US08564017B2
A drift layer has a thickness direction throughout which a current flows and has an impurity concentration N1d for a first conductivity type. A body region is provided on a portion of the drift layer, has a channel to be switched by a gate electrode, has an impurity concentration N1b for the first conductivity type, and has an impurity concentration N2b for the second conductivity type greater than the impurity concentration N1b. A JFET region is disposed adjacent to the body region on the drift layer, has an impurity concentration N1j for the first conductivity type, and has an impurity concentration N2j for the second conductivity type smaller than the impurity concentration N1j. N1j−N2j>N1d and N2j
US08564015B2
An organic light-emitting diode with high color rendering is provided, which includes: a substrate; a first electrode disposed over the substrate; a light-emitting region disposed over the first electrode, in which the light-emitting region includes a plurality of light-emitting layers and at least one spacer, the spacer being disposed between any two of the light-emitting layers and each of the light-emitting layers individually including a dye; and a second electrode disposed over the light-emitting region. Accordingly, the organic light-emitting diode according to the present invention can exhibit high color rendering and high illumination efficiency.
US08564012B2
A method for manufacturing an optoelectronic apparatus includes attaching bottom surfaces of first and second packaged optoelectronic semiconductor devices (POSDs) to a carrier substrate (e.g., a tape) so that there is a space between the first and second POSDs. An opaque molding compound is molded around portions of the first and second POSDs attached to the carrier substrate, so that peripheral surfaces of the first POSD and the second POSD are surrounded by the opaque molding compound, the space between the first and second POSDs is filled with the opaque molding compound, and the first and second POSDs are attached to one another by the opaque molding compound. The carrier substrate is thereafter removed so that electrical contacts on the bottom surfaces of the first and second POSDs are exposed. A window for each of the POSDs is formed during the molding process or thereafter.
US08564010B2
An LED device includes a strip-shaped electrode, a strip-shaped current blocking structure and a plurality of distributed current blocking structures. The current blocking structures are formed of an insulating material such as silicon dioxide. The strip-shaped current blocking structure is located directly underneath the strip-shaped electrode. The plurality of current blocking structures may be disc shaped portions disposed in rows adjacent the strip-shaped current blocking structure. Distribution of the current blocking structures is such that current is prevented from concentrating in regions immediately adjacent the electrode, thereby facilitating uniform current flow into the active layer and facilitating uniform light generation in areas not underneath the electrode. In another aspect, current blocking structures are created by damaging regions of a p-GaN layer to form resistive regions. In yet another aspect, current blocking structures are created by etching away highly doped contact regions to form regions of resistive contact between conductive layers.
US08563991B2
An optical semiconductor device has a semiconductor substrate, an optical semiconductor region and a heater. The optical semiconductor region is provided on the semiconductor substrate and has a width smaller than that of the semiconductor substrate. The heater is provided on the optical semiconductor region. The optical semiconductor region has a cladding region, an optical waveguide layer and a low thermal conductivity layer. The optical waveguide layer is provided in the cladding region and has a refractive index higher than that of the cladding region. The low thermal conductivity layer is provided between the optical waveguide layer and the semiconductor substrate and has a thermal conductivity lower than that of the cladding region.
US08563987B2
The semiconductor device 100 of this invention includes: a semiconductor layer 2 arranged on the principal surface of a substrate 1 and made of a wide bandgap semiconductor; a trench 5 which is arranged in the semiconductor layer 2 and which has a bottom and a side surface; an insulating region 11 arranged on the bottom and side surface of the trench 5; and a conductive layer 7 arranged in the trench 5 and insulated from the semiconductor layer 2 by the insulating region 11. The insulating region 11 includes a gate insulating film 6 arranged on the bottom and the side surface of the trench 5 and a gap 10 arranged between the gate insulating film 6 and the conductive layer 7 at the bottom of the trench 5. The gate insulating film 6 contacts with the conductive layer 7 on a portion of the side surface of the trench 5 but does not contact with the conductive layer 7 at the bottom of the trench 5. The thickness of the insulating region 11 measured from the bottom of the trench 5 through the lower surface of the conductive layer 7 is greater around the center of the trench than beside its side surface.
US08563980B2
Manufacturing an array substrate includes forming data and gate lines which cross and a gate electrode on a substrate. The data line is discontinuously disposed to be separated from the gate line, or the gate line is discontinuously disposed to be separated from the data line. Active and gate insulating layers including bridge and source electrode vias are formed on the substrate. The bridge vias correspond to adjacent discontinuous sections of the data line or the gate line. The source electrode via corresponds to the data line. Pixel, source, and drain electrodes and a bridge line are formed on the substrate. The pixel electrode and the drain electrode are integral. The source electrode is connected to the data line through the source electrode via. The bridge line connects adjacent discontinuous sections of the data line or adjacent discontinuous sections of the gate line through bridge vias.
US08563977B2
A transistor is constituted of a gate electrode 2, a gate insulation layer 3, a semiconductor layer 4 formed of an amorphous oxide, a source electrode 5, a drain electrode 6 and a protective layer 7. The protective layer 7 is provided on the semiconductor layer 4 in contact with the semiconductor layer 4, and the semiconductor layer 4 includes a first layer at least functioning as a channel layer and a second layer having higher resistance than the first layer. The first layer is provided on the gate electrode 2 side of the semiconductor layer 4 and the second layer is provided on the protective layer 7 side of the semiconductor layer 4.
US08563969B2
A compound having the structure represented by the following formula (1) or (1)′ as at least a part: wherein FA is a fused aromatic ring, and Ar is an aromatic group.
US08563968B2
The present invention provides an EL device that contains a quantum-dots-containing layer in which quantum dots hardly coagulate even under high-temperature conditions, e.g., at a temperature of 90° C. or more, that has a good performance even if heat treatment was carried at a high temperature in its production process, that can retain its emission characteristics for a prolonged period of time, and that has high durability. An electroluminescent device comprises a pair of electrodes, and an electroluminescent layer containing at least a luminescent layer, situated between the electrodes. The luminescent layer contains quantum dots whose surfaces are protected by one or more protective materials. At least one of the protective materials has a glass transition temperature and a melting point of 90° C. or more.
US08563966B2
A new devices structure of nano tunneling field effect transistor based on nano metal particles is introduced. The nano semiconductor device, comprising a source and a drain, wherein each of the source and drain comprise an implanted nano cluster of metal atoms, wherein the implanted nano cluster of metal atoms forming the source has an average radius in the range from about 1 to about 2 nanometers, and the implanted nano cluster of metal atoms forming the drain has an average radius in the range from about 2 to about 4 nanometers. Processes for producing the nano semiconductor device are detailed.
US08563962B2
Disclosed is a memory device provided with a plurality of memory cells and a lead-out line (12) shared among the memory cells. Each memory cell is provided with a transistor (6) formed above a substrate (1) and a variable resistance element (10) having a lower electrode (7), an upper electrode (9) that comprises a noble metal, and a variable resistance layer (8) disposed between the lower electrode (7) and the upper electrode (9). The resistance value of the variable resistance layer (8) changes reversibly in response to electric pulses that go through the transistor (6) and are applied between the lower electrode (7) and the upper electrode (9). The lead-out line (12) is in direct contact with the upper electrodes (9) of the memory cells.
US08563958B2
Reflected light caused by the state of the surface of a wafer, a foreign material, or a defect is superimposed on a haze frequency component caused by the type and thickness of a film or a surface irregularity. In order to detect a haze frequency component caused by a haze present on the surface of an object to be inspected, light propagating from the object to be inspected is detected and converted into an electric signal. The electric signal is sampled at a predetermined sampling time interval and converted into digital data. A frequency component caused by a foreign material, a defect or the like is separated from the digital data to ensure that a haze frequency component is selected. The haze frequency component is caused by a stain attached to the surface of the wafer, hazy tarnish, a surface irregularity or the like.
US08563955B2
The invention concerns a passive terahertz radiation source configured to emit electromagnetic radiation having frequency in the range of 10 GHz to 50 THz and a method for generating a terahertz radiation. The passive terahertz radiation source comprises: a source of a pulsed excitation light; an emitter comprising one or more emitter elements, each emitter element comprising a semiconductor layer being arranged such that at least a portion of a first major surface of said semiconductor layer is exposed to the excitation light, wherein each emitter element is configured such that upon exposure to the excitation light, a gradient of the charge carrier density is generated in the semiconductor layer in the area of transition between a first area of the semiconductor layer and a second area of the semiconductor layer, the gradient being substantially parallel to the first major surface of the semiconductor layer.
US08563950B2
An energy beam drawing apparatus includes a member, positioned between an energy beam source and a substrate, on which a deposit is deposited and a removing unit which removes the deposit. The removing unit includes a catalyst for generating, from a gas, an active species for decomposing the deposit by irradiation with the energy beam, a supplying mechanism for supplying the gas to a position where the active species is generated, and a moving mechanism for moving, when executing processing of removing the deposit, the catalyst to a first position which is irradiated with the energy beam, and moving, when executing drawing processing on the substrate, the catalyst to a second position which is not irradiated with the energy beam.
US08563942B2
The invention relates to a multi-beam deflector array means for use in a particle-beam exposure apparatus employing a beam of charged particles, said multi-beam deflector array means having an overall plate-like shape with a membrane region and a buried CMOS-layer, said membrane region comprising a first side facing towards the incoming beam of particles and a second side opposite to the first side, an array of apertures, each aperture allowing passage of a corresponding beam element formed out of said beam of particles, and an array of electrodes, each aperture being associated with at least one of said electrodes and the electrodes being controlled via said CMOS layer, wherein the electrodes are pillared, standing proud of the main body of the multi-beam deflector array means, the electrodes being connected to one side of the main body of the multi-beam deflector array means by means of bonding connections.
US08563929B2
A two fields-of-view system has both fields of view imaged simultaneously to the same image plane. For example, an optical system comprising of two or more FOV where a common dual band focal plane array is used in order to image both spectral bands independently. Each spectral band is passed through a common imager, but split off by a beam splitter so that each spectral band sees a different field of view centered at the same point. The two fields of view are separated spectrally but enabled to be imaged simultaneously due to the spectral separation of the focal plane array and the use of a beam splitter. Such a system allows viewing two fields of view simultaneously.
US08563928B2
Methods and apparatus for producing sub-diffraction limited images utilizing an exponential scaling effect. An exemplary system provides an optical source that focuses an optical beam onto a target. The focused optical beam has sufficient optical intensity to induce an exponential signal response within the target. A detection device detects the exponential signal response. A scanning device scans the focused optical source and another device records the detection of the exponential signal response for purposes of producing a sub-diffraction limited image. The system further includes a display device that displays at least a portion of the recorded detection.
US08563927B2
A shielding member for a charged particle beam apparatus includes a conductive substrate; and a through hole extending through the conductive substrate. The conductive substrate is comprised of a material having a specific electrical resistivity in a range from about 106 Ωcm to about 1012 Ωcm.
US08563920B2
A radio-frequency ion guide (20) for converging ions by a radio-frequency electric field and simultaneously transporting the ions into the subsequent stage is composed of eight rod electrodes (21 through 28) arranged in such a manner as to surround an ion optical axis (C). Each of the rod electrodes (21 through 28) is disposed at a tilt with respect to the ion optical axis (C) so that the radius r2 of the inscribed circle (29b) at the end face of the ion exit side is larger than the radius r1 of the inscribed circle (29a) at the end face of the ion injection side. Accordingly, the gradient of the magnitude or depth of the pseudopotential is formed in the ion's traveling direction in the space surrounded by the rod electrodes (21 through 28). Ions are accelerated in accordance with this gradient. Therefore, even in the case where the gas pressure is relatively high and ions have many chances to collide with gas, it is possible to moderate the ions' slowdown and prevent the ions' delay and stop.
US08563919B2
A phantom for simulation of perfusion, for use in dynamic flow imaging. The phantom includes a first compartment having a first inlet and a first outlet, and a second compartment having a second outlet. The first and the second compartments have fluid communication with each other, to simulate perfusion between the first and the second compartments. The first and the second outlets are separately controllable to adjust outflow of fluid from each compartment and to adjust fluid pressure in each compartment, thereby controlling rates of communication of fluids between the first and the second compartments.
US08563906B2
In one embodiment, an insulating microwave packaging material (200) includes a microwave interactive material substrate (205) joined to a second substrate (210) along bond lines (212) to define closed cells (214). Upon impingement of the insulating microwave packaging material (200) by microwave energy in a microwave oven, the closed cells (214) expand to form insulating pockets (216). One side of the insulating pocket (216) bulges and lofts above the opposite side. When a food product is situated on the insulating microwave packaging material (200), the insulating pockets (216) insulate the food product from the microwave oven environment.
US08563901B2
A method and apparatus are described for providing top heat to assist with baking in an oven appliance having a gas bake burner. The top heat is provided by a heating element positioned in the top of the oven cavity. This top heating element is operated in a manner that assists the bottom, gas bake burner with properly browning the food on both its top and bottom. The operation of the both the top heating element and the gas bake burner can be varied to provide proper cooking and browning based upon e.g., the type of food being cooked, the amount of food being cooked, and the level of browning desired.
US08563891B2
A welding assembly including a current generator, an electrode electrically coupled to the current generator, the electrode including a first engagement surface, and a workpiece including at least two members, wherein at least one of the members includes a second engagement surface, defines a recess in the second engagement surface, and is electrically coupled to the current generator.
US08563889B2
An electrical discharge assembly for processing a workpiece having a cooling passage with first and second portions includes a first electrode having a first shape for machining the first portion of the cooling passage and a second electrode having a second shape for machining the second portion of the cooling passage. In a method for repairing cooling passages in a workpiece, a first electrode having a first shape is positioned in a cooling passage. The first electrode is electrically powered to machine a first portion of the cooling passage. A second electrode having a second shape is positioned in the cooling passage. The second electrode is electrically powered to machine a second portion of the cooling passage.
US08563887B2
A trip latch assembly is provided for an electrical switching apparatus, such as a circuit breaker. The circuit breaker operating mechanism includes a pole shaft. The trip latch assembly includes a trip latch pivotably coupled to the circuit breaker housing and being movable between a latched position and an unlatched position. A trip latch reset spring is structured to bias the trip latch toward the latched position. A spring housing at least partially overlays the trip latch reset spring. A trip latch spring link includes a first end movably coupled to the pole shaft, and a second end cooperating with the spring housing. When the circuit breaker needs to be reset, the trip latch spring link engages the spring housing, in order apply torque to the trip latch reset spring. When the circuit breaker is closed, the bias of the trip latch reset spring on the trip latch is removed.
US08563881B2
An input device and an electronic apparatus having the same are provided. The input device includes a main body, and a plurality of keys each having a contact part which contacts a pressing unit and a non-contact part which extends from the contact part and is spaced apart from the pressing unit. The contact parts and the non-contact parts of the keys may be arranged in a zigzag pattern. The electronic apparatus includes the above-mentioned input device and a display device which is provided in the main body.
US08563878B2
The grommet disclosed includes a first diameter tubular section that allows a wire harness to pass through, and a second diameter tubular section that is provided on the first diameter tubular section. The first diameter tubular section is provided with an outer tubular section that extends in the axial direction. A projecting end of the outer tubular section is connected to the second diameter tubular section. A vehicle body latch portion is provided on an outer periphery or a resin inner of the second diameter tubular section. A grommet-pushing side of the first diameter tubular section is not secured to a wire harness. A grommet-inserting side of the first diameter tubular section is secured to the wire harness. The turning portion is deformed when the grommet is inserted into a through-hole in a vehicle body panel so that the first diameter tubular section is elongated.
US08563863B2
A smooth-bore plastic tubing with an outer helical support bead is resistant to collapse and incorporates plural conductors disposed outside of the tubing bore and insulated both from ambient and from one another. The conductors may have a desired relatively high thermal conductivity to tidal air flow within the tubing, while also having a comparatively high thermal resistance to ambient. The conductors may be electrical conductors, or may include fiber optic conductors as well in the same tubing structure. A method for making the tubing includes extruding a molten thermoplastic ribbon with an elevated plateau portion defining at least one conductor-receiving groove. The plastic ribbon is wrapped to form a tube and at least one conductor is embedded in the groove of the plateau portion. Finally a molten thermoplastic bead is then applied atop the plateau portion and atop of the embedded conductor providing a unitary flexible tubing structure with substantially smooth inside and outside surfaces free of crevices which could retain soil or bacteria.
US08563861B2
An inner conductor cap, with a connector end and a cable end, is provided with an inner conductor socket at the cable end and an inner conductor interface at the connector end. The inner conductor socket may be dimensioned to mate with a prepared end of an inner conductor of a coaxial cable. At least one material gap may be provided between a sidewall of the inner conductor socket and an outer diameter surface of the prepared end when the inner conductor cap is mated with the prepared end. A rotation key may be provided for rotating the inner conductor cap.
US08563860B1
An electrical power cable extension cord with a coiled section between the first and the second ends and at least one metal core conductor contained within the electrical power cable extension cord for transmitting electrical current to supply electrical power to a power device. The coiled section has a coiled diameter of approximately five times or more greater than the diameter of the electrical power cable extension cord.
US08563846B2
A thin film type solar cell and a method for manufacturing the same is disclosed, the thin film type solar cell comprising a substrate; a plurality of front electrodes on the substrate at fixed intervals by each first separating part interposed in-between; a plurality of semiconductor layers on the front electrodes at fixed intervals by each contact part interposed in-between; and a plurality of rear electrodes connected with the front electrodes through the contact part, provided at fixed intervals by each second separating part interposed in-between, wherein a main isolating part is formed in the outermost front electrode, the outermost semiconductor layer, and the outermost rear electrode, wherein an auxiliary isolating part is formed in at least one of the outermost front electrode and the outermost rear electrode, wherein the auxiliary isolating part is positioned on the inside of the main isolating part.
