the digester; generating vapor by evaporating the first stream of black liquor by heating the first stream with fresh steam; heating fibrous material in the digester with the generated vapor from the evaporated first stream of black liquor; extracting a second stream of black liquor from the digester; flashing the second stream of black liquor to generate flashed black liquor and flashed black liquor vapor; introducing the flashed black liquor vapor to at least one heat exchanger to indirectly heat a clean evaporable liquid to produce clean steam from the clean evaporable liquid; and steaming, with the clean steam produced in the at least one heat ex-changer, cellulosic feed material before feeding the cellulosic feed material to the digester plant.
US08512510B2
A plasma processing method is arranged to supply a predetermined process gas into a plasma generation space in which a target substrate is placed, and turn the process gas into plasma. The substrate is subjected to a predetermined plasma process by this plasma. The spatial distribution of density of the plasma and the spatial distribution of density of radicals in the plasma are controlled independently of each other relative to the substrate by a facing portion opposite the substrate to form a predetermined process state over the entire target surface of the substrate.
US08512499B2
An approach to providing folded flute ends in z-filter media is provided. The approach generally involves providing an initial deformation in a flute or corrugation to form at least one foldable tip and then folding the at least one foldable tip over. Techniques for both supported deformation and unsupported deformation are provided. Preferred corrugated media having fold arrangements, filter constructions having such fold arrangements, and filter system using such filter constructions are provided.
US08512491B2
A method of bonding a first substrate and a second substrate includes the steps of rotating first substrate with an adhesive mass thereon, and second substrate contacting the mass and overlying the first substrate, controlling a vertical height of a heated control platen spaced apart from and not contacting the second substrate so as to control a temperature of the adhesive mass, so as to at least one of bond the first and second substrates in alignment with one another, or achieve a sufficiently planar adhesive interface between the first and second substrates.
US08512480B2
The present invention relates to a light duty liquid detergent composition comprising a low molecular weight hydrophobically modified cellulosic polymer, to provide improved foaming properties.
US08512468B2
A geopolymer mortar formed by mixing about 35% to about 45% by weight pozzolanic material, about 35% to about 45% by weight silicon oxide source, about 15% to about 20% by weight alkaline activator solution, and about 0.3% to about 2.5% by weight copper ion source. The pozzolanic material may be fly ash and the silicon oxide source may be sand. The alkaline activator solution may be a sodium hydroxide solution containing sodium silicate. The geopolymer mortar may have a viscosity in the range of about 25,000 to about 50,000 centipoise. The geopolymer mortar may be formed by further mixing one or more additives, such as surfactants, thermal spheres, anti-sagging agents, adhesion primers, or fibers. The geopolymer mortar may be applied as a protective coating on a surface of a structure.
US08512467B2
The disclosure relates to zinc oxide (ZnO) nanoparticle dispersions and to such dispersions having a defined color, and films obtained from such dispersions. The zinc oxide dispersions can be used as a UV-absorber, for catalytic applications, electronic applications, production of antifungal or antibacterial materials, sensors, actuators, photovoltaic devices, conductive coatings, among other applications.
US08512466B2
Phosphorus-containing oligomer is represented by formula (1): (R1 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, or a phenyl group; n is the number of repeating units and an integer of 1 or more; X is a structural unit represented by structural formula (x1) or (x2) below; Y is a hydrogen atom, a hydroxyl group, or a structural unit represented by the formula (x1) or (x2); and, in the formula (x1) or (x2), R2, R3, R4, and R5 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group, or an aralkyl group), wherein the content of components whose n is 2 or more in the formula (1) is in the range of 5% to 90% in peak area in GPC measurement.
US08512465B2
The invention relates to the use of copolymers which as well as other monomers contain in copolymerized form 10% to 90% by weight of monomers containing heterocyclic basic groups, and which do not contain vinylpyrrolidone as a monomer component, as additives in paints for improving the adhesion of the solid paint film to a substrate.The invention also relates to cured and uncured polymer compositions comprising copolymers which as well as other monomers contain in copolymerized form 10% to 90% by weight of monomers containing heterocyclic basic groups, and which do not contain vinylpyrrolidone as a monomer component, as adhesion improver additions.