US12188309B2
A control line clamp includes a clamping element for retaining one or more control lines alongside a pipe; a first collar; and a second collar. The clamping element is arranged to be attached to the pipe by positioning the first and second collars around the pipe on opposing sides of the clamping element and moving the first and second collars relatively towards each other in an axial direction.
US12188307B2
What is provided is a method and apparatus wherein a swivel can be detachably connected to an annular blowout preventer thereby separating the drilling fluid or mud into upper and lower sections and allowing the fluid to be displaced in two stages, such as while the drill string is being rotated and/or reciprocated. In one embodiment the sleeve or housing can be rotatably and sealably connected to a mandrel. The swivel can be incorporated into a drill or well string and enabling string sections both above and below the sleeve to be rotated in relation to the sleeve. In one embodiment the drill or well string does not move in a longitudinal direction relative to the swivel. In one embodiment, the drill or well string does move longitudinally relative to the sleeve or housing of the swivel.
US12188301B2
A fixed cutter drill bit may include a bit body defining a bit axis and having a plurality of blades extending therefrom. A plurality of cutters are secured to the blades at different circumferential positions relative to the bit axis. Each cutter may define a cutter sweep profile as the bit body rotates about the bit axis. One or more of the cutters may form overlapping cutter sweep profiles to define a kerf therebetween. The cutters include a shaped cutter comprising a cutting face and a shaped portion on the cutting face aligned for engaging and removing the kerf.
US12188294B2
A multi-layer laminate includes a glass panel unit, an intermediate film, and a transparent plate. The transparent plate is assembled to the glass panel unit via the intermediate film. The glass panel unit includes a first and second glass panel, and an evacuated space. The evacuated space is interposed between the first and second glass panel. A method for manufacturing the multi-layer laminate includes a step. The step includes exhausting a gas from a bag, loaded with the glass panel unit, the intermediate film, and the transparent plate, to cause the bag to shrink and thereby assembling, using the bag thus shrunk, the glass panel unit and the transparent plate via the intermediate film. The step includes raising a pressure inside the bag from a pressure at an initial stage of heating while increasing a temperature of the intermediate film to a predetermined temperature at which the intermediate film softens.
US12188285B2
A vehicle door hinge device may include a case set diagonally provided toward an outside of a vehicle body at a location of the vehicle body corresponding to an end portion of a door, and including a slide case slidable with respect to a main case, a sliding arm provided on the slide case, and pivotally connected to a door hinge bracket fixed to the end portion of the door in an outside of the slide case, and a driving unit including first and second screws that are motor-driven and disposed in an interior of the main case in a longitudinal direction of the main case to be coupled to the slide case and the sliding arm, respectively, and configured to simultaneously slide the slide case and the sliding arm with respect to the main case.
US12188282B2
A system for adjusting a vehicle door relative to a vehicle body including an electromotive adjusting device, a control device configured to control the adjusting device and receive an operating command and control the adjusting device based on the receipt of the operating command for adjusting the vehicle door. A sensor device for detecting an object, the control device configured for collision protection monitoring, in order to recognize an object detected by the sensor device in a recognition area as a collision obstacle. The control device is configured to limit an adjustment of the vehicle door on recognition of a collision obstacle to an adjustment path dependent on the location of the collision obstacle, in that the control device determines a projection of the collision obstacle and defines the adjustment path in dependence on the projection.
US12188276B2
A latch module for controlling an opening and a closing of a door of an appliance includes a latch, a spring that applies an elastic force to the latch, a motor; and a cam that contacts a contact surface of the latch and is coupled to the motor to drive the cam to pivot the latch. The cam includes a first radius, a second radius, and a third radius in a circumferential direction at an outer circumference of the cam. The latch is positioned at a first basic position when the first radius of the cam contacts the contact surface of the latch, positioned at a second basic position when the second radius of the cam contacts the contact surface of the latch, and positioned at a third basic position when the third radius of the cam contacts the contact surface of the latch.
US12188275B2
A furniture drive includes a main part and an actuator arm rotatably mounted on the main part about a first rotational axis. The actuator arm has multiple levers, and a securing interface arranged on an imaginary securing interface plane and via which the furniture front part can be secured to the actuator arm. The actuator arm can be moved continuously with respect to the first rotational axis between a first rotational position, which corresponds to a closed position of the furniture front part that can be secured to the actuator arm and which can be assigned a rotational angle α of 0°, and a second rotational position, which corresponds to a maximum open position of the furniture front part that can be secured to the actuator arm and which can be assigned a rotational angle α greater than 0°.
US12188271B2
A door holding device is disclosed herein. The device includes a first hinge engagement region and a second hinge engagement region. At least one of the first or second hinge engagement regions includes at least one magnetic element and the device is configured to hold a door in an open state when the at least one magnetic element engages a door hinge plate.
US12188270B2
According to a first aspect of the invention, there is provided a tailpiece attaching arrangement (100) comprising a cylindrical frame (102), a cylindrical attaching member (104) and a locking member (106) wherein the cylindrical attaching member (104) is configured to attach the tailpiece (108) into the cylindrical frame (102), and the locking member (106) is configured to lock the attaching member (104). According to a second aspect of the invention, there is provided a lock arrangement (126) comprising the tailpiece attaching arrangement (100) and a lock cylinder (128).
US12188269B2
A locking device for a lock including a box and a cover, such that the device can be isolated, which box includes therein a motor, a worm screw connected to the shaft of the motor, a locking shaft which is capable of sliding through a hole towards the outside of the box, and an elastic element with two ends, connecting the locking shaft with the worm screw, wherein one end of the elastic element is securely connected to the locking shaft and the other end is inserted between two threads of the worm screw such that, upon activating the motor, the worm screw rotates, moving the elastic element in order to drive the locking shaft, which transitions from being retracted to being extended and vice versa.
US12188266B2
The invention relates to an anti-theft device (100) configured for being attached to merchandise to be protected, in particular textile products, wherein the anti-theft device (100) comprises a housing (102) and a locking mechanism (130), which has a needle (106), wherein the needle (106) is adjustable between a locking position, in which it engages with the merchandise to be protected, and a release position, in which detachment and removal of the anti-theft device (100) from the merchandise to be protected are permitted, wherein the needle (106) has a curved, preferably arcuate shape and is accommodated in the housing (102) when in the release position.
US12188265B2
The egress window assembly uses a three piece window frame design that allows an outer egress frame to be manually separated from the window assembly to provide emergency egress from the vehicle or structure. In addition to the egress window frame, the egress window assembly includes an egress window frame, an interior window frame, an exterior window frame and a release mechanism that detachably secures the egress frame to the exterior window frame. The release mechanism uses rotating handles on the interior window frames and internal slides bars that shift between the locked and unlocked positions that free the egress frame from the egress window assembly.