US08563837B1
The present invention relates to an inbred sunflower line, designated CIN683A/B. The invention relates to the seeds of inbred sunflower line CIN683A/B, to the plants of inbred sunflower line CIN683A/B and to the methods for producing a sunflower plant, either inbred or hybrid, by crossing the inbred line CIN683A/B with itself or another sunflower line. The invention further relates to methods for producing a sunflower plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred sunflower lines derived from the inbred CIN683A/B.
US08563834B1
The invention provides seed and plants of the hybrid corn variety designated 570007. The invention thus relates to the plants, seeds and tissue cultures of the variety 570007, and to methods for producing a corn plant produced by crossing a corn plant of variety 570007 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety 570007.
US08563828B1
A novel maize variety designated PH17C4 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH17C4 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH17C4 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH17C4 or a locus conversion of PH17C4 with another maize variety.
US08563826B1
A soybean cultivar designated 5555821658 is disclosed. Embodiments of the invention include the seeds of soybean 5555821658, the plants of soybean 5555821658, to plant parts of soybean 5555821658, and methods for producing a soybean plant produced by crossing soybean 5555821658 with itself or with another soybean variety. Embodiments of the invention include methods for producing a soybean plant containing in its genetic material one or more genes or transgenes and the transgenic soybean plants and plant parts produced by those methods. Embodiments of the invention also relate to soybean cultivars, breeding cultivars, plant parts, and cells derived from soybean 5555821658, methods for producing other soybean cultivars, lines or plant parts derived from soybean 5555821658, and the soybean plants, varieties, and their parts derived from use of those methods. Embodiments of the invention further include hybrid soybean seeds, plants, and plant parts produced by crossing 5555821658 with another soybean cultivar.
US08563825B1
A soybean cultivar designated 5571721658 is disclosed. Embodiments of the invention include the seeds of soybean 5571721658, the plants of soybean 5571721658, to plant parts of soybean 5571721658, and methods for producing a soybean plant produced by crossing soybean 5571721658 with itself or with another soybean variety. Embodiments of the invention include methods for producing a soybean plant containing in its genetic material one or more genes or transgenes and the transgenic soybean plants and plant parts produced by those methods. Embodiments of the invention also relate to soybean cultivars, breeding cultivars, plant parts, and cells derived from soybean 5571721658, methods for producing other soybean cultivars, lines or plant parts derived from soybean 5571721658, and the soybean plants, varieties, and their parts derived from use of those methods. Embodiments of the invention further include hybrid soybean seeds, plants, and plant parts produced by crossing 5571721658 with another soybean cultivar.
US08563818B1
A novel soybean variety, designated XBP32006 is provided. Also provided are the seeds of soybean variety XBP32006, cells from soybean variety XBP32006, plants of soybean XBP32006, and plant parts of soybean variety XBP32006. Methods provided include producing a soybean plant by crossing soybean variety XBP32006 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP32006, methods for producing other soybean varieties or plant parts derived from soybean variety XBP32006, and methods of characterizing soybean variety XBP32006. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP32006 are further provided.
US08563806B2
The invention provides isolated promoter polynucleotides that are root-specific and/or induced by plant parasitic nematodes. The promoters of the invention are useful for controlling expression of nucleic acids of interest in plant roots and are particularly useful for controlling transcription of nucleic acids encoding agents that disrupt formation or maintenance of parasitic nematode feeding sites in plants.
US08563802B2
To apply a clear pattern to an absorbent article such as sanitary napkin without worsening the soft and comfortable touch to skin and allowing the colorant from coming into direct contact with the skin of a wearer.An absorbent article comprising a liquid-permeable sheet, a liquid-impermeable sheet, an absorber sandwiched between the liquid-permeable sheet and the liquid-impermeable sheet, and side sheets joined to at least a part of the right and left both sides of the liquid-permeable sheet and to at least a part of the liquid-impermeable sheet, wherein a plurality of recess parts are provided in the side sheet, at least the portion provided with the recess part has a colored layer between the side sheet and the liquid-permeable sheet, and the recess part appears in a color different from the portion other than the recess part. The recess part is provided by stacking the liquid-permeable sheet, the colored layer and the side sheet in this order and applying embossing from the side sheet side to the region where the colored layer is present.
US08563800B2
A sacral wound dressing having a bottom end with three substantially V-shaped projections. In use, a protective layer of the wound dressing is removed to expose an adhesive layer and an absorbent layer, the wound dressing is folded over on itself substantially along a central axis, a medial V-shaped projection is inserted into a superior portion of the gluteal cleft of the person to adhere the medial projection to the skin within the gluteal cleft, two lateral V-shaped projections are then pushed against a superior portion of the buttocks of the person to adhere the lateral projections to the skin, and the opposing lateral ends and the top end of the wound dressing are then pushed against the skin of the person until the wound dressing is properly adhered to the sacrococcygeal region over the sacral wound.
US08563798B2
A bandage for improved wound care is disclosed. The bandage comprises a non-adherent, deformable inner layer, a leak-proof outer layer that is substantially coextensive with the inner layer, and an absorbent middle layer contacting both the inner and outer layers. An adhesive strip and adhesive tabs along the bandage's side attach and adjust the fit of the bandage to securely hold the absorbent layer in contact with the wound, without any adhesive touching the skin, thereby eliminating pain and discomfort upon removal or replacement. The bandage allows substantial freedom of motion without slipping. The adhesive strip and tabs secure the bandage in place without any adhesive touching the skin, thereby providing convenience and causing no pain or discomfort upon removal or replacement of the bandage. The bandage may use a non-stick netting material layer to improve patient comfort, and elastic cuffs to improve fit and leakage.
US08563797B2
A method for safely disposing of medicines includes converting the medicines into a partially solid mass that may be incinerated. The medicines may be treated with a bittering agent capable of denaturing the stored medicines and with a coloring agent capable of providing a characteristic color to the denatured medicines. The medicines may also be treated with a thickening agent that is capable of converting the denatured medicines into a partially solid disposable mass, prior to incinerating the medicines.
US08563796B2
The invention relates to a coating composition for the storage or containment of waste that is toxic to health and/or the environment, comprising a composition based on an epoxy resin and a curing composition free from an aromatic amine curing agent. The invention also relates to the use of this composition for the coating of said waste.
US08563793B2
Processes utilizing the integration of (i) processes and the associated equipment used to purify and recover propylene from propane- and/or C4+-containing refinery hydrocarbon streams, with (ii) catalytic dehydrogenation are disclosed. This integration allows for elimination of some or all of the conventional fractionation section of the dehydrogenation process, normally used to purify propylene from unconverted propane in the reactor effluent. Significant capital and utility savings are therefore attained.
US08563789B2
In this invention we are disclosing a process for the synthesis of hydrocchlorofluoro olefins (HCFO) and/or hydrofluoroolefins (HFO). The process is based on the steps of fluorination of hydrochloropropenes or hydrochloropropanes to form hydrochlorofluoropropenes and/or hydrofluoropropenes, followed by gas phase, catalytic fluorination of the hydrochlorofluoropropenes to form hydrofluoropropenes.
US08563788B2
A process for recovering butanol from a mixture comprising a water-immiscible organic extractant, water, butanol, and optionally a non-condensable gas, is provided. The butanol is selected from 1-butanol, 2-butanol, isobutanol, and mixtures thereof. The extractant comprises at least one solvent selected from the group consisting of C7 to C22 fatty alcohols, C7 to C22 fatty acids, esters of C7 to C22 fatty acids, C7 to C22 fatty aldehydes, and mixtures thereof.
US08563786B2
Disclosed is a method for producing an optically active alcohol including reacting a titanium compound, an aromatic magnesium compound and a carbonyl compound in the presence of an optically active biphenol compound having a predetermined structure and an ether compound having a predetermined structure.
US08563775B2
This invention relates to the preparation of (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.
US08563763B2
The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
US08563762B2
This disclosure concerns a metal oxide surface treatment with a fluoroalkyl silanizing agent.
US08563759B2
A process for extracting lipids from microalgae; the process involves pretreating a quantity of non-homogenized microalgae with an aliphatic alcohol for a predetermined period of time. The pretreatment liberates a substantial portion of lipids from the microalgae without requiring energy intensive cell membrane disruptive technologies. The liberated lipids are then treated with a transesterification reagent to form fatty acid methyl esters. The fatty acid methyl esters are separated from the resulting mixture and may be further purified to remove remaining solvents or other impurities. The fatty acid methyl esters produced by the process are suitable as a green energy biodiesel product.
US08563752B2
The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.
US08563750B2
Novel forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.
US08563748B2
The present invention relates to a process for the preparation of a ring-substituted N-phenylhydroxylamine by reduction of the correspondingly substituted nitrobenzene compound, wherein the reduction is carried out by reacting the substituted nitrobenzene compound with hydrazine in the presence of a ruthenium catalyst.
US08563732B2
The invention relates to oxyimino compounds of (Formula I), and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein: Y is CO or SOm; Z is hydrogen, each optionally substituted lower alkyl, lower alkenyl, aryl, heterocyclyl etc. R1 and R2 are each independently hydrogen, each optionally substituted lower alkyl, lower alkenyl, cycloalkyl, aryl, heterocyclyl etc., each X is independently ═O, optionally substituted lower alkyl, cyano, nitro etc., m is 1 or 2, p is O, 1 or 2 and q is O or 1. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
US08563728B2
The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5α-androst-1-en-3-one-17β-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO2)2O in presence of base to produce an intermediate compound of Formula (XIII), wherein R represents C1-6 alkyl, C1-6 halo alkyl, C6-10 aryl, halo aryl; (ii) condensing compound of Formula (XIII) with 2,5-bis(trifluoromethyl)aniline (III), Formula (III) in the presence or absence of a base to produce Dutasteride (I).
US08563722B2
The present invention relates to a method comprising reducing a ketone of formula I: with an enantioselective hydrogenating agent to form substantially enantiomerically pure alcohol of formula II: where R—R4 and m are as defined herein. The method of the present invention is useful for making CCR2 modulators as wells as precursors CCR2 modulators.
US08563721B2
The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
US08563713B2
The present disclosure is directed to antibodies specific to carbamazepine, immunogens used to produce the antibodies, and immunoassay kits and methods for using the antibodies.
US08563709B2
A miRNA-inhibiting RNA complex has a double-stranded structure, in which at least one RNA strand that includes a miRNA-binding sequence is linked to the two strands at at least one end of the double-stranded structure. The complex can efficiently inhibit miRNAs. In particular, RNAs in which two RNAs containing a miRNA binding sequence are positioned between two double-stranded structures were able to strongly inhibit miRNA. These RNAs can be expressed from, for example, a PolIII promoter, and by integration into a vector, miRNAs can be stably inhibited for a long period of time.
US08563707B2
Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.
US08563700B2
The present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect. The therapeutic effectiveness of the combination is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate. The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent(s). The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate. In each case, such combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone.
US08563688B2
A peptide or peptide derivative comprising: (i) WDLYFEIVW (SEQ ID NO: 1); or (ii) a variant amino acid sequence comprising one, two, three or four L-amino acid substitutions in WDLYFEIVW (SEQ ID NO: 1); or (iii) the retro-inverso variant of the peptide or peptide derivative of either one of parts (i) and (ii), wherein said peptide or peptide derivative has procoagulant activity. A peptide or peptide derivative comprising: (i) an amino acid sequence comprising imfwydcye; or (ii) a variant amino acid sequence comprising one, two, three, four, five or six amino acid substitutions in imfwydcye, wherein said peptide or peptide derivative has procoagulant activity.
US08563682B2
Guanylin cyclase C compound of the inventions are disclosed. Conjugated compounds comprising guanylin cyclase C compound of the inventions conjugated to detectable or therapeutic moieties are disclosed. Methods of detecting, imaging and treating cancer and treating diarrhea are disclosed.
US08563681B2
This invention provides a process for producing fine PPS resin particles and dispersion thereof by industrially applicable simple operation. This invention further provides very fine PPS resin particles, and furthermore provides fine PPS resin particles uniform in particle size. This invention is a process for producing fine polyphenylene sulfide resin particles comprising the following steps (a) and (b); (a) a step of heating a polyphenylene sulfide resin in an organic solvent, for obtaining a solution with the polyphenylene sulfide resin dissolved therein (dissolution step) (b) a step of flushing-cooling the aforementioned solution, for precipitating the fine particles of the polyphenylene sulfide resin (precipitation step).
US08563680B2
Thermoplastic molding compositions, comprising A) from 10 to 99.99% by weight of a polyamide B) from 0.01 to 20% by weight of a high-functionality polyetherol with an OH number of from 3 to 1350 mg KOH/g of polyetherol (to DIN 53240, part 2), C) from 0 to 70% by weight of further additives, where the total of the percentages by weight of components A) to C) is 100%.
US08563668B2
A resin composition is provided that includes two or more types of compounds selected from the group consisting of (Component A) a compound comprising a silicon atom having a total of one or two alkoxy and hydroxy groups, (Component B) a compound comprising a silicon atom having a total of three alkoxy and hydroxy groups, and (Component C) a compound comprising a silicon atom having a total of four alkoxy and hydroxy groups. There are also provided a relief printing plate precursor that includes a relief-forming layer formed from the resin composition, a process for producing a relief printing plate precursor that includes a layer formation step of forming a relief-forming layer from the resin composition and a crosslinking step of thermally crosslinking the relief-forming layer so as to form a crosslinked relief-forming layer.
US08563667B2
The present invention relates to a composition for thermosetting silicone resin including: (1) a dual-end silanol type silicone resin represented by formula (I) in which R1 represents a monovalent hydrocarbon group, and n is an integer of 20 to 10,000, provided that all R1 groups may be the same or different; (2) a trialkoxysilane; and (3) a condensation catalyst.
US08563666B2
A curable silicone composition comprising: (A) a liquid organopolysiloxane having in one molecule at least two epoxy groups; (B) a compound containing groups that react with the epoxy groups; (C) a thermally conductive filler; and (D) a silicone powder, preferably, an epoxy-containing silicone powder; possesses excellent handleability and workability in combination with low viscosity and that, when cured, forms a cured body of excellent elasticity, adhesiveness, and thermal conductivity.
US08563633B2
A compound includes a lignophenol derivative having a weight average molecular weight in a range of 5000 to 10000, and satisfying the following formula (1): 3.0≦pH value≦4.5 (1) wherein the pH value is a determined value for a liquid mixture containing 0.2 g of the lignophenol derivative added to 40 ml of pure water.
US08563632B2
A sealant composition comprising a binder and a filler material. The binder comprising a residual pitch product and an elastomeric material and, optionally, asphalt, a microcrystalline wax, and/or oil. The filler material is present in an amount of between about 11 vol. % and about 67 vol. % of the sealant composition. In one embodiment, the filler material is present in an amount of between about 25 wt. % and about 70 wt. % of the sealant composition.
US08563631B2
The invention mainly relates to the use of a (co)polymer having a main chain essentially consisting of (meth)acrylic units and polyoxyalkylated side-chains containing statistically-distributed hydrophobic units as an adjuvant for lowering the viscosity of hydraulic compositions.
US08563625B2
The invention relates to hydrophilized curable silicone compositions which contain organopolysiloxanes, hydrophilizers and at least one stabilizing phosphorous compound. The compositions are particularly suitable as curable impression materials in dental applications, especially as wash impression materials.
US08563622B2
The present application relates to novel monodisperse, gel-type or macroporous picolylamine resins which are based on at least one monovinylaromatic compound and at least one polyvinylaromatic compound and/or a (meth)acrylic compound and contain tertiary nitrogen atoms in structures of the general formula (I) as functional group, where R1 is an optionally substituted radical from the group consisting of picolyl, methylquinoline and methylpiperidine, R2 is a radical —(CH2)q—COOR3, R3 is a radical from the group consisting of H, Na and K, m is an integer from 1 to 4, n and p are each, independently of one another, a number in the range from 0.1 to 1.9 and the sum of n and p is 2, q is an integer from 1 to 5 and M is the polymer matrix, a process for preparing them and their uses, in particular the use in hydrometallurgy and electroplating.
US08563614B2
The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
US08563612B2
The invention relates to an antimicrobial agent where a cysteine compound is covalently bound to a substrate, in particular by binding through an S—S bridge via a spacer molecule to the substrate. The spacer comprises a carbon chain, optionally interrupted by one or more heteroatoms, e.g. O, S, N, P and Si; the chain is optionally substituted with one or more alkyl groups, preferably lower alkyl groups with 1-5 carbon atoms, hydroxyl groups or alkoxy groups. Also, the invention refers to a substrate that is coated with the antimicrobial agent of the invention. The agent has excellent antimicrobial properties and can be used to coat surfaces and substrates of various devices, such as medical devices or devices used in food handling, in order to prevent or inhibit accumulation and/or growth and/or proliferation and/or the viability of microorganisms and/or formation of biofilm.
US08563610B2
This invention relates to the identification and treatment of the effects of products derived from oxidative pathways for polyunsaturated fatty acid (PUFA) metabolism, i.e., oxidative stress in a patient by monitoring the metabolism of DHA or by administering DHA.
US08563606B2
The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.
US08563599B2
Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.
US08563594B2
Disclosed herein are compositions and methods for treating pain using S1P3 receptor inhibitors.
US08563590B2
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and the manufacture of medicaments for such treatment.
US08563589B2
Embodiments of the invention relate to the treatment of neuropathic pain in mammals. Embodiments of the invention include methods for treating neuropathic pain with benzimidazole derivatives with PPARgamma agonist activity, as well as methods for preparing medicaments used in such treatments of mammalian pain.
US08563584B2
The present application relates to novel substituted enaminothiocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
US08563580B2
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
US08563575B2
The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia. The compound is represented by the formula (I): wherein the symbols are defined in the specification.
US08563574B2
Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and a diluent NNDMA (N,N-dimethylacetamide); useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting.
US08563572B2
Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.
US08563569B2
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
US08563565B2
A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.
US08563564B2
The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-α), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.
US08563557B2
The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar′ is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each R2 is independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and R1 is as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof.
US08563549B2
Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
US08563547B2
(6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of the compounds in preparing medicaments for treating infectious diseases caused by Mycobacterium tuberculosis, especially infectious diseases caused by multi-drug resistance Mycobacterium tuberculosi are also disclosed.
