US12048974B2
A system includes a welding torch, a welding power supply unit, a remote device, and control circuitry. The welding power supply unit is configured to supply power to the welding torch. The remote device is coupled between the welding torch and the welding power supply unit. Additionally, the remote device is configured to detect a polarity of a welding operation. The control circuitry is configured to determine if the detected polarity is appropriate based on one or more welding parameters. Further, the control circuitry is configured to adjust the polarity of the welding operation.
US12048970B2
A laser processing apparatus includes a laser oscillator; a processing head; a driver that controls a relative positional relationship between a workpiece and the processing head; control circuitry that controls the laser oscillator and the driver in order for the laser beam to scan a processing path on the workpiece; detection circuitry that observes a state of the workpiece being processed and outputs a result of observation as a time series signal; processed state observation circuitry that obtains evaluation information including a determination result that indicates whether a processed state of the workpiece is satisfactory or defective by evaluating the processed state of the workpiece on the basis of the time series signal for each of a plurality of sections obtained by dividing the processing path; and estimation circuitry that estimates a cause of a defect on the basis of the evaluation information of two or more of the sections.
US12048969B2
An article comprising additively manufactured metal portions is described. The article comprises a first additively manufactured metal portion, and a second additively manufactured metal portion coupled to the first additively manufactured metal portion at a welded joint. The article further comprises a resistive heating material disposed within an interior of the welded joint, the resistive heating material comprising a different material than the first additively manufactured metal portion and the second additively manufactured metal portion.
US12048962B2
A method and apparatus for producing semi-solid material castings from its liquid state in a shot chamber of a die casting machine where the liquid material is poured into a shot chamber and rapidly cooled from its liquid state to temperatures below its liquidus. High-intensity ultrasonic vibration is coupled to the plunger, shot plate, or sprue-spreader while the cast material is injected by the plunger to fill the die cavity. The combined action of rapid cooling from the shot chamber, vigorous pushing by the plunger, and radiation of ultrasonic vibration on the cast material in the shot chamber directly turns the initial liquid material directly into a semi-solid slurry by breaking up dendrites and making these dendritic fragments globular. The slurry is then injected into the die cavity to form a casting.
US12048955B2
An improved refractory removal system may provide a top, bottom, and nozzle assemblies. At least one of the top or bottom assemblies may provide a rotation mechanism that allows a nozzle or the nozzle assembly to be rotated about a central axis or axis of rotation. The system may provide one or more securing mechanism(s) that allow the system to be secured in a desired position of a refractory vessel that refractory material is to be removed from. The nozzle assembly may provide an axial actuation mechanism that allows the nozzle to be moved away or towards the central axis. The nozzle assembly may also provide a linear actuation mechanism that allows the nozzle to be moved up or down along the central axis. It shall be recognized that the system provides at least three degrees of motion to the nozzle, thereby allowing the system to be utilized for a variety of situations.
US12048954B2
A scraping tip is attached to a blow gun. The scraping tip includes a neck and a head attached to the neck. The neck is hollow cylindrical and centered about a main longitudinal axis. The head has an internal cavity, a first angled face, a second angled face, a first nozzle, and a second nozzle. The internal cavity is in gaseous communication with an interior of the neck. The first angled face is in a first angled plane, while the second angled face is in a second angled plane. The first nozzle is hollow cylindrical, centered about a first longitudinal axis, merges with the internal cavity, and terminates in the first angled face. The second nozzle is hollow cylindrical, centered about a second longitudinal axis, merges with the internal cavity, and terminates in the second angled face. The scraping tip allows focused high velocity air to aid with scraping.
US12048946B2
A process of coating an open-cell foam substrate includes the steps of arranging two rollers separated by a gap; positioning the substrate above the gap; providing a coating material onto the substrate, feeding the substrate through the gap so as to achieve a layer of the coating material on the substrate, wherein the coating material is selected from the group consisting of a polysiloxane derivative, acrylic polymer, butyl rubber, natural rubber, nitriles, styrene block copolymers with ethylene, styrene block copolymers with propylene, styrene block copolymers with isoprene and polyvinyl ether and modifying the coating with tackifiers; plasticizers; crosslinking agents; chain transfer agents; chain extenders; adhesion promoters; aryl or alky copolymers; fluorinated copolymers; hexamethyldisilazane; and silica.
US12048942B1
A mixing device may define a mixing chamber including a vortex mixing portion, a primary gas path along which a first gas stream moves to the vortex mixing portion, and a secondary gas path along which a second gas stream moves to the vortex mixing portion. The mixing device may have a mixer body, an outer gas guide positioned in the mixer body to guide the second gas stream to the vortex mixing portion, and an inner gas guide at least partially positioned in the mixer body to guide the first gas stream to the vortex mixing portion. A portion of the inner gas guide may be positioned in the outer gas guide to form an annular gap between the gas guides to define the secondary gas path about the primary gas path to create a vortex of the first and second gas streams in the vortex mixing portion.
US12048930B2
A heater (22) for heating a substantially transparent or translucent cover of a reaction vessel. The heater has a board (80) having a front face, an opposing back face, and an aperture (1062) through which an excitation beam can pass into a reaction vessel via a cover of the reaction vessel, and/or through which reaction light can pass from the reaction vessel via the cover. A thermally conductive, heat-spreading layer (86) radiates heat towards the cover, the heat-spreading layer being arranged on the front face of the board that is arranged to face the cover. At least one heating element outputs heat to the heat-spreading layer (86), the heating element being arranged on the back face of the board that is arranged to face away from the cover. The heat-spreading layer (86) is in thermal communication with the heating element by at least one heating via 82 through the board.
US12048929B2
An array platform for three-dimensional cell culturing and drug testing and screening is disclosed. In the array platform, a hydrogel-cell mixture injection area is configured to inject a plurality of kinds of hydrogel-cell mixtures. Cell observation areas are connected to the hydrogel-cell mixture injection area. Electrodes are disposed under the cell observation areas and automatic cell quantification and three-dimensional cell co-arrangement of the plurality of kinds of hydrogel-cell mixtures in the cell observation areas through the electrodes to imitate a structure of body's tissues. A drug injection area is configured to inject a plurality of kinds of drugs. Drug combination generators respectively correspond to the cell observation areas and are connected to the drug injection area. Each drug combination generator has a microfluidic channel structure and configured to generate drug combinations according to the plurality of kinds of drugs.
US12048922B2
A system and method use a converter and a movable storage silo for receiving, processing, and transporting spent catalysts. The spent catalysts can be utilized in the manufacture of cement instead of being disposed in landfills. A hydraulic sub-system remove dusts from the spent catalyst prior to storage in the silo.
US12048920B2
A system for removing an existing core from a diesel emission control device (DECD) housing and a system for installing a replacement core into the DECD housing. The system for removing the existing core comprising a core press station, a control station, and a decore shaft. The system for installing the replacement core comprising a core press station, a control station, and a recore shaft. A stuffing funnel and spacer may be used to install the replacement core. In certain embodiments, processes for removing the existing core and installing the replacement core may comprise the steps of pressing the existing core out of the DECD housing, collecting the existing core into a collection container, sealing the collection container, wrapping the replacement core with matting, lubricating the matting, and pressing together the replacement core and the existing DECD housing.
US12048912B2
A lithium adsorption molded body includes a lithium adsorbent and a copolymer including a repeating unit represented by and a repeating unit represented by in which R1 and R2 are each independently hydrogen or a C1 to C10 alkyl group.
US12048910B2
A vertically oriented plasma reactor is provided. In another aspect, a plasma reactor includes a vertically elongated vacuum chamber, a wall internally projecting within a middle section of the housing, magnets, electrodes and a radio frequency source. A further aspect employs a workpiece-entry port and an opposite workpiece material-exit port, with one located adjacent a top end and the other adjacent a bottom end of a vertically elongated reactor housing or vacuum chamber. Yet another aspect employs a moving or falling-bed plasma reactor for use in activating biochar material.
US12048906B2
A powder transfer bag includes a balloon or a membrane sealing its mouth. A connector to be used with the bags allows the bag to connect to a hydration device. A method of hydrating material in a powder transfer bag is provided.
