US10323301B2
Provided is a hydrogen storing alloy represented by the general formula: (RE1-a-bSmaMgb)(Ni1-c-dAlcMd)x (where 0.3
US10323300B1
A method to separate rare earth material from a rare earth magnet. At least one embodiment comprises a method that heats a provided rare earth magnet to at least 600° C. whereby the rare earth magnet absorbs a dry gas. Separated rare earth materials are created. Magnetic rare earth materials are produced from the separated rare earth materials.
US10323298B2
A single-heating stage method for reclaiming or recovering metals like nickel and vanadium from a petroleum waste byproduct has three steps: melting the petroleum waste byproduct in a reducing atmosphere, generating agglomerated metal in the melted byproduct, and lifting the agglomerated metal to an exposed surface of the melted byproduct. The metal precipitates out of the molten byproduct, agglomerates into a separate portion, and rises to an exposed surface of the melted petroleum waste byproduct even though the metal may have greater density than the molten petroleum waste byproduct. The original petroleum waste byproduct stratifies into a byproduct remnant and the agglomerated metal disk. The agglomerated metal disk is separable from the byproduct remnant and may be additionally separated into constituent metals in those embodiments with multiple metals in the disk.
US10323296B2
A process for extraction of copper from an arsenical copper sulfide concentrate is provided. The process includes atmospheric oxidative leaching of a feed slurry including the arsenical copper sulfide concentrate and an acidic iron sulfate-containing leach solution, in the presence of oxygen, to produce a leach slurry including copper and arsenic dissolved into the leach solution. After dissolving the copper and arsenic, and before precipitating the arsenic dissolved during the oxidative leaching, pre-precipitation solids are recovered from the leach slurry to produce the pre-precipitation solids and a resulting pregnant leach solution including the copper and arsenic. Scorodite-containing seed is introduced to the pregnant leach solution including the copper and arsenic to induce precipitation of the arsenic dissolved during the oxidative leaching, as scorodite. Solids are recovered from the pregnant leach solution to produce the solids, including the scorodite, and an arsenic-reduced pregnant leach solution including the copper. The arsenic-reduced pregnant leach solution including the copper is subjected to solvent extraction for recovering copper and thereby producing a raffinate including sulfuric acid and iron sulfate, and at least a portion of the raffinate including the sulfuric acid and iron sulfate is recycled to the oxidative leaching.
US10323294B2
Provided is an austenitic stainless steel foil that demonstrates a high degree of stretch formability and little deformation anisotropy with respect to stretch forming despite having a sheet thickness of 60 μm or less. The austenitic stainless steel foil of the present invention has a sheet thickness of 5 μm to 60 μm, a recrystallization rate of 90% to 100%, and a texture in which the total of the area ratio of a crystal orientation in which the difference in orientation from the {112}<111> orientation is within 10°, the area ratio of a crystal orientation in which the difference in orientation from the {110}<112> orientation is within 10°, and the area ratio of a crystal orientation in which the difference in orientation from the {110}<001> orientation is within 10°, in a measuring field thereof, is 20% or less.
US10323293B2
A high-carbon hot rolled steel sheet with excellent hardenability and small in-plane anisotropy, and a method for manufacturing the steel sheet are provided. The steel sheet has a chemical composition including, by mass %, C: 0.20 to 0.48%, Si: not more than 0.1%, Mn: not more than 0.5%, P: not more than 0.03%, S: not more than 0.01%, sol. Al: not more than 0.10%, N: not more than 0.005% and B: 0.0005 to 0.0050%, the balance including Fe and inevitable impurities. The steel sheet includes a microstructure containing ferrite and cementite. The cementite has an average grain size of not more than 1.0 μm. The steel sheet has an in-plane anisotropy of r value, Δr, of not more than 0.1 in absolute value.
US10323283B2
The present invention relates to the use of the editing profile of PDE8A pre-mRNA as a specific bio marker of ADARs activities in evolved primate, particularly in Human tissues. The present invention also relates to an in vitro method for predicting in Human an alteration of the mechanism of the ADARs catalyzed pre-mRNA editing of target genes, by analyzing the PDE8A pre-mRNA editing profile in a peripheral tissue sample containing cells expressing said PDE8A pre-mRNA, such as blood sample. The present invention is also directed to an in vitro method for the screening of potential therapeutic compound and to predict and assess therapeutic efficacy and/or efficiency or to diagnose potential severe brain or peripheral drug side effects implementing said PDE8A pre-mRNA editing profile as specific biomarker. The present invention is further directed to a method for determining the PDE8A pre-mRNA editing profile in Human, particularly by capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) method after amplification by a nested PCR. Finally the invention relates to particular nucleic acid primers implemented in said nested PCR and kit comprising such sets of primers and human cells capable of expressing PDE8A and ADARs.
US10323280B2
The invention encompasses methods for increasing genetic progress in livestock, and for genetic dissemination, including the use of amniocentesis to obtain fetal amniocytes for use in genomic evaluation and cloning.
US10323278B2
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
US10323274B2
A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
US10323273B2
The present invention relates to methods and uses where a combination of (i) an enzyme exhibiting 5′→3′ exonuclease activity and specifically degrading 5′-phosphorylated strands of double-stranded nucleic acids is used, and (ii) one or more primer pair(s), each primer being 5′ phosphorylated, in a method comprising at least a first and a second amplification reaction of a first and a second template, respectively, for preventing contamination of the second amplification reaction with amplification products of the first amplification reaction, as well as novel methods and kits using the combination. Also, the present invention relates to kits comprising the enzyme and either 5′-phosphorylated primers or a polynucleotide kinase.
US10323268B2
Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
US10323261B2
A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The polyhydroxyalkanoate copolymer molecules (i) comprise 3-hydroxybutyrate monomers and 4-hydroxybutyrate monomers, (ii) have a monomeric molar percentage of 4-hydroxybutyrate monomers of 23.5 to 75%, and (iii) have a biobased content of ≥80%. Also provided is a method of making a polyhydroxyalkanoate copolymer composition. The method comprises culturing an organism in the presence of one or more carbon raw materials under conditions under which (a) the one or more carbon raw materials are converted to 3-hydroxybutyryl-CoA and 4-hydroxybutyryl-CoA and (b) the 3-hydroxybutyryl-CoA and the 4-hydroxybutyryl-CoA are polymerized to form the polyhydroxyalkanoate copolymer molecules, thereby forming the composition. The organism has been genetically engineered to comprise particular enzymatic activities, and to not comprise other particular enzymatic activities. The one or more carbon raw materials, taken together, have a biobased content of ≥80%.
US10323254B2
According to the present invention, a transgenic plant, wherein expression of the BSS1 gene having activity to bind to a BIL1 protein to inhibit the transfer of the BIL1 protein into the nucleus so as to down-regulate brassinosteroid signaling is suppressed or promoted, and a method for regulating plant growth, wherein expression of the BSS1 gene in a plant body is suppressed or promoted, are provided.
US10323250B2
The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus Mortierella. The present invention provides a polynucleotide which contains any one nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to 28, or a variant thereof.
US10323245B2
The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
US10323243B2
Embodiments of the disclosure concern methods and compositions related to generation and/or use of proofreading reverse transcriptases, including those that are thermophilic or hyperthermophilic. The disclosure encompasses specific recombinant polymerases and their use. In some embodiments, the polymerases are utilized for RNA sequencing in the absence of generation of a cDNA intermediate.
US10323237B2
A lysozyme having improved enzymatic activity is disclosed. The amino acid sequence of the lysozyme is a modified amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence with at least 80% sequence identity of SEQ ID NO: 2, wherein the modification is a substitution of histidine at position 166 or a corresponding position with lysine.
US10323236B2
Engineered nucleases (e.g., zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and others) are promising tools for genome manipulation and determining off-target cleavage sites of these enzymes is of great interest. We developed an in vitro selection method that interrogates 1011 DNA sequences for their ability to be cleaved by active, dimeric nucleases, e.g., ZFNs and TALENs. The method revealed hundreds of thousands of DNA sequences, some present in the human genome, that can be cleaved in vitro by two ZFNs, CCR5-224 and VF2468, which target the endogenous human CCR5 and VEGF-A genes, respectively. Our findings establish an energy compensation model of ZFN specificity in which excess binding energy contributes to off-target ZFN cleavage and suggest strategies for the improvement of future nuclease design. It was also observed that TALENs can achieve cleavage specificity similar to or higher than that observed in ZFNs.
US10323228B2
Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
US10323222B2
The invention relates to a device (1) for automated inoculation of a culture medium, the device being of the type comprising: a clamp (2) suitable for gripping the inoculation tool; a clamp-holder (3); a support base (4) carrying the assembly formed by the clamp (2) and the clamp-holder (3); and a support structure (5) for supporting the support base (4) and for enabling the support base (4) to be moved along three axes. The device is characterized in that the assembly formed by the clamp (2) and the clamp-holder (3) is an assembly mounted to move in pivoting in such a manner that it is tiltable relative to the support base (4), in that the clamp (2) is fitted with pivot branches (6) mounted to pivot between two positions, one being an open position and the other being a closed position, pivoting being driven by drive means (7) preferably acting on return means (8), and in that the clamp (2) is a rotary clamp mounted to revolve about an axis (BB′) that is transverse and preferably orthogonal to the pivot axis (AA′) of the branches (6) of the clamp (2).
US10323212B2
Polyols are produced by an alkoxylation process in which a vegetable oil containing hydroxyl functional groups is combined with a DMC catalyst to form a mixture, the DMC catalyst is then activated by adding ethylene oxide and/or propylene oxide to the vegetable oil/catalyst mixture, and ethylene oxide and propylene oxide are added to the mixture containing activated DMC catalyst in amounts such that the total of percentage of ethylene oxide in the polyol plus percentage of primary hydroxyl groups in the polyol produced is from 50 to 77% and the percentage of primary hydroxyl groups is at least 30% but less than 50%. These polyols are useful for the production of molded polyurethane foams, particularly, hot-cure molded polyurethane foams.
US10323209B2
The present invention relates to extracted lipid with high levels, for example 90% to 95% by weight, oleic acid. The present invention also provides genetically modified plants, particularly oilseeds such as safflower, which can used to produce the lipid. Furthermore, provided are methods for genotyping and selecting plants which can be used to produce the lipid.
US10323205B2
A method for reducing timing chain stretch in an engine comprising a step of lubricating said timing chain with a lubricating oil composition that includes a major amount of a base oil; and a minor amount of an additive package including (a) at least one overbased calcium detergent, (b) at least one borated dispersant, (c) a metal dialkyl dithiophosphate, and (d) at least one molybdenum compound. The lubricating oil composition has a TBN value of at least 7.5 mg KOH/g of the lubricating oil composition, at least 80 ppm of molybdenum, based on the total weight of the lubricating oil composition, a weight ratio of total calcium in the lubricating oil composition to total molybdenum in the lubricating oil composition of less than 8.4; and a weight ratio of nitrogen from the dispersant in the lubricating composition to total boron in the lubricating oil composition of from 2.6 to 3.0.
US10323202B2
A method for removing hydrogen sulfide (H2S) from an acid gas comprises feeding the gas to a membrane separation unit, collecting the product gas from the membrane unit, heating the permeate stream to the necessary inlet temperature for catalytic oxidation of H2S and feeding the heated permeate stream to a catalytic oxidation unit, where H2S is oxidized to SO2. The heating of the permeate stream is accomplished by using a fraction of the feed gas to heat the permeate stream in a separate heater or by using a steam-fired heater. The method is especially suited for use on an off-shore facility.
US10323199B2
The present invention relates to a Fuel Supplement comprising of selected plant oils mixed in given proportions, which when added to fuels like petrol and diesel can reduce harmful emissions during combustion of fuel. It can significantly decrease the Sulphur content in fuels and thus protect the environment from harmful pollutants. It improves the fuel lubricity and engine performance. It also increases the flash point of Diesel.
US10323192B2
The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.
US10323188B2
The present invention relates to liquid-crystalline media comprising one or more pleochroic dyes and one or more compounds selected from the group of compounds of formulae I, II and III, in which the parameters have the meaning indicated in Claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
US10323179B2
A quantum dot having a perovskite crystal structure and including a compound represented by Chemical Formula 1: ABX3+α Chemical Formula 1 wherein, A is a Group IA metal selected from Rb, Cs, Fr, and a combination thereof, B is a Group IVA metal selected from Si, Ge, Sn, Pb, and a combination thereof, X is a halogen selected from F, Cl, Br, and I, BF4, or a combination thereof, and α is greater than 0 and less than or equal to about 3; and wherein the quantum dot has a size of about 1 nanometer to about 50 nanometers.
US10323164B2
A hydrogenated block copolymer composition, comprising: a component (A) comprising at least one polymer block comprising a vinyl aromatic hydrocarbon as a primary component and at least one polymer block comprising a conjugated diene compound as a primary component and having a weight-average molecular weight of 30,000 or higher and 500,000 or lower, and a component (B) comprising at least two polymer blocks comprising a vinyl aromatic hydrocarbon and at least one polymer block comprising a conjugated diene compound as a primary component and having a weight-average molecular weight of 50,000 or higher and 1,000,000 or lower, wherein the composition satisfies predetermined requirements.
US10323160B2
Provided are polytriglyceride-AAG compositions, and corresponding coatings and coated articles. Also provided are methods for preparing the polytriglyceride-AAG compositions, and corresponding reagents including β-ketoimide compositions and triglyceride-AAG (acetoacetyl group) compositions. Coatings using the polytriglyceride-AAG compositions may be useful for, e.g., replacing bisphenol-A cross-linked coatings used in food and beverage containers, coating metal articles, and the like.
US10323158B2
A coating slip includes water, at least one pigment and at least one modified starch, exhibiting: a weight-average molecular weight ranging from 250 000 to 2 000 000 Da; and a solubility, measured according to a test A, ranging from 50 to 85%. A process for the preparation of the slip, and a process for coating paper using this slip are also described.
US10323157B2
The present disclosure provides plated particles for use in silver/silver chloride ink for making medical devices. The plated particles include a plurality of silver coated inert particles. The silver coating of each silver coated inert particle is about 10 to 50% by weight of the silver coated inert particle. The silver/silver chloride ink includes a plurality of silver coated inert particles and a plurality of silver chloride particles. A medical device includes a backing layer, a silver/silver chloride ink layer and a conductive adhesive layer.
US10323154B2
The present disclosure is directed to a white ink composition for use in digital offset printing, including a first white colorant including a first plurality of white pigment particles, wherein an average diameter of at least about 40% of the first plurality of white pigment particles is in a range of about 250 nanometers to about 350 nanometers, a second white colorant including a second plurality of white pigment particles, wherein an average diameter of at least about 40% of the second plurality of white pigment particles is in a range of about 350 nanometers to about 550 nanometers, at least one dispersant, at least one component selected from a curable monomer or a curable oligomer, and a photo-initiator. Also provided is a method of digital offset printing using the white ink composition of the present disclosure.
US10323151B2
Disclosed herein are implementations of a radiative cooling formulation, an apparatus including a substrate coated with the radiative cooling formulation, and a method of applying a coating of the radiative cooling formulation to an object. In one implementation, a radiative cooling formulation includes a binder which includes a first polymer and a second polymer that are practically water insoluble and are substantially non-absorbing to light having wavelengths in a solar spectrum. The radiative cooling formulation further includes a solar reflector material embedded in the binder.
US10323150B2
An azo compound and an ink composition containing the azo compound are used as inks for ink jet recording and have excellent gas (ozone) resistance when recording is done on special ink jet paper. The azo compound is represented by formula (1) or a tautomer thereof, or a salt of these. In formula (1), R1 represents a C1-C4 alkyl group, R2 represents a cyano group, R3 and R4 each independently represent a C1-C4 alkoxy, R5-R10 each independently represent a group represented by formula (2), and R11-R13 each independently represent a nitro group. In formula (2), R14 is an anilino group, and R15 is a mono- or di-C1-C6 alkylamino group
US10323148B1
This invention involves the addition of ester bottoms to an asphalt paving composition to improve the usable temperature range (UTR). The ester bottoms are a byproduct of refining a feedstock containing all or a portion of vegetable oil or animal fat.
US10323146B2
The present invention relates to bituminous coated materials including a granular fraction and a binder, characterised in that in the granular fraction all or part of the elements are selected from among lightweight, non-absorbent aggregates with a density of less than 1.6 t/m3 and a water absorption coefficient of less than 15%. The invention also relates to the use of light, non-absorbent aggregates with a density of less than 1.6 t/m3 and a water absorption coefficient of 3% to 15% for the production of light bituminous coated materials. The invention further relates to pavements obtained by applying at least one layer of the coated materials according to the invention and to a method for applying a surface course to a surface raised above the ground which includes a step of applying coated materials according to the invention.
US10323142B2
Described herein is a curable composition comprising: (a) a perfluoroelastomer gum having a carboxylic acid integrated absorbance ratio of at least 0.015; and (b) a compound comprising at least one oxazole moiety, and cured articles thereof.
US10323126B2
A siloxane compound containing structures represented by the following general formulae (1) and (2): wherein R1 and R2 independently represent a hydrogen atom, a halogen atom, an alkyl group having from 1 to 3 carbon atoms, a halogenated alkyl group, a thiol group, an acetyl group, a hydroxyl group, a sulfonic acid group, a sulfoalkoxyl group having from 1 to 3 carbon atoms, or an alkoxyl group having from 1 to 3 carbon atoms; x and y independently represent an integer of from 0 to 4; and A represents a single bond or an azomethine group, an ester group, an amide group, an azoxy group, an azo group, an ethylene group, or an acetylene group, and wherein R3 and R4 independently represent an alkyl group, a phenyl group, or a substituted phenyl group; and n represents an integer of from 1 to 100.