US08563545B2
A novel compound able to inhibit JAK is disclosed, that comprises a compound according to Formula I: or a pharmaceutically acceptable salt thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
US08563542B2
The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4′ each independently H alkyl; or R4 and R4′ together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.
US08563523B2
The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.
US08563522B2
Methods of maintaining and/or attenuating a decline in the quality of life of a mammal comprising the step of administering to the mammal a composition comprising an effective amount of mannoheptulose wherein the effective amount of mannoheptulose provides a dosage to the mammal on a daily basis from about 0.001 gram per kilogram of body weight of the mammal to about 1 gram per kilogram of body weight of the mammal.
US08563520B2
The present invention relates to methods to treat glaucoma and glaucoma-related conditions through the regulation of changes in gene expression that are mediated by high intraocular pressure or α2 macroglobulin administration. Glaucoma, retinal ganglion cell (RGC) death and chronic ocular hypertension are treated using pharmaceutical compositions which comprise substances that inhibit the expression or activity of intraocular pressure-regulated early genes (IPREGs) or their gene products that are up-regulated by high intraocular pressure or α2 macroglobulin administration and/or which increase the expression or activity of IPREGs or their gene products that are down-regulated by high intraocular pressure or α2 macroglobulin administration. The invention also relates to methods of identifying an IPREG and methods to test for chronic ocular degeneration and the onset of RGC stress in an individual by measuring the expression level of IPREG proteins.
US08563517B2
The present invention is directed to novel compounds of formula I and pharmaceutically acceptable salts, enantiomers thereof having inhibiting properties of dipeptidyl peptidase IV enzyme (DP-IV inhibitors). The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds along with its composition in the prevention or treatment of diseases associated with DP-IV enzyme. wherein, A is defined as R3-R4 wherein R3 and R4 are together or independently defined as peptides having amino acids ranging from 1 to 10, B is chemical bond between peptide and substituted amine, R1, and R2 are as defined in specification.
US08563516B2
The present invention provides Foxp3 peptides comprising the amino acid sequence of SEQ ID NOs: 3-5, 7-9, 12, 15-19, 22, 24, 27-30, 37, 67 or 74, and Foxp3 peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility, and also provides drugs for regulating regulatory T cells comprising these Foxp3 peptides. The Foxp3 peptides of this invention find use as vaccines.
US08563515B2
The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin.
US08563509B2
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
US08563508B2
The invention describes peptide analogues of α-melanocyte-stimulating hormone (α-MSH), which possess an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to α-MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.
US08563507B2
An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.
US08563504B2
The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.
US08563501B2
A method includes positioning an effective amount of a thermal target material at a treatment site of a patient. The treatment site, that is, the location of the thermal target material, comprises a location adjacent to biological tissue to be treated. The thermal target material includes carbon molecules preferably in a carrier fluid. Regardless of the particular structure of the carbon, the carbon molecules in the material heat very rapidly in response to incident microwave radiation and radiate heat energy. The heat energy radiated from an effective amount of the thermal target material when subjected to an effective quantity of microwave energy causes localized heating around the thermal target material. This localized heating may be applied for therapeutic purposes. However, the microwave radiation necessary to produce therapeutically effective heating is insufficient to cause cellular damage in the biological tissue by direct absorption in the tissue.
US08563499B2
A fabric softener active composition, comprising from 65 to 95% by weight of a bis-(2-hydroxyethyl)-dimethylammonium chloride fatty acid ester having a molar ratio of fatty acid moieties to amine moieties of from 1.80 to 1.96, an average chain length of the fatty acid moieties of from 16 to 18 carbon atoms and an iodine value of from 0 to 50, from 2 to 8% by weight of a fatty acid triglyceride having an average chain length of the fatty acid moieties of from 10 to 14 carbon atoms and an iodine value of from 0 to 15, and from 3 to 12% by weight of an alcohol selected from ethanol, 1-propanol and 2-propanol has low melt viscosity, high stability towards dealkylation in the molten state and low flammability.
US08563492B2
A skin cleaning agent containing from 2 to 25% by weight of a cleaning body having a mean grain size of from 100 to 1000 μm and containing at least 50% hydrogenated castor oil; from 2 to 30% by weight of surfactants; from 0.1 to 10% by weight of thickeners; water and optionally further auxiliaries.
US08563485B2
A tribo-system includes a metal substrate having a surfactant layer chemisorbed to a side thereof, a lubricant established on the metal substrate, and a plurality of nanoparticles dispersed in the lubricant. Each of the nanoparticles includes i) an inorganic core having a predetermined size and shape, and ii) a surfactant shell chemisorbed to a surface of the inorganic core, where the surfactant shell has a predetermined thickness. The adhesive force and energy between the metal substrate surface and the nanoparticles is higher than the adhesive force and energy between individual particles of the nanoparticles.
US08563472B2
The present invention relates to the use of mixtures containing 2-hydroxyphenylaldehyde and 2-hydroxyphenylketone heterocycloylhydrazone compounds and copper for controlling the growth of fungi and algae.
US08563471B2
The present invention relates to novel suspension concentrate and suspoemulsion formulations comprising a herbicidally active amount of 2-(2′-nitro-4′-methylsulphonylbenzoyl)-1,3-cyclohexanedione(mesotrione), as well as agrochemically acceptable salts thereof, having a particle size, as defined herein, of less than 1 micron and to the use of thereof in controlling weeds in crops of useful plants.
US08563470B2
Disclosed is an insecticidal composition comprising by weight based on the total weight of the composition: a) from about 9 to about 91% of one or more anthranilic diamide insecticides; and (b) from about 9 to about 91% of a cyclodextrin; wherein the ratio of component (b) to component (a) is about 1:10 to about 10:1 by weight. Also disclosed are inclusion complexes of the anthranilic diamide insecticides with the cyclodextrin.Also disclosed is a geotropic propagule coated with an insecticidally effective amount of the aforedescribed composition. Further disclosed is a liquid composition comprising the insecticidal composition, and a method for protecting a geotropic propagule and plant derived therefrom from a phytophagous insect pest.
US08563467B2
A method of preparing activated carbon, is disclosed, comprising: exposing carbonaceous material to microwave radiation in the presence of water to produce activated carbon.
US08563460B2
A catalyst unit is described comprising a cylinder with a length C and a diameter D, wherein said unit has five holes arranged in a pentagonal pattern extending longitudinally therethrough, with five flutes running along the length of the unit, said flutes positioned equidistant adjacent holes of said pentagonal pattern. The catalyst may be used particularly in steam reforming reactors.
US08563458B2
A method of polymerizing olefins with catalyst systems, such as, for example, a multimodal catalyst system, wherein the catalyst system is stored at a controlled temperature to minimize loss of catalyst system productivity.
US08563453B2
To provide a high zirconia fused cast refractory which hardly has cracks, and has excellent durability and reusability, at the time of production of the refractory and during use for a glass melting furnace. A high zirconia fused cast refractory which has a chemical composition comprising from 85 to 95 mass % of ZrO2, at least 2.5 mass % of SiO2, at most 0.04 mass % of Na2O, at most 0.04 mass % of B2O3, and at most 0.04 mass % of P2O5, containing SrO as an essential component, and containing at least one of K2O and Cs2O, wherein contents of SrO, K2O and Cs2O satisfy the relations of the following formula (1) and (2) at the same time: 0.20≦[0.638×CK2O+0.213×CCs2O+0.580×CSrO]/CSiO2≦0.40 (1) 0.10≦0.580×CSrO/CSiO2 (2)
US08563450B2
Glass batch compositions for the formation of high-modulus, and high-strength glass fibers as well as fibers suitable for use as textile and reinforcements are disclosed. Fibers formed of the composition are especially suitable for use in high-strength, low-weight applications such as windmill blades and high strength and modulus applications where strength and stiffness are required in the composite. The glass composition is up to about 70.5 weight % SiO2, about 24.5 weight % Al2O3, about 22 weight % alkaline earth oxides and may include small amounts of alkali metal oxides and ZrO2. Fiberglass-reinforced composite articles such as windmill blades are also disclosed.
US08563444B2
Methods for forming metal silicate films are provided. The methods comprise contacting a substrate with alternating and sequential vapor phase pulses of a silicon source chemical, metal source chemical, and an oxidizing agent, wherein the metal source chemical is the next reactant provided after the silicon source chemical. Methods according to some embodiments can be used to form silicon-rich hafnium silicate and zirconium silicate films with substantially uniform film coverages on substrate surface.
US08563443B2
A method of forming a dielectric film having at least Si—N, Si—C, or Si—B bonds on a semiconductor substrate by atomic layer deposition (ALD), includes: supplying a precursor in a pulse to adsorb the precursor on a surface of a substrate; supplying a reactant gas in a pulse over the surface without overlapping the supply of the precursor; reacting the precursor and the reactant gas on the surface; and repeating the above steps to form a dielectric film having at least Si—N, Si—C, or Si—B bonds on the substrate. The precursor has at least one Si—C or Si—N bond, at least one hydrocarbon, and at least two halogens attached to silicon in its molecule.
US08563442B2
In order to provide a method for manufacturing a single crystal SiC substrate that can obtain an SiC layer with good crystallinity, an Si substrate 1 having a surface Si layer 3 of a predetermined thickness and an embedded insulating layer 4 is prepared, and when the Si substrate 1 is heated in a carbon-series gas atmosphere to convert the surface Si layer 3 into a single crystal SiC layer 6, the Si layer in the vicinity of an interface 8 with the embedded insulating layer 4 is left as a residual Si layer 5.
US08563434B2
A method of fabrication of electrical contact structures on a semiconductor material includes depositing an oxide of a desired contact material by a chemical electroless process on a face of the semiconductor material and reducing the oxide via a chemical electroless process to produce a contact of the desired contact material. A method of fabrication of a semiconductor device incorporating such electrical contact structures and a semiconductor device incorporating such electrical contact structures are also described.
US08563427B2
A semiconductor chip includes a substrate with a barrier region and a conductive diffusion region formed in the substrate and is surrounded by the barrier region. The conductive diffusion region may provide a conductive oath from top of the substrate to bottom of the substrate.
US08563424B2
Methods for forming cobalt silicide are provided. One method for forming a cobalt silicide material includes exposing a substrate having a silicon-containing material to either a wet etch solution or a pre-clean plasma during a first step and then to a hydrogen plasma during a second step of a pre-clean process. The method further includes depositing a cobalt metal layer on the silicon-containing material by a CVD process, heating the substrate to form a first cobalt silicide layer comprising CoSi at the interface of the cobalt metal layer and the silicon-containing material during a first annealing process, removing any unreacted cobalt metal from the substrate during an etch process, and heating the substrate to form a second cobalt silicide layer comprising CoSi2 during a second annealing process.
US08563419B2
A method of manufacturing the IC is provided, and more particularly, a method of fabricating a cap for back end of line (BEOL) interconnects that substantially eliminates electro-migration (EM) damage. The method includes forming an interconnect in an insulation material, and selectively depositing a metal cap material on the interconnect. The metal cap material includes RuX, where X is at least one of Boron and Phosphorous.
US08563417B2
The invention generally relates to a packaging method of an ultra-thin chip, more specifically, the invention relates to a method for packaging the ultra-thin chip with solder ball thermo-compression in wafer level packaging process. The method starts with disposing solder balls on metal pads arranged on the front surface of semiconductor chips that are formed at the front surface of a semiconductor wafer. The solder balls are soften by heating the wafer, a compression plate is applied with a pressure on the top ends of the solder balls thus forming a co-planar top surface at the top ends of the solder balls. A molding compound is deposited on the front surface of the wafer with the top ends of the solder balls exposed. The wafer is then ground from its back surface to reduce its thickness to achieve ultra-thin chip.
US08563416B2
A solder bump support structure and method of manufacturing thereof is provided. The solder bump support structure includes an inter-level dielectric (ILD) layer formed over a silicon substrate. The ILD layer has a plurality of conductive vias. The structure further includes a first insulation layer formed on the ILD layer. The solder bump support structure further includes a pedestal member formed on the ILD layer which includes a conductive material formed above the plurality of conductive vias in the ILD layer coaxially surrounded by a second insulation layer. The second insulation layer is thicker than the first insulation layer. The structure further includes a capping under bump metal (UBM) layer formed over, and in electrical contact with, the conductive material and formed over at least a portion of the second insulation layer of the pedestal member.
US08563414B1
Conductive carbon films having a resistivity of less than about 0.2 Ohm-cm, preferably less than about 0.05 Ohm-cm, are deposited by PECVD. Conductive carbon films are essentially free of sp3-hybridized carbon and contain predominantly sp2 carbon, based on IR spectral features. Carbon content of the films is at least about 75% atomic C. Conductive carbon films may contain hydrogen, but are typically hydrogen-poor, containing less than about 20% H. In some embodiments, conductive carbon films further contain nitrogen (N). For example, conductive films having a CxHyNz composition, where nitrogen is present at between about 5-10% atomic, have both high conductivity and low roughness, because introduction of nitrogen delays formation of crystallites in the film. The films are deposited at a process temperature of at least about 620° C., and at a pressure of less than about 20 Torr in a dual-frequency plasma process dominated by low frequency (LF) plasma.
US08563398B2
Methods of forming an electrically conductive path under a barrier oxide layer of a semiconductor-on-insulator (SOI) substrate and an integrated circuit including the path are disclosed. In one embodiment, the method includes forming an electrically conductive path below a barrier oxide layer of a semiconductor-on-insulator (SOI) substrate, the method comprising: forming a first barrier oxide layer on a semiconductor substrate; forming the electrically conductive path within the first barrier oxide layer; and forming a second barrier oxide layer on the first barrier oxide layer. The electrically conductive path allows reduction of SRAM area by forming a wiring path underneath the barrier oxide layer on the SOI substrate.
US08563397B2
The present invention relates to a semiconductor device and its manufacturing method including the steps of: forming a first semiconductor element layer having a first wiring over a substrate; forming a second semiconductor element layer having a second wiring and fixed to a first structure body having a first sheet-like fiber body, a first organic resin, and a first electrode; preparing a second structure body having a second sheet-like fiber body, a second organic resin which is not cured, and a second electrode; disposing the second structure body between the first and second semiconductor element layers so that the first wiring, the second electrode, and the second wiring are overlapped with each other over the substrate; and curing the second organic resin.
US08563393B2
A method for manufacturing a semiconductor device which prevents damage to alignment marks used for alignment between a superjunction structure and process layers at subsequent steps. In the related art, recesses are made in a semiconductor substrate before the formation of the superjunction structure and used as alignment marks and in order to prevent damage to the alignment marks, the alignment marks are covered by an insulating film such as a silicon oxide film during the subsequent process of forming the superjunction structure, but the inventors have found that damage may penetrate the cover film, reach the semiconductor substrate and destroy the marks. In the method according to the invention, alignment marks for alignment between the superjunction structure and process layers at subsequent steps are formed after the formation of the superjunction structure.
US08563390B2
A semiconductor device includes capacitors connected in parallel. Electrode active portions and a discharge active portion are defined on a semiconductor substrate, and capping electrodes are disposed respectively on the electrode active portions. A capacitor-dielectric layer is disposed between each of the capping electrodes and each of the electrode active portions that overlap each other. A counter doped region is disposed in the discharge active portion. A lower interlayer dielectric covers the entire surface of the semiconductor substrate. Electrode contact plugs respectively contact the capping electrodes through the lower interlayer dielectric, and a discharge contact plug contacts the counter doped region through the lower interlayer dielectric. A lower interconnection is disposed on the lower interlayer dielectric and contacts the electrode contact plugs and the discharge contact plug.
US08563379B2
A method for producing a semiconductor device includes preparing a structure having a substrate, a planar semiconductor layer and a columnar semiconductor layer, forming a second drain/source region in the upper part of the columnar semiconductor layer, forming a contact stopper film and a contact interlayer film, and forming a contact layer on the second drain/source region. The step for forming the contact layer includes forming a pattern and etching the contact interlayer film to the contact stopper film using the pattern to form a contact hole for the contact layer and removing the contact stopper film remaining at the bottom of the contact hole by etching. The projection of the bottom surface of the contact hole onto the substrate is within the circumference of the projected profile of the contact stopper film formed on the top and side surface of the columnar semiconductor layer onto the substrate.
US08563376B2
A method of forming a hybrid semiconductor structure on an SOI substrate. The method includes an integrated process flow to form a nanowire mesh device and a bulk CMOS device on the same SOI substrate. Also included is a semiconductor structure which includes the nanowire mesh device and the bulk CMOS device on the same SOI substrate.
US08563368B2
A thin film transistor substrate according to an embodiment of the present invention includes: an insulation substrate; a gate line formed on the insulation substrate; a first interlayer insulating layer formed on the gate line; a data line and a gate electrode formed on the first interlayer insulating layer; a gate insulating layer formed on the data line and gate electrode; a semiconductor formed on the gate insulating layer and overlapping the gate electrode; a second interlayer insulating layer formed on the semiconductor; a first connection formed on the second interlayer insulating layer and electrically connecting the gate line and the gate electrode to each other; a drain electrode connected to the semiconductor; a pixel electrode connected to the drain electrode; and a second connection connecting the data line and the semiconductor to each other.
US08563366B2
A resistor structure incorporated into a resistive switching memory cell or device to form memory devices with improved device performance and lifetime is provided. The resistor structure may be a two-terminal structure designed to reduce the maximum current flowing through a memory device. A method is also provided for making such memory device. The method includes depositing a resistor structure and depositing a variable resistance layer of a resistive switching memory cell of the memory device, where the resistor structure is disposed in series with the variable resistance layer to limit the switching current of the memory device. The incorporation of the resistor structure is very useful in obtaining desirable levels of device switching currents that meet the switching specification of various types of memory devices. The memory devices may be formed as part of a high-capacity nonvolatile memory integrated circuit, which can be used in various electronic devices.