US12188263B2
An electromagnetic door lock is provided for locking the door of a domestic appliance. The electromagnetic door lock may include a rotating cam that rotates about an axis between an open-door position and closed-door position. The rotating cam may cooperate with a hook fixed to a door of a domestic appliance. A locking device locks the rotating cam in the locking position. The locking device includes an electromagnetic actuator configured for moving a locking pin between a locking position and an unlocking position. A door sensing device includes a door sensing element movable between a first position and a second position that respectively correspond to the open-door position and to the closed-door position of the rotating cam. At least one contactless proximity sensor may detect the locking position of the locking pin.
US12188260B2
The present disclosure provides a lock device with double-unlocking mode comprises a lock box, a lock cover set, a fingerprint unlocking module, and a coded wheel lock set. The lock box has a box and a front cover. The fingerprint unlocking module has a master unit electrically connected with a power, a charging hole, an electric unlocking component, and a fingerprint sensor. The master unit controls the electric unlocking component to lock or to unlock in accordance with sensing results of the fingerprint sensor. When a code of the coded wheel lock set is set correctly, the lock cover set is manually operated to unlock. The fingerprint unlocking module is not used for performing unlocking, the unlocking operation may be manually completed. Indeed, the present disclosure improves the issue that the current electronic lock is not able to be unlocked immediately by normal means in a power failure case.
US12188253B1
A parapet, including a parapet body and a support rod. The parapet body defines a mounting groove passing through a bottom of the parapet body. The support rod extends in an up-down direction. The support rod is detachably fixedly connected in the mounting groove. The support rod includes a socket portion, and the socket portion extends out of a bottom opening of the mounting groove for insertion into a ground.
US12188251B2
Tent couplers include a pivot interlocking member and a bridged interlocking member. The bridged interlocking member comprises a bridge that extends between a tether-receiving portion and a tent support-receiving portion that includes a tent support receiver configured to couple to a tent support. The pivot interlocking member includes a tent fabric receiver configured to couple to a tent fabric. The pivot interlocking member defines a bridge-receiving aperture and an entrance slot interconnected thereto. Tent couplers are selectively configured between a linking configuration and an interlocked configuration. In the linking configuration, the pivot interlocking member is positioned for insertion and removal of the bridge from the bridge-receiving aperture via the entrance slot. In the interlocked configuration, the bridge is positioned within the bridge-receiving aperture, and the pivot interlocking member is oriented within a range of interlocked orientations that restrict removal of the bridge from the bridge-receiving aperture.
US12188248B2
A lighting tower system is provided. The lighting tower system includes a tower positioned in an upright orientation within a bed of a vehicle. The tower includes a base tube section and an upper tube section. The base and upper tube sections include a common longitudinal axis and are arranged to slide relative to one another in a telescoping relationship to move each tower between a retracted position and a fully extended position. The lighting tower system includes a light assembly coupled to and extending from the upper tube section of the tower. The light assembly is configured to rotate with respect to the common longitudinal axis and to tilt with respect to an axis perpendicular to the common longitudinal axis. The lighting tower system includes a mounting configuration configured to attach and detach the tower to the bed of the vehicle in the upright orientation.
US12188239B2
A set of panels including first and second panels. The first and second panels respectively include first and second edges. The first edge includes a locking strip with a locking element configured to cooperate with a locking groove at the second edge for locking the first edge to the second edge. The locking element includes a first locking surface at a first angle from a plane parallel to the first panel surface and the locking groove includes a second locking surface at a second angle from a plane parallel to the third panel surface. The first angle is different from the second angle such that the first locking surface converges towards the second locking surface at a cooperation part in a locked position. The first locking surface cooperates with the second locking surface at the cooperation part.
US12188238B2
Building panels, such as a floor panels or wall panels. The panels including a first mechanical locking system at respective parallel and opposite third and fourth edges, such as long edges, configured to cooperate for horizontal and vertical locking between two adjacent building panels, preferably by means of a folding motion. The panels further including a second locking system at respective parallel and opposite first and second edges, such as short edges, configured to cooperate for horizontal and vertical locking of two adjacent building panels. An upper edge portion of one of the third edge or fourth edge, preferably the third edge, includes a first lower lip portion configured to cooperate with a first upper lip portion of an upper edge portion of the other of the third and fourth edge of an adjacent panel when the third and fourth edges are arranged in locking engagement.
US12188237B2
An adjustable deck shelf assembly has repositionable components to enable the assembly to be secured to variably dimensioned and assembled deck railings. A shelf is secured to a hinged shelf support board with tight dimensional tolerances or with a removable locking shaft in a mechanical interference fit to permit removal and storage of the shelf and assembly. Hinged truss shelf supports secured to support legs can be deployed to support the shelf and retracted for storage. An adjustable deck shelf/seat assembly incorporates variable-height outriggers attached to truss shelf supports and a variable-height shelf support board to enable the assembly to be arranged as a shelf or as a seat. The shelf alternatively may be secured to the deck shelf assembly with slots and hooks.
US12188235B2
A sealing device including a waterproofing layer including at least one thermoplastic elastomer P1 and an outer layer of non-woven fabric directly adhered to at least portion of the second major surface of the waterproofing layer, wherein the outer layer of non-woven fabric including at least one polymer P2. Further, a method for producing a sealing device, to the use of a layer of non-woven fabric including or essentially consisting of polypropylene fibers for reducing blocking of a waterproofing layer including at least one propylene-based thermoplastic elastomer, and to a method for covering a roof substrate using the sealing devices of the present invention.
US12188232B2
A concrete form system includes a concrete form and a rebar tree. The concrete form includes at least one support column disposed at a lower portion of the concrete form and first and second connection branches disposed at an upper portion or the concrete form. The first and second connection branches are configured to be connected to second and first connection branches, respectively, of another concrete form. The first and second connection branches at least partially form one or more channels therebetween. The rebar tree includes a rebar mounting assembly configured to hold one or more pieces of rebar in one or more desired positions. The rebar mounting assembly is configured to be disposed within at least one of the one or more channels at least partially formed by the first and second connection branches.
US12188229B2
A tile, which may be a component of a modular flooring system, includes a plurality of cells on its underside, adjacent cells being interconnected to form two sets of channels parallel to the upper surface and open to the underside of the tile. The tile may have recesses in its upper surface, into which inserts can be pressed to form a decorative pattern. The channels may be used as ducting for cables under the floor surface. The cables can be held in place by clips that bridge between a pair of the cells. The cables may include a lighting cable, which can be arranged to transmit light to the upper surface of the tile through inserts that are translucent.
US12188225B2
The present invention relates to a constructive assembly which allows constructing walls that are not necessarily vertical, allows including ventilated regions, and does not require the use of mortar or adhesives. The resulting construction has a high finish quality and this quality does not depend on the skill of the operator in charge of constructing same. This invention is characterized by the combination of rigid profiles distributed in parallel and blocks configured to be readily inserted between the profiles and attached thereto without requiring additional fixing elements.