US12048904B2
A zeolite membrane composite for use in separation of a highly-permeative component through permeation from a vapor mixture or a liquid mixture comprising multiple components, the zeolite membrane composite comprising an inorganic porous support and a zeolite membrane provided thereon, wherein the zeolite membrane contains zeolite of a CHA-type aluminosilicate, and in a X-ray diffraction pattern obtained through irradiation to the zeolite membrane surface with X-ray, a peak intensity at around 2θ=17.90 has a value of less than 0.5 times a peak intensity at around 2θ=20.80 and a peak intensity at around 2θ=9.6° has a value of 2.0 times or more and less than 4.0 times a peak intensity at around 2θ=20.8°.
US12048899B2
This invention discloses a hollow fiber membrane and its preparation method and application, belonging to the field of membrane separation. The preparation method adopts a spinning device with a triple-orifice spinneret, including the casting solution, bore fluid and outer solution. The bore fluid, casting solution and outer solution are respectively co-extruded from the inner, middle and outer orifice of the spinneret, respectively, to form the nascent membrane. The nascent membrane is immersed in external coagulation bath to form a hollow fiber membrane. The outer solution and bore fluid are weakly-polar non-solvents of membrane-forming material and are water soluble. Based on the characteristics of the bore fluid and the outer solution, on the one hand, the mass exchange rate between solvents and non-solvents can be slowed down, the formation of dense skin is effectively avoided, and the surface porosity of the membrane is improved. On the other hand, the liquid film between solvents and non-solvents can finally dissolve in the coagulation bath without remaining in the hollow fiber membrane and spinning device. The hollow fiber membrane is prepared without double dense skins, and the surface porosity of the inner and outer surfaces of the hollow fiber membrane is improved, which is good for the improvement of membrane flux.
US12048897B2
A method of forming a forward osmosis membrane having a porous substrate and a rejection layer is provided. The method comprises a) forming a thin film of a polymer solution on a suitable substrate, wherein the polymer solution contains at least one polymer and optionally one or more additives in a suitable solvent, b) immersing the thin film in a coagulant bath to form the porous substrate; and c) forming a rejection layer on the porous substrate. A forward osmosis membrane is also provided.
US12048895B2
In general, the subject matter described herein relates to wettable materials that can be used to expose a liquid phase to a gas phase. An example method includes: providing a material including a polymeric substrate and at least one of: a silicate coating disposed over the polymeric substrate; or a polar mineral additive dispersed within the polymeric substrate at a loading from about 1% to about 25%, by weight; and using the material in a chemical process in which the material is at least partially covered by a liquid phase and the liquid phase is exposed to a gas phase.
US12048894B2
The invention provides a method for the capture of at least one acid gas in a composition, the release of said gas from said composition and the subsequent regeneration of said composition for re-use. The method comprises the step of capturing an acid gas by contacting said acid gas with a capture composition comprising at least one salt of a carboxylic acid dissolved in a solvent system consisting substantially of water.
US12048890B2
According to various aspects and embodiments, a system and method for two-stage filtration is provided. The system includes an inlet fluidly connectable with wastewater, a first stage filter assembly that is fluidly connectable with the inlet and has a rotary drum with a filter surface configured for radially inward fluid flow, a second stage filter assembly that is fluidly connectable with the first stage filter and has a plurality of filter discs configured for radially outward fluid flow, and an outlet fluidly connectable with filtrate generated by the second stage disc filter assembly.
US12048884B2
An accelerated game engine is described for calculating and illustrating legal moves for an active player's pieces. The game engine obtains a game state of the four-player chess game describing positions of pieces. The game engine removes a first branch of calculations including moves placing a captain piece of the first active player in check. The game engine further removes and/or retains branches of calculations relating to moves based on whether the King is in check. The client device can display a graphical user interface illustrating the board and the pieces. In response to receiving a selection of a piece to move by the first active player, the client device illustrates, via the graphical user interface, valid moves of the selected piece.
US12048882B2
A method includes selecting a computing device interaction, configuring a user accessory based on the selected computing device interaction, and performing the computing device interaction using the configured user accessory. The method also includes quantifying a computing device interaction performance of one or more users and controlling the user accessory based on quantifying the computing device interaction performance. A body part of one of the one or more users is inserted into or received by the user accessory.
US12048876B2
A server-side gaming method performed by a framework for monitoring the delivery of remotely-rendered content to a user device. The framework comprises a provisioning server for generating and managing impression content, a remote server for generating a plurality of frames of remotely-rendered content that comprise gaming content and the impression content, and an API, for sending and receiving data between the user device and the remote server. The method comprising obtaining received frame information from the user device, using the API, that represents the frames of remotely-rendered content received by the user device. It is determined whether the received frame information comprises data relating to a new frame, where the new frame comprising new gaming content and new impression content. Based on the determination, an indication that the new impression content has been received at the user device is sent from the remote server to the provisioning server.
US12048872B2
Disclosed is an apparatus including a touch sensitive user interface and a processor. The processor is configured to detect a first contact at a first position on the user interface, determine a movement of the first contact from the first position and if the movement is less than a predetermined movement threshold, when a release of the first contact is detected, move a first object on the user interface from an initial position on the user interface to an area at or near the first position. If the movement is greater than the predetermined movement threshold to identify a second position corresponding to an area near an end point of the movement and when the release of the first contact is detected, execute an action on the second position from the first object.
US12048868B2
A plurality of motion sensors capable of capturing IR video, depth video, and RGB images. Periodically emitting IR pulses. Capturing IR video, depth video, and RGB images of a user. Generating a point cloud of the user. Generating a 3D model of the user including the point cloud of the user. Inputting the IR video, depth video, and RGB images into a machine learning model. Estimating a set of joints of the user in the 3D model. Tracking, based on the estimated set of joints of the user in the 3D model, the user's motion over a period of time. Determining a number of repetitions of an exercise performed by the user. Determining a feedback value. Calculating, based on the number of repetitions and the feedback value, a user exercise score. Providing, via a graphical user interface, the user exercise score and the feedback value to the user.
US12048863B2
There is provided a skill level determination and management system and method. The system includes a sensor for automatically sensing shot data of a golf shot hit by a golfer on a range area towards a target on the range area. A comparing component is provided for comparing an end location of the golf shot to a target location and grading the shot, taking into consideration at least a difference between the end location of the golf shot and the target location, and a skill level associated with the golfer. A skill level management component is provided for updating the skill level associated with the golfer based on the grade.
US12048857B2
A method of proportioning a finished foam at or near a hazard comprising proportioning and delivering a first finished foam to the hazard, determining if the first finished foam extinguishes or suppresses the hazard, if not, selecting an amount of a fluorinated additive, and proportioning a foam solution including the selected amount of the fluorinated additive to form a fluorinated finished foam. A foam injection system is also disclosed.
US12048852B2
A light delivery device for delivering light therapy includes a light source configured to emit light, one or more first piercing members extending from a distal surface of the light delivery device, the one or more first piercing members being light-transmissive and being configured to be inserted into a subdermal or intradermal portion of the skin of the subject as the distal surface is placed against the skin of the subject. The one or more first piercing members are configured to, when inserted into the skin of the subject, deliver the light to the subdermal or intradermal portion of the skin of the subject.
US12048849B2
A subcutaneous device that includes an electronics-containing housing and a clip configured to anchor the device to an internal structural body component of a patient is injected and anchored to the structural body component. An instrument pre-loaded with the device is caused to be inserted through an incision in the patient and advanced to the structural body component. A pushing force is received on the instrument that causes the clip of the device to be pushed onto the structural body component so that the structural body component is located in a sandwiching region between a top portion of the clip and the housing of the device. Force is applied to the structural body component between the top portion of the clip and the housing of the device to anchor the device to the structural body component.
US12048848B2
In one example, the disclosure describes a method comprising receiving, by processing circuitry, information indicative of one or more evoked compound action potential (ECAP) signals. The one or more ECAP signals are sensed by at least one electrode carried by a medical lead. The processing circuitry determining that at least one characteristic value of the one or more ECAP signals is outside of an expected range. Responsive to determining that the at least one characteristic value of the one or more ECAP signals is outside of the expected range, the processing circuitry performs a lead integrity test for the medical lead.