US08563365B2
An exemplary embodiment of the present invention provides a chip for use in fabricating a three-dimensional integrated circuit, the chip comprising a wafer, one or more metallic-filled, electrical vias, and one or more hollow, fluidic vias. The wafer can comprise a first surface and a second surface. The one or more metallic-filled, electrical vias can extend through the wafer. Each electrical via can be in electrical communication with an electrical interconnect proximate the first surface, providing electrical communication between chips in the integrated circuit. The one or more hollow, fluidic vias can extend through the wafer. Each fluidic via can be in fluid communication with a fluidic interconnect, providing fluid communication between adjacent chips in the integrated circuit. Each fluidic interconnect can comprise a first end proximate the first surface, a second end, and a cap proximate the second end, defining an air-filled space within the fluidic interconnect.
US08563363B2
A fabricating method of a semiconductor package structure is provided. A dielectric layer having a first surface and a second surface is provided. A patterned metal layer has been formed on the first surface of the dielectric layer. An opening going through the first and the second surfaces is formed. A carrier having a third surface and a fourth surface is formed at the second surface. A portion of the third surface is exposed by the opening of the dielectric layer. A semiconductor die having a joining surface and a side-surface is joined in the opening. At least a through hole going through the third and the fourth surfaces is formed. A metal layer having at least a heat conductive post extending from the fourth surface of the carrier to the through hole and disposed in the through hole and a containing cavity is formed on the fourth surface.
US08563360B2
A power semiconductor device package includes a conductive assembly including a connecting structure and a semiconductor die having an aperture formed therethrough, the aperture being sized and configured to spacedly receive the connecting structure. In an alternative embodiment, a power semiconductor device package includes a conductive assembly including a connecting structure and a pair of semiconductor die disposed on either side of the connecting structure in spaced relationship thereto.
US08563355B2
A phase change memory (PCM) cell includes a transistor, a PCM structure, and a heater. The transistor has a first current electrode and a second current electrode in a structure, and a channel region having a first portion along a first sidewall of the structure and having a second portion along a second sidewall of the structure. The second sidewall is opposite the first sidewall. The transistor has a control electrode that has a first portion adjacent to the first sidewall and a second portion adjacent to the second sidewall. The PCM structure exhibits first and second resistive values when in first and second phase states, respectively. The heater is on the structure and produces heat when current flows through the heater for changing the phase state of the phase change structure.
US08563352B2
Low-relief texture can be created by applying and firing frit paste on a silicon surface. Where frit contacts the surface at high temperature, it etches silicon, dissolving silicon in the softened glass frit. The result is a series of small, randomly located pits, which produce a near-Lambertian surface, suitable for use in a photovoltaic cell. This texturing method consumes little silicon, and is advantageously used in a photovoltaic cell in which a thin silicon lamina comprises the base region of the cell. When the lamina is formed by implanting ions in a donor wafer to form a cleave plane and cleaving the lamina from the donor wafer at the cleave plane, the ion implantation step will serve to translate texture formed at a first surface to the cleave plane, and thus to the second, opposing surface following cleaving. Low-relief texture formed by other methods can be translated from the first surface to the second surface in this way as well.
US08563344B2
A method for producing microelectromechanical structures in a substrate includes: arranging at least one metal-plated layer on a main surface of the substrate in a structure pattern; leaving substrate webs open beneath a structure pattern region by introducing first trenches into the substrate perpendicular to a surface normal of the main surface in a region surrounding the structure pattern; coating the walls of the first trenches perpendicular to the surface normal of the main surface with a passivation layer; and introducing cavity structures into the substrate at the base of the first trenches in a region beneath the structure pattern region.
US08563342B2
A method of making a semiconductor optical integrated device includes the steps of forming, on a substrate, a plurality of semiconductor integrated devices including a first optical semiconductor element having a first bonding pad and a second optical semiconductor element; forming a plurality of bar-shaped semiconductor optical integrated device arrays by cutting the substrate, each of the semiconductor optical integrated device arrays including two or more semiconductor optical integrated devices; alternately arranging the plurality of semiconductor optical integrated device arrays and a plurality of spacers in a thickness direction of the substrate so as to be fixed in place; and forming a coating film on a facet of the semiconductor optical integrated device array. Furthermore, the spacer has a movable portion facing the first bonding pad, the movable portion protruding toward the first bonding pad and being displaceable in a protruding direction.
US08563341B2
The present invention discloses a thin film transistor array substrate and a manufacturing method for the same. A transparent conductive layer and a first metal layer are deposited on a substrate, and a multi-tone mask is utilized to form a gate electrode and a common electrode. A gate insulative layer and a semi-conductive layer are deposited on the substrate with the gate electrode and the common electrode, and the semi-conductive layer is patterned by a second mask to retain a region of the semi-conductive layer that is there-above the gate electrode. A second metal layer is deposited on the substrate with the gate insulative layer along with the retained semi-conductive layer, and the second metal layer is patterned by a third mask to form a source electrode, a drain electrode, and a pixel electrode. The present invention provides a simple manufacturing method.
US08563338B2
Provided is a light emitting diode (LED) package including a phosphor substrate; an LED chip mounted on the phosphor substrate; a circuit board mounted on the other region of the phosphor substrate excluding the region where the LED chip is mounted; an electrode connection portion for electrically connecting the LED chip and the circuit board; and a sealing member that covers the LED chip, the circuit board, and the phosphor substrate.
US08563335B1
A method of controlling a polishing operation includes polishing a substrate, during polishing obtaining a sequence over time of measured spectra from the substrate with an in-situ optical monitoring system, for each measured spectrum from the sequence of measured spectra applying a Fourier transform to the measured spectrum to generate a transformed spectrum thus generating a sequence of transformed spectra, for each transformed spectrum identifying a peak of interest from a plurality of peaks in the transformed spectrum, for each transformed spectrum determining a position value for the peak of interest in the transformed spectrum thus generating a sequence of position values, and determining at least one of a polishing endpoint or an adjustment of a pressure to the substrate from the sequence of position values.
US08563321B2
A enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance the chemiluminescence are provided, in which the enhancing reagent contains an alkyl bis-quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and an alkyl bis-quaternary ammonium salt of Formula I.
US08563319B2
A nitrogen dioxide sensor comprising a first beam having a first functionalized sensing surface capable of sensing nitrogen dioxide, the first beam capable of producing a first resonant frequency; and a second beam having a second functionalized reference surface not capable of sensing nitrogen dioxide, the second beam capable of producing a second resonant frequency, wherein differential sensing of nitrogen dioxide may be performed, further wherein the first beam and the second beam are each functionalized with one or more soft bases having comparable viscoelastic properties is provided. In one embodiment, the sensor is a nano-sensor capable of low drift and accurate detection of nitrogen dioxide levels at the zeptogram level. Methods of making and using a nitrogen dioxide sensor are also provided.
US08563315B2
A Mixture of substances is provided for precise calibration of the mass scale of mass spectrometers equipped with ion sources that operate at atmospheric pressure (AP) with ionization of the analyte molecules, for example by APCI (chemical ionization), or by APPI (photoionization), often at high temperatures of up to 470° C. Out of physical reasons, the mass scale of any time-of-flight mass spectrometer deviates in the lower mass range from the theoretical relation between charge-related mass m/z and flight time t. A closely spaced arrangement of low mass calibration reference points is necessary if high mass accuracy is to be achieved for substances of low molecular weight. APCI and APPI sources are increasingly used in time-of-flight mass spectrometers with orthogonal ion injection (OTOF MS) for the detection of non-polar and weakly polar compounds, in particular, for analyte molecules with relatively low molecular weights. Calibration substances in solutions that are easily handled, nontoxic, stable at the high temperatures involved, will accept both positive and negative ionization, and supply enough reference points for calibration in the mass range up to 500 daltons. Mixtures of saturated fatty acids dissolved in toluene may be used. For photoionization, also mixtures of phenyl and naphthyl fatty acids.
US08563311B2
The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
US08563307B2
Disclosed are methods of using blastomere-like stem cells to (1) decrease the level of myeloid-derived suppressor cells, (2) modulate immune response, (3) overcome a myeloid-derived suppressor cell-mediated immunosuppression, and (4) treat a cellular proliferative disorder. The blastomere-like stem cells, positive for CD66e, can be isolated from blood, bone marrow, or skeletal muscle.
US08563300B2
An incubator comprising: a culture chamber configured to accommodate culture; a dish structure configured to contain a liquid; an ultrasonic vibrator provided in a part of the dish structure, the ultrasonic vibrator configured to atomize the liquid; and a gas-liquid contact structure configured to bring the atomized liquid into contact with air in the chamber to be cultured.
US08563299B2
A process for converting a feed gas containing at least one of CO, CO2, and/or H2 to a liquid product using biomass that grow on the surface of carriers suspended in a fermentation broth within the vessel of a moving bed bioreactor (MMBR). An injector is used to at least partially dissolved the feed gas in the fermentation broth, at least partially entrain the gas in the broth as microbubbles and to introduce the mixture of the entrained gas and broth into the vessel in a substantially horizontal direction. The injection of the mixture creates eddy current in the surrounding liquid for thoroughly mixing the fermentation broth in the vessel and for keeping the biomass carrier moving to provide sufficient shear so as to maintain a biofilm thickness on the carrier in a desirable range.
US08563296B2
Embodiments of a process for discharging amine byproducts formed in an amine-based solvent are provided. The process comprises the steps of contacting the amine-based solvent with flue gas comprising carbon dioxide, oxygen, nitrogen, NOx, SOx, or mixtures thereof to form a carbon dioxide-laden amine-based solvent that contains the amine byproducts. Carbon dioxide is separated from the carbon dioxide-laden amine-based solvent to form a carbon dioxide-depleted amine-based solvent. The amine byproducts from the carbon dioxide-depleted amine-based solvent are fed to an algae source.
US08563293B2
The present invention relates to compositions and methods for protection against bacterial contamination. The invention provides bactericidal yeast expressing bacteriocin proteins and methods of using the bactericidal yeast.
US08563289B2
The present invention relates to methods for producing variants of a parent RP-II protease and the variants having altered properties as compared to the parent RP-II protease.
US08563285B2
The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
US08563284B2
This invention relates to mutant xylanases, nucleic acids encoding them, and methods of using these xylanases.
US08563282B2
This disclosure provides for materials and methods for converting biomass to biofuels. The materials include a colloid mill with or without cellulase enzymes, and the methods include the use of a colloid mill and optionally cellulose enzymes to pretreat biomass for use in a biomass to biofuel production process.
US08563276B2
The invention relates to a method for enzyme cleavage of polysaccharides comprising a first sequence [→4)-β-D-GlcpA-(1→4)-α-L-Rhap3 sulphate-(1→]n and a second sequence [→4)-α-L-IdopA-(1→4)-α-L-Rhap3 sulphate-(1→]m, the first and second sequences respectively comprising two monosaccharide units connected by an osidic bond, wherein said method is such that: said polysaccharide sequences are provided; a microorganism capable of producing an enzyme substance of the lyase class is provided; and said enzyme substance is brought into contact with said polysaccharide sequences in such a way as to bring about cleavage of the osidic bond according to a β-elimination reaction. The invention is characterized in that a microorganism belonging to the bacteria of the Ochrobactrum genus is chosen for producing said enzyme substance.
US08563274B2
Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided.
US08563273B2
A peptide comprising at least 5 amino acid residues and less than 15 amino acid residues, the peptide including an amino acid sequence as set forth in SEQ ID NO: 7 as well as pharmaceutical compositions, kits and methods for diagnosing and treating amyloid associated diseases.
US08563271B2
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
US08563268B2
The present invention relates to isolated polypeptides having tyrosinase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US08563261B2
A method for diagnosing, or differentially diagnosing, interstitial cystitis (IC) involves detecting or measuring increased expression of a biomarker Endothelin 1 (ET-1) in a biological sample from a mammalian subject, particularly in the urine or urothelial tissue. An increased level of expression of ET-1 above the level of expression in the same sample of a healthy mammalian subject is an indication of a diagnosis of IC. Such diagnosis may further involve identify other clinical symptoms of IC. Additionally the method may use additional biomarkers, such as Hb-EFG, EGF, APF, IL-8, IL-6, and cGMP. Assay methods and diagnostic reagents and kits for such diagnosis are provided. Methods and compositions for treating IC by reducing the action, production or synthesis of ET-1 in the urine or urothelium and/or inhibiting its binding to its ETA and/or ETB receptors are also provided.
US08563258B2
The invention pertains to a method for the determination of basophil activation induced by a test substance by flow cytometric measurement of the changes of the mean or median fluorescence intensities (MFI) of the basophilic FcεRI receptor present on the cell surface of basophils (MFI-FcεRI) and/or the IgE antibodies bound to the FcεRI receptor (MFI-IgE), and the CD63 antigen exposed on the cell surface of basophils after their activation (MFI-CD63), by means of a mixture of anti-CD63, anti-FcεRI or anti-IgE, and anti-CCR3 antibodies each labelled with a distinct fluorophore, of which at least one antibody acts as a basophil selection marker and at least two antibodies act as basophil activation markers, and bringing the mean fluorescence intensities of the activation markers in correlation to obtain an Activation Index. These methods combining the measurement of an early (such as IgE, FcεRI or CD203c) and a late basophil activation marker (such as CD63), respectively, provide a markedly improved clinical sensitivity in allergy diagnosis over existing methods which consider only one activation marker, such as CD203c or CD63, expressed in percentage of basophil activation. It is also an aspect of the present invention to provide an ex-vivo allergy provocation test comprising the above-mentioned flow cytometric measurement and analysis of the results as well as a test kit for carrying out the test in-vitro.
US08563257B2
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
US08563242B2
The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy.
US08563241B2
There are disclosed methods and kits for identifying a subject having genetic predictors of predisposition to abnormal international normalized ratio (INR) fluctuation during warfarin therapy. In an embodiment, a method includes testing the subject to check for a presence of a predetermined genetic variation. The predetermined genetic variation is correlated with abnormal INR fluctuation during warfarin therapy. The subject is identified as having a predisposition to abnormal INR fluctuation during warfarin therapy when the testing indicates the presence of the predetermined genetic variation. In one embodiment, a kit includes a test to check the subject for a presence of a predetermined genetic variation. The predetermined genetic variation is correlated with abnormal INR fluctuation during warfarin therapy. The kit includes an indicator to identify the presence of the predetermined genetic variation so as to identify the subject as having a predisposition to abnormal INR fluctuation during warfarin therapy.
US08563236B2
The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.
US08563226B2
The invention relates to a method (3) of fabricating a mold (39, 39′) including the following steps: (a) depositing (9) an electrically conductive layer on the top (20) and bottom (22) of a wafer (21) made of silicon-based material; (b) securing (13) the wafer to a substrate (23) using an adhesive layer; (c) removing (15) one part (26) of the conductive layer from the top of the wafer (21); and (d) etching (17) the wafer as far as the bottom conductive layer (22) thereof in the shape (26) of the one part removed from the top conductive layer (22) to form at least one cavity (25) in the mold. The invention concerns the field of micromechanical parts, particularly, for timepiece movements.
US08563214B2
The present invention relates to a radiation sensitive resin composition comprising [A] an alkali-soluble resin, [B] a 1,2-quinonediazide compound and [C] a radical trapping agent.The radiation sensitive resin composition can provide an interlayer insulating film which satisfies general requirements for an interlayer insulating film such as high light transmittance and has excellent heat-resistant dimensional stability, heat discoloration resistance and adhesion to a substrate along with the improvement of process efficiency for improving product yield at a high resolution and has excellent storage stability.
US08563211B2
A process for making a latex emulsion suitable for use in a toner composition includes co-emulsifying a bio-based resin with an insoluble component, such as a pigment or wax, whereby the resin encapsulates the insoluble component. The resulting latex, including the insoluble component encapsulated in the resin, may then be utilized to form a toner. The insoluble component may thus be included in toner particles, which might otherwise be difficult to achieve, using emulsion aggregation processes.
US08563198B2
Disclosed is a photomask having a wavelength-reducing material that may be used during photolithographic processing. In one example, the photomask includes a transparent substrate, an absorption layer having at least one opening, and a layer of wavelength-reducing material (WRM) placed into the opening. The thickness of the WRM may range from approximately a thickness of the absorption layer to approximately ten times the wavelength of light used during the photolithographic processing. In another example, the photomask includes at least one antireflection coating (ARC) layer.
US08563197B2
Design rules for circuit patterns of a semiconductor device are identified, and schematic layouts of the circuit patterns are generated according to the design rules. Lithography friendly layout (LFL) circuit patterns are generated from the schematic layouts. Target layout circuit patterns are generated from the LFL circuit patterns. Optical proximity effect correction (OPC) is performed on the target layout circuit patterns to generate OPC circuit patterns. A mask is fabricated from the OPC circuit patterns, and may be used fabricate a semiconductor device.
US08563196B2
A ventilation system for a fuel cell power module is provided. The ventilation system includes a ventilation enclosure for evacuating fluids from the fuel cell power module, the ventilation enclosure having an air inlet for providing ingress of air to the enclosure. The ventilation system further concludes a ventilation shaft in fluid communication with the ventilation enclosure and an evacuation pump arranged to exhaust fluid from the ventilation enclosure to a desired location.
US08563190B2
A fuel cell comprises: multiple unit cells stacked upright in a vertical direction or stacked in a vertically inclined orientation; an insulating plate arranged on a vertically upper-side end of the stacked multiple unit cells; a cooling medium supply manifold arranged to distribute a supply flow of a cooling medium into the multiple unit cells and a cooling medium discharge manifold arranged to join together discharged flows of the cooling medium from the multiple unit cells; and a de-airing passage formed to release a gas accumulated in either the cooling medium supply manifold or the cooling medium discharge manifold, wherein the cooling medium supply discharge manifold and the cooling medium discharge manifold are respectively connected to a cooling medium supply piping and a cooling medium discharge piping on a vertically lower-side end of the fuel cell, and the de-airing passage is formed such that a portion of the de-airing passage is made in the insulating plate wherein the portion of the de-airing passage extends in a direction perpendicular to a stacking direction of the unit cells, and the de-airing passage is connected to either the cooling medium discharge manifold or the cooling medium supply manifold on a vertically upper end side of the cooling medium discharge manifold or the cooling medium supply manifold.