US12188217B2
A modular grid comprises a faceplate having at least one front opening and at least two tabs on its periphery, a sleeve configured to abut on the faceplate, and at least two attachments, each attachment being configured for insertion into an opening formed in a corresponding one of the at least two tabs and into a corresponding opening formed on the perimeter of the sleeve. The modular grid may be mounted on an extremity of a conduit, whether at its inlet or outlet side, and be shaped for mating with the extremity of the conduit. A perimeter of the faceplate may be circular, square, oval, rectangular, triangular, pentagonal, hexagonal, or octagonal.
US12188201B2
An excavator including a lower traveling body; an upper turning body turnably mounted to the lower traveling body; a hydraulic actuator configured to drive a driven part including the lower traveling body and the upper turning body; a hydraulic pump configured to supply hydraulic oil to the hydraulic actuator; a motor configured to drive the hydraulic pump; and a power storage device configured to supply power to the motor. The power storage device is mounted at a right front portion of the upper turning body. The hydraulic pump and the motor are mounted at a rear portion of the upper turning body.
US12188197B2
A lift bracket system for lifting a building structure such as a foundation and the like comprising a lift plate having a top surface and a bottom surface, the top surface for insertion under the building structure; a generally cylindrical housing affixed to the lift plate and extending perpendicularly from the top surface and the bottom surface of the lift plate, the housing defining a generally circular opening through the lift plate, the opening being disposed away from the center of the lift plate; and at least one gusset for supporting the lift plate, the gusset having a first end and a second end, the gusset disposed beneath the lift plate, wherein the first end of the gusset is attached to the bottom surface of the lift plate and the second end of the gusset is attached to the housing.
US12188187B2
The invention relates to a guide plate for laterally guiding a rail in a rail attachment point formed on a railroad tie, wherein the guide plate has a top side having a support surface for supporting a spring element, an underside, by way of which the guide plate is supported on the railroad tie during use, a support segment having a support surface, by way of which the guide plate is supported, during use, on a shoulder provided on the railroad tie, and possesses a guide segment which is formed opposite to the support segment, and on which a guide surface is present, on which a rail is laterally guided during use. In order to counteract twisting of the rail and concomitantly the risk of the occurrence of track warping at high outdoor temperatures when using such a guide plate in a rail attachment point, a latch projection is formed in lateral end segments of the guide surface, in each instance, projecting away from the guide surface in the longitudinal direction of the guide plate, which is provided for the purpose of engaging, during use, under the longitudinal side of the rail that is assigned to the guide surface, in each instance, wherein the distance between the latch projections amounts to at least 60% of the width of the guide surface.
US12188181B2
Processes disclosed are capable of converting biomass into high-crystallinity nanocellulose with low mechanical energy input. In some variations, the process includes fractionating biomass with sulfur dioxide or a sulfite compound and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; and mechanically treating the cellulose-rich solids to form nanofibrils and/or nanocrystals. The total mechanical energy may be less than 500 kilowatt-hours per ton. The crystallinity of the nanocellulose material may be 80% or higher, translating into good reinforcing properties for composites. The nanocellulose material may include nanofibrillated cellulose, nanocrystalline cellulose, or both. In some embodiments, the nanocellulose material is hydrophobic via deposition of some lignin onto the cellulose surface. Optionally, sugars derived from amorphous cellulose and hemicellulose may be separately fermented, such as to monomers for various polymers. These polymers may be combined with the nanocellulose to form completely renewable composites.
US12188173B2
The present invention relates to a clothing processing apparatus comprising: a cabinet provided with an inlet; a first chamber provided inside the cabinet to provide a space in which clothes are accommodated and communicating with the inlet; a second chamber provided inside the cabinet and forming a space separated from the first chamber; a supply unit, provided inside the second chamber, for supplying at least any one of air and moisture to the first chamber; a door having a first body rotatably fixed to the cabinet to open and close the inlet, and a second body fixed to the first body to form a front side of the cabinet; a control unit for controlling the supply unit; and a voice recognition unit, provided in the door, for recognizing a voice generated by a user and transmitting a control command corresponding to the recognized voice to the control unit.
US12188170B2
A drying appliance includes a cabinet with a processing chamber operably disposed therein. A blower delivers process air through an airflow path. The airflow path includes the processing chamber. A condensing airflow path has an inlet positioned within a front panel of the cabinet and an outlet positioned within a bottom panel of the cabinet. A condensing blower moves condensing air from the inlet to the outlet. An airflow seal extends downward from a front edge of the cabinet. The airflow seal separates a low-pressure region proximate the inlet from a high-pressure region proximate the outlet to block convection between the outlet and the inlet.
US12188157B2
A process for forming a fiber tow, involves a wet spinning procedure comprising the steps of: dissolving cellulose pulp N in an alkaline aqueous solvent to form a cellulose spin dope composition, spinning the cellulose spin dope composition in a coagulation having a p H of more than 7.0, preferably a pH of at least 10, to produce a fiber tow, and passing the produced fiber tow through a sequence of consecutive stretching and washing steps in which the formed fiber tow is washed with a washing liquid by a counter-current flow washing procedure.
US12188155B2
A spinneret for extruding fibers includes a plate having a proximal surface and a distal surface. The spinneret includes a plurality of holes formed in the plate that extend between the proximal surface and the distal surface of the plate. The holes are spaced from one another, and each hole has a distal end that extends along a central axis. The spinneret has a plurality of contoured entrance zones formed in the proximal surface of the plate, whereby each contoured entrance zone is associated with one of the holes. Each contoured entrance zone extends distally from the proximal surface of the plate to a proximal end of the hole associated therewith. Each contoured entrance zone has substantially no planar or flat surfaces normal to the direction of the central axis of the distal end of the hole associated therewith.
US12188154B2
Method and apparatus for decortication of plant stalks, involving flattening the plant stalk into two substantially planar stalk sides adjoined at their edges; splitting the two substantially planar stalk sides one from the other; bending the flat stalk piece with the hurd on the outside of the bend and bast on the inside of the bend; separating the segments such that the bast pulls away from the hurd and spans the gap between the two segments; bringing a stripper into abutment with the spanning bast and moving the stripper so as to draw the bast, which strips the bast away from the hurd; and removing the bast from the stripper.
US12188142B2
A strengthened component includes a sacrificial material mold of the component having an outer surface, an insert having an inner surface and an outer surface opposite and spaced from the inner surface such that the strengthening insert inner surface abuts the mold outer surface, and a metallic layer deposited over the exposed mold outer surface and the exposed strengthening insert outer surface, where the sacrificial material mold is removed from the strengthened component.
US12188139B2
The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.