US12048844B2
Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.
US12048835B2
A syringe including a proximal end, a distal end, and a cylindrical sidewall extending between the proximal end and the distal end, wherein the distal end comprises a conical distal end wall and a fluid nozzle at a distal end of the conical distal end wall; a cylindrical load bearing wall extending axially from the cylindrical sidewall past a proximal end of the conical distal end wall; and a plurality of radial ribs positioned around a periphery of the conical distal end wall, wherein a longitudinal axis of the plurality of radial ribs extends radially inward from the cylindrical load bearing wall towards the fluid nozzle over at least a portion of the conical distal end wall.
US12048834B2
A drive assembly for a drug delivery system includes a plunger member configured to engage and move a stopper within a container, with the plunger member having a first position and a second position axially spaced from the first position, a leadscrew configured to move the plunger member from the first position to the second position, and a biasing member configured to bias the leadscrew in a rotational direction, where rotational movement of the leadscrew is configured to move the plunger member from the first position to the second position.
US12048826B2
A catheter system may include a catheter assembly, which may include a catheter adapter. The catheter adapter may include a distal end, a proximal end, and a lumen extending through the distal end of the catheter adapter and the proximal end of the catheter adapter. The catheter assembly may include a catheter, which may extend distally from the distal end of the catheter adapter. The catheter system may include an instrument extending through a distal opening of the catheter. The instrument may include a coil spring.
US12048825B2
Tattoo machines configured to drive a needle towards a marking area. The tattoo machines include a motor, a first arm, a second arm, and a primary spring. The first arm is operatively connected to the motor and driven by the motor towards the marking area. The second arm is spaced from the first arm and configured to couple to the needle. The primary spring is biased to move the first arm and the second arm away from the marking area. The second arm is driven towards the marking area when the first arm is driven towards the marking area by the motor.
US12048810B2
A method, such as in a controller associated with a respiratory therapy device, determines whether high flow therapy is being used by a patient. The method may include determining whether a property of a flow of air being delivered by a respiratory therapy device along an air circuit to an unsealed patient interface contains a significant oscillation within a breathing rate frequency band. The method may also include generating, dependent on the determination, an indication of whether high flow therapy is being used by the patient.
US12048809B2
An auxiliary sputum excretion method for a non-invasive ventilator and the invasive ventilator, solving the technical problem of how to help a patient with non-invasive ventilation to excrete sputum. In the auxiliary sputum excretion method, a sputum excretion operation is initiated in each respiratory cycle of a patient after the non-invasive ventilator determines that the patient needs sputum excretion during a normal mechanical ventilation of the non-invasive ventilator for the patient, and the sputum excretion operation is stopped in response to determining that the patient needs to stop the sputum excretion.
US12048807B2
A power supply section for an e-vaping device includes a sensor housed in a housing, a sensor holder holding the sensor, the sensor holder disposed in the housing to divide the housing into a first portion and a second portion, and the sensor and the sensor holder configured to substantially prevent air flow from the first portion into the second portion, and a power source disposed in the second portion. The construction of this unit insures that gases that may be produced by outgassing of the battery cell will be vented to the environment and that those gases will be isolated from the air that is mixed with the vaporized e-liquid and inhaled by the user.
US12048806B2
A component for a vapour provision system comprises a reservoir for storing aerosolisable substrate material, the reservoir bounded by a boundary wall with at least one movable section configured to move to reduce a storage volume of the reservoir; an outlet in the reservoir for dispensing aerosolisable substrate material from the reservoir; a one-way outlet valve at the outlet configured to open for the dispensing of the aerosolisable substrate material; and a dispensing arrangement operable to increase pressure of aerosolisable substrate material in an outlet volume of the reservoir which is not bounded by the movable section, so as to open the outlet valve and dispense a portion of aerosolisable substrate material, the subsequent absence of the dispensed portion reducing the pressure to allow the movable section of the boundary wall to move to reduce the storage volume.
US12048804B2
Methods of securely dispensing a substance to an intended user are provided. In some instances, a method of securely dispensing a substance to an intended user includes moving a valve of a locking cap fixedly secured to a housing containing the substance to an open state that allows the substance to be dispensed from the housing to the intended user; determining that a unique biometric attribute of the intended user is detected; and dispensing the substance from the housing to the intended user in response to determining that the unique biometric attribute of the intended user is detected.
US12048798B2
An interface device between a hemodialysis machine and venous and arterial tubes includes: a first port adapted to be connected to an output port of the hemodialysis machine and a venous port to inject blood into the venous tube. The interface device includes a second port adapted to be connected to an input port of the hemodialysis machine and an arterial port for receiving blood from the patient from the arterial tube. The interface device is further adapted to selectively allow or prohibit the passage of blood between the first and second ports and the venous and arterial ports respectively.
US12048797B2
Disclosed is a ventricular decompression and assisting apparatus (100). The apparatus (100) includes a pigtail and a catheter that is introduced percutaneously into a femoral/radial/brachial vein or artery and is advanced into the ventricle where blood is drawn and mechanically pumped back with an external blood pump (40) and pumped back downstream into the aorta (2) or venous system or the pulmonary artery using another suitable catheter from a second access into the femoral/radial/brachial artery or any vein and with tip thereof positioned at a desired location thus forming a ventricular vent loop. The desired cardiac circulation is maintained with smart pumping, monitoring and control while relieving the load on the heart muscle to rebuild strength thereof. The apparatus (100) provides user friendly simplified approach to ventricular venting and unloading as a means for mechanical circulatory support of the left heart, right heart or both circulations even simultaneously.
US12048792B2
The present invention has to do with a method and system for preformed peritoneal dialysis (PD) catheter weighted anchors. The peritoneal dialysis catheter weighted anchors can be inserted and retrieved using standard techniques and available insertion/retrieval systems. The peritoneal dialysis catheter weighted anchors can be attached and secured to all types of PD catheters as an ancillary anchor device.
US12048791B2
Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employs relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.
US12048785B2
An apparatus, system, and method are disclosed for dry fogging system. The system includes a first liquid tank including compressed air and a first liquid configured to disinfect and sterilize. The system further includes a second liquid tank including a second liquid. The system further includes a control panel configured to regulate dispensing of the first liquid and the second liquid. The first liquid tank, the second liquid tank, and the control panel are modular and configured to detach.
US12048781B2
A three-dimensional biomimetic artificial blood vessel that is biodegradable and biocompatible, is inspired by the morphological structure and physiological role of blood vessels having small diameter in the human circulatory system. A method of production by electro spinning is also disclosed.
US12048780B2
The technology relates to a 3D printed hydrogel formed from a maleimide containing polymer cross-linked using a bis-thiol containing cross-linking agent having at least two thiol functional groups, processes for preparing the 3D printed hydrogel, and uses thereof.
US12048775B2
The present disclosure provides methods of stabilizing surgical screws comprising the intraoperative mixing of reactive putties to yield a homogenous putty composition (HPC) into which the screw is inserted, wherein the HPC comprises a polyurethane or polyurethane urea copolymer, one or more particulate materials, and one or more additive materials.
US12048768B2
This disclosure relates to gastro-resistant, controlled release dosage forms comprising Compound (I): or a pharmaceutically acceptable salt and/or solvate thereof, the pharmacokinetic properties of these dosage forms, and the preparation of the same. The novel dosage forms disclosed herein are useful in reducing the risk of QT prolongation in a subject and in treating a disorder in a subject in need thereof, e.g., a subject diagnosed with schizophrenia, for example, in treating the negative symptoms in a subject diagnosed with schizophrenia having the CYP2D6 EM genotype.
US12048752B2
Disclosed is a suspension of gas-filled microbubbles in a physiologically acceptable liquid carrier comprising a lipid mixture of a first lipid having transition temperature of about 41° C. such as DPPC or DPPG, a second lipid having transition temperature of about 55° C. such as DSPC or DSPG, and a PEGylated DSPE such as DSPE-PEG2000, DSPE-PEG3000, or DSPE-PEG5000, and methods of preparation thereof.