US08563187B2
The subject of the present invention relates to a method and a protector for reducing degradation of fuel cell systems at transitions in operation, in particular at electrodes or catalysts in a combustion chamber of a stack of a PEM fuel cell system in startup and shutoff events of the fuel cell system. A switchable material delivery device is provided for varying a delivery of material to the fuel cell system, so that a transition from a first state of the fuel cell system to a second state of the fuel cell system can be initiated, such that a potential difference between different electrodes can be effected. At least one reducing mechanism is provided for reducing the potential difference between the different electrodes during the transition, in which the reducing mechanism includes at least one compensating device for an unequal gas distribution by reducing the proportions causing degradation, to reduce degradation. The compensation device includes at least one short-circuiting unit, with which the different electrodes can be short-circuited, in order to reduce the potential difference.
US08563184B2
A fuel cell system (1), especially in a motor vehicle, is provided with a fuel cell (2), which generates electric current during the operation from anode gas and cathode gas, with a residual gas burner (3), which reacts anode waste gas with cathode waste gas into burner waste gas during the operation; with an air delivery device (17), which feeds air as cathode gas to the fuel cell (2) via a fuel cell air line (12) during the operation; and with a first heat exchanger (14), which couples a waste gas line (13) removing burner waste gas from the residual gas burner (3) with the fuel cell air line (12) in a heat-transmitting operation. The start-up process of the system (1) is improved with an auxiliary burner (20), which reacts air with a fuel into an auxiliary burner waste gas during the operation; with a bypass air line (24), which is connected on the inlet side to the fuel cell air line (12) between the air delivery device (17) and the first heat exchanger (14) and which is connected to the fuel cell air line (12) on the outlet side between the first heat exchanger (14) and the fuel cell (2). A second heat exchanger (23) couples an auxiliary waste gas line (21) removing auxiliary burner waste gas from the auxiliary burner (20) with the bypass air line (24) in a heat-transmitting manner.
US08563180B2
Various hot box fuel cell system components are provided, such as heat exchangers, steam generator and other components.
US08563177B2
A galvanic element, for example a battery or an accumulator, in particular a lithium-ion cell, includes a negative electrode, a positive electrode, and a separator lying between the negative electrode and the positive electrode. In order to increase the specific capacitance, the negative electrode includes at least one layer system, said layer system including at least two graphene layers and at least one polymer layer. A polymer layer lies between two graphene layers.
US08563169B2
Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device.
US08563164B2
A cylindrical type alkaline storage battery includes a cylindrical container having electrical conductivity, and an electrode assembly contained in the container, the electrode assembly being a roll obtained by rolling up a positive electrode plate, a negative electrode plate and a separator together. Provided that the maximum diameter of the container is Dmax and that the number of turns of the positive electrode plate is N, the relationship N≧[0.5×Dmax−2.65] is fulfilled (where “[ ]” represents Gauss' notation). Where the battery is of AA size, for example, the number N of turns is four or more. Also, provided the circumferential position of the roll starting end of the positive electrode plate is a reference position, the angle θ measured from the circumferential position of the roll terminating end of the positive electrode plate to the reference position ranges from 180° to 270°.
US08563161B2
A power supply system including a plurality of batteries includes a busbar, a terminal and a busbar module. The busbar connects a first electrode of one of the batteries with a second electrode of another one of the batteries. The terminal is mounted on the busbar and is contacted with the first electrode. The busbar module has a bulkhead defining a space accommodating the busbar. A locking member is extended from the bulkhead into the space and restricts the busbar. An abutment portion is provided at an edge part of the terminal. The abutment portion abuts the locking member when the terminal is rotated about the first electrode.
US08563155B2
Disclosed herein is a battery module constructed in a structure in which a plurality of plate-shaped battery cells are sequentially stacked in a module case, wherein each of the plate-shaped battery cells includes an electrode assembly of a cathode/separator/anode structure mounted in a battery case formed of a laminate sheet including a resin layer and a metal layer, a plurality of heat dissipation members are disposed at two or more interfaces between the battery cells, and a heat exchange member integrally interconnecting the heat dissipation members is mounted to one side of a stack of the battery cells, whereby heat generated from the battery cells during the charge and discharge of the battery cells is removed by the heat exchange member.
US08563153B2
A battery module including a row of batteries; and end plates coupled to ends of the row of batteries, wherein the end plates include a reinforcing portion for increasing strength of the end plates.
US08563152B2
A battery cell includes a power generating element, an electrode connected to the power generating element and configured to electrically connect the power generating element to outside, and an exterior member configured to cover the power generating element. The exterior member includes an insulating layer and a conductive layer, and the conductive layer includes a connection section electrically connected to the outs.
US08563148B2
Subject: A process for producing a magnetic recording medium, having a magnetic recording layer and a protective layer on a substrate which is a non-magnetic support, wherein the medium is able to greatly inhibit migration of a lubricant from the protective layer to the surface of the metal pressing plate having a mirrored finish in a hot pressing step during production of the magnetic recording medium, while maintaining satisfactory scratch resistance, suitable adhesion with the magnetic recording layer and the protective layer, and excellent read and write properties of the magnetic recording medium.Means to Achieve the Subject: A process for producing a magnetic recording medium, comprising: forming a laminate on a substrate which is a non-magnetic support, wherein the laminate has an adhesive layer, a magnetic recording layer and a protective layer in this order from the side near the substrate, and embedding the laminate into the substrate by carrying out hot pressing on the protective layer to provide a level smooth plane formed by the surface of the substrate and the uppermost surface of the laminate; wherein the protective layer contains a binder resin and particles composed of a mixture including polyethylene and polytetrafluoroethylene.
US08563144B2
An organic electroluminescent (EL) device is provided which uses an electron-transport layer including hole blocking capability. The device includes a stack structure, with an emitting layer and an electron-transport layer provided between an anode and a cathode. The electron-transport layer is a mixture of at least two materials. This mixture may include an organic compound and one or more other organic compounds, or may include a metal or inorganic compound and one or more other metal or inorganic compounds, or may include one or more organic compounds and one or more metal or inorganic compounds. By incorporating a hole blocking capability into the electron-transport layer, structure and fabrication of the device is simplified and efficiency is increased.
US08563141B2
Disclosed is a carrier for manufacturing a printed circuit board, which includes a first carrier including a first binder having a first opening and a first metal layer formed in the first opening of the first binder, and a second carrier, stacked with the first carrier and including a second binder having a second opening and a second metal layer which is formed in the second opening of the second binder and which partially overlaps with the first metal layer, so that the carrier is simply configured and the binders are formed not only on the lateral surfaces of the metal layers but also on the upper surfaces thereof, thus improving the reliability of bonding of the carrier at the periphery. A method of manufacturing the carrier and a method of manufacturing a printed circuit board using the carrier are also provided.
US08563132B2
Glass fiber-treating agent which includes: (A) 5-95% by weight of an acetylene glycol or an ethylene oxide and/or a propylene oxide adduct of an acetylene glycol; and (B) 5-95% by weight of a silicone surfactant which may be polyoxyalkylene-modified. The glass fiber-treating agent reduces dynamic and static surface tension and contact angle. The glass fiber-treating agent provides excellent wetting, penetration, and antifoaming properties when glass fibers are treated therewith.
US08563127B2
An absorbent composite comprising: a base material and water-absorbent resin particles; wherein the following conditions (1) to (4) are fulfilled: (1) the weight ratio of water-absorbent resin relative to the total weight of the base material and water-absorbent resin is 65 to 99 wt %, (2) the water-absorbent resin particles adhering directly to the base material constitute 50 wt % or more of the total water-absorbent resin particles; (3) the average absorption capacity of the water-absorbent resin particles is 50 g/g or more; and (4) the amount of residual monomers in the water-absorbent resin is 200 ppm or less.
US08563120B2
The present invention relates to a multi-layered microporous polyolefin film for a battery separator and a method for preparing the same. The microporous multi-layered film of the present invention has a characteristics to have both the low shutdown temperature conferred by the polyethylene and the high melt fracture temperature conferred by the polypropylene and heat-resistant filler. In addition, it has the high strength and stability conferred by the micropores prepared under wet process and the high permeability and high strength conferred by the macropores prepared under dry process. Therefore, this multi-layered film can be used effectively to manufacture a secondary battery with high capacity and high power.
US08563111B2
Disclosed is a digital information media having an adhesion promotion layer supported on a dummy (L1) substrate that enables secure bonding of the L1 layer, directly or indirectly, to the rest of the stack of layers in the digital information media. Certain materials including metals, metal alloys, or metalloids enhance adhesion between the adhesive layer and the L1. By applying an adhesion promotion layer of such materials on an inner surface of the L1, the bond between the adhesive and the adhesion promotion layer improves bonding and reduces a tendency for the L1 to delaminate from the rest of the stack. The tendency for breakage of the media at the juncture between the adhesion promotion layer and the adhesive is reduced, and incursion of moisture or oxygen through the interface between the adhesion promotion layer and the adhesive is inhibited.
US08563110B2
Optical information media containing an ultraviolet protection layer are described. The protection layer will reduce or eliminate damage to the media's data layer and substrate.
US08563109B2
A pressureless polymer pipe, a composition therefore, and a process of preparing the composition are described. The pipe is characterized in that the polymer comprises a propylene polymer composition where the propylene base polymer is a heterophasic propylene copolymer having a matrix of a propylene homopolymer and a dispersed phase of an elastomeric copolymer of propylene and at least one olefin comonomer; has a comonomer content of 2-7% by weight, based on the weight of the heterophasic propylene copolymer; has a melt flow rate MFR (2/230), determined according to ISO 1133 C4, of 0.1-2.0 g/10 min; has a broad molecular weight distribution as defined by its rheology shear thinning index, SHI0/50, measured at 200° C. of 9-30; has a tensile modulus, determined according to ISO 527-2/1B at 1 mm/min and 23° C. of at least 1800 MPa; has an impact strength, determined according to ISO 179/1 eA of at least 6 kJ/m2 at 0° C. and at least 2 kJ/m2 at −20° C. The composition is a polymer composition as defined above. The process is characterized by polymerizing in the presence of a stereospecific Ziegler-Natta catalyst including an electron donor:(i) a propylene homopolymer matrix in at least one loop reactor at a temperature of at least 80° C. and a pressure of 4600-10000 kPa; and (ii) an elastomeric copolymer of propylene and at least one olefin comonomer in at least one gas-phase reactor at a lower temperature than in stage (i); to obtain a base polymer of heterophasic propylene copolymer as defined above.
US08563106B2
The present invention provides a thermoplastic resin composition producing an extremely small amount of outgas and providing a molded article having excellent antistaticity. The present thermoplastic resin composition comprises a thermoplastic resin and is characterized in that the amount of outgas is 1500 μg/g or less. The composition may comprise a surface resistivity reducing substance in an amount of 0.1 to 70 parts by mass relative to 100 parts by mass of the thermoplastic resin. The present invention is suitable to a composition comprising a styrenic resin as the thermoplastic resin. The surface resistivity reducing substrate is preferably a polyamide elastomer comprising a hard segment formed of polyamide 12 and a soft segment formed of poly(alkylene oxide)glycol. The polyamide elastomer preferably has a refractive index of 1.5 to 1.53, a melting point of 130 to 160° C., a solution viscosity of 1.35 to 1.70 and a surface resistivity of 1×108 to 1×1011Ω.
US08563103B2
A polylactide hydrosol polymer formulations suitable for thin film articles and methods of making the thin film articles are provided. The formulations and methods can be use to make articles such as gloves, condoms, catheters and the like using dip forming, and various casting processes.
US08563098B2
An inflatable article is provided with a layer impermeable to inflation gases. The layer has an elastomer composition that includes at least, as a predominant elastomer by weight, a thermoplastic styrene (TPS) elastomer and a platy filler. The platy filler has an equivalent diameter (Dv (0.5)) of between 20 and 45 micrometers, and has a shape factor (F) greater than 65.
US08563092B2
Technologies are generally described for methods and systems of forming a palladium sulfide film on a substrate including flexible substrate. A palladium sulfide precursor may be applied to the substrate. The palladium sulfide precursor may comprise a palladium organothiolate. The palladium sulfide precursor may be heated under reaction conditions sufficient to decompose the palladium sulfide precursor to form the palladium sulfide film or patterns, the latter using various lithography techniques.
US08563089B2
Disclosed are a functional reinforcing filler including inorganic particles surface-modified with an alkenylsilanol obtained by hydrolyzing an alkenylalkoxysilane compound, and a method for preparing the same.Since the disclosed functional reinforcing filler has a functional group having a double bond, it has good reactivity for styrene-butadiene rubber and sulfur. Thus, when used as a functional reinforcing filler in the manufacture of rubber, it allows improvement of physical properties through adjustment of the addition amount of sulfur without additional use of the coupling agent. In addition, because of superior hydrolysis reactivity, the problem of alcohol can be solved and a rubber mixture with long scorch time can be prepared. In particular, when the functional reinforcing filler of the present invention is used in the manufacture of tires, improvement in modulus, tensile strength, rotational resistance and wet traction performance can be expected.
US08563087B2
Flexographic printing precursors are prepared by providing an elastomeric mixture of one or more elastomeric resins and non-metallic fibers having an average length of at least 0.1 mm and an average diameter of at least 1 μm, and adding a vulcanizing composition and optional other components to the elastomeric mixture. The elastomeric mixture is then mechanically treated to orient the non-metallic fibers predominantly in the same dimension in the elastomeric mixture. It is then vulcanized and formed into a laser-engraveable layer having two orthogonal dimensions. The non-metallic fibers are predominantly oriented in one of the two orthogonal dimensions.
US08563084B2
A process and a device for coating substrates with a stoichiometric gradient in an in-line coating system include at least two evaporation devices, each with an evaporator tube. The evaporator tubes are implemented so as to be tiltable independently of one another, whereby the transition area of the two vapor lobes can be adapted to the requirements of the gradient profile. Furthermore, the spacing of the evaporator tubes from the substrate and each other can be set.
US08563081B2
Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.
US08563072B2
The present invention relates to hydronium stabilized silicic acid nanoparticles, to the formulation obtained from the said diluted suspension, to the powder obtained from the said dehydrated suspension and to the preparation or dosage form obtained from the said suspension, formulation or powder, to their preparation and their use in all kinds of applications in the domains of food, medicine, pharmaceutics, cosmetics. The present invention provides a stable suspension of colloidal silicic acid nanoparticles having a pH lower than 0.9, a molar silicon concentration between 0.035 and 0.65, a free water concentration of at least 30% (w/v) and a ratio between hydronium ion and Si molar concentrations higher than 2 and preferably inferior to 4. The present invention further provides a method for preparing a stable suspension of colloidal silicic acid nanoparticles, which comprises the steps of providing an aqueous inorganic or organic silicon solution and quick mixing said aqueous inorganic or organic silicon solution with water containing a strong acidic compound at a temperature inferior at 30° C., preferably comprised between 1 and 25° C., to form a suspension of colloidal silicic acid nanoparticles having a pH lower than 0.9, stabilized by hydronium ions, the ratio between hydronium ions and Si molar concentrations being higher than 2 and preferably inferior to 4, for a molar silicon concentration between 0.035 and 0.65 and a free water concentration of at least 30% (w/v).
US08563067B2
Carbon dioxide is dissolved in liquid dairy products loaded and transported in bulk containers so as to improve product shelf life, thereby providing options for more economical shipment, as by rail and ocean vessels and for extended transport by truck and to facilitate extended storage of perishable products and to avoid the necessity of multiple treatments for pathogen reduction.
US08563063B2
A melon peeler system designed to safely and quickly separate the rind from a melon for consumption. The melon peeler system includes a melon peeler assembly having a concave base, a horizontal blade, fasteners, and vertical supports. The concave base has a smooth surface and serves as a melon cutting guide. The horizontal blade is supported a user-determined distance above the concave base by the vertical supports and the blade is a small, flat cutting edge sufficiently sharp to slice through a melon but not sufficiently sharp to easily cut a user. Suction cups fasteners located on the bottom of the device provide stability and allow the assembly to be removably affixed to a planar surface of the user's choice.
US08563059B2
The invention in particular relates to an oven (1) for baking food products (3). In order to improve automated heating procedures, the oven (1) comprises a camera (7) and a distance sensor (8), for example, which are used in concert to enable precise extraction of product-features that are relevant and used with automated heating procedures.
US08563049B2
The present invention relates in general to a sweet. More specifically, the present invention relates to a sweet which provides beneficial effects on the teeth. The sweet according to the present invention promotes good oro-dental hygiene, and more particularly provides oro-dental care, and promotes and maintains healthy teeth and gums. It is characterized in that it contains microalgae and/or extracts of microalgae, and more particularly Chlorella and/or extracts of Chlorella. Finally, the present invention also relates to the use of a sweet, preferably a sugar-free sweet, containing Chlorella for promoting and maintaining good oro-dental health.
US08563046B2
Certain exemplary embodiments can provide a composition of matter comprising chlorine dioxide dissolved in acetic acid. When stored, a concentration of the chlorine dioxide in the composition of matter can be retained, with respect to an initial concentration of chlorine dioxide in said composition of matter, at, for example, greater than 30% for at least 28 days. Certain exemplary embodiments can provide a method comprising releasing chlorine dioxide from a composition comprising chlorine dioxide dissolved in acetic acid.
US08563043B2
A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses.
US08563040B2
Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones.
US08563035B2
Oral tablet compositions of dexlansoprazole or pharmaceutically acceptable salts or hydrated forms thereof having a gradual release and processes for the manufacture of the tablet composition and its use in the treatment of gastrointestinal disorders.