US10323125B1
One or more embodiments relate to providing substrate for separating a first gas component from a gaseous mixture, said substrate comprising a benzimidazole-linked polymer. Also provided is a method for synthesizing a substrate for separating a first gas component from a gaseous mixture, the method comprising performing a free condensation reaction between an aryl-o-diamine and an aryl-aldehyde to yield a benzimidazole-linked polymer. Other embodiments related to providing a CO2 separation membrane comprising benzimidazole-linked polymer residing within a matrix.
US10323123B2
Methods of metal-catalysed polymerisation are described using a metal catalyst of formula (III): wherein R3 in each occurrence is independently selected from C1-10 alkyl and aryl that may be unsubstituted or substituted with one or more substituents; y is 0 or 2; and Z−is an anion. Methods described include Buchwald-type and Suzuki-type polymerisation.
US10323121B2
Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
US10323115B2
A bio-polyol composition and a bio-polyurethane foam are provided. The bio-polyol composition includes polyol, a surface-modified lignin, and a surfactant represented by formula 1. wherein R is represented by CnH2n+1, n is an integer of 0 to 3; x/y is between 5 and 13; a is an integer of 1 to 100; b is an integer of 1 to 100.
US10323098B2
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
US10323097B2
The present invention concerns human antibodies recognizing the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
US10323096B2
The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and inflammatory disorders and/or for preventing or reducing the risk of graft rejection in transplantation.
US10323093B2
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.
US10323092B2
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.
US10323085B2
The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of chronic pain and/or symptoms of chronic pain, and to a method of treating and/or preventing chronic pain and/or symptoms of chronic pain using an anti-CGRP antibody.
US10323084B2
The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
US10323079B2
The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
US10323077B2
This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
US10323075B2
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US10323069B2
A Senecavirus A polypeptide generally includes at least a portion of 151-434 of SEQ ID NO:1, amino acids 435-673 of SEQ ID NO:1, or amino acids 674-937 of SEQ ID NO:1. The Senecavirus A polypeptide may be used as a capture antigen in a method or device for detecting antibody that specifically binds to the Senecavirus A polypeptide. The Senecavirus A polypeptide may be used as a immunogen to vaccinate a subject having or at risk of having a Senecavirus A infection.
US10323062B2
The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting enzyme (ACE) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrate of the present invention significantly inhibits ACE activity, and thus brings blood pressure regulating effect and antihypertensive effect. Therefore, the fraction of the oyster enzyme hydrate of the invention or the peptide separated from the same can be effectively used as an active ingredient of a pharmaceutical composition for the prevention or treatment of cardiovascular disease.
US10323055B2
The present invention pertains to methods of extracting cardiac glycosides from cardiac glycoside containing plant material, such as Nerium oleander, through use of aloe. It further provides for compositions resulting from such extractions, pharmaceutical compositions, cosmetic compositions, and methods of treating skin conditions.
US10323040B2
The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.
US10323034B2
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
US10323020B2
The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
US10323015B2
The present disclosure relates to a leveling compound for electrodepositing metals. The compound is of formula (I) or a salt thereof:
US10323012B2
The present disclosure relates to miliusane and analogs thereof that are useful as anti-virals, such as anti-HIV and anti-influenza virus agents. The present disclosure provides methods for treating viral infections, such as AIDS, HIV, and influenza infections.
US10323010B2
The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.
US10323008B2
Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.
US10322999B2
The present invention relates to a novel oxindole derivative having anticancer activity, a preparation method thereof, and a method for treating cancer using the same. More specifically, the present invention relates to an oxindole derivative produced as a result of CH alkylation and subsequent intramolecular cyclization reaction using a rhodium (III) catalyst, a preparation method of the same, and a method for treating cancer containing the same as an active ingredient. The novel oxindole derivatives according to the present invention have excellent anticancer activity against various human cancer cell lines and are expected to be useful for the treatment of cancer. In addition, the preparation method of an oxindole derivative using the rhodium (III) catalyst of the present invention can be applied and introduced into a wide range of functional groups, and is a reaction having positional selectivity and chemical selectivity. As a reaction for synthesizing a new drug or a compound having biological activity, it will be useful.
US10322996B2
A method for producing derivatives of N-retinoylaminoalkane sulfonic acid, the method comprising providing retinoic acid, chloroformate, aminoalkanesulfonic acid selected from the group consisting of cysteic acid and alkyl ester thereof, cysteinesulfinic acid and alkyl ester thereof, homocysteic acid and alkyl ester thereof, homocysteinesulfinic acid and alkyl esters thereof, taurine and derivatives thereof, and an organic solvent, and a base, mixing said components under substantial absence of oxidizing compounds thereby forming a reaction mixture comprising a liquid phase, wherein the liquid phase is one phase and the derivatives of N-retinoylaminoalkane sulfonic acid are formed in said liquid phase.
US10322994B2
Fatty amide compositions and their derivatives are disclosed. The fatty amides comprise a reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with a primary or secondary amine. Derivatives made by reducing, quaternizing, sulfonating, alkoxylating, sulfating, and sulfitating the fatty amide are also included. The amine reactant can be diethylenetriamine or (2-aminoethyl)ethanolamine, which provide imidazoline amides or esters, respectively. In one aspect, the ester derivative of the C10-C17 monounsaturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin. The compositions are valuable for cleaners, fabric treatment, hair conditioning, personal care, antimicrobial compositions, agricultural uses, and oil field applications.
US10322992B2
Methods of synthesizing cerium oxide and polyaniline nanocomposites, including nanospheres enclosing a hollow core, are specified. Properties of the cerium oxide and polyaniline nanocomposites are described, as well as a method of using the nanocomposites as photocatalysts for the reduction of an aromatic nitro compound using visible light. A method for reusing the nanocomposites as photocatalysts is also discussed.
US10322985B1
The present invention relates generally to methods and systems for removing oxygen from at least one product stream of a hydrocarbon oxidative dehydrogenation process. More specifically, in some embodiments, the oxidative dehydrogenation process is an ethane oxidative dehydrogenation process for producing ethylene.
US10322984B2
The invention relates to a process for the metathesis of olefins implemented with a catalyst comprising a mesoporous matrix and at least the elements molybdenum and aluminum, said elements being incorporated into said matrix by means of at least two precursors of which at least one precursor contains molybdenum and at least one precursor contains aluminum.
US10322981B2
A substantially zero carbon emission process for making amorphous poly alpha olefins including, converting alkanes to olefin monomers ethylene, propylene, and 1-butene or combinations thereof using renewable electric power in an oxidative-coupling of methane plant including the steps of passing alkanes through an ethylene plant while adding oxygen, passing the first polymerization grade ethylene through a 2-butene plant, passing a first of the two 2-butene streams and one of the polymerization grade ethylene through a propylene plant, and passing a second of the two 2-butene streams through a 1-butene plant. The next step in the process for making amorphous poly alpha olefins includes polymerizing at least one of the polymerization grade alkenes which includes applying a temperature of 130 degrees Fahrenheit to 175 degrees Fahrenheit to at least one of the polymerization grade alkenes and scrubbing at least one boiler stack gases.
US10322979B2
A process for separating dimethyl biphenyl (DMBP) isomers, including contacting a mixture of 3,3′-DMBP, 3,4′-DMBP and 4,4′-DMBP in a first solvent with a 12-member ring zeolite exchanged with potassium or barium, or combinations thereof, and adsorbing the 3,3′-DMBP onto the 12-member ring zeolite, such as by passing the mixture through at least one packed bed of the potassium and/or barium exchanged 12-member ring zeolite.
US10322971B1
Fast-setting flowable fill compositions for filling ground trenches are described. The compositions set quickly but retain a low strength psi at 28 days. The compositions also reduce bleed water on the surface of the fast-setting flowable fill and therefor enable quicker application of surface repair material, e.g., pavement patches, to the trench. The compositions consist of aggregate, Portland cement, accelerant, water and sometimes air. The compositions may have a compressive strength of between 5 psi and 60 psi after 2 hours, a compressive strength of between 10 psi and 100 psi after 4 hours, a compressive strength of between 75 psi and 500 psi after 28 days, a penetration resistance of between 1.5 tsf and 75 tsf after 2 hours, a penetration resistance of between 4.5 tsf and 200 tsf after 4 hours, and a shrinkage of less than 2% as measured by ASTM C490. Also disclosed are methods of filling a trench with fast-setting flowable fill.
US10322970B2
A reaction resin mortar curable by frontal polymerization is described, comprising at least one radically polymerizable compound (a), at least one thiol-functionalized compound (b) and at least one polymerization initiator (c), wherein the weight ratio of the at least one radically polymerizable compound (a) and the at least one thiol-functionalized compound (b) is in the range of 10:1 to 2:1 and wherein the polymerization initiator (c) is selected from compounds which can be thermally activated and/or thermally released at a temperature of above 30° C. and/or ammonium persulfates which are formed in-situ from at least one organically substituted ammonium salt and at least one inorganic persulfate as well as a method for fixing anchor rods, rebars or the like in bore holes using the reaction resin mortar.
US10322968B2
The present invention is a dispersant composition for a hydraulic composition, which includes (A) a high-molecular compound having a naphthalene ring-containing monomer unit, (B) a polymer having a weight average molecular weight of 1,000 or more and 1,000,000 or less, and having: a monomer unit having a group selected from a carboxylic acid group, a phosphate group, a group that changes to a carboxylic acid group by hydrolysis, and a group that changes to a phosphate group by hydrolysis; and a monomer unit having an alkyleneoxy group, and (C) a specific compound represented by the general formulas (C1) to (C4).
US10322967B2
The present invention is a dispersant composition for a hydraulic composition, which includes (A) a polymer compound having a naphthalene ring-containing monomer unit and (B) a specific alkylene oxide added compound represented by the general formulas (B1) to (B3), wherein a molar ratio of a total amount of the component (B) to the naphthalene ring-containing monomer unit in the component (A) is 0.4% or more and 30% or less.
US10322962B2
A method for producing substrate tubes of quartz glass includes continuously supplying a hollow cylinder of quartz glass to a heating zone, softening the hollow cylinder zonewise in the heating zone, and drawing off a tubular strand from the softened portion. The hollow cylinder has an outer diameter Ca, an inner diameter Ci and an inner bore. The tubular strand has an outer diameter Ta and an inner diameter Ti. The following parameters are applicable to the hollow cylinder and the tubular strand: Ca>180 mm, Cr>3 with Cr=Ca/Ci, Tr<1.6 with Tr=Ta/Ti and Ci/Ti<2.5. The blow pressure in an inner bore is adjusted to a value in the range of 4 to 10 mbar. Substrate tubes, obtained by cutting the tubular strand to the desired length, serve as semi-finished products for the manufacture of preforms for optical fibers.
US10322959B2
Method for the continuous thermal hydrolysis of sludges containing organic matter, said method comprising the steps of: simultaneously injecting pressurized steam (100) into said sludges and mixing said sludges with said steam by means of a dynamic mixer-injector (4) so as to obtain a single-phase mixture, conveying said single-phase mixture towards a tube reactor (4) under pressure and bringing about the plug flow of this mixture into said reactor for a retention time that is sufficient and at a temperature that is sufficient to enable the thermal hydrolysis of the organic matter present in said sludges, cooling said single-phase mixture at its exit from said tube reactor to a temperature enabling the subsequent digestion of the hydrolyzed organic matter that it contains, depressurizing said cooled single-phase mixture.
US10322957B2
A dual tank wastewater treatment system for performing an extended aeration process to provide a natural, biological breakdown of the organic matter in wastewater using, for example, but not limited to, a continuously operating air pump and diffuser bar system for aeration purposes and a flexible media filter. The air pump used is stronger than conventional air pumps and the diffuser bar is designed to provide more efficient oxygen transfer than conventional diffuser systems by mixing air against the system flow to provide better mixing and longer retention time in the aeration process. The flexible media filter provides a final filtration and polishing of the effluent before it passes through a flow equalization apparatus and exits the system.
US10322951B2
A reverse osmosis membrane apparatus 17 including an RO membrane 17a that yields recycled water 18 and concentrated water 19 from pre-treated raw water (inflow water 16), salts being removed in the recycled water and salts being concentrated in industrial park waste water 11; monitoring apparatuses 21A and 21B disposed at an inflow water line L1 through which the inflow water 16 flows into the reverse osmosis membrane apparatus 17 or a concentrated water line L2 through which the concentrated water 19 flows out from the reverse osmosis membrane apparatus 17, which monitor the presence of chemical fouling causal substances in the inflow water 16 or the concentrated water 19; and a chemical supply section 22, which is a removal apparatus that removes the chemical fouling causal substances from the inflow water 16 on the front upstream side of the inflow into the reverse osmosis membrane apparatus 17, upon the presence of chemical fouling causal substances in the inflow water 16 or the concentrated water 19 being confirmed. Thus, the chemical fouling preventing system removes chemical fouling causal substance from inflow water 16 before it enters the reverse osmosis membrane apparatus 17.
US10322949B2
Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
US10322945B2
A water purifying apparatus for purifying cooling water of a power generator includes a cooling water tank, a steam condenser, an intermediate tank, a demineralizer, a boiler and a controlling member. The controlling member receives water and ammonia added-water so as to produce a mixed cooling water. The controlling member is configured to mix water which meets a predetermined quality criterion of electrical conductivity so as to supply the mixed cooling water to the cooling water tank. The cooling water tank is configured to flow the cooling water to the intermediate tank. The intermediate tank is configured to permit the outflow of the cooling water to the steam condenser if the buoyant force produced by the cooling water is strong enough to lift a pontoon. The water purifying apparatus can purify water with less cost, and protect the power generator from copper corrosion.
US10322936B2
Organosilicon chemistry, polymer derived ceramic materials, and methods. Such materials and methods for making polysilocarb (SiOC) and Silicon Carbide (SiC) materials having 3-nines, 4-nines, 6-nines and greater purity. Processes and articles utilizing such high purity SiOC and SiC.
US10322930B2
A semiconductor arrangement and methods of formation are provided. The semiconductor arrangement includes a micro-electro mechanical system (MEMS). A via opening is formed through a substrate, first dielectric layer and a first plug of the MEMS. The first plug comprises a first material, where the first material has an etch selectivity different than an etch selectivity of the first dielectric layer. The different etch selectivity of first plug allows the via opening to be formed relatively quickly and with a relatively high aspect ratio and desired a profile, as compared to forming the via opening without using the first plug.
US10322925B2
Caging structures are disclosed for caging or otherwise reducing the mechanical shock pulse experienced by MEMS device beam structures during events that may cause mechanical shock to the MEMS device. The caging structures at least partially surround the beam such that they limit the motion of the beam in a direction perpendicular to the beam's longitudinal axis, thereby reducing stress on the beam during a mechanical shock event. The caging structures may be used in combination with mechanical shock-resistant beams.
US10322924B2
A low-impact and modular mobile fuel delivery apparatus is disclosed with a self-propelled unit, a pump unit, and a tank unit. The self-propelled unit is adapted to minimally impact the terrain over which it travels and includes a lift for carrying the pump unit and for moving the pump unit between first and second heights. The pump unit includes a pump for drawing fuel from the tank unit and for supplying fuel to a retractable fuel-delivery hose.
US10322921B2
A one-piece board level shielding element with a top cover peel panel is secured to a circuit board to shield and provide access to a shielded component. The shielding element is formed with a top having a peel line to facilitate removal of the peel panel with a peel tool. Once the repair is completed, a new cover is put on to the remaining side-walls to reestablish the shielding. The shield top cover is formed with a peel tool insertion slot and an adjacent peel start slot. The peel panel is removed by a peel tool having a peel hook mounted to a cylindrical peel key that is inserted into the insertion slot and hooks the cover at the peel start slot. Upon rotating the peel key away from the peel start slot, the peel panel is easily removed. A fixture plate may be used to support the peel tool and assist in removal of the peel panel.
US10322919B2
A maintenance apparatus, in particular for lifting and moving components of a system for processing semiconductor devices. The apparatus comprises a beam and an arm with means for lifting a component, the arm being mounted to the beam via a connecting unit and so as to be pivotable in a horizontal plane, wherein the connecting unit is displaceable along the beam, and wherein the arm is displaceable perpendicularly to the beam, and wherein a load accommodation means is provided on the pivotable arm.
US10322916B2
The present disclosure discloses a winch comprising a motor having a rotator, a brush holder assembly electrically coupled to the rotator, and a coil assembly surrounding the rotator, a motor casing covering at least a part of the motor which comprises a plurality of conducting columns electrically coupled to the coil assembly and the brush holder assembly, a driving shaft drivably connected to the motor, a gear reduction unit drivably connected to the driving shaft, a first support frame detachably connected to the motor casing, a second support frame detachably connected to the gear reduction unit, and a winding drum located between the first support frame and the second support frame. The winch as disclosed facilitates mounting and dismounting, and provides improved waterproofness.
US10322915B2
A locking head is configured such that it can be moved within and along the longitudinal axis of a telescope, which comprises at least two telescope sections, by means of a telescoping device, comprising a base body, at least one releasing device which is configured to release a telescope section lock and at least one coupling device which is configured to couple a telescope section with the telescoping device. The locking head comprises an operating member which mechanically acts on the releasing device and the coupling device in order to operate the releasing device and the coupling device. The operating member comprises a first link guide for the releasing device and a second link guide for the coupling device, wherein the links for the first and second link guides extend in a single plane or in parallel planes.
US10322911B2
A rigging assembly has no loose parts that an up-rigger may drop. The rigging assembly includes a length of steel cable terminating in a loop at each end. One loop extends through an oblong master link, while the other loop extends through a swivel hook. The ground-rigger can attach the hook of a hoist's chain to the master link on the ground. The ground-rigger can then tie the up-rigger's rope onto the master link. The up-rigger then pulls the rigging assembly and the hoist's chain up to the beam, leaving the master link and chain under the beam. Then the up-rigger grabs the hook end of the rigging basket assembly, bends it over the beam, and attaches the swivel hook end to the master link, thus creating a loop around the beam to support the hoist's chain and load, which is known in the industry as creating a basket.