US12048748B2
This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
US12048742B2
The present disclosure provides an immunogenic composition comprising: a) i) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; ii) an HCV E1 polypeptide; or iii) an HCV E2 polypeptide; b) a polypeptide (also referred to herein as a “T-cell epitope polypeptide” or an “HCV T-cell epitope polypeptide”) comprising T-cell epitopes (e.g., CD4+ and CD8+ T-cell epitopes that are conserved among some HCV genotypes and that are presented through one or multiple HLA alleles common within the human population) present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide.
US12048741B2
Recombinant viruses include one or more SHREK proteins and are thereby rendered non-infective and can be safely used in vaccines, e.g. to treat or prevent infections and to eliminate e.g. latent virus reservoirs.
US12048728B2
The present invention relates to novel formulations of soluble Fc receptors and especially to formulations containing high concentrations of soluble FcγRIIB receptor. The invention further relates to the use of such formulations as pharmaceutical compounds for the treatment of autoimmune diseases, infections and other conditions where the immune system is involved.
US12048727B2
The present invention relates to a synergistic formulation comprising the essential oils of plants from western Himalayas, which have versatile medicinal properties. The present invention also relates to a process for development of synergistic value added anti-acnes products using the essential oils from these plants of western Himalayas. The developed synergistic formulation is useful in inhibiting different P. acnes strains thereby exhibiting antibacterial activity.
US12048724B2
A method for reducing muscle contraction of a facial muscle or reducing the appearance of a fine line or wrinkle is disclosed. The method can include topical application of a composition to facial skin and/or to the fine line or wrinkle. The composition can include an effective amount of Rosmarinus officinalis leaf extract, an effective amount of Lavendula stoechas extract, and an effective amount of Acmella oleracea extract. Topical application of the composition to facial skin can reduce muscle contraction of the facial muscle. Topical application of the composition to the fine line or wrinkle can reduce the appearance of the fine line or wrinkle.
US12048721B2
Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.
US12048698B2
In one aspect, the present invention provides a method for treating or ameliorating the effects of a HER2 positive cancer in a subject. In some embodiments, the method comprises administering a combination therapy comprising an anti-HER2 antibody and tucatinib. In some embodiments, the method further comprises administering a chemotherapeutic agent (e.g., an antimetabolite) to the subject. Pharmaceutical compositions and kits are also provided herein.
US12048691B2
The disclosure provides a tebipenem pivoxil HBr formulation in the form of a tablet core comprising at least 70% (w/w) tebipenem pivoxil HBr, and in certain embodiment more than 80% (w/w) tebipenem pivoxil HBr. The disclosure provides a tebipenem pivoxil HBr tablet core comprising at least 70% w/w tebipenem pivoxil HBr, 5-25% w/w of a diluent, 0.5 to 5% w/w of a glidant, 0.5 to 5% w/w of a lubricant, and optionally 0.5 to 5% w/w of disintegrant. The disclosure provides methods of treating a patient who has a bacterial infection such as complicated urinary tract infection (cUTI), acute and chronic pyelonephritis, an upper or lower respiratory infection, or bacteremia by administering a formulation of the disclosure to the patient.
US12048679B2
The molecular mechanism of the function of TBC1D15 in NOTCH activation and stabilization is associated with maintenance and expansion of tumor-initiating stem-like cells (TICs). We herein demonstrate that TBC1D15 preferentially binds an NUMB isoform and NOTCH1-PEST domain and stabilizes NOTCH1 protein. This interaction enhances phosphorylation of NUMB, taking it away from NUMB-mediated ubiquitin degradation of NOTCH. Thus, TBC1D15 acts as a switch to augment NOTCH signaling in TICs. We also have identified inhibitors of TBC1D15 such as latanoprost acid and a salt thereof, which blocks the NOTCH-TBC1D15 interaction and selectively kills CD133-positive TICs, resulting in a reduction in the tumor size in a patient-derived, hepatocellular carcinoma xenograft model.
US12048676B2
The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.
US12048673B2
A filling machine for filling capsules with at least one product includes operating stations for operating on the capsules, and a moving system for transferring the capsules through the operating stations that include first and second dosing stations that are configured to fill the capsules with respective products. The moving system includes a linear electric motor, a guide rail, which includes a stator of the motor, and transfer carriages associated with the guide rail and provided with respective seats to house bodies and caps of the capsules. The transfer carriages have respective rotors of the motor interacting independently with respective magnetic fields generated by the stator to move the respective transfer carriages along the guide rail with an intermittent motion at the first dosing station when the first dosing station is activated and/or with a continuous motion at the second dosing station when the second dosing station is activate.
US12048670B2
A method, apparatus, and device for controlling a moxibustion manipulator are disclosed. The method includes: acquiring acupuncture point position information; determining coordinate information of the moxibustion manipulator based on the acupuncture point position information and safe distance information, and controlling the moxibustion manipulator to move to a position corresponding to the coordinate information; acquiring coordinate information of a light spot, and determining a plane corresponding to the light spot based on the coordinate information of the light spot; determining rotation angle information of the moxibustion manipulator based on the plane corresponding to the light spot, the rotation angle information being used to adjust an angle of the manipulator relative to the plane corresponding to the light spot; and controlling, based on the rotation angle information, the moxibustion manipulator to adjust the angle.
US12048666B2
Systems and processes for determining pressure settings for a percussive massage applicator are described. According to one embodiment, a method comprises obtaining an operational current measurement of the motor when the motor has a load. difference value is determined between the current measurement and the operational current measurement. The difference value is compared to two or more predetermined ranges of values that correspond to a pressure level of the percussive applicator. The pressure level may be provided as feedback to the user.
US12048652B2
A protective eye mask for practicing winter sports and in particular alpine skiing is provided. The protective eye mask is provided with an electrically powered lyquid crystal (LC) lens having at least one LC layer made of guest-host (GH) type liquid crystals.
US12048645B2
The present invention relates to a menstrual cup, the menstrual cup according to the present invention comprising: a main body having an open end and a space therein in which menstrual blood is collected; an outlet on the other end of the main body; a stopper packing for blocking the outlet; and a connection part which has one end thereof connected to the stopper packing and the other end thereof directly or indirectly connected to the main body, and which is made of an elastic material so as to move the stopper packing to the original position thereof, if the stopper packing has been spaced away from the outlet due to an external force and then the external force is removed.
US12048635B2
A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.
US12048628B2
A method of coating a bone material in a container is provided. The method comprising adding the bone material to an opening of the container and sealing the opening of the container so that the bone material is disposed within an interior of the container; adding a liquid coating material to the interior of the container through an inlet of the container so as to coat at least a portion of the bone material with the liquid coating material; removing any excess coating material from the container from the interior through an outlet of the container; and removing the coated bone material from the container. A system of coating bone material under a sterilized environment is also provided.
US12048611B2
Described is a two-part, screw retained dental implant prosthesis. The dental implant prosthesis includes both a primary substructure (made of for example, titanium) and a secondary superstructure (made of for example, zirconia). The primary substructure includes a top side and a bottom side, with substructure holes passing through the primary substructure from the top side to the bottom side. The primary substructure is formed to align with and secure against a dental implant as affixed in a patient's jaw. Alternatively, the secondary superstructure is formed to be affixed with the primary substructure. Thus, the primary substructure can be affixed with the dental implant, with the secondary superstructure thereafter being affixed with the primary substructure.
US12048607B2
A method and a system for determining an orthodontic treatment plan including a tooth stripping step are provided. The method comprises: acquiring a 3D digital model of a first tooth and a second tooth of the subject, the second tooth being adjacent the first tooth; receiving a stripping request for stripping tooth material, from at least one of the first tooth along a first stripping plane and the second tooth along a second stripping plane; determining, along a surface of the first tooth, a first area of interest; determining, along the surface of the second tooth, a second area of interest; determining a distance between a first set of vertices associated with the first area of interest and a second set of vertices associated with the second area of interest; in response to the distance being greater than a predetermined distance threshold, denying, by the processor, the stripping request.