US12188136B2
Disclosed is a hypochlorous acid generating electrode that is substantially free from rhodium, which is comparable in performance to a rhodium-containing electrode and is more durable than the rhodium-containing electrode. The electrode to be used for generating hypochlorous acid by electrolyzing water that contains a chloride ion has excellent hypochlorous acid water generation ability and durability, in which the electrode has an electrode substrate comprising titanium or titanium alloy, and a composite layer that is electrically connected with the electrode substrate and that contains iridium or a compound thereof, tantalum or a compound thereof, and ruthenium or a compound thereof and/or platinum, and does not contain rhodium oxide.
US12188124B2
Described herein is a technique capable of suppressing or preventing an inside of a source gas nozzle from being heated to a substrate processing temperature when a source gas is supplied through the source gas nozzle into a reaction tube in which a substrate is accommodated. According to one aspect of the technique, there is provided a substrate processing apparatus including: a reaction tube made of a first material and capable of accommodating a substrate; and a source gas nozzle provided in the reaction tube and at least a part thereof made of a second material whose reflectance is higher than that of the first material and whose surface is rougher than that of the first material by bubbles contained therein, wherein a source gas is supplied through the source gas nozzle.
US12188123B2
A method for depositing an iodine-containing film on a substrate material comprises: exposing the substrate material to a vapor of a film-forming composition comprising an iodine-containing precursor having a formula of CaHxIyFz, wherein a=1-10, x≥0, y≥1, z≥0, x+y+z=a, 2a or 2a+2; provided that when a=1, x=2 and z=0, y is not equal to 2, and depositing the iodine-containing film formed by the iodine-containing precursor on the substrate material through a vapor deposition method. The method further comprises exposing the substrate material to a vapor of a co-reactant nitrogen-containing molecule having a general formula CxHyFzNH, where x=1-6, y=0-13, z=0-13, and a=1-2 or CxHyFzN—R1, where x=1-6, y=0-13, z=0-13, and R1 is a C1-C5 hydrocarbon.
US12188113B2
The present disclosure relates to an austenitic stainless steel contains C≤0.10 mass %, Si≤0.50 mass %, 3.0≤Mn≤8.0 mass %, P≤0.30 mass %, S≤0.30 mass %, 7.0≤Ni≤12.0 mass %, 18.0≤Cr≤28.0 mass %, 1.0≤Mo≤3.0 mass %, 0.03≤V≤0.50 mass %, 0.0003≤B≤0.0300 mass %, 0.0001≤Ca≤0.0300 mass %, 0.35≤N≤0.80 mass %, W≤2.0 mass %, Zr≤0.20 mass %, Cu≤0.5 mass %, Al≤0.10 mass %, and O≤0.050 mass %, with a balance being Fe and unavoidable impurities. The austenitic stainless steel has a number density of coarse alloy carbonitrides of 3×105 pieces/mm2 or less.
US12188102B2
A method for manufacturing a recovered steel sheet having an austenitic matrix presenting at least one mechanical property (M) equal or above a target value Mtarget is provided. The method includes a calibrating process involving heat treatments on at least 2 samples of the steel, corresponding to Pareq values P, submitting said samples to X-ray diffraction so as to obtain spectrums including a main peak whose width at mid height FWHM is being measured, measuring a mechanical property (M) of said samples, measuring a recovery or recrystallization state of each sample, drawing a curve of M as a function of FWMH in a domain where the samples are recovered from 0 to 100%, but not recrystallized. The method further includes calculating a FWHMtarget corresponding to a target mechanical property Mtarget, determining a pareq value Ptarget of the heat treatment to perform to reach Mtarget and selecting a time ttarget and a temperature T°target corresponding to the Ptarget value. The method further includes feeding a recrystallized steel sheet having a Mrecrystallization, cold-rolling the recrystallized steel sheet in order to obtain a steel sheet having a Mcold-roll and annealing the cold rolled steel sheet at a temperature T°target during a time ttarget.
US12188098B2
This invention provides a kit or a device for the detection of pancreatic cancer, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting pancreatic cancer, comprising measuring the miRNA(s) in vitro.
US12188096B2
Disclosed herein is a clear cell renal cell carcinoma (ccRCC) biomarker set. Also disclosed herein is a detection system using the biomarker set disclosed herein, methods of determining whether a subject has or shows recurrence of clear cell renal cell carcinoma, method of determining whether a renal mass sample is benign or malignant, method of detecting response of a subject to systemic treatment, and a kit for carrying out the same.
US12188093B2
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.
US12188089B2
Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
US12188085B2
In some embodiments described herein are methods for three-dimensional analysis of a biological sample, comprising migrating a population of spatial probes into the biological sample in each of three dimensions, wherein each spatial probe comprises a targeting domain and a migration domain. Also provided are kits and compositions for use according to any of the methods described herein.
US12188075B2
A microfabricated device defining a high density array of microwells is described for cultivating cells from a sample. The device may be incubated to grow a plurality of cells, which may be split into an analysis portion and a reserve portion. Methods are provided for screening a biological entity of interest using the microfabricated device, for example, for screening phosphate solubilizing bacteria or other bacteria producing acids.
US12188066B2
Provided is a method for resolving an optical isomer from a racemate by using supercritical fluid extraction technology. The method is mainly applied to the separation of a product obtained after enzymatic resolution. Taking a preparation process of D-pantolactone as an example, the key point is to separate D-pantolactone and L-pantolactone from an enzymatic resolution liquid by means of supercritical fluid extraction.
US12188064B2
The invention relates to subtilase variants and detergent compositions comprising the variants, as well as methods of producing the variants and methods for stabilizing a subtilase variant.
US12188062B2
Compositions and methods comprising novel deaminase polypeptides for targeted editing of nucleic acids are provided. Compositions comprise deaminase polypeptides. Also provided are fusion proteins comprising a DNA-binding polypeptide and a deaminase of the invention. The fusion proteins include RNA-guided nucleases fused to deaminases, optionally in complex with guide RNAs. Compositions also include nucleic acid molecules encoding the deaminases or the fusion proteins. Vectors and host cells comprising the nucleic acid molecules encoding the deaminases or the fusion proteins are also provided.
US12188054B2
The present invention relates to novel monooxygenases which are useful in the hydroxylation of aromatic hydrocarbons. They are particularly useful for the production of 1-naththol and 7-hydroxycoumarin from naphthol and 7-Ethoxycoumarin, respectively.
US12188043B2
The present invention discloses a system for targeted gene editing and related uses.
US12188038B2
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of transducing target cells using a device. The device may include at least one continuous channel. The method may include delivering target cells and viral vectors into a transduction region of the channel. After transducing for some incubation time, a flushing solution may be delivered. The method may include collecting transduced cells after the transducing incubation time and the delivering of the flushing solution.