US10322909B2
The present disclosure relates to a car door for a lift car having a guide mechanism and a door leaf. The guide mechanism comprises in this case a sliding shoe, which is connected to the door leaf of the car door. Furthermore, the guide mechanism comprises a receiving part which surrounds the sliding shoe on at least three sides. The sliding shoe has, in a sliding direction, an extent which corresponds to at least 30% of the extension of the door leaf in this direction.
US10322906B2
Apparatus and methods for forming three dimensional structures from a sheet of material of a desired medium are described. Examples described include an apparatus for folding a sheet of material to create a folded structure, the apparatus having a first and second array of creasing elements, and at least one actuator for causing relative movement of the first and second array of creasing elements from a first position to a second position.
US10322905B2
A method for generating a folding instruction for folding a stack of sheets into a document includes the steps of, for each sheet of the stack of sheets, receiving a folding action on the sheet defined by a fold type and an orientation relative to an observer, the fold type selected out of a mountain fold right, a mountain fold left, a mountain fold bottom, a mountain fold top, a valley fold right, a valley fold left, a valley fold bottom and a valley fold top; generating a function which has the folding action and the sheet as input and an ordered list of new sheets with an orientation relative to the observer of each new sheet of the list of new sheets as output; repeatedly applying the previous steps to each sheet of the at least one list of new sheets until the sheets in the last applied previous steps form the document; and generating a folding instruction including a concatenation of the at least one generated function on the stack of sheets, the folding instruction intended to be transmitted to a folding device for folding the stack of sheets into the document. A folding device and a document processing system for applying the method are also disclosed.
US10322904B2
An example printing apparatus in accordance with the present disclosure may comprise a platen (10) on which print media may advance and which may comprise a hole (20) that is open towards a print media advance surface and in fluid communication with a vacuum source (40) and with a pressure sensor (50). In implementations of the apparatus a control unit (60) may detect the presence of print media at the hole (20) if the pressure sensor (50) measures an air pressure below a predetermined threshold.
US10322902B2
Disclosed herein is a sheet processing apparatus comprising a sheet tray configured to hold a bundle composed of the sheets fed from conveyance rollers, a wait path configured to keep waiting following sheets upstream the conveyance rollers, an accumulating tray configured to hold a sheet bundle, delivery rollers configured to nip the sheet bundle mounted on the sheet tray and the following sheets, to set off from one another, and to deliver them to the accumulating tray, and to switch back the following sheets to the sheet tray, and a conveyance member configured to convey the following sheets from the sheet tray.
US10322895B2
A material conveyor, included in a transfer device of an image forming apparatus and configured to use position control of rotary bodies, includes a first rotary body and a second rotary body disposed opposing each other in an opposing region through which a material is conveyable, and a contact and separation device configured to cause at least a surface, of at least one of the first rotary body and the second rotary body to move, between a separated position and a contact position. The contact and separation device is configured to cause the at least the surface to move from the separated position to the contact position, at a first speed, and then to move at a second speed slower than the first speed. A method of position control includes moving at least the surface at different speeds or based on a distance relative to a threshold distance.
US10322891B2
The invention relates to an unloading system for bulk material from a transport vessel (4), in particular a container, into a silo or another hopper. With this system, the unloading process of the bulk material is easier, more cost-efficient, less time-consuming, more effective, contamination-free and emission-free. To do so, a basic frame (2) is provided which can be fixed to the transport vessel (4) to be unloaded. A screw trough (7) which can be shifted and locked horizontally, with a worm drive (8) as well as a pressurizable dust seal (12) between the screw trough (7) and the unloading opening of the transport vessel (4), are arranged on the basic frame (2). Moreover, a dosing device (11) for dosing the bulk material to be delivered and transport brackets (14) for forklift trucks are provided on the screw trough (7). The unloading device (1) is connected to the transport vessel (4) to be unloaded in such a way that the dust seal (12) is connected in a dust-proof manner to a flexible discharge device (17) of a container liner (14) and thereby forms a dual gasket.
US10322877B2
A production line comprises one or more assembling stations and at least one module for carrying containers for supplying to the assembling stations parts which are necessary during the execution of a working cycle. In one example, the module includes a paternoster conveying system including a plurality of drawings for containing the parts. The module includes two endless lateral chains and two lateral guide rails engaged with each drawer. The paternoster system and guide rails selectively position the drawers to downwardly angularly rotate toward the workstation when facing the workstation to increase ergonomic access to the parts for the assembling station operator.
US10322875B2
Device for keeping articles in temporary storage, including a frame having series storage sections provided with supports for series of holders, at least one first and at least one second platform configured for receiving at least one holder, wherein the platforms can be moved by a first movement unit from a position in which both are aligned with one of the storage sections to a position in which both are aligned with another one of the storage sections, wherein the device has been provided with a second movement unit for, in a first direction, horizontally moving one or more holders from the platform at a first frame side to the holder supports of a selected storage section, while moving the series of holders supported thereon over the selected storage section and moving one or more holders from the storage section to the platform at a second frame side.
US10322873B2
An apparatus comprising one or more of a surface treatment apparatus having an air treatment member and a refuse container wherein at least one of the surface treatment apparatus and the refuse container is provided with one or more of (a) a dust control member providing a dust control agent comprising one or more of a liquid mist, positive ions and negative ions to an area below a dirt emptying outlet of a dirt collection region of the surface treatment apparatus; and, (b) a treatment applicator providing a treatment agent comprising one or more of a deodorizing agent, a disinfecting agent and a sanitizing agent to an interior volume of the air treatment member and an interior volume of the refuse container.
US10322871B2
An apparatus includes a superstructure including cylindrical vessel with a conical bottom section and an opening near the base of the cone; an air assisted puffer device near the base of the cone; an air blower attached near the base of the cone, wherein the air blower is configured to produce air velocities of at least about 40 ft/min; a gently sweeping elbow attached after the blower exit; and a hatch fitted to the top of the vessel that allows for a funnel to be connected to the tank thereby allowing bulk barite powder to be loaded into the top of the tank from bulk bags. A barite powder blend including: a blend of barite particles with a size of about 1 micron and barite particles with a size of at least about 325 mesh, wherein the D50 of the blend is not greater than about 325 mesh.
US10322868B2
Exemplary embodiments are directed to cable dispenser systems that generally include at least two cable assemblies. The cable assemblies includes at least one cable that includes an elongated cord. The cable assemblies include a support element configured and dimensioned to support the at least one cable thereon. The systems include a housing configured and dimensioned to receive the cable assemblies. The housing includes at least one opening for dispensing each of the cable assemblies. Dispensing a first cable assembly from the opening repositions a second cable assembly adjacent to the opening. Exemplary embodiments are also directed to methods of cable assembly dispensing.
US10322867B2
A cork-insulated cooler having a constant friction hinge assembly is described. The cooler is comprised of an outer basin having an open top, a plurality of cork panels lining the outer basin, a transparent inner basin having an open top which is constructed and arranged to hold and maintain the plurality of cork panels against the outer basin, a lid hingedly connected to the inner and outer basin, such that the lid can be positioned anywhere between a completely closed position to a completely open position and anywhere in between with the lid supporting itself in the chosen position.
US10322865B2
A vacuum food storage system includes a vacuum container having an air valve, and a cordless vacuum unit capable of being supported on top of the container for extracting air from the container through the air valve. To provide a more substantive visual indication of the presence of a vacuum in the container, a resilient seal between the vacuum unit and the container resiliently suspends the vacuum unit so that, as the vacuum increases, the entire vacuum unit is drawn down onto the container. A hands-free operation and more evocative audible indication of the presence of a vacuum is provided by employing a pressure-equalizing valve that abruptly opens to provide a channel between an interface chamber and ambient air when a vacuum sensor indicates a predefined vacuum level within the container.
US10322864B2
A synthetic resin bottle prevents a trunk from undergoing unsightly deformation in response to reduced pressure inside the bottle and also increases flexibility in terms of container design and secures a label attachment area sufficiently. A synthetic resin bottle includes a mouth, a trunk, and a bottom, with a reduced pressure absorbing region configured to be displaced toward the inside of the bottle in response to reduced pressure inside the bottle. The trunk includes a cylindrical-shaped straight region, which has a length of not less than 100 mm in an axis direction extending along a center axis of the trunk and in which no irregularities are provided. The straight region has a weight of not less than 11 times a weight of the reduced pressure absorbing region.
US10322863B2
Provided is a tight fastening type size-free container carrying bag which has a simple configuration, can be manufactured at a low cost, and can be reliably fit to various shapes of containers size freely to stably hold the containers. Employed is a technical means corresponding to a bag body in which a pair of sheet materials made of a thermoplastic resin material faces and overlaps each other, an opening is formed at a top portion, and a bottom surface is included at a bottom portion, wherein at least one container holding portion is formed in the bag body, wherein a holding zone in which a plurality of spot joining portions formed by joining inner surfaces of both the sheet materials of the bag body each other in dot shapes is provided is formed in the container holding portion.
US10322862B2
Methods, systems, and apparatus, including a packing-list-pouch comprising a back sheet and a front sheet attached to a pocket, a protective lip sheet attached to cover a top edge of the front sheet, and a removable release liner attached to an exterior surface of the back sheet via an adhesive coating. The packing-list-pouch may include a flap sheet attached to the protective lip sheet and an adhesive strip configured to fasten a bottom portion of the flap sheet to the front sheet to form a resealable closure over an opening of the pocket and the protective lip sheet.
US10322858B2
A container includes a casing defining an opening and formed with a first abutting edge surrounding the opening. A cover is selectively mounted onto the casing for closing the opening, wherein the cover has a second abutting edge laterally extending therefrom and abutting against the first abutting edge when the cover closes the opening. A puller extends from the second abutting edge of the cover. A snapping device is formed between the casing and the puller. The snapping device includes a plug formed on the puller and a socket defined in the casing for receiving the plug. Two weakened portions are formed on the puller such that the puller is irreversibly curved after being lifted due to the weakened portion and the curved puller is used as a basis for easily identifying whether the container is illegally operated or not.
US10322851B2
A plastic bag is provided. The bag may include a rectangular bottom with first, second, third, and fourth edges. It may include a first side extending from a first edge of the bottom, a second side extending from a second edge of the bottom, a third side extending from a third edge of the bottom, and a fourth side extending from a fourth edge of the bottom. The first side may have a first vertical seam and a first flap set. The third side may have a second vertical seam and a second flap set. The bottom, the first side, the second side, the third side, and fourth side are integrally formed from a single sheet of a plastic material. The first vertical seam may extend from a top of the first side to at least the first flap set. The second vertical seam may extend from a top of the third side to at least the second flap set. A method of manufacture thereof is also provided.
US10322850B2
A bakery tray includes a base and a pair of opposed side walls extending upward from side edges of the base. Front and rear walls extend upward from front and rear edges of the base. A plurality of recesses for receiving bakery items therein are formed in the base. This increases the number of bakery items that can be received in the tray and/or permits a decrease in the stacking height of the trays, thereby permitting another tray to be received on the stack. In one embodiment, the recesses are a plurality of parallel troughs formed in an upper surface of the base. In another embodiment, the plurality of recesses are formed in the ribs in the base, such that the bakery items are received in the recesses.
US10322849B2
A tray includes a base and a pair of opposed side walls extending upward from the base. Each of the side walls includes a plurality of feet providing multiple stacking heights with an identical tray. Each side wall including a recess on an inner, upper edge. A rear wall extends upward from a rear the base between the side walls. A front wall extends upward from a front of the base between the side walls, the front wall including a portion lower than the side walls.A dolly that can be used with the tray includes a deck having a pair of contiguous support surfaces. A reinforcement rod supports the pair of support surfaces. A caster includes a caster plate secured to the deck, the reinforcement rod between the caster plate and the deck.
US10322839B2
The flanged container for a dairy product or similar food composition is provided with a hollow body and a generally planar annular flange connected to the top of the body, the flange having outer straight side edges and an inner edge defining a circular upper opening of the container. The body has a planar bottom and a lower portion tapering from a generally cylindrical upper portion toward the bottom in a curved manner. The lower portion has a height h1 in some embodiments not less than 14 mm and the ratio h1/H is less than 2:5 where H is the height of the container. The side wall of the body has a thickness profile such that the average thickness of the lower portion is more than the average thickness of the upper portion. Several identical containers can be grouped in a pack with breakable junctions at the outer straight side edges.
US10322826B2
A spacecraft propulsion system operated in the presence of an ambient flux of cosmic rays is provided, wherein the cosmic rays interact with deuterium-containing nuclear micro-fusion fuel material to generate products having useful kinetic energy. The propulsion system comprises a supply of the deuterium-containing particle fuel material, along with means (such as a gun) for projecting the material (e.g. as successive packages in the form of shell projectiles) outward from a spacecraft. The spacecraft has means (such as a pusher mechanism) for receiving at least some portion of the generated kinetic-energy-containing products to produce thrust upon the spacecraft.
US10322825B1
Provided is a testbed for conducting an experiment on a substance in a cryogenic liquid state in a microgravity environment. Such a testbed includes a frame with rectangular nominal dimensions, and a source section supported by the frame for supplying the substance to be evaluated in the cryogenic liquid form. An experiment supported by the frame includes an experiment vessel in fluid communication with the storage tank to receive and condense the substance into the cryogenic liquid state. A sensor senses a property of the cryogenic liquid in the experiment vessel as part of the experiment, and a bus section includes a controller configured to control delivery of the substance to the experiment vessel, and receives property data indicative of the property sensed by the sensor for subsequent evaluation on Earth.
US10322817B2
A ballistic parachute associated with an aircraft is deployed where the aircraft includes a first part and a second part, the two parts are detachably coupled to each other when the ballistic parachute is deployed, and the ballistic parachute is coupled to the first part of the aircraft. A landing zone associated with the second part of the aircraft is determined and it is decided whether to decouple the two parts, including by deciding whether the landing zone associated with the second part of the aircraft is inhabited. If it is decided to decouple the two parts from each other, they are decoupled from each other.
US10322813B2
A casing structure interposed between the engine and the nacelle of an aircraft, the structure including a shroud surrounding the engine having an engine axis and including a stationary portion and a plurality of sectors; a radial arm providing the connection to the nacelle; fasteners for securing the plurality of shroud sectors to one another or to the radial arm; and the fasteners include two series of holes formed in two parallel side walls of the shroud sectors for the purpose of receiving two respective series of bolts, each passing through a corresponding set of orifices of an adjacent shroud sector or of an adjacent radial arm, a hinge arranged between each of the shroud sectors and the stationary portion of the shroud to enable the shroud sectors to be pivoted in individual manner about a common pivot axis perpendicular to the side walls arranged along the engine axis.
US10322809B2
An armrest system may include an inner sidewall panel attached to a vehicle frame. The inner sidewall panel may abut at least two parallel frame members of the vehicle frame. The system may further include a ledge molded into a shape of the inner sidewall panel. The ledge may be positioned horizontally along a front surface of the inner sidewall panel and may be positioned between the at least two parallel frame members.
US10322807B2
A passenger seat tray table mechanism that deploys by way of a controlled sequence of translational and rotational movements. Dependent on tray table mechanism position, the mechanism provides simultaneous unlocking of one motion and locking out of another motion in a predetermined mechanical sequence to avoid passenger entrapment and collisions with surrounding cabinetry of furniture. A wide range of table positions are achievable while all possible paths of table movement can be controlled.
US10322803B2
A method includes generating an unmanned aerial vehicle (UAV) control signal to fly the UAV over a worksite and capture imagery information at different geographic locations. The imagery information is used to generate a tree inventory metric that indicates a tree inventory at the worksite, or is used to generate a productivity metric that identifies a productivity category for a geographic location at the worksite. The method also generates an action signal based on the tree inventory metric or productivity metric, such as an action signal to deploy machines to different geographic location, or an action signal to update a worksite completion metric.
US10322800B2
A device for the transportation of people and cargo is described. The device is a gyro-rotating flying device including a pod structure configured to transport one or more contents. The pod structure includes a gyro pod to contain the one or more contents. An engine is included to propel the pod structure into flight. A power supply provides energy for the engine and a control unit. The control unit allows a user the ability to regulate operation of the engines. Manipulation of the engine adjusts the orientation of the pod structure and engine around the gyro pod. The gyro pod is configured to remain level during flight.
US10322792B2
Systems and methods are provided for composite part design. One embodiment is a method for selectively analyzing feasibility of optimizing fiber orientations for layers of a multi-layer composite part subdivided into panels that each comprise a fraction of an area of the composite part. The method includes identifying stacking sequence rules that constrain the composition of sublaminates that comprise consecutively stacked layers utilized during optimization, for each panel of the composite part, analyzing the panel by identifying ply counts that constrain a number of plies at the panel, selecting a number of sublaminates to utilize during optimization of the panel, calculating ply count ranges for a laminate, based on the number of sublaminates and the stacking sequence rules, and determining whether the ply counts for the panel comply with the ply count ranges for the laminates.
US10322786B1
A method for controlling a marine engine's operating mode includes operating the engine in an initial operating mode according to an initial set of mapped parameter values configured to achieve an initial fuel/air equivalence ratio of an air-fuel mixture for combustion. If measured operating conditions of the engine meet lean-burn mode enablement criteria, the engine is operated in lean-burn mode according to a lean-burn set of mapped parameter values configured to achieve a lean-burn fuel/air equivalence ratio that is less than the initial fuel/air equivalence ratio. If the measured engine operating conditions no longer meet the lean-burn mode enablement criteria, the engine is operated in the initial operating mode. Transitions between the lean-burn mode and the initial operating mode are monitored. If the transitions indicate that the engine's operating mode is unstable, the engine is prevented from operating in the lean-burn mode until after a reset condition has been met.