US12048603B2
In a method for closing a space between a first tooth and a second tooth, a pair of dental matrices is used. The pair of dental matrices is selected using a matrix selection tool, such as a gauge having a distal end section with color coded sections.
US12048602B2
An electric toothbrush includes a toothbrush body. The toothbrush body includes a toothbrush head. The toothbrush head includes a handle part, a first platy body disposed below the handle part, and a first brushing sheet and a second brushing sheet disposed side by side and below the first platy body. The lower surface of the first platy body is provided with a first brush bristle, the rear side surface of the first brushing sheet is provided with a second brush bristle, and the front side surface of the second brushing sheet is provided with a third brush bristle.
US12048592B2
A three-dimensional ultrasound imaging support apparatus includes: a processor configured to generate a three-dimensional ultrasound image based on a plurality of two-dimensional ultrasound images which are imaged by an ultrasound probe at different positions of a certain portion of a subject and an imaging position of the ultrasound probe for each imaging; estimate an imaging portion corresponding to the two-dimensional ultrasound image and to the three-dimensional ultrasound image; determine, by using a guideline in which a plurality of imaging targets to be imaged are defined in advance for each portion of the subject, for the estimated imaging portion, whether or not all of the plurality of imaging targets defined in advance in the guideline are imaged; and perform notification indicating that the imaging target which is not imaged is present in a case where it is determined that the imaging target which is not imaged is present.
US12048591B2
Ultrasound diagnosis apparatus, method for displaying ultrasound image, and computer program product
Provided is a method for displaying an ultrasonic image, the method comprising: acquiring data by transmitting ultrasound pulses to a subject and receiving echo signals reflected from the subject; detecting microcalcified tissues in the subject by analyzing the acquired data; and displaying an image representing the detected microcalcified tissues.
US12048586B2
Embodiments disclosed herein are directed to a stabilization feature configured to be coupled to an ultrasound probe, or similar medical device and grasped by one or more fingers of a user. The user can then manipulate the stabilization feature and probe assembly without requiring any opposing pressure to be applied by the thumb. As such a user is free to use the thumb to operate controls disposed on the probe, or stabilize a skin surface, or the like. The stabilization feature can include a first portion configured to be grasped by one or more fingers, and a second portion configured to engage the probe. Further, the second portion can engage the probe through a sheath to maintain a sterile barrier therebetween. Alternatively, the first portion can be grasped by one or more fingers through a sheath to maintain a sterile barrier therebetween.
US12048575B2
Systems and methods are provided for imaging coronary trees via registration of angiographic projections with computed tomographic data. In one example, a method for imaging a coronary artery of interest in a patient may include acquiring computed tomography (CT) imaging data depicting a coronary tree, acquiring a single angiographic projection of the coronary artery of interest, registering the single angiographic projection to the CT imaging data, and determining a fractional flow reserve (FFR) of the coronary artery of interest based on the single angiographic projection registered to the CT imaging data.
US12048574B2
A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (STN). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures. A statistical shape model is applied for variation modes of the STN, or the corresponding regions of interest, and its predictors on high-quality training sets obtained from high-field, e.g., 7T, MR imaging. The partial least squares regression (PLSR) method is applied to induce the spatial relationship between the region to be predicted, e.g., STN, and its predictors. The prediction accuracy for validating the invention is evaluated by measuring the shape similarity and the errors in position, size, and orientation between manually segmented STN and its predicted one.
US12048566B2
Indirect, oscillometric, digital blood pressure monitoring systems and methods enabling self-calibration to obtain absolute blood pressure values using algorithmic analysis of arterial pressure pulses to establish an oscillometric profile and compensate for intervening effects on digital arterial pressure. Proper algorithmic analysis is dependent upon proper positioning and maintained engagement of a digital cuff on the digit of a user and subsequent hydraulic coupling of the cuff to the arteries within the digit.
US12048558B2
A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.
US12048553B2
Systems and methods are provided for medical diagnosis and analysis using mixed model inversions. For example, a medical analyzer using mixed model inversions according to an embodiment of the present disclosure can be used to diagnose traumatic brain injury (TBI), which allows for isotropic and anisotropic inversions to be performed, enabling more accurate information about brain stiffness to be obtained.
US12048551B2
The invention provides an advanced, modular, intraoperative neurophysiological monitoring (IONM) system, referred to as a “NeuroNet-VII” System, which is the first IONM system designed with a USB hub architecture comprising serially-connected functional “pods which provides multi-modality simultaneous data acquisition which supports all data types useful in operating rooms, diagnostic laboratories, intensive care units, and epilepsy monitoring units. The unique pod architecture makes the IONM system highly modular compared to current systems which typically place components in a limited number of centralized enclosures. The modular architecture of the invention also provides for real-time collection of data so that information may be communicated with a remotely-located physician; a user needs only to purchase pods that are needed; repair of a single pod may easily be replaced without disabling the entire system; and advances in hardware designs may be implemented for a specific pod without requiring replacement of the entire system.
US12048549B1
A street greening quality detection method based on physiological activation recognition is provided. The street greening quality detection method includes establishing a greening quality factor index system, and obtaining and uniformly processing street greening images; collecting raw data, and performing reclassification and differential wave processing on the raw data to obtain valid physiological data that can be used for activation feature recognition of greening quality factors; calculating physiological activation feature parameters, training the physiological activation feature parameters by transfer learning fusion to determine importance of physiological activation features, and recognizing weighted average greening activation indexes of the greening quality factors; analyzing weighted average greening activation index data of the greening quality factors to form a street greening quality detection model; and inputting annotated street samples to be analyzed into the street greening quality detection model to obtain annotated results of street greening quality grading detection target data.
US12048545B2
A connection device for a deflectable medical device, such as a catheter, comprises an elongate planarity wire having a proximal end and a distal end, an elongate activation wire having a proximal end a distal end, a passage and an interface. The passage extends through the planarity wire near the distal end of the planarity wire. The distal end of the activation wire extends through the passage. The interface is between the passage and the activation wire, and may comprise one or more of the following: a hook and bore interface, a detent interface, a mechanical interface, or a metallurgical interface.
US12048534B2
Systems, methods, and apparatuses for enabling non-invasive, physiological sensors to obtain physiological measurements from a region of tissue of a patient are disclosed. Anchoring components can attach to patient tissue sites and sensor heads such that the tissue sites do not move during sensing. Interlocking mechanisms maintain tissue sites within a limited range of horizontal movement and vertical distance from the sensor head.
US12048530B2
Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided.
US12048529B1
A hardware sensor system comprising a piezo sensor outputting charge data corresponding to a motion, an insulated cable from the piezo sensor to a receiver, to transmit the charge data, an insulated charge to voltage converter on the receiver, the insulated charge to voltage converter converting the charge data to voltage data, an analog-to-digital converter to convert the voltage data to digital data, and an uploader to upload the data to a server for processing.
US12048528B2
An annotation method, an annotation device, a storage medium, and an identification system are provided. In an annotation method according to an aspect of the present invention, a computer executes: a step of acquiring sensor data in which the outputs of a sensor are arrayed in time series; and a step for providing a plurality of labels to the acquired sensor data. The plurality of labels include a first label and a second label, wherein the first label is provided to a first time segment, and the second label is provided to a second time segment that comes after the first time segment in the time series. In addition, the first time segment and the second time segment are set to have an overlapping segment in which the first time segment and the second time segment partially overlap each other in the time series.
US12048526B2
Methods and systems of displaying flow-volume loops of a patient and variability of the flow-volume loops across measured breaths are disclosed. The methods comprise obtaining a physiological dataset of the patient on a data acquisition device, applying a smoothing and curve fitting algorithm to the physiological dataset on a processing device to obtain real-time volume and flow data at a plurality of time instances, applying a visualization algorithm on the processing device to the volume and flow data to create a series of flow-volume loops based on the volume and flow data, and outputting a plot of the flow-volume loops on a display device to aid evaluation or diagnosis of the patient.