US08563017B2
A disinfectant wet wipe that contains a germicidal solution and a nonwoven web material is provided. The germicidal solution includes a peracid and peroxide, which can act synergistically together to be efficacious against pathogens when exposed thereto. To stabilize the solution over a period of time (e.g., during storage), a variety of aspects of the wipe are selectively controlled in accordance with the present invention. For example, the nonwoven web material used in the wipe is formed from a synthetic polymer and is relatively hydrophobic in nature. Without intending to be limited by theory, it is believed that such materials possess a lower reduction potential for peroxides/peracids than cellulosic-based materials. In this manner, significant degradation of the peroxide or peracid contained in the germicidal solution is limited. To improve the wettability of the nonwoven web material, one or more surfactants are also employed in the germicidal solution. Besides improving wettability, the present inventors have surprisingly discovered that certain surfactants may also improve the stability of the solution.
US08563012B2
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
US08563008B2
The disclosure provides novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including the sequences for the preparation of immunogenic compositions and vaccines, antibodies, and to their for treating gestational malaria. Diagnostic methods and kits are described.
US08563005B2
The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection by Actinobacillus suis. These immunogenic compositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective against A. suis. In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.
US08562992B2
The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
US08562989B2
A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
US08562988B2
The present invention concerns methods and compositions for forming anti-cancer vaccine complexes. In preferred embodiments, the anti-cancer vaccine complex comprises an antibody moiety that binds to dendritic cells, such as an anti-CD74 antibody or antigen-binding fragment thereof, attached to an AD (anchoring domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, wherein two copies of the DDD moiety form a dimer that binds to the AD moiety, resulting in the formation of the vaccine complex. The anti-cancer vaccine complex is capable of inducing an immune response against xenoantigen expressing cancer cells, such as CD138negCD20+ MM stem cells, and inducing apoptosis of and inhibiting the growth of or eliminating the cancer cells.
US08562981B2
Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
US08562971B2
The use of a probiotic Lactobacillus rhamnosus and a probiotic Bifidobacterium longumin the manufacture of a medicament or therapeutic nutritional composition for administration to an infant during at least the first three months of life for the long-term prophylaxis of diarrhea in infants and young children.
US08562966B2
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
US08562960B2
The present invention relates to a cosmetic composition containing a unique polymer blend, which includes: (a) a first polymeric film-former having a first glass transition temperature ranging from about −20° C. to about 0° C.; (b) a second polymeric film-former having a second glass transition temperature that is at least 50° C. higher than the first glass transition temperature; and (c) a third cross-linked polymeric film-former. The cosmetic composition of the present invention can be applied to human skin or keratinous fibers for forming a film thereon with exceptionally long wearability, reduced flaking and smudge properties, and good removability by warm water.
US08562946B2
A new system accomplishes easy, interchangeable production of multiple PET radiopharmaceuticals through the use of a simplified eluant-only generator and a kit based synthesis technique employing lyophilized or freeze dried ligand. Thus, by simply switching the lyophilized ligand vial kit, any number of 62Cu-labeled radiopharmaceuticals (62Cu-ligand) can be interchangeably synthesized with only one 62Zn/62Cu generator.
US08562944B2
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
US08562935B2
The present invention is directed towards methods (processes) of providing large quantities of carbon nanotubes (CNTs) of defined diameter and chirality (i.e., precise populations). In such processes, CNT seeds of a pre-selected diameter and chirality are grown to many (e.g., hundreds) times their original length. This is optionally followed by cycling some of the newly grown material back as seed material for regrowth. Thus, the present invention provides for the large-scale production of precise populations of CNTs, the precise composition of such populations capable of being optimized for a particular application (e.g., hydrogen storage). The present invention is also directed to complexes of CNTs and transition metal catalyst precurors, such complexes typically being formed en route to forming CNT seeds.
US08562931B2
A method for cyclically preparing monomer boron and coproducing potassium cryolite using potassium fluoborate as an intermediate material, which includes following steps: A) adding hydrofluoric acid to boric acid or boron oxide to enable a reaction to form fluoboric acid; B) adding a potassium sulphate aqueous solution to the fluoboric acid to enable a reaction to form the potassium fluoborate; C) putting the potassium fluoborate into a reactor, adding aluminium to react with the potassium fluoborate to form the monomer boron and potassium cryolite; D) extracting the potassium cryolite, sending the potassium cryolite to a rotary reaction kettle together with concentrated sulphuric acid to enable a reaction to form hydrogen fluoride gas and aluminium potassium sulphate, potassium sulphate, collecting the hydrogen fluoride gas and dissolving it into water to obtain the hydrofluoric acid; E) recycling the obtained hydrofluoric acid to Step A to leach the boric acid or boron oxide.
US08562930B2
Hazardous process gases are heated to auto ignition temperatures by rods and cylinders in a heating chamber. The heated gases and oxygen mix in a combustion chamber, and the gases ignite and combust. Air is introduced to cool the hot combustion products. Particles are separated from the cooled gases. Pure non hazardous gases and air are exhausted.
US08562929B2
A method for producing ammonia suitable for use as a reductant in a combustion exhaust gas treatment system is provided that includes the electrolytic hydrolysis of urea under mild conditions. The ammonia generator, which includes an electrolysis apparatus including an electrolytic flow cell, an alkaline electrolyte composition, and a recirculation system, may be operatively coupled to an exhaust gas treatment system to provide an apparatus for reducing nitrogen oxides (NOx) and/or particulate in exhaust gases.
US08562921B2
A process for the production of high purity ethyl acetate from ethanol is described. The process involves reacting ethanol over a suitable catalyst in a reactive distillation column. The reactive distillation setup allows overcoming the reaction equilibrium for increased conversion of ethanol. Hydrogen is removed as the distillate and ethyl acetate is obtained as a bottoms product from the reactive distillation column. A feed of hydrogen at the bottom of the column and a suitable hydrogenation catalyst placed at the bottom of the column allows for a significant reduction of impurities such as butan-2-one and/or n-butyraldehyde in the ethyl acetate product. Adding side reactors to the reactive distillation column allows additional catalyst holdup for improved reactant conversion.
US08562919B2
It is to provide a device for sampling feces that enables an accurate and quantitative evaluation by decreasing the variations of feces sampling levels, wherein the confirmation of the presence or absence of feces sampling can be performed hygienically and simply from an outside of a container. A device for sampling feces comprising a feces sampling stick 10, a container body 20, and a fitting body (30, 40) fitted to the inner part of the container body; the feces sampling stick having a gripping part 11 and a stick part 12, being provided with a feces sampling part 14 at the end; the container body having an opening part to fit the fitting body on one side, and a bottom part 21 on the other side, wherein a feces-suspending liquid container part for preserving a liquid for suspending feces 22 is formed in a space between the lower part of the container body and the lower side of the fitting body; the fitting body having a tubular guide part 34 that enables introduction of the stick part of the feces sampling stick, a first leveling hole 35 to remove excess feces, and a second leveling hole 42 below the first hole for further removing excess feces; wherein a domain for detecting collected feces 39 is formed in a tubular guide part adjacent to the upper end of the first leveling hole.
US08562909B2
A decapping/recapping device for removing closures from sample tubes and for reclosing sample tubes with the same closures is presented. The device comprises individual closure holders, each holder comprising a passive closure gripper for holding a closure, at least one actuator for actuating the passive closure gripper when removing a closure from a tube or reclosing a tube with its respective closure and at least one tube gripper cooperating with the at least one actuator for biasing a tube and its closure away from each other when removing the closure and for biasing the tube and its closure towards each other when reclosing the tube. One actuator is coupled to one passive closure gripper of a closure holder when removing a closure from a tube or when reclosing a tube with its respective closure and is decoupled from a passive closure gripper when the closure holder is holding a closure.
US08562902B2
A direct smelting plant for producing molten metal from a metalliferous feed material using a molten bath based direct smelting process is disclosed. The plant includes a plurality of crane access zones that are outboard of a gas delivery main to enable solids injection lances to be removed from and replacement lances to be positioned in openings in a side wall of a direct smelting vessel. The plant also includes a plurality of crane access zones that are inboard of the gas delivery main to enable gas injection lances to be removed from and replacement lances to be positioned in openings in the side wall of the vessel.
US08562901B1
The current invention provides a method to fabricate a crack-free continuous fiber-reinforced ceramic matrix composite by eliminating shrinkage stresses through a unique combination of freeze forming and a non-shrinking matrix composition. Cracks related to drying shrinkage are eliminated through freeze forming and cracks related to sintering shrinkage are eliminated by using a matrix that does not shrink at the given sintering temperature. After sintering, a crack-free ceramic composite is obtained.
US08562898B2
A method for forming a resin molded article includes a step of extruding a thermoplastic resin intermittently at a predetermined speed from an extrusion slit, such that the resin droops downward in a shape of a sheet. The method further includes the steps of: feeding the extruded sheet-shaped resin downward by a pair of rollers; and forming the sheet-shaped resin with a mold. In the step of feeding the sheet-shaped resin, one of the rollers is pressed against the other, but not to the extent of crushing the sheet-shaped resin, regardless of the thickness of the sheet-shaped resin. In addition, a surface temperature of each of the rollers is set lower than a temperature of the sheet-shaped resin and within a predetermined temperature range. This method can prevent sliding contact between the rollers and the sheet, while preventing the sheet from being wound around the rollers.
US08562894B2
A method for processing reinforcing filler-filled synthetic resins and applications made therefrom wherein the resulting articles have the ability to be plated to form a structurally aesthetic product substantially free of visual defects. The process utilizes an accelerated heat and cool process to form a resin-rich surface that is substantially free of any reinforcing fillers, such as fiber strands and/or bundles, on the external surface of the article. As such, the resulting article is capable of being plated to form an article that is substantially free of visual defects caused by these fillers on the surface of the article.
US08562888B2
A system and method for dispensing a sealant over aircraft fasteners secured to a surface in the aircraft. The system includes a nozzle tip having a shroud configured for placement over the fasteners. Sealant is metered to the shroud via an orifice within the nozzle tip. The shroud is sized to leave a space between it and the fastener to control the amount of sealant applied to the fastener upper surface and along the interface between the fastener and aircraft surface. Pressurized fluid urges the sealant through the orifice.
US08562886B2
A composite laminate includes a plurality of sheets of prepreg stacked one over another, and a scrim layer provided on an exterior surface of the sheets of prepreg. Each prepreg sheet is formed of fibers preimpregnated with resin. The scrim layer and the sheets of prepreg form a composite laminate whereby the scrim layer constitutes an outer, exposed surface of the composite laminate. The scrim layer may be a nonwoven carbon or glass fiber scrim that has absorbed resin from the sheets of prepreg. A method of making a composite laminate includes placing into a mold a scrim and a plurality of sheets of prepreg, with the scrim extending between an exterior surface of the sheets of prepreg and an inner surface of the mold; forming a composite laminate whereby the scrim is adhered to the sheets of prepreg; and removing the composite laminate from the mold. An outer layer of the composite laminate includes the scrim.
US08562879B2
Methods are disclosed in which two or more forming chambers are used to process inorganic fibers by gravity-laying methods. The methods may comprise using a first forming chamber to open inorganic fibers and using a second forming chamber to process the opened inorganic fibers, optionally to blend the opened inorganic fibers with additional inorganic fibers and/or with particulate additives, and to collect the inorganic fibers as a mat. The methods may comprise using a first forming chamber to form a first inorganic fiber layer and a second forming chamber to form a second inorganic fiber layer, and consolidating the first and second inorganic fiber layers so as to provide a multilayer gravity-laid inorganic fiber web.
US08562878B1
A method for making a composite polymeric material with electrical conductivity determined by stress-tuning of the conductor-polymer composite, and sensors made with the stress-tuned conductor-polymer composite made by this method. Stress tuning is achieved by mixing a miscible liquid into the polymer precursor solution or by absorbing into the precursor solution a soluble compound from vapor in contact with the polymer precursor solution. The conductor may or may not be ordered by application of a magnetic field. The composite is formed by polymerization with the stress-tuning agent in the polymer matrix. The stress-tuning agent is removed following polymerization to produce a conductor-polymer composite with a stress field that depends on the amount of stress-tuning agent employed.
US08562877B2
A method for making a carbon nanotube structure is provided. The method includes the following steps. A carbon nanotube array on a substrate is provided. The carbon nanotube array is divided with a separating line to form a strip-shaped carbon nanotube array. A carbon nanotube film is pulled out from the strip-shaped carbon nanotube array.
US08562875B2
Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.
US08562874B2
A method for preparing uniquely sized nanoparticles of CaF2 by simultaneously spray drying a first NH4F and a biocompatible salt solution and a second Ca(OH)2 and biocompatible salt solution to form CaF2 solid particles in a soluble salt matrix wherein the salt is more soluble than CaF2. The salt matrix may then be dissolved and the separate CaF2 nanosized particles collected for use as a dental therapeutic material. The technique is useful in the preparation of other discrete, nanoparticle sized compounds and combinations by carefully choosing the solvents and solutes of the two spray dried solutions.
US08562868B2
The present invention is related to ternary metal transition metal non-oxide nano-particle compositions, methods for preparing the nano-particles, and applications relating in particular to the use of said nano-particles in dispersions, electrodes and capacitors. The nano-particle compositions of the present invention can include a precursor which includes at least one material selected from the group consisting of alkoxides, carboxylates and halides of transition metals, the material including transition metal(s) selected from the group consisting of vanadium, niobium, tantalum, tungsten and molybdenum.
US08562867B2
The present invention provides polymeric compositions that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.
US08562866B2
A preparation method of zinc manganese silicate is provided. The method includes the following steps: step 1, preparing silicon dioxide sol with distilled water, anhydrous ethanol and tetraethyl orthosilicate; step 2, preparing a mixture solution of a zinc salt and a manganese salt; step 3, adjusting the silicon dioxide sol to be neutral or acidic; step 4, adding the mixture solution of the zinc salt and the manganese salt into the silicon dioxide sol to form a gelatin; step 5, drying the gelatin, keeping the temperature, grinding, reducing with keeping the temperature in a reductive atmosphere to obtain zinc manganese silicate. The preparation method has simple technique and low equipment requirement. The particles of the zinc manganese silicate phosphor prepared by the method have a regular size, uniform shape and good luminescent performance.
US08562865B2
A method of producing an M-C-N-O based phosphor with reduced non-uniform emission and improved color purity is provided. The method of producing an M-C-N-O based phosphor comprising a group IIIB element (M), carbon (C), nitrogen (N) and oxygen (O) comprises: heating a mixture comprising a group IIIB element-containing compound and a nitrogen-containing organic compound to form a pyrolysate; disintegrating the resulting pyrolysate-containing product; and firing the disintegrated product.
US08562858B2
In a process for the aqueous suspension polymerization of vinyl chloride, alone or in mixture with other monomers, in the presence of at least one of dialkylperoxydicarbonate, peroxyester and diacyl peroxide, the polymerization composition according to the invention comprises at least one dialkylhydroxylamine as a shortstopping agent along with a totally or partially hindered phenolic antioxidant.
US08562842B2
A method of fabricating a nanoimprint stamp includes forming a resist pattern having a nano size width on a stamp substrate by performing imprint processes repeatedly. In the imprint processes, resist layers that are selectively etched are sequentially used. The stamp substrate is etched using the resist pattern as an etch mask.
US08562841B1
One possible embodiment of the invention could be a continuous flow separator for biodiesel formation and a method of operating same. The separator could comprise tank with hollow interior forming a main compartment, a weir-formed compartment, and a sump, the weir being formed at one end of the tank, the sump being formed in the tank bottom, the main compartment being located over the sump; a set of horizontally stacked plates received within the main compartment over the sump, each plate features a series of conical structures, cone apertures, and trough apertures; wherein the plates are so configured and stacked that the cone apertures align to form series of cone aperture columns while the trough apertures align to form series of trough aperture columns. The biodiesel moves up the cone aperture columns over a weir into the separate compartment while glycerine descends the trough aperture columns to the sump.
US08562835B2
A fluid filter, particularly suitable for high pressure and high volume use, comprises a cylindrical housing (201) having an attachment plate (209) at an inlet end (202) to which is attached a plurality of bundles (303) of fibers (211), with the fibers being left unsecured at their distal end adjacent an outlet (203) of the housing. Between the bundles is provided a balloon (212) which can be distended in order to crush the fibers around the periphery of the housing. In use, a fluid to be filtered is introduced into the inlet end, adjacent to where the fibers are secured. In order to flush the filter the pressure within the balloon is released, and a flushing fluid is passed through the housing in the same direction.
US08562819B2
We provide a process to manufacture a base stock, comprising hydrocracking, separating, and dewaxing, wherein the base stock has a ratio of Noack volatility to CCS VIS at −25° C. multiplied by 100 from 0.15 to 0.40. We also provide a base stock made by a process, and a base oil manufacturing plant that produces the base stock.
US08562816B1
A method for treating crude oil and petrochemical product tank bottoms treats the tank bottoms sludge with a paraffin modifier that converts the tank bottom sludge, in the presence of a hydrocarbon diluent (cutter stock) and heat, into three separate phases. The resulting three phase separation is stable enough that there is no need for the use of any mechanical equipment such as centrifuges or decanters to enhance the separation.
US08562811B2
Methods for electrochemical production of formic acid are disclosed. A method may include, but is not limited to, steps (A) to (D). Step (A) may introduce water to a first compartment of an electrochemical cell. The first compartment may include an anode. Step (B) may introduce carbon dioxide to a second compartment of the electrochemical cell. The second compartment may include a solution of an electrolyte and a cathode. The cathode is selected from the group consisting of indium, lead, tin, cadmium, and bismuth. The second compartment may include a pH of between approximately 4 and 7. Step (C) may apply an electrical potential between the anode and the cathode in the electrochemical cell sufficient to reduce the carbon dioxide to formic acid. Step (D) may maintain a concentration of formic acid in the second compartment at or below approximately 500 ppm.