US10322784B2
Combination of marine vessel and outboard motor, wherein at least one outboard motor is attached in a predetermined position to the transom of the marine vessel, the motor being mounted so as to translate according to a path with at least one motion component having an orientation parallel to the direction of the transverse axis of the hull and/or parallel to the transom of said hull and alternatively towards one or the other side of the hull.
US10322772B1
An improved snowmobile ski dampener for dampening articulation between a steering spindle and a snowmobile ski. The ski dampener may be constructed of an elastomeric material and include one or more progressive surfaces that progressively come in contact with a base surface of the steering spindle as progressively increased compressive loads are applied between the steering spindle and snowmobile ski. As the progressive surfaces come in contact with the base surface, the shape factor of the ski dampener may change (e.g., increase), reducing compressive strain for a given compressive stress. Various design and material characteristics including width, shape of the progressive surface, and durometer and bulk modulus of the elastomeric material may be selected to provide various performance characteristics such as dampening effect, impact absorption, approach angle, initial flex force, and service life.
US10322770B1
An electricity aided bicycle and an auxiliary power controlling method thereof are provided. The electricity aided bicycle includes a driving circuit, a rotating speed detector and a command voltage generator. The driving circuit receives a command voltage, and drives an auxiliary motor of the electricity aided bicycle based on the command voltage. The rotating speed detector generates a detection signal having a plurality of pulses based on a rotation status of a driving gear of the electricity aided bicycle. The command voltage generator receives the detection signal, and is configured to: calculate times between two adjacent pulses in the detection signal, operate numerical value derivation operation based on the times to generate an estimated velocity value, set an electricity aid strategy table and calculate the command voltage based on the estimated velocity value and the electricity aid strategy table.
US10322767B2
An improved pedal driven scooter may have a mainframe, a joint-frame, a front balance and steering mechanism, one or two front steering wheel(s), a rear drive wheel, and a drive mechanism. The pedals are pushed rearward and move independent of each other within an adjustable angle range. The drive mechanism translates the alternative movement of the pedals into unidirectional rotation, which is further multiplied, and drives the real wheel. A leaning control mechanism allows a rider to stay mounted when the vehicle is stopped. The scooter can be folded with the joint frame pivoting at both ends, such that the rear-wheel docks between or near the front wheel(s) and the scooter can be carried as if it were a carry-on luggage. The scooter may be further folded for storage with the help of a folding hinge which connects a lower part and an upper part of the front steering mechanism.
US10322763B2
A head lamp device of a straddle-type vehicle, comprises at least one lamp unit including at least one light source and a plurality of emission ports through which light emitted from the light source is output; and a cover member including a transmission section which transmits in a forward direction of a vehicle body, the light output through the plurality of emission ports, and covering a front portion of the lamp unit, wherein the transmission section includes a first surface, and a second surface bent with respect to the first surface, and an edge is provided on a ridge line formed by the first surface and the second surface, and wherein the edge extends through a gap formed between two adjacent emission ports of the plurality of emission ports.
US10322758B2
A track link comprises a body defining a top surface, a bottom surface, a first side surface and a second side surface, a proximate end and a distal end, a first bore adjacent the distal end defining a first longitudinal axis and a second bore adjacent the proximate end defining a second longitudinal axis; wherein either the first bore or the second bore is a blind bore, forming a counterbore configured to house a seal assembly and the counterbore defines a wall that forms an angle with the longitudinal axis of the bore that is greater than zero degrees.
US10322748B2
A motor controller includes control systems that control actuation of a motor. Each control system includes a drive circuit and a calculation unit. The calculation unit of each control system is connected to an independent rotation angle sensor. The calculation units include master and slave calculation units. The master and slave calculation units control actuation of the corresponding drive circuit based on a current instruction value calculated by the master calculation unit and a detection result of the rotation angle sensor connected to the master calculation unit. When the detection result of the rotation angle sensor connected to the master calculation unit is abnormal, the master and slave calculation units each use a detection result of the rotation angle sensor connected to the slave calculation unit to control the actuation of the corresponding drive circuit.
US10322744B2
A pulley assembly for a road wheel actuator assembly includes a driven pulley assembly, a driven pulley, and a belt. The driven pulley assembly includes a driven pulley and a retainer. The driven pulley is at least partially disposed about a ball nut that is operatively connected to a rack bar. The retainer is received within the driven pulley. The belt is arranged to connect the driven pulley assembly to the drive pulley.
US10322738B1
A collapsible structure for interlinking front and rear wheels of a golf cart is disclosed herein. It comprises an upper frame having two shaft racks, two handles and a supporting rod; a lower frame pivotally connected to the supporting rod and having a first assembling seat pivotally connected to the two shaft racks, two sliding sleeves, each having an upper connecting rod, a rear wheel joint rod and a front wheel push rod, and a second assembling seat having an oblique guide slot and a guiding tooth row in the oblique guide slot for connection to the front wheel push rod; two rear wheel assemblies connected to the two rear wheel joint rods; and a front wheel assembly comprising a guide rod having an annular teeth for engaging with the guiding tooth row in the oblique guide slot.
US10322733B2
A gangway connection system guides at least one power cable and has a clamping part which has at least one feed through for the power cable. The feed through extends along a longitudinal axis and between an inlet opening and an outlet opening, and has a longitudinal-section profile with an inner and an outer longitudinal-section contour. At least one of the longitudinal-section contours is curved at least regionally. Alternatively or in addition, the gangway connection system is characterized in that the power cable extends helically in a cable longitudinal direction and the clamping part has an outer face directed in the cable longitudinal direction. The clamping part has at least one abutment surface for the power cable. The abutment surface extends in an inclined manner with respect to the cable longitudinal direction.
US10322732B1
An improved method of production of a coupler knuckle, a core assembly for production of a coupler knuckle, and coupler knuckle having an improved interior configuration for handling forces imparted on the knuckle and transferring said imparted forces through the knuckle and improving handling of linear force loads and their transmission. The knuckle interior has a force handling structure that includes spaced apart layers and cavities, with a cavity extending between the nose section and the tail section thereof.
US10322727B1
Systems and methods for analyzing sensor data to determine an inferred emotional state of a vehicle operator and generate a recommendation based on the inferred emotional state are disclosed. According to embodiments, an electronic device may analyze image data depicting a vehicle operator to identify a behavior. The electronic device may also compare vehicle dynamics data to baseline vehicle dynamics data to determine if the vehicle dynamics data differs from the baseline vehicle dynamics data by a threshold amount. Based on the identified behavior and the vehicle dynamics data, the electronic device may determine an inferred emotional state of the vehicle operator. The electronic device may generate a recommendation for the vehicle operator based on the inferred emotional state.
US10322722B2
A method of controlling an autonomously operating vehicle includes determining if the vehicle is currently occupied by a passenger, or if the vehicle is not currently occupied by a passenger. When the vehicle is currently occupied by a passenger, a vehicle controller controls at least one vehicle system to operate using a set of passenger present operating parameters. The set of passenger present operating parameters control the vehicle to provide a minimum level of passenger comfort. When the vehicle is not currently occupied by a passenger, the vehicle controller controls at least one vehicle system to operate using a set of passenger not-present operating parameters. The set of passenger not-present operating parameters control the vehicle for one of optimal energy efficiency, or for optimal vehicle diagnostic performance.
US10322718B2
A vehicle stability control system includes a signal collection sensor and a vehicle controller (10). The signal collection sensor is configured to collect a vehicle condition information parameter, and the vehicle controller (10) is configured to calculate a control yaw moment according to the vehicle condition information parameter. The control yaw moment is used to cancel a difference between an estimated yaw moment and an actual yaw moment. The vehicle controller (10) is further configured to determine according to the vehicle condition information parameter whether the vehicle (100) is in a stable region or a non-stable region in the case of tire blow-out, and allocate the control yaw moment to four wheels (101) according to a vehicle stability condition, thus implementing vehicle stability control. A vehicle stability control method and a vehicle (100) with the vehicle stability control system are also disclosed.
US10322714B2
A vehicle is provided with an engine, a battery, a second motor generator generating a driving force by using electric power of the battery, and an electronic control unit (ECU) controlling the engine and the second motor generator. The ECU is configured to be capable of executing rotation speed increase control for controlling the rotation speed of the engine so that the sound pressure of the engine is increased in response to an increase in the vehicle speed of the vehicle. In a charge depleting (CD) mode in which the state of charge (SOC) of the battery is consumed, the ECU limits the execution of the rotation speed increase control compared to a charge sustaining (CS) mode in which the SOC is maintained in a predetermined range.
US10322710B1
A method for controlling a mild hybrid vehicle may include determining, by a controller, whether an engine of the mild hybrid vehicle operates based on a demand torque of a driver of the mild hybrid vehicle; determining, by the controller, a torque of a starter-generator of the mild hybrid vehicle that assists a torque of the engine according to the demand torque of the driver based on a temperature of a turbocharger of the mild hybrid vehicle when the engine is operated; and operating, by the controller, the starter-generator to assist the torque of the engine based on the determined torque of the starter-generator.
US10322705B2
Methods and systems are provided for a pressure tapping device for a motor vehicle where a portion of the pressure energy generated at the fuel storage reservoir is transmitted to a working medium, physically separate from the fuel via the pressure tapping device. The pressure tapping device is fluidically coupled to a pressure actuator and enables the pressure operation via transmission of the pressure energy and adjustment of valves diverting flow from the fuel storage reservoir to the engine intake through the pressure tapping device.
US10322703B2
A camera cleaning system for a vehicle includes a camera including a lens cover and a motor. A cleaning assembly includes an arm including a cleaning material. The motor selectively adjusts a position of the arm and the cleaning material relative to the lens cover of the camera. The motor selectively adjusts a position of the arm and the cleaning material relative to vehicle from a first position to a second position. The camera selectively generates video signals when the camera is in the first position. The cleaning assembly is in contact with the lens cover when the camera is in the second position.
US10322696B2
A vehicle includes at least one imaging device configured to generate image data indicative of a vicinity of the vehicle. The vehicle also includes a user interface display configured to display image data from the at least one imaging device. A vehicle controller is programmed to monitor image data for the presence of moving external objects within the vicinity, and to activate the user interface display to display image data in response to detecting a moving external object in the vicinity while the vehicle is at a rest condition. The controller is also programmed to assign a threat assessment value based on conditions in the vicinity of the vehicle, and upload image data to an off-board server in response to the threat assessment value being greater than a first threshold.
US10322687B2
The present disclosure relates to electrical systems in general and embodiments of the teachings may include stabilization circuits for a vehicle electrical system comprising: a first connection for a first electrical system branch; a second connection for a pole of a first energy store of the first electrical system branch; a third connection for a second electrical system branch; a fourth connection for a third electrical system branch; a grounding connection for connection of the stabilization circuit to ground; a second energy store; a third energy store; a serial disconnection switch element between the second connection and the grounding connection; and a decoupling switch element connecting the first connection to the fourth connection. The second energy store is connected between the grounding connection and the third connection. The third connection is connected via the third energy store and a first converter to the fourth connection.
US10322673B2
A driving assistance device includes: an imaging unit; a projection unit that projects an image based on image information from the imaging unit toward a projection surface; and an adjustment unit that is configured to form image information that an image sensor of the imaging unit acquires to be adjusted image information that is adjusted for the projection surface, wherein the adjustment unit includes an optical correction structure that causes the image sensor to acquire the adjusted image information by optical correction.
US10322670B2
A motor vehicle has a central light control device, a plurality of peripheral light control devices distributed within the vehicle, and a plurality of interior light modules, each of which has a plurality of light sources and is associated with a peripheral light control device.
US10322669B2
A vehicle vanity visor assembly including an illuminated mirror. The assembly includes a component including a mirror portion and a light pipe portion, with the two portions separated by an air gap. The component may be a single piece of mirror stock. The light pipe portion includes one or more corners extending around the mirror portion, and the light pipe portion defines air gaps in the corner to assist in guiding light through the corners.
US10322651B2
A child safety seat is for use on a vehicle seat. The vehicle seat has a safety belt. The child safety seat includes a seat base, a seat panel, and a seat body. The seat base has a seat assembly portion and a backrest portion. The seat panel is openably pivoted to the seat assembly portion for rotating between an open position and a closed position. The seat body is disposed on the seat panel. When the seat panel rotates to the open position, the safety belt passes over the seat base for attaching the seat base to the vehicle seat. When the seat panel rotates to the closed position, the seat panel clamps the safety belt cooperatively with the seat base.
US10322646B2
A fuel cell vehicle provided with an exhaust duct structure is capable of reliably diluting hydrogen flowing into an exhaust duct. The fuel cell vehicle includes a vehicle body, an air-cooled fuel cell mounted in the vehicle body to generate power by allowing hydrogen gas and oxygen in air to react with each other, an exhaust duct through which exhaust air of the fuel cell is guided to a rear end of the vehicle body and is discharged outside the fuel cell vehicle, and a fan guiding air into the exhaust duct to dilute hydrogen in the exhaust duct.
US10322643B2
A capacitive circuit with a supercapacitor is connected in series with a traction battery to provide a current sensor to produce a sensed signal that is linear across the operating range of the traction battery. The linear response of the capacitive circuit is an improvement over merely measuring the voltage across the battery, which is not linear over some ranges, e.g., 20% to 80% state of charge.
US10322633B2
A regenerative brake control device of a vehicle, which is configured to control a rotary electric motor that is configured to drive wheels at a regeneration ratio corresponding to a selected regeneration stage to thereby obtain a regenerative brake force, includes: a selecting section which is manually operated to select a regeneration stage from a plurality of regeneration stages which have been set; and a control section which is configured to make control so that, when a predetermined operation is performed on the selecting section, a regeneration stage in which the predetermined operation has not been performed on the selecting section is automatically changed to another regeneration stage.
US10322631B2
A fuel filling aperture opening and closing device includes a closing member turned to an open position to open a fuel filling aperture by an introduction of a fuel filling nozzle. The closing member is provided with a flap member having a ring-shaped seal member, and an urging device urging the flap member to be positioned at a closed position. The seal member is provided with seal portions respectively inside and outside, and one of the inner and outer seal portions is a plate-shaped portion pressed by the urging against a projection piece bordering an opening edge portion of a pass-through opening of the fuel filling nozzle, and the other of the inner and outer seal portions is formed by an inside circumferential projecting portion and an outside circumferential projecting portion respectively pressed against the flap member.
US10322630B2
Provided is a fuel tank which allows effective suppression of the deformation of a fuel tank body and has excellent durability. This fuel tank is equipped with: a fuel tank body; connecting members which partially connect the opposed inner wall surfaces of the fuel tank body to each other, and/or abutment portions where the opposed inner wall surfaces of the fuel tank body partially abut on each other; and reinforcing members which are provided integrally with the outer wall surfaces of the fuel tank body and reinforce the outer wall surfaces. The fuel tank is configured such that the reinforcing members are equipped with: base portions which are disposed at positions corresponding to the connecting members and/or the abutment portions; and extension portions which extend along the outer wall surfaces from the base portions.
US10322625B2
A vehicle door structure includes two doors, a weatherstrip, a moving device and a control device. The two doors are disposed adjacently at a vehicle side portion with no pillar therebetween. The weatherstrip is provided at one of the doors and is disposed to change a distance between the weatherstrip and the other door. The moving device moves the weatherstrip in a direction of putting the weatherstrip into contact with and a direction of separating the weatherstrip from the other door. When it is determined that the two doors are closed and neither is opening or closing, the control device controls movement of the moving device to put the weatherstrip into contact with the other door. When a single door is closed and the counterpart door is opening or closing, the control device controls movement of the moving device in the direction of separating the weatherstrip from the other door.
US10322622B2
A vehicular door structure has a side door adapted to open and close an opening of a vehicle body, and the side door includes a door storage part having a storage area, and a door speaker. The door speaker is located above the door storage part in a virtual up-down direction and disposed near a central part in the up-down direction of the side door.
US10322620B2
A vehicle air conditioning system is configured to cool a passenger compartment having a first zone and a second zone. An air handler has a recirculation door movable from a first position in which only fresh air from outside the vehicle enters the air handler and a second position in which only recirculation air from the first zone enters the air handler. A controller is connected to the first sensor, the recirculation door and a control panel. The controller is configured such that in response to the control panel being set to: provide cooling only to the second zone; the recirculation door being set to provide fresh air; and a first sensor's conditions being meet, the controller changes the setting of the recirculation door from fresh air to recirculated air to the air handler over-riding a manual setting of the position of the recirculation door.
US10322612B2
An adapter for mounting an accessory to a fixed feature positioned below a load bed of a vehicle is described. The adapter may include a mounting member, an aperture positioned on the mounting member, and a locking member capable of being inserted through the aperture, where the locking member is capable of selectively engaging the fixed feature. The adapter may also include at least one rail attached to the mounting member, and an accessory securing member positioned on the rail, the accessory securing member capable of selectively engaging an accessory.
US10322611B2
A system is used with a pneumatic tire mounted on a wheel rim to keep a tire cavity of the pneumatic tire from becoming underinflated from a set pressure. The first system includes a plurality of pumps attached circumferentially to the wheel rim, each pump having a piston for inflating the tire cavity and a weight for moving the piston, and a stop mechanism for each pump, the stop mechanism including a stop piston, a stop cylinder, a first spring, and a second spring, when air pressure in the tire cavity reaches the set pressure, the set pressure overcomes a force of the first spring against the stop piston and moves the stop piston into a stopping engagement with the weight, when air pressure in the tire cavity is below the set pressure, the second spring overcomes the force of the first spring and moves the stop piston away from the weight.