US12048525B2
An impedance reflector apparatus, systems, and methods are provided for detecting a marker implanted within tissue that includes a switch for changing a configuration of an antenna of the marker. The apparatus includes a set of transmit electrodes coupled to a signal generator for transmitting a drive current into tissue to generate an electromagnetic field around the marker, a set of receive electrodes configured to detect voltage signals within the tissue corresponding to the electromagnetic field, and a light source for delivering light pulses into the body to open and close the switch to change the configuration of the antenna of the marker. A processor coupled to the receive electrodes processes the detected voltage signals to identify changes in the electromagnetic field that are synchronized with the light pulses to determine whether the marker is operating properly.
US12048511B2
A video processing method improves the repeatability of point-of-care (POC) mean pixel intensity (MPI) analysis, for example by rejecting low-quality input data using image features. Using these features, the method selects high-quality frames and achieves an improvement in correlation and standard error for the MPI-absorbance relationship. In another example, a mobile device (e.g., smartphone) based image processing method produces an MPI output with smaller variances, lower limits of detection (LODs), and a higher dynamic range than existing methods. This method has improved performance in the presence of additive and multiplicative ambient light noise.
US12048499B2
A method of verifying torque measurements of a reaction torque transducer of an instrument drive unit includes a controller receiving a verification signal, generating an acceptable range of torques, receiving a torque signal, comparing the torque signal to the acceptable range of torques, and stopping a motor if the torque applied by the motor is outside of the acceptable range of torques. The verification signal is indicative of the current drawn by the motor and the torque signal is indicative of torque applied by the motor.
US12048498B2
A bi-planar robotic arm device for vascular interventional surgery includes an operating table, a frame assembly, an outer arm assembly, and an inner arm assembly. The frame assembly includes a standing column, a sliding block, a sliding platform, a support, and a screw stepper motor. The standing column is arranged on the operating table. The support is arranged on the standing column. The sliding platform is arranged on the support. The sliding platform is connected to the sliding block. The sliding block is connected to the screw stepper motor and can slide along the sliding platform under the action of the screw stepper motor. The outer arm assembly is connected to the standing column. The inner arm assembly is connected to the outer arm assembly and the sliding block. The inner arm assembly and the outer arm assembly can move relative to each other.
US12048486B2
An ophthalmic technician is present with a patient in an exam room to operate eye examination equipment and transmit patient information to remote location. At that remote location, a skilled technician is present to provide the necessary optical care, and may operate the phoropter from the remote location. Using video and/or teleconferencing equipment and a phoropter located in the patient examination room along with management software, the system works to determine the final optical prescription for the patient. That information, coupled with findings from other devices which are integrated with the management software, and that the patient uses locally, are reviewed by a remote-based optometrist or ophthalmologist.
US12048477B2
A method of disassembling a surgical instrument for reprocessing, includes accessing an interior housing of a surgical instrument to expose a slider assembly, an elongated outer shaft including a drive plate and knife assembly extending therethrough, and a torsion spring of the surgical instrument. The method further includes grasping an upper leg of the torsion spring to disengage the upper leg from a slot defined within the drive plate, disengaging the drive plate from the slider assembly, and removing the torsion spring from the slider assembly.
US12048465B2
A sternal closure device includes an insertion member, a receiver member and a joint locking mechanism. The joint locking mechanism includes a dual pawl assembly and a dual ratchet assembly. The dual pawl assembly includes a pair of pawl arms that include heads with outward facing teeth. The dual ratchet assembly includes a pair of ratchet arms with inward facing teeth that are configured for an intermeshed engagement with the teeth on the corresponding pawl arms. Alignment tabs on the ratchet arms are captured within guide channels on the receiver member. The configuration and number of the teeth contribute to the strength of the device. The locking mechanism contributes to efficiency, speed, and strength of the closure.
US12048457B2
A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having opposing proximal and distal ends and defining a lumen that extends between the proximal and distal ends. One or more windows are defined in the cannula at or near the distal end, and one or more compliant deflection devices are arranged at or near the distal end and at least partially receivable within the one or more windows. Each compliant deflection device includes a radial biasing member that extends radially inward toward a centerline of the cannula.
US12048452B2
A surgical instrument includes an end effector, and a shaft assembly. The end effector includes an ultrasonic blade, a rotating body, and a clamp arm movable between an open and a closed position. The shaft assembly extends along an axis and includes clamp arm clocking assembly and a clamp arm pivot assembly. The clamp arm clocking assembly can drive the rotating body and the clamp arm between a first clocked position and a second clocked position. The clamp arm pivot assembly includes an actuator body defining a track, where the actuator body can actuate to drive the clamp arm between the open position and the closed position while the actuator body is in a rotational position relative to the ultrasonic blade. The track houses a portion of the clamp arm in the first clocked position and the second clocked position while the actuator body is in the rotational position.
US12048450B2
A hollow rod developable actuator tool including a first link comprising an outer cylinder, a second link comprising a first tool member pivotably connected to the first link at a first joint mounted in a first cavity in the wall of the outer cylinder, a third link comprising a second tool member pivotably connected to the first tool member at a second link, and a fourth link comprising an inner cylinder to which the second tool member is also pivotably connected at a third link mounted in a second cavity in the wall of the inner cylinder. When the inner cylinder of the fourth link is rotated in relation to the outer cylinder of the first link the actuator tool transitions from a first state where the tool is closed to a second state where the tool is open.
US12048447B2
A shockwave transducer for a lithotripter includes a shockwave source and a body with an exit aperture. The transducer is configured to generate a shockwave propagating from the body and through the exit aperture. The body comprises at least one diffuser, which engages into the shockwave propagating from the body. This diffuser includes a material characterized by a propagation velocity of the shockwave that is different from the propagation velocity of the shockwave in the surrounding medium.
US12048446B2
A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.
US12048441B2
An orthopedic broach is disclosed. The orthopedic broach includes a cutting tip and a broach handle. The broach handle includes a lever, a spring, and a latch. The lever is movably coupled to the handle and to an end of the spring. The latch is movably coupled to the handle and the opposite end of the spring. In use, the lever is movable from an opened position, where the latch is positioned in a released position, so that the cutting tip can be inserted into the handle, to a closed position where the latch is moved to an engaged position wherein the cutting tip is securely coupled to the latch, and thus the handle. The handle includes a spring stop to prevent the spring from further deflection to prevent the latch from moving to the released position and thus prevent decoupling of the cutting tip when excessive forces are applied.
US12048439B2
A drill bit for drilling into bone, including at least a first, second and third longitudinally extending substantially straight flute blades, wherein the drill bit has an extrapolated outer profile established by rotation of the first, second and third flute blades 360 degrees about a longitudinal axis thereof, the extrapolated outer profile includes a first surface having tangents more perpendicular than parallel to the longitudinal axis, and the extrapolated outer profile includes a second surface having tangents more parallel than perpendicular to the longitudinal axis.
US12048432B2
A swing head mechanism and a medical stapler. The swing head mechanism comprises a rotating component, a swing head pull rod (93), and a housing. At least one first fitting member and at least one second fitting member are respectively provided on the outside of the rotating component and the inside of the housing. When the rotating component rotates relative to the housing until the first fitting member is opposite to the second fitting member, the first fitting member and the second fitting member form an elastic embedding fit. The swing head mechanism facilitates an operator to set different swing angles of a stapler head portion, and can avoid uncontrollable swing of the stapler head portion.
US12048430B2
An organization device for maintaining a suspensory graft fixation device (i.e., an implant and suture) in a desired position. The device includes a substrate having top and bottom edges with first and second panels extending therebetween. The device also includes a first central longitudinal axis extending in a direction from the top edge to the bottom edge between the first and second panels. The first and second panels are foldable about the axis between open and closed positions. The device also includes an opening extending through the bottom edge and into the first panel, and a plurality of top slits and bottom slits. The plurality of top slits includes at least one top slit which is aligned with the first opening. The device additionally includes a tabs adjacent the opening. The slits and tabs are configured to maintain suture of a suspensory graft fixation device in an organized manner.
US12048424B2
Embodiments of a surgical instrument including an actuation lockout system as well as its method of use are disclosed. In one embodiment, a surgical instrument includes a trigger and a driveshaft coupled to the trigger such that actuation of the trigger causes the driveshaft to move from a first position to a second position, thereby resulting in deployment of a surgical fastener. An actuation lockout system restrains distal movement of the driveshaft until a force greater than or equal to a threshold force is applied to the trigger.