US12188035B2
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
US12188031B2
An expression increasing element comprising a 36 nucleotide DNA sequence that can be used to increase the expression of genes, and in particular to increase the expression of endogenous plant genes, in plants is disclosed. Also disclosed are plants, plant parts, and commodity plant products comprising the expression increasing element along with related methods of using the expression increasing element and plants comprising the expression increasing element.
US12188028B1
The present invention provides methods, computer systems and computer-implemented products for making synthetic regulatory elements, and provides polynucleotide's, transgenic cells, and transgenic organisms (including viruses and viral vectors) produced by these methods. The invention thereby provides regulatory sequences to meet various gene expression objectives, including the ability to stack a plurality of heterologous genes for expression in a single cell, while avoiding gene silencing or reduced expression levels.
US12188027B2
Provided is a vector capable of co-expressing two different target proteins on the microbial surface using two promoters derived from Lactobacillus, and a method of expressing target proteins on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows different foreign proteins to be stably expressed on the surface of the microorganism. Furthermore, provided is a surface expression vector containing the gene pgsA encoding a poly-gamma-glutamate synthetase complex, and a method of expressing a target protein on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows the foreign proteins to be stably expressed on the surface of the microorganism.
US12188022B2
A nucleic acid aptamer specifically recognizing soluble ST2 protein and its application, belonging to the field of variation or genetic engineering, are described. The technical problem addressed includes how to specifically detect sST2 protein. In order to address this technical problem, nucleic acid aptamers of single-stranded DNA with nucleotide sequences are shown in SEQ ID No. 1-10, respectively. SELEX technology, combined with high-throughput sequencing technology and bioinformatics analysis, reduces the rounds of screening and obtains candidate nucleic acid aptamers, and further analyzes its affinity and specificity to obtain a nucleic acid aptamer that specifically recognizes sST2 protein. The nucleic acid aptamer has the characteristics of high specificity, high stability, convenient synthesis, and easy labeling of functional groups, and the like, and may be used for the detection of sST2 protein and the preparation of biosensors, diagnosis and prognosis of cardiovascular diseases and other products.
US12188015B2
Provided are compositions, methods, and kits for CRISPR-based editing of DNA targets by Type I CRISPR-associated (Cas) enzymes.
US12188012B2
Provided herein are compositions that include nucleic acid fragments produced from double-stranded template nucleic acids, such as cell free DNA. The compositions can be used as positive or negative controls for quality of library preparation methods, calibration of an instrument such as a sequencing instrument, and/or a validation for a nucleic acid sequencing test. Also provided are methods for making the nucleic acid fragments.
US12188006B2
Provided is a novel technique for reducing damage and death of microbial cells through a method for producing highly viable dried microbial cells, the method being characterized by subjecting dried microbial cells to an alternating temperature treatment.
US12188005B2
Disclosed herein are modified NK cells, compositions comprising modified NK cells, and methods for treating a tumor or hyperproliferative disease in a subject. In some embodiments, the modified NK cells include NK cells including a heterologous nucleic acid molecule encoding a CD16 protein comprising a valine at amino acid position 158 (CD16-V158), a heterologous nucleic acid molecule encoding a CCR7 protein, or both. In some embodiments, methods include treating a subject with a tumor by administering a composition comprising an anti-cancer monoclonal antibody and administering a composition comprising the modified NK cells to the subject. Also disclosed are methods of making modified NK cells by obtaining a population of NK cells from a subject and transfecting the population of NK cells with a heterologous nucleic acid molecule encoding CD16-V158, a heterologous nucleic acid molecule encoding a CCR7 protein, or both.
US12188004B2
The invention provides methods and compositions for administration of allogeneic lymphocytes as an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells.
US12188001B2
There is provided a connector, for introducing or extracting a material to or from at least one receptacle, comprising a housing extending between a distal end and a proximal end, the housing comprising, at least at one end, a pierceable seal; a hollow needle mounted, at least partially, within the housing between the distal end and the proximal end of the housing, a first end of the hollow needle being connected or connectable to a first corresponding receptacle, and a second end of the hollow needle facing the pierceable seal at an end of the housing; and an actuating mechanism acting on the housing or the hollow needle to enable the hollow needle to pierce the pierceable seal thereby forming a communication through the pierceable seal, such that material is able to transfer through the connector.
US12187994B2
A two-position screw cap culture tube includes a snapping ring on the tube, with a pair of recesses in the snapping ring that provide an aerobic clearance, and a snap groove on the cap. The snap groove engages with the snapping ring when the cap is screwed into a first position that provides a second aerobic clearance between the top of the tube and the cap, to provide an air path and an aerobic culturing system. The snap groove disengages with the snapping ring and the tube is pressed against the underside of the cap to block the air path and provide an anaerobic culturing system.
US12187993B2
An apparatus for maintaining a cell suspension of a biomaterial for a bio 3D printer includes: a body detachably coupled to a syringe; a vent formed inside the body in a longitudinal direction of the syringe; a pipette fixture extending downward from the body and formed in a tapered shape whose outer diameter decreases downwardly; an air discharge port formed inside the pipette fixture, connected to the vent, and communicated into the syringe; a syringe fixing arm protruding from the body in a direction perpendicular to the longitudinal direction of the syringe to surround an upper flange of the syringe and fixed to the syringe; and a pipette coupled to the pipette fixture and having a hollow tapered shape whose inner diameter decreases downwardly and having a lower end positioned in an outlet of the syringe.
US12187991B2
An apparatus for modifying a responsive liquid held in a barrel or other liquid container includes a transducer for producing vibration energy within the audio frequency range in response to an audio signal input and a coupler affixed to the transducer such that vibration energy produced in the transducer is transferred to the coupling device. The coupling device has a pusher end that extends beyond the front plane of the transducer and that contacts and pushes against the barrel wall when the apparatus is tied to the barrel wall. By determining the resonances of the liquid-filled barrel, audio input signals having sufficiently high levels at determined resonant frequencies can be chosen to achieve a maximum response in the liquid contained in the barrel. The apparatus is particularly suited for the sonic aging of whisky.
US12187989B2
A cleaning solution for temporary adhesive for substrates contains: tetrabutylammonium fluoride; dimethyl sulfoxide; and a liquid compound having a solubility parameter of 8.0 or more and 10.0 or less and having a heteroatom. The tetrabutylammonium fluoride is preferably contained at a content of 1 mass % or more and 15 mass % or less in 100 mass % of a total of the tetrabutylammonium fluoride, the dimethyl sulfoxide, and the liquid compound. The dimethyl sulfoxide is preferably contained at a content of 5 mass % or more and 30 mass % or less in 100 mass % of a total of the tetrabutylammonium fluoride, the dimethyl sulfoxide, and the liquid compound.