US08562797B2
An electrode for use in a electrochemical sensor comprises carbon modified with a chemically sensitive redox-active compound, excluding an electrode based on carbon having derivatised thereron two redox-active species wherein at least one of said species is selected from anthraquinone, phenanthrenequinone and N,N′-diphenyl-p-phenylenediamine (DPPD). The invention further provides a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material; and a counter electrode, wherein the ratio of the surface area of the working electrode to the surface area of the counter electrode is from 1:10 to 10:1. Also provided is a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material, and a counter electrode, wherein the area of the working electrode is from 500 μm2 to 0.1 m2. The uses of these electrodes and sensors are also described.
US08562788B2
A process for manufacturing fiberboard by preparing a fiber slurry mixture including containing cellulose fibers and water then atomizing a liquid bituminous material, such as asphalt. The liquid bituminous material is atomized by mixing it with a pressurized gas, such as compressed air, forming a mist comprising droplets of bituminous material having a diameter between 20 microns and 50 microns. A water spray solidifies the bituminous material droplets thereby forming bituminous particles which fall into the fiber slurry within the spray chamber. From there the slurry is sheared, dewatered, and dried, forming a finished fiberboard.
US08562786B2
A method of making a fabric-creped absorbent cellulosic sheet. A papermaking furnish is compactively dewatered to form a nascent web. The nascent web is applied to a translating transfer surface and is fabric-creped from the transfer surface at a consistency of from about 30 to about 60 percent utilizing a creping fabric. The creping fabric travels at a fabric speed that is slower than the speed of the transfer surface. The nascent web is creped from the transfer surface and redistributed on the creping fabric to form a creped web with a drawable reticulum having a plurality of interconnected regions of different local basis weights. The creped web is dried to form a dried web, and the dried web is drawn. The drawing step includes drawing the dried web between a first draw roll and a second draw roll.
US08562778B2
A tape adhering apparatus and a tape adhering method for adhering an ACF tape formed from an anisotropic conductive film to a target adhering area on a substrate are disclosed. It is an objective of the invention to provide a tape adhering apparatus and a tape adhering method that enable shortening of a time consumed by operation for adhering one cut piece of an ACF tape. According to the present invention, the separator is peeled from the cut piece of the ACF tape by letting the tape conveyor means convey the tape member in synchronism with the transfer action of the transfer base and thereafter a cut portion of the ACF tape to be next adhered is placed at the cutting position of the tape cutting means by letting the tape conveyor means continually convey the tape member in the forward conveyance direction.
US08562776B2
Embodiments of the invention are directed to methods and apparatus for infrared imagers including fast electrostatic shutters and offset compensation. Fast electrostatic shutters are used for video image correction including image offset compensation where temporal noise and scene nonuniformity are corrected. This method provides a shutterless experience for the user because the image will be blocked for only one frame at a time. A method of manufacturing an electrostatic infrared shutter includes a conductive infrared-transparent substrate, covering it with an insulating layer, depositing adhesive and a thin film stack, delineating a working area, providing contacts, heat-treating the assembly, and making the polymer non-reflective in the infrared.
US08562774B2
In some embodiments, a nonwoven fabric includes a first web that is at least partially formed of extruded strands which include an auto-adhesive material. The nonwoven fabric is adapted to be bonded to another item that includes a similar auto-adhesive material. In other embodiments, a method of forming a nonwoven fabric includes extruding a plurality of strands that are formed of an auto-adhesive material. The method further includes routing the plurality of strands toward a moving support, depositing the plurality of strands onto the moving support, and then stabilizing the plurality of strands to form a web. In other embodiments, a fastening system includes a nonwoven fabric that has a web which is formed of a plurality of extruded strands that include an auto-adhesive material. The fastening system further includes a foam layer that has a surface with a plurality of free-standing struts that include a similar auto-adhesive material.
US08562772B2
This invention relates to an improvement for applying a layered structure onto a convex surface of a lens. After thermoforming the layered structure, a curvature direction of the layered structure is inverted. The structure is then applied on the lens surface by continuously pushing the structure against the lens surface, starting from a contact point between a convex surface of the structure and the convex surface of the lens. The curvature direction of the layered structure is then inverted again, so that it recovers the curvature direction that resulted from thermoforming. Stresses within the layered structure are then reduced, and the structure can be assembled with the lens without defects.
US08562769B2
A foam roofing underlayment is provided with a reinforcement membrane having an array of fastener elements for engaging fastener elements on a flexible roof membrane. The underlayment is formed by molding foam between the reinforcement membrane and a carrier membrane. The underlayment in secured to the roof using washers having fastener elements for engaging the fastener elements of the flexible roof membrane. An anti-peel flap with fastener elements is provided around the periphery of the washers. A slip sheet is used between the underlayment and the flexible roof membrane to permit accurate positioning of the flexible roof membrane prior to engagement of the fastener elements. The interstices between the fastener elements provide lateral moisture paths to vents in the flexible roof membrane.
US08562767B2
A bearing component formed from a bearing steel, wherein the component has an outer surface and comprises through-hardened bainite and/or martensite and has a substantially homogeneous chemical composition, at least a part of the bearing component having a compressive residual stress profile comprising −25 to −1000 MPa at the near surface, wherein the near surface is defined as a region 500 microns or less below the outer surface.
US08562763B2
A high strength α+β-type titanium alloy, containing, by mass %, 4.4% to less than 5.5% of Al, 1.4% to less than 2.1% of Fe, and 1.5 to less than 5.5% of Mo and including, as impurities, Si suppressed to less than 0.1% and C suppressed to less than 0.01% and a balance of Ti and unavoidable impurities.
US08562759B2
Disclosed herein are iron-based alloys having a structure comprising fine-grained ferritic matrix and having a 60+ Rockwell C surface, wherein the ferritic matrix comprises <10 μm Nb and W carbide precipitates. Also disclosed are methods of welding comprising forming a crack free hardbanding weld overlay coating with such an iron-based alloy. Also disclosed are methods of designing an alloy capable of forming a crack free hardbanding weld overlay, the methods comprising the step determining an amorphous forming epicenter composition, determining a variant composition having a predetermined change in constituent elements from the amorphous forming epicenter composition, and forming and analyzing an alloy having the variant composition.
US08562756B2
The present invention is aimed at providing a method for producing an NdFeB sintered magnet having a higher coercivity and higher squareness of the magnetization curve than ever before. A method for producing an NdFeB sintered magnet according to the present invention includes the steps of forming a layer containing Dy and/or Tb on the surface of an NdFeB sintered magnet base material and then performing a grain boundary diffusion process for diffusing Dy and/or Tb from the aforementioned layer through the crystal grain boundaries of the magnet base material into the magnet base material by heating the magnet base material to a temperature equal to or lower than the sintering temperature thereof, and this method is characterized in that a) the content of a rare earth in a metallic state in the magnet base material is equal to or higher than 12.7 at %; b) the aforementioned layer is a powder layer formed by depositing a powder; and c) the powder layer contains Dy and/or Tb in a metallic state by an amount equal to or higher than 50 mass %.
US08562752B2
A process chamber for processing semi-conductor wafers. The chamber includes at least one rotor within the process chamber. The rotor is adapted to receive and/or process semi-conductor wafers. The top of the process chamber also includes a tiltable rim. This rim tilts from a non-inclined position to an inclined position. The wafers may be loaded into and unloaded from the process chamber when the rim is in its inclined position.
US08562749B2
A wafer fabrication process with removal of haze formation from a pellicalized photomask surface is provided. The wafer fabrication process includes pre-print wafer processing, wafer print processing using at least one photomask having a pellicle, photomask clean processing, wafer print processing using the photomask, and post-print wafer processing. The photomask clean processing step includes directing a laser through the pellicle towards an inorganic particle disposed on the photomask to remove the particle from the photomask by thermal decomposition.
US08562744B2
A coating device includes two workspaces, two first slide rails, two second slide rails, two transporting loops, a number of rotating platforms, and a number of loading poles. The first slide rails are respectively fixed on the bottoms of the workspaces. The second slide rails are respectively fixed on the tops of the workspaces. The transporting loops are movably positioned on the first slide rails respectively. The rotating platforms are rotatably positioned on the transporting loops and capable of being driven by the transporting loops to rotate and slide along the first slide rails. The loading poles are positioned between the rotating platforms and the second slide rails, and are used for holding substrates. The loading poles are capable of being transported from one workspace to another workspace.
US08562743B2
A high pressure processing system including a chamber configured to house a substrate. A fluid introduction system includes at least one composition supply system configured to supply a first composition and a second composition, and at least one fluid supply system configured to supply a fluid. The fluid supply system is configured to alternately and discontinuously introduce the first composition and the second composition to the chamber within the fluid.
US08562741B2
The present invention relates to an evaporation source for evaporating an organic electroluminescent layer. In particular, the present invention relates to the evaporation source preventing an aperture, through which a vaporized evaporation material is emitted, from being clogged by restricting heat transfer to outward. The evaporation source according to the present invention includes a cell retaining an evaporation material therein; a cell cap installed on the upper part of the cell and having a cell cap aperture for emitting a vaporized evaporation material; an external wall placed in the outside of the cell to support a heating means set up at the outside of the cell; a cover placed above the cell cap, fixed to the upper end of the external wall, and having a cover aperture corresponding to the cell cap aperture; and a shut-off plate placed between the cover and the cell cap and having a shut-off plate aperture corresponding to the cell cap aperture and the cover aperture in the center of the shut-off plate.
US08562738B2
A nitride-based light-emitting device includes a substrate and a plurality of layers formed over the substrate in the following sequence: a nitride-based buffer layer formed by nitrogen, a first group III element, and optionally, a second group III element, a first nitride-based semiconductor layer, a light-emitting layer, and a second nitride-based semiconductor layer.
US08562737B2
A crystal growth method, comprising the steps of: a) bringing a nitrogen material into a reaction vessel in which a mixed molten liquid comprising an alkaline metal and a group-III metal; and b) growing a crystal of a group-III nitride using the mixed molten liquid and the nitrogen material brought in by the step a) in the reaction vessel, wherein a provision is made such as to prevent a vapor of the alkaline metal from dispersing out of the reaction vessel.
US08562736B2
This invention relates to a new class of chemical admixtures for hydraulic cement compositions such as pastes, mortars, grouts and concretes. The cement compositions are comprised of ordinary Portland cement, blended cements, or non-Portland cements made with Supplementary Cementitious Materials. The admixtures contain complexes of metals with derivatives of hydroxycarboxylic acids, and improve properties of cement compositions, including setting, hardness, compressive strength, shrinkage, and freeze-thaw resistance. The invention discloses a method for improving the properties of hydraulic cements by adding the disclosed chemical admixtures to cement compositions, and also discloses methods of preparing said admixtures.
US08562734B2
A low-calcium-cementitious material having a calcium oxide content less than or equal to 10 wt % which is processed at room temperature into a low calcium cement mainly composed of mullite and a method manufacturing of the low calcium cement are provided. The low-calcium-cementitious material includes low calcium fly ash, an alkaline agent, and a congealing agent, wherein the calcium oxide content of the low-calcium-cementitious material is less than or equal to 10 wt %. The low calcium fly ash has a calcium oxide content less than or equal to 10 wt %. The low calcium cement manufacturing method includes providing a low calcium fly ash having a calcium oxide content less than or equal to 10 wt %; providing an alkaline agent; providing a congealing agent; and mixing the low-calcium-content fly ash, the alkaline agent, and the congealing agent and standing the mixture at room temperature to form a low calcium cement.
US08562727B2
Disclosed is an electroless palladium plating solution which can form a plating layer having excellent soldering properties onto electronic components and the like and excellent wire bonding properties. The electroless palladium plating solution comprises a palladium compound, an amine compound, an inorganic sulfur compound and a reducing agent, wherein a combination of hypophosphorous acid or a hypophosphorous acid compound and formic acid or a formic acid compound is used as the reducing agent, and wherein the palladium compound, the amine compound, the inorganic sulfur compound, the hypophosphorous acid compound, and formic acid or the formic acid compound are contained in amounts of 0.001 to 0.1 mole/l, 0.05 to 5 mole/l, 0.01 to 0.1 mole/l, 0.05 to 1.0 mole/l and 0.001 to 0.1 mole/l, respectively. The electroless palladium plating solution is characterized by having excellent soldering properties and excellent wire bonding properties.
US08562711B2
A dry flowable additive for aqueous urea-based fertilizers made of solid urea formaldehyde polymer (UFP), N-(n-butyl) thiophosphoric triamide (NBPT), and, optionally, dicyandiamide (DCD), wherein the liquid fertilizer containing the additive provides reduced nitrogen loss from the soil. Optionally, the dry additive may also be blended with molten or solid urea to form a solid urea-based fertilizer with reduced nitrogen loss from the soil.
US08562707B2
An air cleaner includes a housing and an access cover. The internal volume of the housing can be reached through an opening in a side wall of the housing. A filter element having fluted filter media is removable and replaceable from the air cleaner. The housing is constructed and arranged to cam the element into sealing engagement with the housing. The access cover includes structure to help support and ensure proper seating of the filter element within the housing. A method of installing the filter element in the air cleaner includes sliding a portion of the filter element against a slide surface in the housing. A method of servicing an air cleaner includes tilting the filter element against a tilt surface in the housing to release a seal between the filter element and the housing. The filter element can have a handle to assist in servicing of the air cleaner.
US08562704B2
A filter box for a surface maintenance machine incorporating aspects of a fan housing. In one example, a filter box for a sweeping machine is provided with an impeller fan housing beneath a cylindrical filter. Operation of the impeller fan draws air from a debris hopper, through the cylindrical filter, and through an expansion chamber defined by a scroll conduit prior to outlet to atmosphere.
US08562702B2
The invention relates to an abrasive compact comprising a mass of diamond particles and a silicon containing binder phase wherein the diamond particles are present in an amount less than 75 volume % and the binder phase contains less than 2 volume % unreacted (elemental) silicon. The invention further relates to a method of producing an abrasive compact including the steps of forming a feed diamond powder into a diamond preform, interposing a separating mechanism between the diamond preform and a silicon infiltrant source, heating the diamond preform and silicon infiltrant source until the infiltrant is molten and the preform and infiltrant are isothermal and allowing infiltration from the molten silicon infiltrant source to occur into the diamond preform.
US08562691B2
A training device capable of converting kinetic energy of an agent into electric energy while applying to the agent a resistance force of a variation behavior appropriate to a motion behavior of the agent. According to the training device, a strength and a direction of a resistance force applied to the agent can be varied via a regenerative braking on a motor according to at least one of a variation behavior of a relative posture between an upper body and a leg of the agent and a temporal variation behavior of the relative posture therebetween.
US08562687B2
Disposable modular spacer device of the articulation of a knee including a tibial element, constrainable to an end of the tibial bone in proximity of the articulation of the knee and including a lower surface and an upper surface provided with a radius of curvature R2, and a femoral element, including an inner surface, constrainable to an end of the femoral bone at the articulation of the knee and an outer convex surface, provided with a radius of curvature R1 and in contact with the upper surface of the tibial element, the tibial element and the femoral element having various dimensions or sizes, the tibial element being configured so as to be coupled with any size of the femoral element to adapt the dimensions of the modular spacer device with the dimensions of the bone ends to which it should be connected.
US08562686B2
A joint prosthesis includes a bone engaging portion having a first recess portion, and an internal wall defining a second recess portion, an articulating component, an insert component having (i) a first insert portion configured to snugly fit within said second recess portion in contact with the internal wall, and (ii) a projecting portion that fixedly projects from said first insert portion and is configured to snugly fit with the first recess portion so as to rotationally fix the first insert portion within the second recess portion, said insert component also having a first coupling portion, and a mating component configured to mate with said articulating component and having a second coupling portion configured to mate with the first coupling portion to form a fixed male/female couple at variable version and inclination angular orientations with respect to the insert component.
US08562682B2
An intervertebral joint prosthesis having a ball component (22) for engagement with a first vertebra (26) and a trough component (24) for engagement with a second vertebra (27) adjacent to the first vertebra is disclosed. The trough component (24) includes a generally concave surface (50) having a substantially flat portion (52). When the ball component (22) and the trough component (24) are engaged to their respective vertebrae, the ball component (72) and the trough component (24) engage each other, permitting rotation and translation of the vertebrae with respect to each other. Both components include a flange (34, 56) for engaging a vertebra. The invention also contemplates a method for and a tool for use in implanting a two-piece intervertebral joint prosthesis.
US08562677B2
Shells for mammary prostheses and other devices are created by spraying a silicone dispersion onto a mandrel. Several coats of dispersion are applied with an interval for evaporation of solvent from the dispersion between application of coats. The shells created are uniform in thickness and have a desirably defect-free surface.
US08562675B2
In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
US08562674B2
An insertion system is provided for delivering an intraocular lens into an eye. The insertion system has an inserter for delivering the lens and a lens case for holding the lens prior to delivery. The inserter has a handpiece having a longitudinal axis, a proximal end, and a distal end. The inserter also has a nosepiece disposed at the distal end of the inserter, the nosepiece having a rotational axis that is substantially perpendicular to the longitudinal axis and a load chamber with a transfer interface for receiving the lens. The case has a transfer port for transferring the lens from the case into the load chamber. Once the lens is transferred into the load chamber, the nosepiece is adapted to rotate approximately 180 degrees about the rotational axis between a first position for loading the lens and a second position for delivering the lens into the eye.
US08562672B2
A prosthetic valve including a replacement valve having a tubular valve body wall, an expandable stent having a framework with first and second ends, and suturing holding the framework to the valve body at the first and second ends. The suturing at the first end is colored differently from the suturing at the second end.
US08562665B2
A circumferentially connected stent in a non-expanded state with a longitudinal axis, includes a first expansion column strut pair having a first expansion strut, a second expansion strut with a joining strut. The first expansion column strut pair defines a chevron shaped slot, and a plurality of the first expansion strut pair forms a first expansion column. A second expansion column strut pair includes a first expansion strut, a second expansion strut and a joining strut. The second expansion column strut pair defines a chevron shaped slot, and a plurality of the second expansion strut pair forms a second expansion column. A first serial connecting strut column is formed of a plurality of first connecting struts, and the first connecting strut column couples the first expansion column to the second expansion column.