US12048413B2
A diagnostic assistance method for a disease based on an endoscopic image of a digestive organ with use of a convolutional neural network (CNN). A diagnostic assistance method for a disease based on an endoscopic image of a digestive organ with a CNN trains the CNN using a first endoscopic image of the digestive organ and at least one final diagnosis result on positivity or negativity to the disease in the digestive organ, a past disease, a severity level, and information corresponding to a site where an image is captured, the final diagnosis result corresponding to the first endoscopic image, and the trained CNN outputs at least one of a probability of the positivity and/or the negativity to the disease, a probability of the past disease, a severity level of the disease, an invasion depth of the disease, and a probability corresponding to the site where the image is captured.
US12048407B2
A household appliance includes: a treatment container having a treatment compartment and a loading opening for loading items to be treated; a treatment compartment door by which the loading opening is closeable; and a camera for visually detecting the treatment compartment. An area of the treatment compartment detectable by the camera is adjustable.
US12048406B2
A system (10) for loading a dishwasher which is designed as, in particular, a commercial conveyor dishwasher (1). The system (10) has a feed conveyor belt (11) for feeding washware (9a, 9b, 9c) to a loading region of the conveyor dishwasher (1). The system (10) also has a sorting arrangement for sorting the washware (9a, 9b, 9c), which is fed to the loading region of the conveyor dishwasher (1) by means of the feed conveyor belt (11), in accordance with predefined or predefinable washware groups. At least one loading arrangement (13a, 13b, 13c) is associated with the sorting arrangement for the purpose of automatically loading the conveyor dishwasher (1) with washware (9a, 9b, 9c) of one of the predefined or predefinable washware groups.
US12048405B2
A dishwasher includes a tub, a basket, a spray device configured to spray washing water, and a sump configured to supply the washing water to the spray device. The spray device includes a first spray rotor including a first spray arm and a shaft integrally formed with the first spray arm to guide the washing water supplied from the sump to the first spray arm, a second spray rotor rotatably coupled to the shaft and including a second spray arm configured to spray the washing water branched from the washing water guided to the first spray arm through the shaft, and a shaft hole formed in the second spray arm to allow the shaft to pass therethrough, and a communication hole formed in the shaft to allow the shaft to communicate with the second spray arm.
US12048403B2
An intelligent robot includes a main body, an environment sensing device, and a control circuit board. The main body includes a body, a protective side plate, and a partition structure. The protective side plate is movably connected to the body. The body and the protective side plate cooperatively defines an accommodation cavity, the protective side plate includes an light transmission region, the partition structure is fixedly connected to the body and received in the accommodation cavity, the partition structure divides the accommodation cavity into a first space and a second space. The environment sensing device is at least partially received in the first space, and capable of transmitting and receiving environmental sensing signals within a preset scanning angle through the light transmission region of the protective side plate. The control circuit board is received in the second space, and electrically connected to the environment sensing device.
US12048400B2
An exemplary dispensing system includes a dispenser, an actuator, a sensor, and a controller. The dispenser includes a container for holding liquid, a liquid pump, an air pump, an outlet nozzle, and a foaming media. The actuator causes the dispenser to dispense liquid or foam. The sensor generates an input signal indicative of a status of the container. The controller receives the input signal, generates at least one output signal, and prevents the dispenser from dispensing liquid or foam if a breach is detected in the container.
US12048395B2
A twist off container and coupling assembly of a micro puree machine includes a container and a coupling on the micro puree machine. An interior surface of the coupling has at least one ramped slot that is angled relative to a lower annular surface of the coupling. The container has at least one protrusion correspondingly angled relative to an upper annular surface of the container. The protrusion is configured to engage the slot when the container is rotated in a clockwise direction and to disengage from the slot when the container is rotated in a counter-clockwise direction. When the container is rotated, the container moves both axially and rotationally relative to the coupling.
US12048390B2
An onboard multi-functional thermal-insulation and explosion-proof pressure steamer, relating to the technical field of heating cooking appliances, and in particular, to the field of cooking appliances mounted on a travelling apparatus, comprising a steamer body and a steamer outer cover covering the top of the steamer body, a steam pot being provided in the steamer body. The steam pot is provided in the steamer body to seal a steam container in the steam pot, and the steam pot is heated by means of the onboard heat energy, heat exchange is performed by means of a heat exchange device to generate high-temperature steam to heat the food material in the steam pot of the steam or to heat the water in a water tank.
US12048387B2
The invention discloses a drinking vessel comprising a beverage container and a spillage receptacle, the latter having an opening which excessively encompasses the vertical projection of the widest outer periphery of the beverage container. The spillage receptacle further comprises an annulated top surface designed to maintain the spillage in the spillage receptacle while the drinking vessel is tilted. The invention also provides a drinking vessel comprising a beverage container, a spillage receptacle which encompasses the vertical projection of the widest outer periphery of the beverage container, and an annulated draining surface (e.g. a funnel) wherein the top end of the spillage receptacle has a wider diameter than a lower holding portion of the drinking vessel, thus protecting the hand of the holder from spillage.
US12048385B2
The present disclosure is directed to biodegradable cutlery, and more specifically to spoons, forks, and knives. The biodegradable cutlery includes a plurality of recesses disposed on the handle forming a rib to resist twisting and bending. An indentation may be disposed along a neck of the cutlery to enhance stability further.
US12048381B2
A pop up cover for a crib is provided for providing a safe, comfortable and isolated environment for a child in a crib. The pop-up cover may be made of breathable fabric panels having an integrated frame, for example a flexible frame, which can be folded (collapsed) on itself, for example when folded in specific ways if appropriate force is applied and which keeps the fabric in a taught, open position when unfolded (preventing the panels form falling inwards onto each other). The pop up cover can be lightweight and compact, quick and easy to set up, dark inside and breathable.
US12048370B2
A manual toothbrush, having a front side and a back side, includes a disposable head comprising a head material and a reusable handle comprising a handle material that is different from the head material. The head is to be repeatedly attached to and detached from the handle by being moved relative to the handle in a direction substantially parallel to a longitudinal axis. The head includes a head material having a head-material density, and the handle includes a handle material having a handle-material density, wherein the handle-material density is greater than the head-material density. The toothbrush is structured and configured so that when the toothbrush is placed on its back side on a substantially planar surface, the toothbrush remains on its back side in a balanced position—and when the toothbrush is thereafter moved out of said balanced position, the toothbrush automatically returns to the balanced position.
US12048366B2
To provide a refill insert that makes it possible to easily replace a molded cosmetic, such as lipstick, that is housed in a container body. A refill insert 1 that is characterized in that an engagement piece 2 that can elastically deform toward the inside is provided to an outer side surface of an insert that holds a lower end of a molded cosmetic 5 and in that a first engagement protrusion 3 and a second engagement protrusion 4 are provided to an outer side surface of the engagement piece at different heights.
US12048360B2
A composite case for an electronic device is provided. The composite case includes: a resilient portion dimensioned to cover two end portions of the electronic device and less than half of a back portion of the electronic device; and a rigid portion dimensioned to fit with the resilient portion, the rigid portion dimensioned to provide a cover for at least part of the back portion of the electronic device. A method of protecting an electronic device is provided. The method includes: attaching a rigid material to a resilient material; dimensioning both the rigid material and the resilient material to contain an electronic device; configuring the rigid material, but not the resilient material, to cover most or all of a back portion of the electronic device; and providing an opening to allow a screen portion of the electronic device to be accessed through the opening in the rigid and resilient material.
US12048353B2
A footwear construction includes a sole assembly having a midsole of a first durometer and a plurality of separate, individually reactive lugs of a second, greater durometer bonded to the midsole. On soft terrain, the individual lugs can remain extended and can engage that terrain to provide grip and traction. On hard terrain, the individual lugs can independently compress into deformation regions of the midsole to enhance traction, so that the midsole also can optionally contact the terrain with portions of the lugs. The sole assembly can include a fabric embedded and encapsulated in the materials of the lugs and the midsole to mechanically bond the lugs to the midsole and impair delamination. The individual lugs can include caps extending into the midsole with voids filled with the midsole material to improve the lug securement. A related method of manufacture also is provided.