US10322604B2
A hybrid wheel including a functional rim, a center disc, and a wheel face insert, wherein the wheel rim and the center disc are made of a specified material, and wherein the wheel face insert is made of a dissimilar material. The wheel face insert can be secured to the center disc by at least one of screws, pins, rivets, or structural adhesive, and/or the wheel face insert can be secured to the functional rim by at least one of screws, pins, rivets, or structural adhesive.
US10322602B2
A display includes one or more first relief structures. Each of the one or more first relief structures consists of a smooth first reflection surface and a plurality of protrusions or recesses, each top surface of the protrusions or each bottom of the recesses is a smooth second reflection surface parallel to the first reflection surface, each of the one or more first relief structures is configured to display a color as a structural color by emitting a plurality of wavelength components of visible light wavelengths in the same direction, and each of the second reflection surfaces has a height or depth relative to the first reflection surface in a range of 0.1 to 0.5 μm.
US10322598B2
A bundle of printing media by eco-stapling often has a smaller thickness than a bundle of printing media by needle stapling by the thickness corresponding to an amount of used staples, although they have the same number of printing media, and there is room capable of stacking bundles in many cases in the eco-stapling. According to an embodiment, when a printing medium that has undergone an image forming process is taken in, stapling processing is performed on the printing medium, and then the printing medium is discharged to the tray, the following process is performed. That is, when the process is performed in accordance with instructed stapling processing, and the printing medium that has undergone the process is discharged outside the apparatus, the amount of printing media stacked on the tray is controlled in accordance with instructed stapling processing.
US10322596B2
A decoloring apparatus includes a reading unit that reads an image formed on a sheet and outputs image information corresponding to the read image. A control unit is configured to recognize the image information output by the reading unit and determine whether decoloring using the decoloring unit is performed on the sheet based on the recognized image information.
US10322589B2
A photocurable ink composition includes polymerizable compounds and a photopolymerization initiator. The polymerizable compounds include vinyl ether group-containing (meth)acrylic esters represented by the following Formula (I): CH2═CR1—COOR2—O—CH═CH—R3 (I) (wherein, R1 represents a hydrogen atom or a methyl group; R2 represents a divalent organic residue having 2 to 20 carbon atoms; and R3 represents a hydrogen atom or a monovalent organic residue having 1 to 11 carbon atoms), dipropylene glycol di(meth)acrylate, and monofunctional (meth)acrylate having an aromatic ring skeleton. The ink composition includes a coloring material.
US10322579B2
In a printing system and a corresponding method, different nozzles of a print head can be activated to eject a nominal ink quantity with different ejection pulses to at least partially compensate for non-uniformities between the different nozzles due to crosstalk. The compensation can reduce system-dependent streaking of the print image.
US10322578B2
A liquid ejection head includes a substrate including an electrically insulating film, an energy generating element provided on the substrate and configured to generate energy used to eject a liquid, a flow path formed through the substrate and communicating with an ejection port configured to eject a liquid, and a wiring layer formed in the electrically insulating film of the substrate, used to drive the energy generating element, provided apart from a wall defining the flow path, and provided to surround the flow path in a plan view of the substrate.
US10322577B2
A printing apparatus and a printing method which can suppress lowering of reading accuracy of a two-dimensional code caused by shift of a printing position of an image are provided. For that purpose, in printing of the two-dimensional code by a plurality of times of scanning, in a case where a boundary between image regions crosses a square-shaped minimum information element (cell) of the two-dimensional code, a printing position of the two-dimensional code is moved so that the boundary between the image regions comes to an end portion of the cell.
US10322571B2
A lamination cassette includes a substrate to accommodate a plurality of first sheets of a first size. A loading template is removably coupled to the cassette via an adapter on the cassette to secure the loading template when inclined for loading. The template includes a first loading section for accommodating a plurality of second sheets of a second size smaller than the first size when loaded onto the substrate. The lamination cassette is configured to support sheets of the first size when the adapter is not coupled to the substrate and the vertical support surface is configured to support sheets of the second size when the loading template is coupled to the substrate. The loading template may also include a second loading section for accommodating a plurality of third sheets having the same size as the second sheets for laminating two pluralities of same size sheets on a single cassette.
US10322569B2
The present invention relates to a substrate bonding method and a display substrate manufactured thereby, the method comprising the steps of: (1) forming a pattern by ink-jet printing a photo-curable adhesive ink on a lower substrate; (2) forming a spacer on the lower substrate by photo-curing the pattern; (3) forming an adhesive layer by ink-jet printing the photo-curable adhesive ink on the surface of the lower substrate on which the spacer is formed; and (4) laminating the adhesive layer of the lower substrate and an upper substrate by performing photo-curing.
US10322553B2
A process for manufacturing tires for vehicle wheels, comprising the step of building on a forming support a carcass structure comprising at least one carcass ply and, at at least one end edge of the carcass ply, at least one annular anchoring structure comprising at least one substantially circumferential annular insert and at least one filling insert associated to said at least one substantially circumferential annular insert. The step of building the carcass structure comprises the steps of positioning the annular anchoring structure on the carcass ply by moving the annular substantially circumferential insert into contact with an end edge of the carcass ply by means of a special positioning member, pulling down the filling insert on the end edge of the carcass ply and turning up a free end portion of the end edge of the carcass ply so as to form a turned up end portion of the carcass ply including said annular anchoring structure. The pulling down of the filling insert on the end edge of the carcass ply is carried out by a special pulling down member while the substantially circumferential annular insert is retained into a contact position with the end edge of the carcass ply by said positioning member.
US10322550B2
The invention relates to a device for the infiltration of fibrous material with resin for the production of a fiber composite component, comprising a mold tool with a cavity enclosed by at least two tool parts, wherein the mold tool is designed for a relative movement of the at least two tool parts, in such a manner that space can be provided inside the cavity, in a first tool position, to hold the fibrous material, and additional space can be provided to accommodate resin, and the size of the cavity can then be reduced by a movement of the mold tool from the first tool position into a second tool position. According to the invention, a flow promoter is included in the cavity, comprising at least one first layer and one second layer, connected to each other in an edge region of the flow promoter to enclose a flow space, wherein the first layer is impermeable to resin while the second layer provides an outlet for guiding resin out of the flow space and into the fibrous material, and wherein the flow space of the flow promoter is filled with resin and/or the flow promoter has an inlet for conveying resin into the flow space. The invention further relates to a corresponding infiltration process and to a use of the device and/or the method.
US10322547B2
To prevent misalignment between substrates and distortion of surface, and to keep film thickness uniformity of thin substrate when two substrates are bonded for bonded member, bonded member manufacturing apparatus of bonding first substrate and second substrate, comprising resin film forming means for forming liquid state resin film on the first substrate, semi-curing means for maintaining outer peripheral section of resin film in uncured state and curing inner section surrounded with outer peripheral section in semi-cured state, and substrate bonding means for bonding first substrate and second substrate by bringing second substrate into contact with resin film, such that one end of outer peripheral section is determined as starting point of contact so that boundary line between contact portion and noncontact portion moves in one direction from starting point to opposite end of outer peripheral section while applying pressing force to second substrate.
US10322537B2
An injection molding apparatus and method for adjusting the axial position of a valve pin in an injection molding system, the apparatus comprising: a top clamp plate, a heated manifold receiving and distributing an injection fluid to an exit of a fluid delivery channel to a cavity of the mold, an actuator comprising a housing having a chamber enclosing a drive member for driving a valve pin along an axial path of travel, the actuator housing slidably mounted and adapted for controlled upstream and downstream movement of the drive member along a path complementary to the axial path of travel of the valve pin, a mounting plate and an axial position adjustment screw screwably mounted within the mounting plate upstream of the housing of the actuator for controllably moving the valve pin to selectable starting or ending injection cycle axial positions.
US10322528B2
The present invention is to a composition made from a polyester produced by the acid or ester polyester process, a cobalt salt and a base, preferably an alkaline metal base. The composition can be made by blending a cobalt salt with a polyester which has been polymerized in the presence a alkaline metal ion derived from a basic alkaline metal compound, e.g. alkaline metal base or basic alkaline metal salt. The composition may optionally comprise an ionic compatibilizer, which may further be blended with a partially aromatic polyamide. This blend can be processed into a container having both active and passive oxygen barrier with an improved color and clarity than that achieved by cobalt alone. The use of the cobalt salt in combination with the base can also be used to improve the color of recycled polyester during processing.
US10322524B2
A treated cellulosic material comprising a cellulosic material having a porous structure defining a plurality of pores, at least a portion of the pores containing a treating agent comprising a polymer comprising a poly(meth)acrylate polymer. The present further describes a method for preparing a treated cellulosic material comprising (a) providing a cellulosic material; and (b) a first treatment protocol comprising impregnating the cellulosic material with an aqueous dispersion comprising a polymer, the polymer comprising a poly(meth)acrylate polymer.
US10322523B2
A process for producing nano veneers generally involving: placing a veneer to be treated in a vacuum vessel; adding a nano carbon powder and nano silicon dioxide suspension in the vacuum vessel; reducing the pressure in the vessel over a first period of time; increasing the pressure in the vessel; letting the contents of the vessel rest over a second period of time. The veneer may optionally be subjected to ultrasonic treatment, ultraviolet solidification treatment, or subsequent pressurization treatments to obtain the final nano veneer product. As a result, veneer manufactured using embodiments of the present invention will have the advantages of high strength, wear resistance, pollution resistance, acid and alkali resistance, water segregation and decay resistance.
US10322522B2
An object detection system in a saw includes an electrically conductive plate positioned at a predetermined distance from the implement, a detection circuit comprising a transformer, and a single cable connecting first terminal and second terminals of the transformer. The single cable includes a first conductor electrically connected to the first terminal of the winding and to the electrically conductive plate, a second conductor electrically connected to the implement, and an electrical insulator positioned between the first conductor and the second conductor.
US10322517B2
A blade assembly for a hair cutting apparatus includes a first blade having teeth extending along a first blade edge, and a second blade having teeth extending along a second blade edge. A distance between the first and second blade edges defines a blade gap. A yoke is coupled to the second blade and configured to convert motion of a drive into reciprocation of the second blade relative to the first blade to cut hair. A spring includes a spring base and at least one spring arm configured to reciprocate with the second blade. A guide assembly includes a guide and a spring retainer, the guide being positioned between the first blade and the second blade, and the spring retainer fixing the spring base relative to the first blade, wherein in response to moving the guide relative to the first blade, the blade gap changes.
US10322512B2
A joint for constructions includes a first element having a first coupling interface, a second element having a second coupling interface, and an interface element configured for coupling to the first coupling interface and the second coupling interface to impose a desired relative angular position on the first element and the second element of the joint. The interface element includes a first positioning structure configured for engaging with the first coupling interface, and includes a second positioning structure configured for engaging with the second coupling interface. The first positioning structure and the second positioning structure of the interface element are angularly staggered with respect to one another.
US10322504B2
Devices and methods for creating a secure overhead anchor from which to perform tasks such as climbing, hauling, lifting, and rescuing tasks with respect to shipping containers (e.g., intermodal containers) are described herein. The disclosure relates to a device that can be placed, for example, into corner castings on standardized shipping containers at a distance, for example by a pole or other comparable component, and which can securely fit into the standardized corner castings of a shipping container even when a twistlock device or similar component is installed in the casting to hold the target container to another container above or below it. A head of the device can be rotated between a first configuration for inserting the device into the casting, and a second configuration for securing the device to the casting. Methods of using the device are also provided.
US10322500B2
A hinge pin extractor operable to urge a pin out of engagement with a hinge assembly can include a base, a receiver, a plunger, and a lever. The receiver can be mounted to the base to engage a portion of the hinge assembly. The plunger can be mounted to the base and configured to urge a pin of the hinge assembly out of engagement during movement from the first end limit of travel to the second end limit of travel. The lever can be pivotally engaged with the base and disposed to engage the plunger to move the plunger along the rectilinear path. The lever and the base and the plunger can be engaged such that pivoting motion of the lever is transmitted to rectilinear motion of the plunger through a single, fixed fulcrum positioned directly in the base.
US10322493B2
An apparatus for polishing a semiconductor wafer using a pad resurfacing arm and an apparatus therefor are disclosed. Embodiments may include providing a semiconductor wafer on a chemical mechanical polishing (CMP) tool, the CMP tool including a polish pad and a pad resurfacing arm which includes a pad cleaning part, a pad conditioning part, and a slurry dispensing part, dispensing a slurry to the polish pad utilizing the pad resurfacing arm, and polishing the semiconductor wafer utilizing the polish pad.
US10322486B2
A grinding machine includes a manual rotating handle provided with a rotation detector that outputs a rotation detection signal so that the position of a grinding wheel with respect to a workpiece can be relatively moved in accordance with the rotation detection signal. The grinding machine further includes a grinding wheel, a moving apparatus that moves the position of the grinding wheel with respect to a workpiece W, a proximity detector that outputs a proximity detection signal corresponding to a relative position or a relative distance between the workpiece and the grinding wheel, a manual rotating handle provided with a rotation detector, and a control apparatus that controls the moving apparatus based on the rotation detection signal. The manual rotating handle is provided with a rotational-torque varying apparatus. The control apparatus controls the rotational-torque varying apparatus based on the proximity detection signal.
US10322485B2
A method for treating a surface of flooring includes applying a composition that includes a silicate to a surface of the flooring and, while the composition is present on the surface, polishing or burnishing the surface. The silicate may be a lithium polysilicate and/or a colloidal silica. The composition may further include a surfactant and/or a leveling agent. When the composition is applied to the surface of the flooring, gravity may enable it to spread substantially evenly across the surface. The acts of applying and polishing or burnishing may be repeated. Such a treatment may result in a surface that has a glossiness of at least 80, as measured by a gloss meter set to a 60° angle of incidence.
US10322477B2
A feed unit is used to feed connection elements from a receiving position to a transfer position along a feed direction. The feed unit has a receiving part to which each connection element can be fed individually. A head piece is movably mounted in the receiving part and has a receiving region for the nuts, and a thrust unit to move the head piece. The head piece is rotated from a first rotational position into a second rotational position, being reached in an intermediate position, by a rotary device. A slider element moves relative to the head piece out of the intermediate position into a transfer position within the head piece such that the nuts are brought out of the head piece into the transfer position. The rotary device has a mechanical forced guidance unit which includes a control sleeve with a curved path into which a control element engages.
US10322458B2
A cutting insert has a first (top) end surface, a second (bottom) end surface, a peripheral side surface connecting the top and bottom end surfaces, and a mounting hole having a central axis O which penetrates the top and bottom end surfaces. Cutting edges are formed on an intersecting edge between the first end surface and the peripheral side surface. The second end surface has an inclined part. When a virtual plane substantially perpendicular to the axis O and passing through any point of the cutting edges is defined, the inclined part is inclined so as to be more distant from the virtual plane, heading from the peripheral side surface to the axis O. A projected part projected in a direction along the axis O is formed in an area around the mounting hole in the inclined part. This reinforces the strength of the mounting hole.
US10322456B1
A flange removal tool assembly includes a cutting tool actuator, vise, annular cutting tool, and center support and accurately removes a weld and a flange of a device, while the device is attached to a fitting in a pressure vessel. Once the weld and the flange are removed, the device can be removed from the fitting and replaced. The assembly allows the operator to quickly inspect the flange of the device during the removal process and reduces the probability of damaging a flange of the fitting.
US10322455B2
An engaging member, a female member and a tool changer that can be downsized are provided, and the engaging member is an engaging member including: an engaging surface that allows a cam provided in a male member to engage therewith; and a dispersing surface that transmits a force provided from the cam via the engaging surface, to a female member body, wherein the dispersing surface includes a first dispersing surface and a second dispersing surface perpendicular to each other, and a cross-sectional shape perpendicular to a longitudinal direction is formed in a substantially triangular shape by the dispersing surface and the engaging surface.
US10322451B2
A transfer pump system has a pump base with a pump chamber, tangential discharge and an outlet. A riser tube extends from the outlet and terminates at a launder in order to move molten metal out of a vessel with relatively little turbulence. A riser tube for use in the system has a proximal end configured to be connected to the outlet and a distal end that terminates at or above the launder.
US10322449B2
A hammer includes a jacket, which includes an inner chamber, an inlet circuit for entry of compressed air, and an outlet circuit for exit of compressed air. The hammer further includes a motion mechanism, for generating a vibratory motion under the action of compressed air; and a punch or beater, connected to the motion mechanism, for coming into contact with the casting to be de-cored, forming a first end of the hammer. The inlet circuit includes an inlet connector for connecting the hammer to a compressed-air circuit; the inlet connector being located at a second end of the hammer, opposite to the end where the punch or beater is located. The outlet circuit has an outlet connector for connecting the hammer to an air recovery circuit. The outlet connector is located at the second end of the hammer, in proximity to the inlet connector.
US10322448B2
An alloy modifying agent for use in preparing a metal semisolid slurry, where the components and mass ratio thereof is silicon:iron:copper:manganese:magnesium:zinc:titanium:lead:aluminum having a mass ratio of (6.05-6.95):(0.15-0.45):(0.12-0.65):(0.002-0.006):(0.001-0.5):(0.025-0.05):(0.002-0.08):(0.002-0.06):(90.5-93.2). Also, a method for preparing the alloy modifying agent and a method for using the alloy modifying agent. The alloy modifying agent is capable of increasing the solid-liquid ratio and the spherical crystal content of the semisolid slurry, increasing the preparation efficiency of the semisolid slurry and the quality of the slurry, and ensuring the quality of a final die casting product.
US10322444B2
An apparatus for rotating an inner stamped part with respect to an outer stamped part is provided. The inner stamped part is nested within an aperture formed within the outer stamped part. The apparatus includes a plurality of grippers that include at least a first gripper positioned at a first edge of the inner stamped part and a second gripper positioned at a second edge of the inner stamped part opposite to the first edge. The plurality of grippers is configured to grip the inner stamped part at the first edge and the second edge, respectively. The plurality of grippers is further configured to rotate the gripped inner stamped part about an axis of rotation. The axis of rotation intersects the first gripper and the second gripper. The plurality of grippers is also configured to open to release the inner stamped part.