US08562661B2
Disclosed are several methods, apparatus, and a system for providing hypertension/high blood pressure symptom relief through a laser based medical instrument. In one embodiment, a method includes generating a radiation of a laser-light created by a laser diode of a medical instrument. In addition, the method includes applying a treatment of the radiation to a portion of a body. The method further includes regulating of a blood pressure and an advanced glycation end product (AGE) in the blood caused by one of a disease associated with hypertension and blood pressure. Additionally, the method includes providing a relief from high blood pressure when the treatment is complete.
US08562659B2
A sleep mask is configured to provide light therapy to a subject. The sleep mask may provide a comfortable delivery mechanism for the light therapy, and may deliver the light therapy to the subject while the subject is asleep, in the process of going to sleep, and/or waking from sleep. In one embodiment, the sleep mask includes one or more of a shield, a strap, a first lighting module, and/or a second lighting module.
US08562655B2
A lumbar plate assembly for use between at least two vertebral bodies is disclosed. The assembly includes a lumbar plate having at least one opening for each vertebral body, a screw configured to secure the lumbar plate to a vertebra through the at least one opening, and a rotatable locking mechanism proximate the least one opening configured to rotate from a first configuration to a second configuration, the first configuration allowing the screw to pass into the opening and the second configuration engaging the screw to prevent withdrawal of the screw from the opening.
US08562652B2
A dynamic anchoring device is described. An element with a shank for anchoring in a bone or a vertebra and with a head connected to the shank is provided with a receiving part for the head and with an elastomeric pressure element acting on the head. The pressure element is formed and located in such a way that, upon a movement of the element from a first angular position of the shank relative to the receiving part into a second angular position, it exerts a return force on the head. Further, a dynamic stabilization device, in particular for vertebrae, is provided. In such a stabilization device, a rod is connected two anchoring devices. At least one of the anchoring devices is constructed as dynamic anchoring element.
US08562649B2
Facet joint replacement implants may be designed for use on multiple adjacent vertebral levels. Each superior implant may have a substantially semispherical concave surface, and each inferior implant may have a cooperating semispherical convex surface that is deformable to enable it to be pressed into the superior implant concave surface to fix the relative orientations of the superior and inferior implants. Thus, the inferior implant may be attached to the same pedicle as the superior implant, but may also be oriented independently of the superior implant and then fixed in position. Similar mounting structures may be used to attach one or more fusion implants to a level adjacent to that of a facet joint replacement implant.
US08562640B2
The invention provides surgical or diagnostic tools and associated methods that offer improved user control for operating remotely within regions of the body. These tools include a proximally-located actuator for the operation of a distal end effector, as well as proximally-located actuators for articulational and rotational movements of the end effector. Control mechanisms and methods refine operator control of end effector actuation and of these articulational and rotational movements. A multi-state ratchet for end effector actuation provides enablement-disablement options with tactile feedback. The tool may also include other features. A force limiter mechanism protects the end effector and manipulated objects from the harm of potentially excessive force applied by the operator. An articulation lock allows the fixing and releasing of both neutral and articulated configurations of the tool and of consequent placement of the end effector. A rotation lock provides for enablement and disablement of rotatability of the end effector.
US08562632B2
An instrument for use in minimally-invasive procedures generally including a pair of coaxially arranged shafts, an end-effector at the distal ends of the shafts, and an actuator at the proximal ends of the shafts. The end-effector is in the form of a suture holder which includes a first, fixed arm at a distal end of a first, fixed outer shaft, and a second, movable arm at a distal end of a second, movable inner shaft. The fixed arm includes a u-shaped end, which defines an opening adapted to receive a portion of an elongate flexible suture material. A closure pin fixed at an end of the movable arm moves back and forth, opening and closing the opening in the u-shaped end of the fixed arm. The closure pin extends from the movable arm into a pin guide opening through one leg of the u-shaped end of the fixed arm.
US08562627B2
Device and method for harvesting and implanting hair follicular units is provided. A combined harvesting and implanting tool or tool assembly provides a harvesting cannula portion detachably coupled to an implanting cannula portion. The harvesting and implanting cannula portions may be coupled by a connector that could be designed to allow for multiple uses of the tool assembly, or alternatively may be designed for single use and rendered non-functional when the implanting cannula portion of the tool is separated from the harvesting cannula portion of the tool.
US08562620B2
Systems, bone cements and methods for treating vertebral compression fractures can utilize a bone cement comprising of a mixable liquid monomer component and a non-liquid component including polymer particles, wherein the non-liquid component is configured for controlled exposure to the liquid monomer over a setting interval of the bone cement. In a method of use, liquid and non-liquid components are mixed, and the bone cement is injected into bone wherein a lengthened setting interval is provided in which the mixture is configured for a flowability that prevents unwanted extravasation.
US08562619B2
A method for filling a bone defect in a subject in need thereof is disclosed. The method includes heating a bone cement composition at a first temperature where the bone cement composition is fluidic, and delivering an effective amount of the fluidic bone cement composition at a second temperature to the bone defect thereby filling the bone defect and allowing the fluidic bone cement composition to solidify, the second temperature being sufficiently high for maintaining the bone cement composition fluidic without causing thermal necrosis. Also disclosed are systems for carrying out the method.
US08562615B2
An apparatus for introducing a bone portal into a bone is described herein. An example apparatus for introducing portals into bone includes a stylet and a handle. The stylet is configured to support an infusion tube assembly. The infusion tube assembly comprises a bone portal. The handle is drivingly coupled to the stylet by a release mechanism. The release mechanism comprises a bone probe that, in a first configuration, extends generally parallel to the stylet. The release mechanism is operative to uncouple the driving coupling between the handle and the stylet upon axial motion of the bone probe relative to the handle. The stylet and bone probe are movable apart from one another to a second configuration.
US08562611B2
Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.
US08562609B2
A device for creating a cavity in a bone, said cavity having a cross-section which has a generally triangular profile having a first side generally parallel with an axis of the bone and a second side forming an acute angle with the first side, and contiguous with a pre-existing conical cavity, includes a shaft having a longitudinal axis and including a proximal portion and a distal portion, wherein the proximal portion has a larger cross section perpendicular to the longitudinal axis than the corresponding cross section of the distal portion, and a broach non-rotationally supported by the shaft and having a first cutting side supported at the acute angle relative to the longitudinal axis of the shaft, wherein the distal portion of the shaft is formed to include witness marks which when registered with an indicator after advancing the shaft facilitate selection of an appropriately sized prosthesis component.
US08562608B2
An orthopedic system prepares a surface of an anatomical structure to receive an orthopedic prosthesis. A method for using the same is also disclosed. The orthopedic system includes a surgical instrument and a guide. The guide includes an anterior portion and a distal portion that is at least partially elevated relative to the anterior portion. The distal portion includes at least one track that is sized to receive the surgical instrument while preparing the surface of the anatomical structure.
US08562593B2
A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.
US08562586B2
Devices and methods are provided for delivery of a positive inotropic agent to the heart of a patient in need thereof. An epicardial patch includes (i) a backing layer which is impermeable to the positive inotropic agent; and (ii) a drug release layer attached to the backing layer and including the positive inotropic agent and a polymeric membrane material. The polymeric membrane material provides controlled release of the positive inotropic agent to the epicardium to a region of the myocardium and in an amount effective to increase contractility. At least one of the backing layer or the drug release layer includes a tissue coupling portion for affixing the epicardial patch to an area of the epicardial surface. The epicardial patch is dimensioned and compliant to substantially avoid impeding myocardial functionality when affixed to the area of the epicardial surface.
US08562584B2
This disclosure relates to drug delivery devices and related systems and methods. In some aspects, a drug delivery device includes a drug vial holder and a mechanism configured to compress a drug vial between upper and lower members of the drug vial holder.
US08562578B2
A drainable pouch is disclosed which comprises a pair of sidewalls of flexible sheet material having side edges joined together to define a cavity having a discharge end provided with an outlet valve for draining the cavity. The sidewalls also are joined together throughout a central region thereof such that the cavity formed by the sidewalls completely surrounds the central region. With this construction, the central region defines a peripheral edge and has at least one opening in a location which is spaced inwardly of the peripheral edge to receive and secure the outlet valve when the discharge end has been folded.
US08562575B2
The Holistic Breast Patch is the first known, non-pharmaceutical, effective device available which inhibits prolactin production safely and aids the relief of discomfort from breast engorgement pain by drying breast milk after pregnancy. The benefits of treatment of prolactin dependent diseases remain to be fully disclosed. It works transdermally and is comprised of a unique, approximately 1½ inch by ¾ inch natural and organic carbonyl disc housed within cotton gauze and nonstick adhesive Telfa®. It meets the Federal Drug Administration's definition of a non-significant risk device (21 CFR 812). Its use will aid in the treatment of prolactin dependent diseases and conditions and eliminate the serious risks of health complications and fatalities that have been documented by the use of prescription drugs, hormones and pharmaceuticals lacking FDA approval for this use by women. Wearing the Patch device is both easy and convenient. Using it as directed expedites the suppression of lactation, significantly reducing the duration of lactation and also alleviates pain associated with breast milk engorgement, in addition to the benefits derived from use in prolactin dependent and related disease treatment.
US08562570B2
An injection device having a safeguard for preventing a filling or adjusting motion of the injection device when a prescribed dispensing motion has been performed, the injection device including an adjusting element and/or a filling element, a blocking mechanism including a first blocking element and a second blocking element, the blocking mechanism allowing a motion of the adjusting and/or filling element in a release position and preventing the motion in a blocking position, and a piston rod including a block trigger element that can bring one of the blocking elements into interaction with the other blocking element thereby creating a blocking position at a prescribed insertion position to cause a blocking of at least one of the adjusting element and/or the filling element.
US08562551B2
A neck brace (10) is disclosed which comprises two sections (12, 14) which are releasably connected to one another along a split line (18). The ring has upwardly facing surfaces (30, 76.1, 20.2) which limit tilting movement of a helmeted head in all directions. The brace further has a column (68, 70) which extends downwardly from the ring for transferring loads to the wearer's back on each side of the spine.
US08562538B2
In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
US08562532B2
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
US08562531B2
There is provided a ultrasonic motion detecting device that detects a three-dimensional motion of an object. The ultrasonic motion detecting device, comprises first and second ultrasonic transducers 13 having piezoelectric elements arranged in an array, which transmit ultrasonic waves to an object and acquire reflection signals from the object, a motion detection unit 20 that extracts an estimation region which is used for estimating a motion of the object from the reflection signals that are acquired by the first and second ultrasonic transducers, and detects a three-dimensional motion within the estimation region, and an image display unit 19 that displays the three-dimensional motion within the estimation region, wherein ultrasonic wave scanning surfaces due to the first and second ultrasonic transducers cross over each other.
US08562525B2
A biological signal processing apparatus includes an obtaining unit that obtains a spectrum of a biological signal that has been obtained, a generation unit that generates a three-dimensional waveform by plotting elements of the spectrum obtained by the obtaining unit in a space defined by a time axis, a frequency axis, and an intensity axis, and a detection unit that detects a specified waveform component using a position along the intensity axis at which a cross-section of the three-dimensional waveform in a time-frequency domain generated by the generation unit is to be observed and a state of the cross-section at the position as criteria for recognition.
US08562524B2
A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
US08562523B2
Methods and apparatus for identifying an extreme epileptic state/event in a patient are provided. One method includes determining at least one of an autonomic index, a neurologic index, a metabolic index, an endocrine index, or a tissue stress index, where at least one determined index is based upon body data. The method also includes identifying a seizure event based upon the at least one determined index and determining at least one seizure severity index (SSI) value indicative of the severity of the seizure event. The method further includes comparing the determined at least one SSI value to at least one reference value and identifying an occurrence of an extreme seizure event, based upon the comparison of the determined SSI value to the at least one reference value.
US08562521B2
A surgical access system including a tissue distraction assembly and a tissue refraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures before, during, and after the establishment of an operative corridor to a surgical target site.
US08562520B2
A surgical access port assembly is provided including a cannula and an obturator insertable through the cannula. The cannula includes a housing having a hollow elongate tubular member extending distally from the housing. A duckbill valve is provided within the housing and includes an outer support rim and a pair of opposed multi-angle leaflets extending inwardly from the outer support rim. Each leaflet includes a lead in portion oriented at a first angle relative to the support rim and an entry portion extending from the lead in portion and oriented at a second angle relative to the support rim. The second angle is greater than the first angle.
US08562512B2
A surgical tool assembly is provided having a surgical tool, a scope; and a detachable clip which couples the tool and scope. The clip includes a first grip which engages a peripheral surface of the tool and a second grip which engages a peripheral surface of the scope. Additionally, the first and second grips may be formed continuously with one another.
US08562510B2
An incubator or open patient care unit (1) is provided, which can be opened and closed by one or more side panes (2). The side pane (2) or each side pane (2) is equipped with essentially vertical guide elements (3, 4). A drive (10) may be provided with an associated analysis unit (11) for the drive (10), wherein the analysis unit (11) receives sensor and/or switching signals, so that the side pane (2) can be automatically opened and/or closed by a preset time or sensor signal.
US08562509B2
A ventricular assist device includes an intravascular blood pump and a collapsible frame. The collapsible frame receives the blood pump therein and is movable between a collapsed state and an expanded state. The collapsible frame engages an interior wall of a body cavity when in the expanded state and is retrievable from the body cavity in the collapsed state.
US08562508B2
A blood pump system includes a first implantable housing, an implantable blood pump independent from the first implantable housing, and a percutaneous extension. The first implantable housing includes a rechargeable power storage device. The implantable blood pump supplements the pumping function of a heart. The rechargeable power storage device supplies electrical power to the implantable blood pump. The percutaneous extension is coupled to the rechargeable power storage device and adapted to traverse the skin. The percutaneous extension is configured to releasably connect to an external power supply adapted to provide power for recharging or supplementing the rechargeable power storage device to power the implantable blood pump.
US08562507B2
Materials and methods related to blood pump systems are described. These can be used in patients to, for example, monitor arterial pressure, measure blood flow, maintain left ventricular pressure within a particular range, avoid left ventricular collapse, prevent fusion of the aortic valve in a subject having a blood pump, and provide a means to wean a patient from a blood pump.
US08562503B2
The invention refers to a disk package for a centrifuge. The disk package comprises a plurality of separating disks provided on each other in the disk package. Each separating disk extends around an axis of rotation for the centrifuge rotor and has tapering shape with an inner surface and an outer surface along the axis of rotation. Each separating disk has inner edge, defining a central opening of the separating disk, and outer edge. Each separating disk is manufactured of a material. The separating disks comprise a plurality of first separating disks comprising a number of distance members, which extend away from the inner surface and/or outer surface. Each distance member comprises at least one contact zone abutting an outer surface and inner surface, respectively, of an adjacent separating disk in the disk package. The contact zone has a continuously convex shape seen in a cross section.
US08562502B2
A centrifugal separator includes: a rotor configured to hold a sample to be separated; a driving device configured to rotate the rotor and including a driving shaft; a chamber configured to contain the rotor and including a through hole through which the driving shaft is passed; a seal member configured to fitted over the through hole of the chamber and the driving shaft; a drain hole configured to discharge liquid in the chamber to an exterior; and an undulated part configured to guide a flow of the liquid and is provided on an upper surface of the seal member.
US08562499B2
A machine for transitioning a box cutout from a flat configuration to a collapsed box configuration includes a first drive wheel configured to drive a box cutout towards a plunging area; a plunger configured to apply force to a central portion of a bottom panel of the box cutout so as to fold the box about a lateral bisecting axis and propel at least a portion of the box cutout downward; and opposed second and third drive wheels configured to grab a box cutout propelled downward by the plunger and further draw the box cutout downward into a collapsed box configuration within a collection area. A box cutout transitioned to a collapsed box configuration in this manner may include a bottom panel having plurality of unbroken minor score lines and broken major score lines.
US08562495B2
An upper body exercise apparatus includes a spring positioned in a housing interior area. First and second cables have respective first ends operatively coupled to the spring and respective second ends extending away from the housing. Respective movements of the first and second cables away from the housing cause the spring to move toward a biased configuration. The exercise apparatus includes a transmission configured such that an outward movement of the first cable in the absence of an outward movement of the second cable causes all of the springs resistance to be transmitted to the first cable, an outward movement of the second cable in the absence of movement of the first cable causes all of the spring's resistance to be transmitted to the second cable, and an outward movement by both cables causes the spring's resistance to be distributed equally between the first and second cables.
US08562494B2
According to one embodiment, an exercise device in the form of an adjustable resistance multi-use toning system that includes a plurality of elongated elastic bands (tension bands or cables) which can have different tension (resistance) values. Each band has a first end and an opposing second end. The device further includes a hollow sleeve that receives at least a portion of each of the elastic bands so as to at least partially envelope the elastic bands while permitting the first and second ends to be accessible. A first fastener is provided for attaching the first ends of the elastic bands to a support member, such as a piece of exercise equipment, a belt to be worn around a body part of a user; or any other structure to which the exercise device can be attached.
US08562493B2
The exercise and training apparatus includes: A base disposed on a supporting surface for the apparatus. An upper body support arrangement secured to the base frame in a manner that allows several positions from generally horizontal position to a generally vertical position. A lower body support arrangement secured to the base frame adjacent to the upper body support having a generally horizontal position. A head support secured to the upper body support arrangement. A pair of hand levers attached to the upper body support one on each side in a manner that allows the user's hands to move the levers in plural directions. A lever secured to the lower body support arrangement capable of receiving the user's legs in a manner that allows the user to move the lever in plural directions. An adjustable resistance device secured to each lever in order to provide resistance to movement of the lever.
US08562488B2
One embodiment of the present invention includes a system and method for alleviating symptoms of a medical disorder of a patient by forced exercise. The system includes an exercise machine having movable portions that move in response to a first contribution by a patient and in response a second contribution by a motor. The system further includes at least one mechanical sensor and a control system programmed to alter the second contribution by the motor in response to the sensed data.