US12048352B2
Shoe which has a band-like device which extends from the upper shaft end to the shoe base on one inner side of the shoe and extends from the shoe base in the direction of the upper shaft end on the opposite inner side of the shoe, wherein the band-like device is designed to exert pressure on a foot arranged in the shoe.
US12048342B2
A swim cap and a method for producing the same is disclosed. A lower portion of the swim cap is shaped as a band, and an upper portion is dome shaped. Stitching joins the lower portion to the upper portion along a horizontal seam. At least two pieces of the lower portion, and a first and second piece of the upper portion, are joined to one another with stitching along a first vertical seam. The second and a third piece of the upper portion are joined to one another with stitching along a second vertical seam. The lower and upper portions are comprised of a substantially waterproof material.
US12048340B2
A dual band adjustable belt loop fastening device configured to extend between two or more belt loops on a garment and to selectively lessen the distance there between the belt loops to secure the waistline of a garment to a wearer and that is also configured to affix/attach items such as holsters, smartphones, or tools thereon or therein while in use.
US12048328B2
An optical module includes a light-emitting portion for emitting light and a display including a first surface having a first transmission region through which at least a portion of the light emitted from the light-emitting portion is transmitted and a first blocking region which is surface-treated to block transmission of the light, and a second surface which the light transmitted through the first transmission region reaches to deliver an image to a user, wherein the first transmission region may include a path changing member for changing a propagation path of the transmitted light.
US12048323B2
The invention relates to a casting apparatus (100) to cast a sheet (50) of a material containing alkaloids, the casting apparatus including: ⋅ a casting box (10) adapted to contain a slurry (18) to be cast to form the sheet, the casting box defining an inner volume; ⋅ a slurry supply element (5) defining a supply channel (15) adapted to feed the slurry along a supply direction in the inner volume of the casting box from an inlet (90), the supply direction forming an angle with a horizontal plane comprised between about −45 degrees and about +45 degrees; ⋅ a movable support (2); ⋅ and a casting element (1) adapted to cast the slurry contained in the casting box onto the movable support so as to form the cast sheet. The invention also relates to a method to cast a sheet of a material containing alkaloids.
US12048319B2
A food composition in the form of a water-in-oil-in water emulsion including water; an oil phase including vegetable oil and a water-in-oil emulsifier including fat crystals; oil-in-water emulsifier, not being egg yolk; egg yolk.
US12048318B2
Sugar substitute compositions comprise natural ingredients that provide added human health benefits and properties and characteristics of sugar, without the caloric content and glycemic index of sugar. Unlike artificial sweeteners, the sugar substitute compositions contain no chemicals or synthetic additives and taste and function like sugar. Specifically, the sugar substitute compositions comprise digestion resistant soluble fiber comprising an oligosaccharide matrix of glucose and/or fructose oligomers, which yield the sugar substitute digestion resistant property and allow it to simultaneously enhance the growth of beneficial bacteria in the human gut. In one particular embodiment, the sugar substitute comprises a digestion resistant soluble fiber, Luo Han Guo extract, and a flavor masking agent comprising Oryza sativa (rice) extract. In another embodiment, the sugar substitute comprises a digestion resistant soluble fiber, Luo Han Guo extract, a flavor masking agent comprising Oryza sativa (rice) extract, and a steviol glycoside.
US12048307B2
The present specification discloses a composition comprising, consisting essentially of, or consisting of hypochlorous acid or free available chlorine and one or more disinfectants, a composition comprising, consisting essentially of, or consisting of hypochlorous acid or free available chlorine, one or more disinfectants and one or more surfactants, a composition comprising, consisting essentially of, or consisting of hypochlorous acid or free available chlorine and one or more surfactants, a composition comprising, consisting essentially of, or consisting of one or more guanide-containing compound and one or more alcohols, kits comprising, consisting essentially of, or consisting of a disclosed composition, as well as methods and uses to clean, disinfect and/or sterilize a device using such compositions, methods and uses to clean, disinfect and/or sterilize a surface area using such compositions, methods and uses to clean, disinfect and/or sterilize a microbial infection in an individual using such compositions.
US12048302B2
Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula and being therein impregnated with a cryopreservation medium. The needle cannula or other device can be received in a capsule and/or other container, which in some forms can contain additional amounts of the cryopreservation medium occurring external of the lumen. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.
US12048293B2
A wildlife exclusion system for railway tracks is provided which includes an exclusion arrangement positioned to span across the railway tracks at a location along a length of the railway tracks. The exclusion arrangement extends generally perpendicular to the railway tracks and has a series of conductive elements spaced apart from each other to form an exclusion are configured to provide an electric shock to wild animals when particular conductive elements within the exclusion area are bridged thereby. Methods of installing a wildlife exclusion system and methods of discouraging wild animals from traveling along railway tracks are also provided.
US12048281B2
The present disclosure provides a method for treating rice. The method comprises the steps of: providing a domestic rice crop plant and at least one ACCase-inhibiting aryloxyphenoxypropanoate herbicide selected from the group consisting of quizalofop or an ester thereof, haloxyfop, fluazifop or an ester thereof, clodinafop, clodinafop-propargyl, diclofop, and diclofop-methyl; applying an effective amount (measured in g AI/Ha) of the at least one aryloxyphenoxypropanoate herbicide to the domestic rice crop plant, post-emergence; thereby creating a treated rice plant; and growing the resulting treated rice plant.
US12048269B2
A harvesting system includes a header pivotally attached to a combine. The header includes a center section to which a left wing and right wing are pivotally attached. A suspension system of the harvesting system includes first and second engageable states that enable dynamic wing behavior and reduce structural load. The first state corresponds to a harvesting configuration of the header in which the wings are allowed to pivot to allow the header to follow changes in terrain. The second state corresponds to a configuration in which the header is elevated relative to the ground. In the second state, the ability of the wings to pivot is minimized as compared to the first state, which allows the header to be maintained in a substantially flat configuration while minimizing the amount of dynamic load imparted by the header on the combine during non-harvesting transport of the header.
US12048268B2
A method and system for fostering controlled growth of a turfgrass in a target area, includes: providing an autobot capable of automatically applying a UVC light treatment to the target grass area, wherein the target grass area comprises C4 turfgrass. The method and system includes coupling a UVC light subsystem to the autobot such that the UVC light subsystem is suspended above the C4 turfgrass within the target grass within a first predetermined range. Next, UVC light is generated by the UVC light subsystem with a wavelength within a second predetermined range. Subsequently, the UVC light is emitted from the UVC light subsystem to the C4 turfgrass at an intensity within a third predetermined range. And the UVC light is moved across the C4 turfgrass within the target grass area using the autobot at night at a speed within a fourth predetermined range.
US12048265B2
A system for dispensing low rate agricultural products, includes a syringe-based agricultural product metering system, at least one agricultural product tube, and an agricultural product metering system. The agricultural product metering system is operably connected to a source of low rate agricultural products. The agricultural product tube is operatively connected to the agricultural product metering system. The agricultural product metering system is configured to dispense liquid low rate agricultural products at a low rate defined as below 3.7 fluid ounces per 1000 row feet.
US12048259B2
An articulating tongue arrangement includes a vehicle attachment section enabling attachment of the articulating tongue arrangement to a tow vehicle, an implement attachment section enabling attachment of the articulating tongue arrangement to an agricultural implement, and an articulating beam assembly located between the vehicle attachment section and the implement attachment section. The articulating beam assembly includes, in turn, a leading end portion movably coupled to the vehicle attachment section at a leading pivoting joint, a trailing end portion movably coupled to the implement attachment section at a trailing pivoting joint, and a beam assembly actuator coupled between the leading end portion and the trailing end portion of the articulating beam assembly. The beam assembly actuator is controllable to adjust an effective tow length of the articulating beam assembly, as measured along a straight line extending from the leading pivoting joint to the trailing pivoting joint.