US10322441B2
A ratcheting hand tool (or “Hickey bar”) for bending rebar comprising a ratchet mechanism, a handle attached to the ratchet mechanism, and a Hickey bar tool head attached to the ratchet mechanism, which tool head may be a detachable.
US10322438B2
A material handling system reduces or eliminates human interaction with articles sorted and deposited into an order container to maintain validation and integrity of the order. Validated articles are inducted onto a sortation conveyor that selectively dispenses or deposits each article at a destination into a container. A shuttle vehicle moves along a first side of row of such containers to replace an empty container in place of any container that holds a completed order and moves the latter onto a transport conveyor.
US10322431B1
An improved apparatus and methods are presented for a new and improved ultrasonic aerosol generation apparatus and air/gas and deployed aerosol movement system, which is able to increase and improve the reliability and quality of coverage and treatment of the various targeted surfaces within an enclosed space, with the generated and deployed disinfecting aerosol, by providing an improved system to detect one or more of any layers and stratifications of gas(s) and deployed aerosols within the atmosphere of the treated area(s) at any time, and a means to remove and effectively disrupt, the said layers, so the deployed aerosol can effectively treat the targeted area(s), as well as additional enhancements to the systems used for processing the atmosphere in the targeted area(s) after the treatment cycle has completed deploying the aerosol, such as improving the cleaning of the dehumidification device, and the effective operation of the dehumidification and filter components.
US10322429B2
A method for managing a live stream of waste stream fluids in which a controller of an applicator unit accesses data indicative of a first concentration of at least one contaminant in a volume of waste stream fluids loaded in the applicator unit, and a contaminant capacity profile indicative of an amount of the at least one contaminant to be applied in the land area. At least a portion of the volume of waste stream fluids loaded in the applicator unit is applied on at least a portion of a land area based on the first concentration of the at least one contaminant in the volume of waste stream fluids and the contaminant capacity profile. The controller generates an updated contaminant capacity profile based at least in part on the volume of waste stream fluids applied on the land area and the first concentration of the at least one contaminant in the volume of waste stream fluids applied to the land area.
US10322423B2
An irrigation nozzle with a rotating deflector is provided whose rotational speed may be controlled by a friction brake. The nozzle may also include an arc adjustment valve having two portions that helically engage each other to define an opening that may be adjusted at the top of the sprinkler to a desired arcuate length. The arcuate length may be adjusted by pressing down and rotating a deflector to directly actuate the valve. The nozzle may also include a radius reduction valve that may be adjusted by actuation of an outer wall of the nozzle. Rotation of the outer wall causes a flow control member to move axially to or away from an inlet.
US10322422B2
A sprinkler can include a turbine, a nozzle, a gear drive and a reversing mechanism. The gear drive and the reversing mechanism rotatably couple the turbine and the nozzle. The gear drive can shift a direction of rotation of an output stage that is coupled to the reversing mechanism. The sprinkler can include at least one arc adjusting gear that moves and arc adjusting tab to contact a shift arm to cause the shifting mechanism to change direction. The arc adjusting gear can engage with the arc tab for adjusting the arc setting and disengage from the arc tab for normal operation.
US10322421B2
A sprinkler includes a housing having a tubular axle, a control device including a base coupled at the housing, a bridge upwardly extended from the tubular axle, a first cover including a top platform and an assembling unit downwardly extended from the top platform, and a second cover, having a center through hole, coupled at a top rim of the base. The bridge has two or more bridge ribs and the assembly unit has two or more corresponding windows. The first cover is coupled at the second cover at a position that the assembling unit is downwardly extended through the center through hole until the in center through hole is covered by the top platform, such that the bridge ribs of the bridge are engaged with the windows of the assembling unit of the first cover to securely couple the control device with the housing in a screw-less manner.
US10322413B2
An actuator pin incorporating a lateral stabilizer for an upper jaw of a demolition shear. The actuator pin includes a head. The head has an outer periphery configured to be receivable within a complimentary configured keeper attached to one side of the clevis end of the actuator such that the head is rotationally fixed with respect to the keeper. A pin cap is secure to a distal end of the pin. The pin cap has an outer periphery configured to be receivable within a complimentary configured keeper attached to another side of the clevis end of the actuator such that the pin cap is rotationally fixed with respect to the keeper.
US10322412B2
A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.
US10322408B2
A method for manufacturing a molybdenum disulfide powder includes conducting a precursor solution preparation step and a hydrothermal synthesis step. The precursor solution preparation step includes providing sodium molybdenum oxide dihydrate and thiourea, and conducting a mixing step. In the mixing step, an acid solution is mixed with the sodium molybdenum oxide dihydrate and the thiourea by titrating so as to form a precursor solution. In the hydrothermal synthesis step, the precursor solution is put into a hydrothermal container for reacting at a temperature ranging from 100° C. to 350° C. for 8 hours to 40 hours, thus the molybdenum disulfide powder is formed.
US10322407B2
The present invention provides a catalyst and a process for the selective oxidation of carbon monoxide (CO) to produce carbon dioxide gas (CO2). The process provides a process which selectively oxidizes CO to CO2 in presence of excess hydrogen. The process provides a selective oxidation of CO to CO2 gas over Cu/CeO2 catalyst between temperature range 40° C. to 90° C. at atmospheric pressure in presence of excess H2, H2O and CO2. The process provides a CO conversion up to 100% without deactivation till 100 h.
US10322403B2
A catalyst coating for use in a hydrolysis catalyst (H-catalyst) for the reduction of nitrogen oxides, a manufacturing method for such a coating, a catalyst structure and its use are described. The H-catalyst includes alkaline compounds, which are capable of adsorbing HNCO and/or nitrogen oxides and which include alkali and alkaline earth metals, lanthanum and/or yttrium and/or hafnium and/or prasedium and/or gallium, and/or zirconium for promoting reduction, such as for promoting the hydrolysis of urea and the formation of ammonia and/or the selective reduction of nitrogen oxides.
US10322400B2
Provided is an adsorbent for capturing carbon dioxide and a method for manufacturing same, and more particularly, to an adsorbent for capturing carbon dioxide, including a magnesium oxide/titanium dioxide composite having wide surface area, large pore volume and good CO2 adsorption performance, and a method for manufacturing same. According to the present invention, a novel MgO based composite metal oxide which may stably adsorb CO2 at a low temperature such as room temperature is provided. The adsorbent for capturing carbon dioxide, including a magnesium oxide/titanium dioxide composite has good thermal stability, and controls basic sites easily, and is used in various fields for capturing carbon dioxide. In addition, by controlling the molar ratio of the metal ions of the magnesium oxide/titanium dioxide composite and controlling morphology, an adsorbent for capturing carbon dioxide having large surface area and pore volume and strong basic sites may be provided.
US10322395B2
The presently disclosed subject matter relates to an industrial system for processing various plant materials to produce marketable materials. Particularly, the system integrates subcritical water extraction technology and includes a pre-processing module and a two-stage extractor (processing module) with constant control of temperature, pressure, and/or residence time. In some embodiments, the final product of the disclosed system can include feedstock constituents for biofuel production (sugars and/or oil), biochar, raw materials for various industries (such as pulp for manufacturing paper or cellulose for use in various industries). The disclosed system can be modular or non-modular, stationary or mobile, and can include prefabricated elements with programmed automatic or manual operation so that it can be easily moved and/or assembled on site.
US10322394B2
The present disclosure provides a Ziegler-Natta catalyst composition comprising a procatalyst, a cocatalyst and a mixed external electron donor comprising a first selectivity control agent, a second selectivity control agent and an activity limiting agent. A polymerization process incorporating the present catalyst composition produces a high-stiffness propylene-based polymer with a melt flow rate greater than about 50 g/10 min. The polymerization process occurs in a single reactor, utilizing standard hydrogen concentration with no visbreaking.
US10322391B2
A reactor device for the release of a gas from a starting material includes a reactor housing having a longitudinal axis and at least one single reactor arranged in the reactor housing, the single reactor including a base plate oriented transversely to the longitudinal axis, a starting material flow channel defining a starting material flow direction, a catalyst arranged in the starting material flow channel, a heating unit for heating the catalyst and/or the starting material and a gas collection chamber arranged above the starting material flow channel for collecting the gas released from the starting material.
US10322386B2
The invention discloses an agitation device comprising an impeller, an agitating shaft and a power device. The impeller includes a disc, a hub and concave blades. Each blade consists of a concave surface which extends radially and has an annular sector-like shape, the projections of the upper and lower portions of the blade in the horizontal plane are two annular sectors, and the radian of the annular sector obtained by the projection of the upper portion is larger than that of the lower portion, and the annular sector-like shape and the rotation direction of blades are the same, so that each portion of the blades directly faces an incoming flow, the utilization efficiency of blades is increased and the impeller has low energy consumption and high gas-liquid dispersion efficiency. The device is efficient and energy-saving, has low power consumption, high mixing performance and high gas holdup and mass transfer performance.
US10322383B2
A liquid treatment apparatus (10) for processing a liquid includes an inlet nozzle (12) having an orifice (16) for directing a flow of liquid through the orifice (16) to define a fluid jet, and a concial diffuser (18) including a tip (20), a base portion (22), and a curved surface (26) therebetween. The conical diffuser (18) is generally aligned with the orifice (16) such that the fluid jet impacts upon the tip (20) of the conical diffuser (18). Moreover, the curvature of the curved surface (26) is selected to maintain a substantially constant Froude number of the liquid along the conical diffuser (18).
US10322382B2
A high performance facilitated transport membrane comprising a metal cation exchanged/chelated carboxylic acid functional group containing functional polyimide, a method of making this a membrane, and the use of this membrane for olefin/paraffin separations, particularly for propylene/propane and ethylene/ethane separations. The facilitated transport membrane has either an asymmetric integrally skinned membrane structure or a thin film composite membrane structure, wherein the top selective layer of the membrane comprises a metal cation exchanged/chelated carboxylic acid functional group containing functional polyimide.
US10322371B2
Methods of sequestering carbon dioxide (CO2) are provided. Aspects of the methods include contacting an aqueous capture ammonia with a gaseous source of CO2 under conditions sufficient to produce an aqueous ammonium carbonate. The aqueous ammonium carbonate is then combined with a cation source under conditions sufficient to produce a solid CO2 sequestering carbonate and an aqueous ammonium salt. The aqueous capture ammonia is then regenerated from the from the aqueous ammonium salt. Also provided are systems configured for carrying out the methods.
US10322368B2
Tightly-coiled helical ducts for centrifugal air separators may be formed with the tools and methods disclosed herein. A helical coil toolset includes a helically grooved mandrel and an entry block. The helical groove of the mandrel has a small helix inside diameter relative to a width of the helical groove. The entry block has a guide channel to guide a tube to the helical groove and a mandrel channel to receive the mandrel. Methods include forming tubing into a tightly-coiled helical duct by filling a tube with fine particles, positioning the tube in the helical groove of a helically grooved mandrel, fixing the tube relative to the mandrel, assembling an entry block around the tube and around the mandrel, and bending the filled tube around the helically grooved mandrel into the tightly-coiled helical duct by rotating the mandrel relative to the entry block.
US10322360B2
A coated granular filtration medium is formed by the deposition of an electrolyte layer onto core particles. The electrolyte layer comprises a cationic polyelectrolyte. The coated granular filtration medium provides a synergistic combination of filtration and in situ coagulation that enables efficient, effective, and economical decontamination of industrial and other wastewaters.
US10322357B2
Embodiments described herein generally relate to humidification-dehumidification desalination systems, including apparatuses that include a vessel comprising a humidification region (e.g., a bubble column humidification region) and a dehumidification region (e.g., a bubble column dehumidification region), mobile humidification-dehumidification (HDH) desalination systems (e.g., systems having a relatively low height and/or a relatively small footprint), and associated systems and methods. Certain embodiments generally relate to methods of operating, controlling, and/or cleaning desalination systems comprising a plurality of desalination units (e.g., HDH desalination units).
US10322351B2
A matchmaking system and method is provided that facilitates optimization of player matches for multiplayer video games. The system may provide a generalized framework for matchmaking using historical player data and analytics. The framework may facilitate automatic determinations of an optimal mix of players and styles to produce the most satisfying user experiences. The system may dynamically update analytical processes based on statistical or otherwise observed data related to gameplay at any given time. In this manner, the system may continually tune the matchmaking process based on observations of player behavior, gameplay quality, and/or other information.
US10322347B2
A system and method are disclosed for dynamically loading game software for smooth game play. A load boundary associated with a game environment is identified. A position of a character in the game environment is then monitored. Instructions corresponding to a next game environment are loaded into a memory when the character crosses the load boundary, such that game play is not interrupted.
US10322344B2
A game method is performed by one or more computers. The method may include, but is not limited to: displaying, on a display, 1) at least one reference indicator; 2) at least one target indicator; and 3) at least one operation indicator; recognizing, as the specific operation, a detected series of operations that an indictor gets contact with a predefined point of the detection area, before on the detection area the indicator slides while keeping the indicator in contact with the detection area; displaying, on the display, a guide indicator for guiding a slide-operational direction to which the indicator is operated to be slide; determining whether the specific operation responsive to the change of the cross position; and reflecting a result of the determination to a game result.
US10322342B2
Provided is an image output device including image acquisition means for acquiring an image related to a subject captured by a user, position information acquisition means for acquiring position information indicating a position where the image is captured, generation means for generating a landscape image in which an image based on the image acquired by the image acquisition means is superimposed on an image obtained by capturing the landscape, when displaying the image obtained by capturing the landscape of position information acquired by the position information acquisition means, and image output means for outputting the landscape image.
US10322330B2
Presented herein is an interactive platform for judging an activity by a participant in an event. The platform includes a client application program downloadable to a mobile device. The program may include a database storing a mobile device identifier (ID), a user ID, user information, and location data of the device. The application may further be configured to display one or more events of the activity as well as an input for receiving a score of the activity from the user. The platform may additionally include a server system connected with the client application programs via a communication network. The server system may be configured for receiving the mobile device ID, the user ID, the user information, and the location data for the client program, and may further be configured to receive the scores from the users, and to adjust the scores according to determined bias of the associated user.
US10322325B2
The present apparatus includes a towel that is detachably connected to a clip and/or a marker. In various embodiments, the towel includes three layers: a first layer for cleaning, a second layer connected to the first layer, and a third layer that acts as moisture barrier between the first layer and the second layer. In some embodiments, the towel may be detachably connected to a clip via an embedded magnet, such that the towel may attach to a user's clothing for easy use.
US10322323B2
A head 2 includes: a face member fc1 having a hitting surface 4; and a body member bd1 having a hosel 6, a sole surface 8, and a toe-side surface 9. The face member fc1 further has a top-side flange FL1 including a top surface 5. The body member bd1 has a hosel-forming part 24 including the hosel 6, a sole-forming part 28 including the sole surface 8, and a toe-forming part 26 including the toe-side surface 9. The hosel-forming part 24 has a heel joint portion Jh joined to a heel-side end of the top-side flange FL1. The toe-forming part 26 has a toe joint portion Jt joined to a toe-side end of the top-side flange FL1. A body missing portion ms1 in which the body member bd1 is not present is provided between the toe joint portion Jt and the heel joint portion Jh.
US10322310B2
An exercise apparatus for performing an abdominal exercise comprising: a frame, a seat having a seating surface (PS) and a pelvic stabilization pad having a lower back engagement surface (ES), an input arm assembly interconnected by a first interconnection to a first resistance mechanism, the input arm assembly including a manually graspable mechanism for manual engagement by a user along a path of travel forwardly away from the pelvic stabilization pad.
US10322306B2
A rotational energy absorber typically for use in a fall arrest system has a coiler, a length of plastically deformable strip and a deformer structure. The plastically deformable strip has a first end attached to the coiler and a second free end and extends past the deformer structure at a position between the first and second ends. Relative rotation of the coiler member and deformer structure causes the strip to be drawn past the deformer structure, plastically deforming the strip and winding the strip coil form about the coiler member.
US10322305B2
A retracting lifeline system, includes: a housing, a first connector attached to the housing, a lifeline, and a hub to which the lifeline is attached at a first end of the lifeline and around which the lifeline is coiled within the housing. The housing includes an opening through which the lifeline exits the housing. The hub is tensioned to rotate in a first direction to cause retracting of the lifeline and coiling of the lifeline around the hub. The retracting lifeline system further includes a second connector attached to a second end of the lifeline. At least a section of the lifeline has an initial ultimate tensile load of at least 8000 pounds and is abrasion resistant (that is, satisfying the abrasion test requirement set forth in the ANSI/ASSE Z359.13 2009 standard) such that the section of the lifeline is available for tie-back anchoring using the second connector. The section of the lifeline is at least partially retractable within the housing.
US10322299B2
When performing a therapeutic procedure, like a high dose rate (HDR) brachytherapy, an elongate introduction element is introduced into a body, a temperature is determined along the introduction element, and it is determined which part of the introduction element is within the body based on the determined temperature. A therapeutic procedure is performed by using the introduction element depending on the determination which part of the introduction element is within the body. This can ensure that the therapeutic procedure is only performed within the body, thereby reducing the likelihood of involuntary affecting, for instance, a patient's outer skin, especially by ionizing radiation which may be used during a HDR brachytherapy.