US12187982B2
A surfactant composition contains: a C12 compound of the following formula (1): where A is an alkylene group having 1 to 3 carbon atoms, x is 1 to 50, and m+n is 9; a C13 compound of the formula (1), where A is an alkylene group having 1 to 3 carbon atoms, x is 1 to 50, and m+n is 10; a C14 compound of the formula (1), where A is an alkylene group having 1 to 3 carbon atoms, x is 1 to 50, and m+n is 11; and a Y compound of the formula (1), where A is an alkylene group having 1 to 3 carbon atoms, x is 1 to 50, and m+n is at least one of 8 or less and 12 or more.
US12187979B2
The disclosure relates to an oximether possessing powerful green fruity anisic banana olfactory properties. The invention furthermore refers to a method of its production, and to fragrance compositions comprising it.
US12187977B2
This invention provides a water-glycol hydraulic fluid comprises from 0.2 to 0.6% by mass of a dimer acid as a fatty acid lubricant, and more than 0.10% by mass and 0.20% by mass or less of a phosphoric acid ester of Formula (1), wherein the sum of the dimer acid and the phosphoric acid ester is more than 0.35% by mass wherein R1 and R2 may be the same or different, each representing a hydrogen atom or a hydrocarbon group having from 1 to 30 carbon atoms, R3 represents a hydrocarbon group having from 1 to 20 carbon atoms, R4 represents a hydrogen atom or a hydrocarbon group having from 1 to 30 carbon atoms, and X1, X2, X3 and X4 may be the same or different, each representing an oxygen atom or a sulfur atom.
US12187974B2
Compositions comprising a) a metal detergent and b) an acid comprising at least one hydrocarbyl-substituted carboxylic acid. The metal detergent comprises at least one alkali metal, alkaline earth metal, or combinations thereof. The weight ratio of the metal detergent a) to the acid b) ranges from 50:1 to 1:10, or 25:1 to 1:10, or 10:1 to 1:10, or 5:1 to 1:7, or 2:1 to 1:3. The compositions may be added to industrial coating or lubricant compositions to reduce corrosion of metal components.
US12187972B1
A treatment process for removing and/or remediating contaminants in a contaminated gas includes flowing a stream of the contaminated gas through a pipeline, treating the flowing stream of the contaminated gas by injecting droplets of a liquid treatment composition containing 35-55 wt % total of one or more hydroxide compounds into the flowing the stream of the contaminated gas in the pipeline such that the liquid treatment composition mixes into the contaminated gas in the flowing stream and remediates contaminants in the contaminated gas, injecting water into the mixed flowing the stream of the contaminated gas and the liquid treatment composition in the pipeline downstream of where the liquid treatment composition is injected into the pipeline, and separating the flowing stream of the treated contaminated gas from any remaining amount of the liquid treatment composition, the water and the precipitates in a separator.
US12187959B2
A polymer composition has been developed that comprising an oil-in-water emulsion comprising an aqueous phase comprising water and an emulsifying surfactant having a cloud point of less than 80° C. and a hydrophilic-lipophilic balance (HLB) of greater than or equal to 8, and an oil phase comprising a high molecular weight oil-soluble polymer, wherein the oil-soluble polymer comprises a copolymer derived from reaction of a hydrophobic monomer and an ionizable monomer in a weight ratio from about 999:1 to about 80:20. Methods of using the compositions for drag reduction and corrosion inhibition are also disclosed.
US12187951B2
A thermal interface material for forming a layer conformable between a first heat transfer surface and an opposing second heat transfer surface to provide a thermal pathway therebetween includes: a matrix material composing 10 wt. % or less of the thermal interface material; a filler dispersed in the matrix material composing at least 80 wt. % of the thermal interface material, the filler including: particles of a first material having a nominal dimension in a range from 1 micron to 100 microns, the first material composing at least 40 wt. % of the thermal interface material; and diamond particles having a nominal dimension of 1,000 nm or less, the diamond particles composing 0.5 wt. % to 5 wt. % of the thermal interface material.
US12187944B2
A liquid-crystal (LC) medium which is based on a mixture of polar compounds and is substantially dielectrically neutral, its use for optical, electro-optical and electronic purposes, in particular as optical retarder or optical compensator in LC displays, an optical retarder or optical compensator containing the LC medium, an optical, electrooptical or electronic device containing the optical retarder or optical compensator, and a process of manufacturing the optical retarder or optical compensator.
US12187930B2
The present application relates to a cross-linkable composition. The present application can provide a cross-linkable composition without degradation of cross-linking efficiency while exhibiting conductivity by containing an ionic compound, and its use.
US12187929B2
Curable adhesive free-standing films and adhesive systems comprising such films are provided. In some embodiments, a curable adhesive free-standing film comprises a blend of: a) a first film-forming polymer or oligomer; b) a first species comprising first unsaturated free-radically polymerizable groups, which may be a) or a species other than a); c) a first transition metal cation; d) a reducing agent; and no oxidizing agent. In some embodiments, an adhesive system comprises: I) a first curable adhesive free-standing film as described preceding; and II) a second curable adhesive free-standing film comprising a blend of: e) a second film-forming polymer or oligomer; f) a second species comprising second unsaturated free-radically polymerizable groups, which may be e) or may be a species other than e); and g) an oxidizing agent. In some embodiments, the curable adhesive free-standing films may be pressure sensitive adhesives prior to cure. Methods of use are provided.
US12187898B2
A method for producing a low-cost fully biodegradable disposable straw. Natural plant powder is prepared. Deacetylated konjac gel is prepared. The taro starch-cassava starch is crosslinked. The raw material is stirred and mixed to obtain the mixed raw material, and the mixed raw material is heated. The heated raw material is added to the beverage straw manufacturing unit to obtain a straw crude. The straw crude is cut to obtain several straws. The quality inspection, the disinfection and the packaging of the straw are carried out, and the fully biodegradable straw is obtained, finally.
US12187894B2
The purpose is to provide rubber compositions and pneumatic tires which have reduced changes in hardness over time. The present invention relates to a rubber composition containing a copolymer obtained by copolymerizing an aromatic vinyl compound and a conjugated diene compound, the rubber composition having a heat aging resistance index defined by equation (1) of 10 or less.
US12187893B2
A thermoplastic composition includes: 40 to 75 wt % of a poly(carbonate-siloxane-arylate); 5 to 45 wt % of a poly(carbonate-siloxane) present in an amount effective to provide 0.75 to 7 wt % of siloxane units; 10 to 40 wt % of a polycarbonate homopolymer; 5 to 15 wt % of an organophosphorus compound in an amount effective to provide 0.1 to 1 wt % of phosphorus; and optionally, 0.1 to 10 wt % of an additive composition. The thermoplastic composition has a melt volume flow rate of greater than 6 cm3/10 min. An article molded from the thermoplastic composition has a 2-minute integrated heat release rate of less than or equal to 65 kW-min/m2 and a peak heat release rate of less than 65 kW/m2 and a notched Izod impact resistance of greater than 30 kJ/m2 or greater than 700 J/m2.