US10322293B2
One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
US10322284B2
A system and method for treating nausea and vomiting are provided, including one or more electrodes (10, 12) applied on or under the skin, the electrodes being connected to an external current source (34). The electrodes can be implanted under the skin and connect to internal stimulator electronics (22), which can form a magnetic inductive link to the external current source (34). Alternatively, the electrodes can be placed on the skin and directly linked by wires to the external current source. As a further alternative, the vagus nerve can be directly stimulated in the neck, or the esophagus, stomach, duodenum, or intestines can be directly stimulated by magnetic stimulation. The electrodes can stimulate the vagus nerve in the neck to reduce nausea and vomiting, or can be arranged near the chest or abdomen, so as to stimulate the esophagus, stomach, duodenum or intestines. Because the current source is provided outside the body, it is not necessary to implant batteries or another power supply in the body.
US10322263B2
An anchor device to simplify catheterization procedures, particularly for insertion and maneuvering of large catheters in tortuous arteries, vessels, or other lumen is disclosed. In some embodiments, the anchor device includes an anchor stent formed from a plurality of zig-zag shaped wire elements that are coupled together. The device further includes a plurality of connector struts attached at a proximal end of the anchor stent, the connector struts coalescing to form a strut tip. A guide device, such as a guidewire, is attached to the anchor stent at the strut tip and may be used to guide the anchor stent into the arteries or other vessels and toward a target treatment site.
US10322258B2
An anion perfume machine in which a throttling and shock absorption water blocking sheet and oscillator generating inclined vibration waves are configured, wherein the water blocking sheet is made of soft silicone material and assuming a cross body with four claws, a round petal is adapted to connect the two adjacent claws to each other, a center of the cross body configured with a barbed hook is exactly in engagement with a through hole of a cross rib configured on a center of a throttle cover; an inclined vibration guide unit is lodged in a oscillator accommodation room configured on a bottom of a vibration wave conduction cup; the oscillation unit is constituted by a silicone seat, thereby generating inclined vibration waves, allowing a large number of upward inclined atomized spouts to be sprayed on the essence oil water cup and flow upward along a wall of a cup.
US10322239B2
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
US10322233B2
A medical device includes a first housing portion (FHP) and a second housing portion (SHP) configured to be to be movable relative to each other from a first position to operatively engage at a second position to couple at least one of a drive device and a needle-inserting device supported by one of the FHP and the SHP to a reservoir supported by the other of the FHP and the SHP. Electronic circuitry configured to detect at least one of a first magnetic interaction between a magnet and at least one of a first magnetically attractive material and a first magnet-responsive device and a second magnetic interaction between the magnet and at least one of a second magnetically attractive material and a second magnet-responsive device, and to provide a signal or a change in state in response to detecting at least one of the interactions.
US10322226B2
Methods for clearing of fecal matter the wall of a colon or other body lumen for diagnostic inspection, the methods being adapted to clearing of fecal matter comprised of particles of various sizes and compositions. Methods are further adapted for application in patients who have undergone a restricted scope of preparation to reduce and/or remediate the particle structure of colon contents, or no preparation at all, before diagnostic inspection.
US10322222B2
Extracorporeal circuit devices that can be used for on-pump open-heart surgery to support surgical procedures such as coronary artery bypass grafting are described. In some embodiments, an oxygenator can include an integral pump. Such an integrated arrangement can advantageously provide an extracorporeal circuit with a lower overall volume than other conventional extracorporeal circuits.
US10322220B2
A method for extracorporeal blood treatment using a medical device including at least a dialyzer device, with the following steps: start of blood treatment by means of hemodialysis on the basis of default values for the hemodialysis; determination of current values or ratios of at least one blood flow, an ultrafiltration quantity, a substitution quantity or a type of substitution; recording of a therapy progress on the basis of an output signal of a sensor means; determination of a time of formation of a secondary membrane on the dialyzer by determination of a cross rate in the dialyzer device; change from the hemodialysis to a hemodiafiltration with post-dilution after a predetermined period of time has elapsed; and regulation of the substitution quantity during hemodiafiltration with post-dilution. Corresponding tools for carrying out the method are arranged in a device for extracorporeal blood treatment.
US10322217B2
An apparatus includes a tubular member defining a lumen and a channel, and a support member. The tubular member has a connection portion configured to be coupled to an organ wall. An outer edge of the connection portion is configured to contact a first portion of an inner surface of the wall when the connection portion is in an expanded configuration such that an interior volume of the organ is in fluid communication with the lumen. The support member is movably disposed within the channel and is configured to minimize movement of the wall relative to the tubular member. An end portion of the support member is disposed within the channel when the support member is in a first configuration. The end portion of the support member configured to contact a second portion of the inner surface of the wall when the support member is in a second configuration.
US10322205B2
The present invention provides methods and systems for the flexible ion generation device includes at least one dielectric layer, at least one trace having a first end and a second end, the at least one trace is engaged to the at least one dielectric layer, and at least one emitter engaged to the trace for emitting ions.
US10322199B2
Technologies (e.g., devices, systems and methods) for sanitizing reservoirs of humidifiers are described. In some embodiments, the technologies include a sanitization gas system and a connector unit. The connector unit is configured to install into a portion (e.g., wall, bottom, top, or lid) of a reservoir, such as a reservoir of a humidifier. The connector unit includes an inlet passageway for supplying sanitizing gas (e.g., ozone) into the reservoir, and an outlet passageway for removing sanitizing gas from the reservoir. In some embodiments at least a portion of the outlet passageway is disposed radially around the inlet passageway. The sanitization gas system may provide a sanitizing gas to the inlet passageway and receive the sanitizing gas from the outlet passageway.
US10322191B2
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
US10322184B2
A therapeutic emulsion is provided comprising a perfluorocarbon emulsion and a therapeutic agent, such as tobramycin. Methods of making and using the emulsion are provided. A method of treating a lung infection is provided.
US10322181B2
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as arthritis.
US10322174B2
Described herein are methods and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), Crohn's Disease (CD), ulcerative colitis (UC) and medically refractive-ulcerative colitis (MR-UC). In particular, disclosed are anti-TL1A antibodies useful for the treatment of IBD.
US10322173B2
ProblemTo provide a chiral nucleic acid adjuvant and anti-allergic agent having anti-allergic effect.SolutionAn adjuvant which comprises oligonucleotides which comprise two to four CpG motifs each represented by 5′-X1CpGX2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two CpG motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3′ end and 5′ end of the oligonucleotide is S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an adjuvant comprising the oligonucleotide represented by the sequence number 67. The present invention relates to an anti-allergic agent comprising these adjuvant.
US10322166B2
The present invention provides compositions of matter suitable for the prevention of and/or treatment of a spinal disorder and/or spinal pain, e.g., caused by and/or associated with intervertebral disc (IVD) degeneration, and methods of treatment of a spinal disorder and/or spinal pain. For example, the compositions of the present invention comprise a modulator of growth differentiation factor (GDF)-6 signaling sufficient to reduce or prevent or delay IVD degeneration and/or to enhance or induce IVD regeneration. The present invention also provides medical devices comprising such compositions, and methods of treatment making use of such compositions.
US10322164B2
Provided are methods and compositions for treatment of cancer. In particular, these methods and compositions may include a compound that induces the translocation of cyclin C from the cell nucleus to the cytoplasm. Also provided are methods of screening tumor cells for susceptibility to compounds that induce the translocation of cyclin C.
US10322161B2
The present specification discloses APY cyclic peptides having EphA4 antagonistic activity, pharmaceutical compositions containing such EphA4 antagonists, and methods and uses of treating an EphA4-based disease, disorder or pathology in an individual using such APY cyclic peptides or pharmaceutical compositions.
US10322153B2
The present invention provides a crude extract, fractions and sub-fractions from the seaweed Fucus distichus (FD), method of preparation and its use for inhibiting the growth of microbial cells, particularly bacteria causing acne or nosocomial infections such as MRSA in humans or MRSP in dogs.
US10322149B2
A method of treating or preventing graft versus host disease (GVHD) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a Myxoma Virus effective to inhibit proliferation of T lymphocytes in the graft and to treat or prevent GVHD in the host subject following infusion of the graft into the subject. After the contacting of the graft with the Myxoma Virus, the method comprises transplanting the virus-treated graft into the subject.
US10322148B2
The present invention relates to a method of cultivating an epithelial stem/progenitor cell population of the amniotic membrane of umbilical cord, the epithelial stem/progenitor cell population having the capacity to differentiate in multiple cell types.
US10322139B2
Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.
US10322138B2
Pregn-4-en-20-yn-3β-one is useful in the treatment of depressive disorders by nasal administration.
US10322132B2
The present invention relates to the use of a compound of formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof, or a pharmaceutical composition containing the same in reducing uric acid level, preventing or reducing inflammations, and preventing or treating uratic or gouty diseases. In particular, the present invention relates to the use of a compound of formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof, or a pharmaceutical composition containing the same in the manufacture of a medicament for the treatment or prevention of hyperuricemia, gout, gouty inflammations, pain and uric acid nephropathy. R1 represents hydrogen, C1-4 alkyl or the like. R2 represents C1-10 alkyl or the like. R3 represents halogen or the like.
US10322131B2
Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description.
US10322130B2
The present invention provides PI3K protein kinase modulators of formula wherein R, Cy1, R1, R2, L1 and Cy2 are as defined herein. The present invention also relates to methods of preparing compounds of formula (I) to pharmaceutical compositions containing them and to methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
US10322125B2
This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.
US10322124B2
The present invention relates to compounds for the treatment of chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD) or asthma or bronchiectasis. The present invention further relates to drug delivery devices suitable to be used in the treatment of chronic obstructive airway diseases such as a nebulizer comprising the present compounds.Specifically, the present invention relates to (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the treatment of chronic obstructive airway diseases, preferably chronic obstructive pulmonary disease (COPD) or asthma or bronchiectasis, more preferably chronic obstructive pulmonary disease (COPD).
US10322123B2
The invention includes compositions comprising NSC59984 or a derivative or analog thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
US10322122B2
Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (OXPHOS) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. The present invention identifies non-toxic small molecules (e.g., drug-like compounds) that are capable of modulating oxidative metabolism. One identified compound comprises meclizine. As described herein, meclizine, and its enantiomer S-meclizine, redirects OXPHOS to glycolysis. Such compounds could be protective or therapeutic in degenerative disorders such as diabetes, Huntington's, Parkinson's, and Alzheimer's disease and/or ischemic disorders including, but not limited to, stroke, heart attack, or reperfusion injuries.
US10322120B2
An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product. The primary package and package insert are contained in an optional secondary package and the package insert does not contain a warning, a dosing instruction, or a dosing table specifically directed to patients suffering from mild, moderate or severe hepatic impairment, and preferably explicitly states that dosing adjustment is not required for mild or moderate hepatic impairment.
US10322108B2
Disclosed are a compound, a stereisomer and a tautomer thereof, a pharmaceutically acceptable salt thereof, and a solvate or a prodrug thereof, which can be used for preventing or treating a RORγ mediated disease. The compound has the structural formula (I).
US10322103B2
The present invention, in one or more embodiments, comprises derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecyl catechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising urushiol esters of general formula (IA) [Formula should be entered here] tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a formulation containing at least one urushiol ester compound.
US10322098B2
The present invention relates to intervertebral disc-related pain, such as low back pain, chronic low back pain, neck pain, chronic neck pain and coccygodynia. A composition for use in the treatment of intervertebral disc-related pain is provided. The composition comprises lactic acid, or a pharmaceutically acceptable salt thereof. The composition is administered into a disc space comprising the nucleus pulposus of an intervertebral disc.
US10322095B2
Disclosed are methods and topical formulations for treating and/or preventing cell proliferative diseases and disorders including breast cancer and ductal carcinoma is situ (DCIS) using local transdermal therapy (LTT). The disclosed methods typically include administering topically to the breast or breasts of the patient a topical formulation comprising an effective dose of the tamoxifen metabolite, N-desmethyl-4-hydroxytamoxifen (i.e., endoxifen or ENX) for treating breast cancer. The topical formulation may be described as a transdermal formulation and the topical formulation may comprise, consist essentially of, or consist of endoxifen as an active ingredient.
US10322091B2
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
US10322088B2
The present disclosure provides a sustained-release composition including a sodium hydrosulfide and a carrier. The carrier is provided for carrying the sodium hydrosulfide with an effective amount and includes a first component and a second component. The first component includes a paraffin wax, and the second component includes a fatty alcohol, a fatty acid or a phospholipid. The present disclosure also provides a method for fabricating the sustained-release composition. The method includes providing a first solution, providing the carrier, providing a second solution, performing an oil-in-water emulsification, and cooling the emulsion. In addition, the present disclosure provides a method for treating the chronic wounds. The method includes administering an effective amount of the aforementioned sustained-release composition to a subject suffered from the chronic wounds.
US10322077B2
Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.
US10322067B2
A stoma dilation device that includes a tubular support defining a continuous pathway through the device; an inflatable dilation balloon located on the tubular support, the inflatable dilation balloon including a dilation region forming a first portion of the device and a retention region forming a second portion of the device; and a balloon inflation lumen. The retention region of the balloon is configured to have a diameter upon full, unrestrained inflation that is greater than the diameter of the dilation region.
US10322065B1
A closure system includes an inner cap including a plurality of driving structures disposed proximate a periphery of a top surface of the inner cap, a child proof element separated from the inner cap configured to be assembled with the inner cap to form a child proof cap, and a key having a plurality of projections. The child proof element when assembled with the inner cap in a child proof mode is configured to require the plurality of projections of the key to engage at least a portion of the plurality of driving structures of the inner cap to remove the assembled child proof cap when the child proof cap is installed on the container.
US10322060B2
A system includes a processor coupled to a memory, the processor and memory configured to determine a proficiency level of a user of a rescue application based on stored data indicative of the user's proficiency level, and based on the user's proficiency level, select a level of operation for the rescue application. The rescue application is executed on a mobile device and configured to control operation of an AED. Each of multiple levels of operation for the rescue application allows the user a different degree of control over the operation of the AED. The processor and memory are configured to present, to the user, a set of instructions associated with the selected level of operation; and to enable control of the AED according to the selected levels of operation. A different set of instructions is associated with each of the multiple levels.
US10322058B1
Disclosed herein are sexual stimulation devices that attach to a shower hose. The devices include a showerhead body and a shower hose-engaging structure to connect the showerhead body to the shower hose. The showerhead body has a plurality of water ports for directing water flowing from the shower hose and a vibrator to produce vibrations for external sexual stimulation. The vibrator can be battery-powered or water-powered units.
US10322051B2
An operating table includes a patient placement table for placing and securing a patient in a required posture; a main body for supporting the patient placement table; engaging pieces for removably coupling the patient placement table to the main body; and a motor for rotating the patient placement table with a head-feet direction of the patient as a rotation axis to hold the patient placement table at any given rotation angle.
US10322028B2
An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, an actuation assembly, and a detection/visualization system. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis. The cannula may be inserted through a sclerotomy incision and advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer. The detection/visualization system is operable to detect or visualize penetration of the choroid of a patient's eye and provide feedback to the operator and/or automatic control of the apparatus based on penetration of the choroid.
US10322027B2
A bite plate configured for use on upper teeth only that is configured to envelope central incisors, lateral incisors, and optionally one of a portion of upper cuspid pairs or entire upper cuspid pairs with lateral extensions that enhances whole body wellness.
US10322019B2
Medical systems and related methods are described. In some embodiments, the medical systems include an outer member defining a slot. In certain embodiments, the outer member at least partially surrounds an inner member, and the outer and inner members are configured so that an implantable medical endoprosthesis can be disposed between the outer and inner members.
US10322014B2
Systems and methods for distracting an intervertebral disc space are provided. The systems use an expandable trial with telescopic stabilizers. The systems and methods of distracting an intervertebral space are provided in a manner that addresses the problem of subsidence. The method includes inserting the trial into the intervertebral space in a collapsed state and, once inserted, the trial is then used for distracting the intervertebral space using an expansion that includes a first stage and a second stage. The first stage includes expanding the trial laterally toward the peripheral zones of the top vertebral plate and the bottom vertebral plate, and the second stage includes expanding the trial vertically to distract the intervertebral space.
US10322013B2
Provided is a measuring instrument for use in artificial knee joint replacement surgery that can perform knee joint alignment measurement more accurately. A measuring instrument for use in artificial knee joint replacement surgery includes a guide section. The guide section is used to indicate, from the outside of a patient, the position of a femoral head center of a hip joint of the patient. The guide section indicates the position of the femoral head center while being arranged based on preliminarily measured relative positions of an anterior superior iliac spine and the femoral head center of the patient. The anterior superior iliac spine is viewable from the outside of the patient.
US10322009B2
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed.
US10322008B2
An intervertebral implant for implantation in a treated area of an intervertebral space between vertebral bodies of a spine is provided. The upper surface and the lower surface of the implant each have a contact area capable of engaging with anatomy in the treated area, and the upper and lower surfaces define a through-hole having an inner surface extending through the spacer body. A first and second sidewalls extend from a front end and a back end, wherein the first and second sidewalls are configured with engagement portions positioned in close proximity to the front end and the back end. The front end and the back end are configured with a threaded hole for receiving an instrument for inserting the intervertebral implant into the intervertebral disc space.
US10322001B2
The present invention relates to an implant having a multilayered coating comprising a porous titanium-based layer on the implant, an optional interface titania layer on and/or in the porous titanium-based layer and a bioactive glass layer on and/or in the porous structure formed by the titanium-based and titania layer(s); as well as to a process for preparing an implant having a multilayered coating.
US10321997B2
A catheter that comprises a sheath that is connected at opposing ends to concentric tubes that move relative to each other in a manner that alternatively covers and exposes a medical device loaded onto the catheter. A portion of the sheath is arranged so as to invert upon itself so that axial movement of one tube relative to the other simultaneously moves the inversion point over or away from the device, alternatively covering or exposing the device.
US10321996B2
In a particular embodiment, the present disclosure provides a delivery apparatus for delivering a medical device. The delivery apparatus includes an elongated component with an engagement portion and a disengagement portion. Rotating the elongated component in a first rotational direction moves the travelling component along the engagement portion in a first axial direction. When the travelling component is located within the disengagement portion, continued rotation of the elongated component in the first rotational direction does not cause further movement of the travelling component in the first axial direction. A biasing member is located proximate the disengagement portion and urges the travelling component to reengage the engagement potion. The delivery apparatus can reduce or prevent damage to the delivery apparatus, or a patient with whom the delivery apparatus is used, by reducing or eliminating torque transfer from the travelling component to an end of the elongated component.
US10321985B2
The invention relates to a vascular prosthesis system for inserting into and for supporting a blood vessel of a patient. The vascular prosthesis system comprises (i) a stent graft element comprising a prosthesis material, and (ii) a stent element free of prosthesis material. Furthermore, a strip-like prosthesis material segment is provided, by means of which the stent graft element and the stent element are connected to each other, in such a way that the strip-like prosthesis material segment forms a prosthesis material bridge.
US10321976B2
A lightweight, small footprint, composite extraction pen, for the delivery of dental filling composite from commercially available composite filled carpules. An electric linear actuator is housed in a slender, pen-like housing configured to accept, constrain and allow the rotational positioning of commercially available composite filled carpules. The carpules are contained within an adaptor that connects to the body of the pen. The linear actuator extends and retracts a piston through a bore in the carpule so as to exert pressure on the composite contained therein. The pen provides precise composite delivery while maintaining a highly visible dental environment.
US10321957B2
Provided is a surgical handpiece for providing an electromagnetic cutting blade. The handpiece, comprises a body portion having an input end and an output end, a plurality of optical fibers for receiving laser energy having a wavelength within a predetermined wavelength range, wherein the optical fibers are received in the body portion at the input end and extend to the output end, and an optical fiber transition region within the body portion for arranging the plurality of optical fibers into a predetermine cutting shape at the output end, wherein laser energy transmitted from the arranged optical fibers at the output end interact with water molecules near the surgical target to generate micro-explosions that result in a cutting effect.
US10321951B2
A needle electrode deployment shaft includes a central member and a plurality of needle electrodes. The central member has a plurality of needle advancement channels formed therein. The needle electrodes are disposed within the advancement channels and each advancement channel terminates in a ramp portion which deflects the needles radially outwardly as they are axially advanced. The ramps may be spirally or acutely configured in order to increase the distance through which the needles may be bent as they are axially advanced. Additionally, the central member may have a radially reduced distal tip in order to decrease tissue insertion forces.
US10321943B1
A medical implant according to the present invention includes a substrate having a plurality of discrete connection portions. Each connection portion has a top surface, a bottom surface, and a through-opening extending between the top surface and the bottom surface. A connecting member extends between each connection portion and connects adjacent connecting portions to each other. At least one of the plurality of connection portions has a first width and at least one of the connecting members has a second width, different from the first width. An outer covering substantially encompasses the substrate. The outer covering extends around the through-openings and encompasses the connecting member.
US10321942B2
Compression screw systems for stabilizing and/or compressing bones of the extremities, characterized by a compression screw component and a hook component. The hook component is received on the compression screw component in any rotational position relative to the compression screw component in order to orient the hook component relative to a bone or bones requiring stabilization and/or compression. The hook component includes an anti-rotation feature, while a configured flange thereof provides a hook that extends about and overhangs a part of the bone. The compression screw component and the hook component may include cooperating structures that allow the hook component to attach to the compression screw component or allow the compression screw component to self-orientate with respect to the hook component upon compressing engagement of the compression screw head with the hook component. The configured flange of the hook component may terminate with a single, double or multiple tined prong.
US10321938B2
Various exemplary methods and devices are provided for fixing bone anchors to bone. In general, the methods and devices can allow for a bone anchor to be fixed to a bone at a desired angle to a surface of the bone. In an exemplary embodiment, a bone anchor assembly is provided that includes a bone anchor configured to engage bone, a receiver member for seating a head of the bone anchor, and a compression member for securing the bone anchor at fixed angle with respect to the receiver member when the compression member is seated within the receiver member. Corresponding engagement features of the compression member and the receiver member can be engaged in a secured configuration to inhibit or prevent removal of the compression cap from the receiver member and optionally to substantially prevent longitudinal and/or rotational movement of the compression member with respect to the receiver member.
US10321925B2
Catheter-delivered endovascular medical devices are described. The devices may include a pull wire connected to a proximal body and a distal body, which may be formed of a basket or other framework that has a plurality of cells. The distal body may move/articulate proximally relative to and toward the proximal body. Methods of using and making the devices are also described.
US10321921B2
Unicortical path detection for a measurement system for monitoring a depth of penetration of a working portion of an instrument in a bone of a patient. The unicortical detection may compare an average cortex thickness in a bicortical path to an actual measured depth of penetration. If the actual depth of penetration exceeds the average thickness, a unicortical path may be detected. Upon detection of a unicortical path, an alert may be provided and/or the instrument may be arrested upon subsequent breaching of the cortex.
US10321919B2
Described herein are specialized endoscopic drilling devices that may be readily powered by a conventional shaver handpiece and further may be utilized to secure a soft tissue graft to a boney surface. More particularly, the devices, systems and methods of the present invention enable the efficient and minimally invasive formation of off-axis sockets and/or tunnels in boney surfaces that may then serve as a site for graft placement by aperture and/or suspensory fixation means. As such, the present invention has particular applicability to the surgical repair and reconstruction of torn or ruptured tissues, such as ligaments and tendons, in the leg, knee and shoulder, for example.
US10321914B2
An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface. A blocking fabric extends across the lumen of the stent to block blood flow. The stent pattern and wall structure provide for small radius of curvature bends to fill narrow channels that cause the perivalvular leaks.
US10321908B2
An apparatus for joining two hollow organ sections with an annular array of surgical staples includes a staple cartridge component, an anvil component, a buttress component and a fastening member. The staple cartridge component includes a plurality of surgical staples arranged in an annular array. The anvil component is movable relative to the staple cartridge component between spaced apart and approximated positions to adjustably clamp the organ sections between the staple cartridge and anvil components. The buttress component is configured and dimensioned to be positioned on a distal surface of the staple cartridge component. In particular, the buttress component includes a buttress member and a plurality of circumferentially arranged tabs extending proximally from the buttress member. The fastening member is configured and dimensioned to engage the plurality of circumferentially arranged tabs to securely position the buttress component on the staple cartridge component.
US10321904B2
An orthopedic distraction device is provides. The orthopedic distraction device includes a first upper paddle for engaging a first bone of a joint, a lower paddle for engaging a second bone of the joint and a displacement mechanism. The displacement mechanism includes a drive assembly operable to move the upper paddle relative to the lower paddle. The lower paddle is releasably connected to the displacement mechanism.
US10321898B2
A system and method for enhanced navigation for use during a surgical procedure including planning a navigation path to a target using a first data set of computed tomography images previously acquired; navigating a marker placement device to the target using the navigation path; placing a plurality of markers in tissue proximate the target; acquiring a second data set of computed tomography images including the plurality of markers; planning a second navigation path to a second target using the second data set of computed tomography images; navigating a medical instrument to a second target; capturing fluoroscopic data of tissue proximate the target; and registering the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the real-time fluoroscopic data and the second data set of computed tomography images.
US10321897B2
The present disclosure relates to a method and a system for determining the fertility status of a female. The method comprises the steps of determining and recording a continuous series of temperature data points relating to a body temperature of the female, identifying if the series of temperature data points comprises at least one pre-determined feature in the series of temperature data points and, if a pre-determined feature has been identified, determining a point in time of ovulation for the series of temperatures based on a pre-determined relation of the pre-determined feature and ovulation.
US10321889B2
Techniques, systems, and devices are disclosed for synthetic aperture ultrasound imaging using spread-spectrum, wide instantaneous band, coherent, coded waveforms. In one aspect, a method includes synthesizing a composite waveform formed of a plurality of individual orthogonal coded waveforms that are mutually orthogonal to each other, correspond to different frequency bands and including a unique frequency with a corresponding phase; transmitting an acoustic wave based on the composite waveform toward a target from one or more transmitting positions; and receiving at one or more receiving positions acoustic energy returned from at least part of the target corresponding to the transmitted acoustic waveforms, in which the transmitting and receiving positions each include one or both of spatial positions of an array of transducer elements relative to the target and beam phase center positions of the array, and the transmitted acoustic waveforms and the returned acoustic waveforms produce an enlarged effective aperture.
US10321884B2
A supporting device according to an embodiment includes a holder, a supporter, and a controller. The holder holds a user terminal that includes a detection surface that detects an input operation by an operator. The supporter is connected to the holder and is movably provided so as to locate a user terminal at a predetermined position, the user terminal being held by the holder. The controller fixes the supporter in a state where the supporter is located at a predetermined position when the detection surface detects the input operation.
US10321870B2
A method of analysis is disclosed. The method comprises: receiving from a mobile device of a subject sensor data and/or device state data, analyzing the data to provide at least one behavioral pattern associated with the subject, comparing the behavioral pattern with a reference behavioral pattern, and estimating the likelihood that the subject is experiencing or is expected to experience an abnormal condition based on the comparison.
US10321869B2
The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging.
US10321861B2
The present invention relates to a pH sensor adapted to be inserted into all soft tissues, such as muscle, fat or other organs e.g. heart, lung, kidney, liver, pancreas, renal gland etc., comprising one or more of: a) means to provide sensor calibration performance information; b) a sensor dislodgement alert, providing an indication to the user if the pH reading falls outside a predetermined range; c) an alert to indicate that the sensor has exceeded its usage period; and d) an alert to indicate that the sensor had exceeded its shelf life. There is also provided a method of assessing the efficacy of a treatment regime comprising the steps of determining any change in the pH of the soft tissue during treatment, where any change in the pH towards the preferred range for the tissue type is indicative of an effective treatment regime and any change in the pH away from the preferred range for the tissue type is indicative of a worsening in the condition of the tissue, and thus an ineffective treatment regime.
US10321860B2
A glucose biosensor includes a plurality of optical fibers configured for placement within the ear canal. A first optical fiber emits light into the ear canal. A plurality of other optical fibers capture and transmit the reflected light back to the glucose biosensor. A plurality of photodetectors are configured in the glucose biosensor to detect the reflected light from the plurality of optical fibers. The glucose biosensor processes the detected light from each photodetector to determine a glucose level measurement. In an embodiment, the glucose biosensor also includes a wireless interface to transmit the glucose level measurements to a glucose meter and/or a gateway.
US10321856B2
A method for monitoring a patient in a bed may involve capturing images of the patient with multiple cameras in a vicinity of the bed, wirelessly transmitting the images of the patient from the multiple cameras to a processor including a memory device, processing the images to provide processed image data pertaining to a position of the patient relative to the bed to a user, and analyzing the processed image data to determine whether the patient is exiting the bed. The method may also optionally involve providing an alarm indicating that the patient is exiting the bed.
US10321855B2
Aspects of gait matching are described herein. In one embodiment, a method of gait matching includes identifying a gait cycle timing in a data sequence captured by an inertial sensor, splitting the data sequence into a gait cycle segment, resampling the gait cycle segment, and estimating a rotation matrix for the resampled gait cycle segment. The rotation matrix, in one embodiment, can be estimated by minimizing a root mean squared deviation between the resampled gait cycle segment and a reference gait cycle segment. The method further includes calculating an aligned gait cycle segment from the resampled gait cycle segment using the rotation matrix, and generating a similarity measure between the aligned gait cycle segment and the reference gait cycle segment.
US10321851B2
The invention is directed to a system and method for providing an ARDS indication of a patient comprising a sampling device for obtaining a gas sample of the exhaled breath of a patient, a measuring unit for measuring a content of n-octane in the exhaled breath of a patient, a controller which is able to distinguish if the patient has or may develop ARDS based on the content of n-octane in the exhaled breath of a patient resulting in a ARDS indication of the patient and provided with a protocol for providing output regarding the ARDS indication of the patient, and a user interface for indicating the ARDS indication to a user.
US10321847B2
To accurately generate the three-dimensional ultrasound data and/or determine the position of the ultrasound scan relative to pre-operative data, a tracking sensor is releasably connected with the ultrasound probe. The connection positions the tracking sensor near a distal end of the probe for insertion into the patient. A needle guide may be similarly releasably connected with the probe and, at least in part, inserted into the patient.
US10321840B2
Methods for constructing classifiers for binary classification of quantitative brain electrical activity data is described. The classifier building methods are based on the application of one or more evolutionary algorithms. In one embodiment, the evolutionary algorithm used is a genetic algorithm. In another embodiment, the evolutionary algorithm used is a modified Random Mutation Hill Climbing algorithm. In yet another embodiment, a combination of a genetic algorithm and a modified Random Mutation Hill Climbing algorithm is used for building a classifier. The classifier building methods are fully automated, and are adapted to generate classifiers (for example, Linear Discriminant Functions) with high sensitivity, specificity and classification accuracy.
US10321826B2
The dynamic positioning of sensors, which exploit the mechanical and physiological changes in tissues, can significantly increase the performance in characterization of tumors. Here, we disclose the Optical Dynamic Imaging (ODI) System for tumor characterization. ODI System estimates size, depth, elastic modulus and optical properties of embedded objects. The ODI System consists of a tactile imaging sensor (TIS), and a near infrared diffuse spectral imaging. To obtain mechanical properties of the target, we compress the region of interest with the probe, then the light from the probe is scattered and captured by the camera as a tactile image. On the other hand, using a light source and the camera as a detector, we obtain the diffuse spectral images. From these images, we compute the absorption coefficient of the embedded tumor phantom. We move the source-detector simultaneously and collect optical information. We termed this maneuver as dynamic positioning. Optical Dynamic Imaging System also provides position and orientation of the light source and the detectors. The combination of the absorption coefficient and tactile data along with location information improves the size, depth, and elastic modulus estimation.
US10321825B2
A system for simultaneously detecting audio-characteristics within a body over multiple body surface locations comprising a coherent light source directing at least one coherent light beam toward the body surface locations, an imager acquiring a plurality of defocused images, each is of reflections of the coherent light beam from the body surface locations. Each image includes at least one speckle pattern, each corresponding to a respective coherent light beam and further associated with a time-tag. A processor, coupled with the imager, determines in-image displacements over time of each of a plurality of regional speckle patterns according to said acquired images. Each one of the regional speckle patterns is at least a portion of a respective speckle pattern. Each regional speckle pattern is associated with a respective different body surface location. The processor determines the audio-characteristics according to the in-image displacements over time of the regional speckle patterns.
US10321819B2
An ophthalmic imaging apparatus of an embodiment scans a subject's eye with OCT to acquire a cross sectional image. A measurement unit performs OCT. An imaging unit acquires a moving image of the subject's eye. A display controller controls a display device to display the moving image acquired by the imaging unit, and two or more scan pattern images corresponding to two or more scan lines representing scan positions and scan directions in the moving image and arranged such that at least two of the two or more scan pattern images intersect one another. An operation unit is used for changing a relative position between the two or more scan pattern images. A measurement controller controls the measurement unit to perform OCT based on the two or more scan lines corresponding to the two or more scan pattern images after the relative position have been changed.
US10321818B2
A system for use in performing ocular examinations, such as convergence and accommodation useful in diagnosing traumatic brain injury (including concussion), includes an assessment device. The assessment device includes a portable carrier having a visual target and a distance measurement component. The system may further include a communications channel and a companion device. The distance measurement component communicates via the communication channel with the companion device. The companion device stores one or more distances measured by the distance measurement component.
US10321817B2
An image display apparatus includes: a light source part generating a plurality of light rays corresponding to respective pixels in an image that changes over time; a projecting part defining an optical path from the light source part to an eye, and forming the image on a retina of the eye by projecting the generated light rays directly on the retina through the optical path; a splitting part splitting a plurality of reflection light rays from positions in a certain site of the eye on the optical path, the positions corresponding to the respective pixels; a detecting part detecting intensities of the reflection light rays that have been split; and a processing part obtaining parameters indicative of conditions of the site at the positions corresponding to the respective pixels, based on intensities of the generated light rays and the intensities of the reflection light rays, for the respective pixels.
US10321815B2
An image pickup module includes: an optical waveguide plate that includes a first waveguide, a second waveguide, and a third waveguide optically coupled to the first waveguide and the second waveguide through a branch portion; an image pickup device; a first optical device and a second optical device both mounted on the optical waveguide plate; an optical fiber; a ferrule into which the optical fiber is inserted; and a plurality of conductive wires. The ferrule includes a notch on a front surface, and distal end portions of the conductive wires are held between the optical waveguide plate and a surface of the notch of the ferrule. The other components are disposed within a plane of projection of the image pickup device.
US10321812B2
The medical instrument 1 includes a wire 5, a flexible sheath 6 through which the wire 5 is inserted, a wire driving unit 4 for driving the wire 5, a passive unit 2 that is put into operation as the wire 5 is driven, a sheath pulling unit 14, 17, 21, 51, and a sheath lock unit 12, 13, 20 for locking movement of the sheath 6.
US10321809B2
A rotary unit includes a first taper tubular portion which is contiguous to a first axial direction side of a unit main body portion and in which a first unit end of the rotary unit is positioned, an outer diameter of the first taper tubular portion becoming smaller toward the first axial direction. The rotary unit includes a first projecting portion extended on an outer peripheral portion of the first taper tubular portion with projecting toward an outer peripheral direction and wound toward a first around-axis direction as the first projecting portion extends from the first axial direction toward a second axial direction.
US10321790B2
A soap dispenser including a rigid cartridge, an inverted dispensing pump, a collar carrying a lever for actuating the pump, and a venting system for equalizing the air pressure in the rigid cartridge, wherein the rigid cartridge and the collar cooperate to removably attach the soap dispenser to a wall-mounted bracket, and further wherein at least the rigid cartridge is disposable and can be made of a recyclable and/or biodegradable material.