US12187882B2
The teachings herein relates to elastomeric particles including 98.5 weight percent or more of an elastomeric ethylene/α-olefin copolymer. The copolymer preferably has a weight average molecular weight of 10 to 2,000 kg/mol. The copolymer preferably has a Mooney viscosity of at least 10 (ML 1+4 at 125° C., ASTM D1646). The particles preferably include 0 to 0.4 weight percent of salts of multivalent metal ions. The salts of multivalent metal ions preferably includes stearates and palmitates of multivalent metal ions. The elastomeric ethylene/α-olefin copolymer preferably is an EPM or an EPDM. The blends including the particles preferably comprise a different elastomer, a filler, or a curing system.
US12187874B2
The invention provides for metal-based flame-retardants that are soluble in flammable or combustible materials and methods for preparation. The flame-retardants of the invention are also effective in reducing the rate of heat, smoke, CO, and CO2 release.
US12187869B2
A polyethylene terephthalate aerogel. There is provided a polyethylene terephthalate (PET) aerogel comprising a porous network of cross-linked recycled PET fibers, wherein the PET aerogel has a thermal conductivity of 0.030-0.050 W/m K. There is also provided a method of forming the PET aerogel.
US12187863B2
Provided is an ethylene-vinyl alcohol copolymer resin composition comprising an ethylene-vinyl alcohol copolymer (X) and a metal compound, wherein the composition satisfies the following formula (1), as an ethylene-vinyl alcohol copolymer resin composition having an excellent gas barrier property in the high humidity environment, particularly an excellent oxygen barrier property in the high humidity environment: ΔA2=A2−A2,0>0 (1) where A2 represents the second virial coefficient when the ethylene-vinyl alcohol copolymer resin composition is subjected to static light scattering measurement using hexafluoroisopropanol as a solvent, and A2,0 represents the second virial coefficient of the ethylene-vinyl alcohol copolymer (X) in the ethylene-vinyl alcohol copolymer resin composition measured in the same manner.
US12187860B2
The present invention addresses the problem of providing; a water absorbent resin powder having a reduced amount of fine powder generated and a reduced amount of fine powder recovered; and a production method for the water absorbent resin. The production method of the present invention includes a drying step and a fine powder granulation step. The drying step is for obtaining a dried polymer by drying a particulate water-containing gel crosslinked polymer which is obtained using an acid group-containing unsaturated monomer as a main component. The fine powder granulation step is for obtaining a fine powder granulated product by adding a binder and an adhesion control agent to a fine powder made of a water absorbent resin. In this production method, the obtained fine powder granulated product is recovered in the drying step or in any step before the drying step.
US12187856B2
Provided herein is technology relating to depolymerization of polymers and particularly, but not exclusively, to methods and systems for de-crosslinking polyacrylate salt-based polymers and other polymers and compositions made from de-crosslinking polyacrylate salt-based polymers and other polymers.
US12187852B1
Oligomers that contain an ethylenically unsaturated group, a silane group, and an aspartate group and/or hydantoin group are described. Also disclosed are methods for producing and using such compounds, such as their use in coating compositions, such as coating compositions suitable for application to optical glass fiber substrates.
US12187851B2
The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.
US12187849B2
A flame-retardant polyimide molding material and a molded article including the flame-retardant polyimide molding material, where the flame-retardant polyimide molding material includes a semi-aromatic polyimide resin (A) and carbon fiber (B), and the flame-retardant polyimide molding material includes 15 to 80 mass % of the carbon fiber (B).
US12187843B2
Thermosetting resin compositions useful for liquid compression molding encapsulation of a reconfigured wafer are provided. The so-encapsulated molded wafer offers improved resistance to warpage, compared to reconfigured wafers encapsulated with known encapsulation materials.
US12187837B2
An aqueous dispersion of a capsule composed of a polymeric shell surrounding a core, the core containing an amine blocked isocyanate, the amine blocked isocyanate comprises at least two isocyanate groups blocked by a blocking group, the blocking groups are independently from each other represented by a secondary amine. The aqueous dispersion is suitable as reactive binder chemistry in coatings and inks.
US12187835B2
The present invention relates to a process for preparing a catalyst for olefin polymerization. Specifically, the present invention relates to a process for preparing a supported metallocene catalyst capable of enhancing the operational stability during olefin polymerization by treating the supported metallocene catalyst with an antistatic agent. In the process for preparing a supported metallocene catalyst according to the embodiment of the present invention, it is possible to enhance the operational stability during olefin polymerization by treating the supported metallocene catalyst with an antistatic agent in an improved method.
US12187828B2
A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.
US12187818B2
Provided are a chitin-based superabsorbent materials and method of preparation thereof. The superabsorbent material comprises chitin crosslinked by an epoxy crosslinker, and guanidine attached to the crosslinked chitin. The preparation method includes dissolving chitin in an aqueous solvent to form a solution; reacting the dissolved chitin with an epoxy crosslinker and guanidine, or a salt thereof, thereby forming a hydrogel; and drying the hydrogel.
US12187817B2
The preparation of water dispersible ceramide conjugates and derivatives of sphingolipid analogues is described. The conjugates and analogues are prepared by reacting a succinimidyl carbonate of a β-Ala derivative with the primary amine of a functionalised spacer. Despite their dispersibility in water, the ceramide conjugates and derivatives of sphingolipid analogues spontaneously incorporate in to the plasma membranes of cells.
US12187811B2
Provided are a cyclic peptide compound simulating a natural product structure and a method for preparation thereof. The method is: the compound of formula I, a divalent palladium catalyst, and a silver salt undergoing an intramolecular arylation in a solvent under heating and stirring to construct a cyclic peptide, to generate the compound of formula II, in which the arylation sites are diverse, and can be extended to the side chain γ-position methyl or methylene of the majority hydrophobic amino acids to perform intramolecular arylation, thus overcoming the previous defect of the restriction of the types of selectable amino acids, and effectively constructing a novel aromatic ring-supported cyclic peptide compound. The aromatic ring support structure forms a novel 3D structure similar to a natural product, and provide a very favorable support for the subsequent construction of a cyclic peptide molecular library and high-throughput drug screening.
US12187797B2
Provided herein are antibodies that bind signal regulatory protein gamma (SIRPγ), as well as SIRPα and/or SIRPβ1, and methods of using such antibodies (referred to as SIRP antibodies). In some embodiments, the SIRP antibodies are human monoclonal antibodies that bind human SIRPγ as well as SIRPα and/or SIRPβ1. In some embodiments, the SIRP antibodies provided herein are useful for treating a disease or condition associated with overactivation and/or hyperproliferation of lymphocytes, myeloid cells, or a combination thereof, or a disease or condition associated with SIRPα, SIRPβ1 and/or SIRPγ activity.
US12187796B2
The present disclosure provides binding agents, such as antibodies, that specifically bind ILT3, including human ILT3, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.
US12187790B2
The present disclosure relates to compositions for treating interleukin 5 (IL-5) mediated diseases, and related methods.
US12187781B2
The present disclosure provides variant major histocompatibility complex class II (MHCII) beta chains, as well as heterodimers and multimers including MHCII alpha chains and the variant MHCII beta chains. Also provided by the present disclosure are nucleic acids, expression cassettes, and expression vectors encoding the MHCII beta chains. The heterodimers and multimers of the present disclosure have a higher affinity for CD4 co-receptors than comparable reagents including wild type MHCII beta chains, and therefore are advantageous for use in methods of phenotyping or activating CD4+ T cells.
US12187772B2
The present disclosure relates to IL10 agonists with improved anti-tumor therapeutic efficacy and uses thereof. Certain IL10 agonists disclosed herein comprise an IgG Fc domain, a linker moiety, and an IL10 moiety.
US12187771B2
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.
US12187768B2
Provided are a promoter polynucleotide, a signal polypeptide and a polynucleotide encoding the signal polypeptide, and use thereof. A vector and a host cell each including the promoter polynucleotide and the polynucleotide encoding the signal polypeptide may efficiently express and/or extracellularly secrete a foreign protein.
US12187763B2
An affinity chromatography resin comprising an anti-tissue factor antibody or antigen-binding fragment thereof attached to a base resin, and methods of using the same.
US12187757B2
The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
US12187756B2
The present invention relates to a synthetic saccharide of general formulate (I) that is related to Clostridium difficile PS-II cell-surface polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Clostridium difficile. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Clostridium difficile bacteria.
US12187753B2
The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
US12187752B2
Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.
US12187751B2
Provided are organometallic compounds as both sensitizer and as acceptor. Also provided are formulations comprising these organometallic compounds. Further provided are OLEDs and related consumer products that utilize these organometallic compounds.
US12187743B2
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
US12187727B2
Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I: or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.
US12187725B2
The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
US12187709B2
A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.
US12187706B2
The present invention provides compounds of Formula (I): Formula (I) wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).
US12187705B2
The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
US12187704B2
Certain antiviral compounds, pharmaceutical compositions, and methods related thereto are disclosed.
US12187702B2
The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 and R3 are each independently hydrogen or an optionally substituted hydrocarbyl group, or R1 and R3 together with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and R2 is a cyclic group substituted at the position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
US12187694B2
Provided herein are inhibitors of SLC26A3, which is an anion (Cl−, HCO3−, oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.
US12187689B2
The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
US12187675B2
The disclosure concerns a process to perform a reaction of alkane transformation into olefins, said process comprising the steps of (a) providing a stream of light alkane-comprising feedstock with one or more alkanes and one or more oxidants selected from CO2 and/or COS; and providing at least one fluidized bed reactor comprising at least two electrodes and a bed comprising particles; (b) putting the particles of the bed in a fluidized state to obtain a fluidized bed; and (c) heating the fluidized bed to a temperature ranging from 600° C. to 1500° C. to conduct the reaction; the process is remarkable in that the step c) is performed by passing an electric current through the fluidized bed; the particles of the bed comprise electrically conductive particles, and in that, at least 10 wt. % of the particles are electrically conductive particles and have a resistivity ranging from 0.001 to 500 Ohm·cm at 800° C.
US12187673B2
An integrated apparatus for hydrogenating olefins wherein the hydrogen stream is generated from the electrolysis of water is described. Water is derived from a first reaction step wherein a first feed stream comprising oxygenated hydrocarbons is reacted to produce a first reacted product stream comprising olefins and a second reacted product stream comprising water. The second reacted product stream is electrolyzed to produce an electrolyzer product stream comprising hydrogen. Hydrogen is used to hydrogenate olefins. A paraffin stream can be obtained from the hydrogenated effluent.
US12187667B2
Disclosed is a preparation system and a preparation method for high-quality xylitol crystals. The preparation system comprises a blending tank, a heat exchanger, a decolorization tank, an ion exchange system, a microporous filter, a first evaporator, a first crystallization kettle, a first centrifuge, a fluidization drying bed, a xylitol dissolution tank, a second evaporator, a second crystallization kettle, a second centrifuge, a hot air drying tank, and a cold air fluidization bed sequentially connected through pipelines. Liquid outlet of the first centrifuge is connected with first inlet of the blending tank. Liquid outlet of the second centrifuge is connected with first inlet of the xylitol dissolution tank. The blending tank is provided with second inlet for receiving xylitol hydrogenation solution. The xylitol dissolution tank is provided with water inlet for pure water. The material output from a product outlet of the cold air fluidization bed is xylitol crystal product. First prepared xylitol crystals are redissolved and recrystallized to prepare xylitol crystals with higher pH and better flavor.
US12187651B2
In a silicon nitride sintered body including silicon nitride crystal grains and a grain boundary phase, dislocation defect portions exists inside at least some of the silicon nitride crystal grains. A percentage of a number of the at least some of the silicon nitride crystal grains among any 50 of the silicon nitride crystal grains having completely visible contours in any cross section or surface of the silicon nitride sintered body is not less than 50% and not more than 100%. It is favorable that a plate thickness of the silicon nitride substrate, in which the silicon nitride sintered body is used, is within the range not less than 0.1 mm and not more than 0.4 mm. The TCT characteristics can be improved by using the silicon nitride substrate in the silicon nitride circuit board.
US12187645B2
Chemical-resistant polymer concrete and methods of use thereof are described herein. The polymer concrete comprises a polymer layer and aggregates. The polymer layer is formed by reacting an epoxy vinyl ester resin promoted with cobalt and catalyzed by a peroxide. A concrete substrate is formed by layering the polymer layer and aggregates in thin alternating layers until a desired thickness is achieved. This layering method can reduce shrinkage of the concrete, thereby preventing cracking, deformation or debonding.
US12187644B2
Glasses containing silicon dioxide (SiO2) and/or boron oxide (B2O3) as glass formers and having a refractive index nd of greater than or equal to 1.80, as measured at 587.56 nm, a density of less than or equal to 5.5 g/cm3, as measured at 25° C., and a high transmittance to, particularly to blue light, are provided. Optionally, the glasses may be characterized by a high transmittance in the visible and near-ultraviolet (near-UV) range of the electromagnetic spectrum and/or good glass forming ability.
US12187642B2
The invention relates to a method for manufacturing insulation products based on mineral wool bound by an organic binder, comprising the following successive steps: (a) providing mineral wool at room temperature, (b) applying, to the mineral wool, an aqueous thermosetting binder composition, (c) drying the mineral wool impregnated with the aqueous thermosetting binder composition to obtain thermosetting mineral wool, (d) shaping the thermosetting mineral wool, and (e) heating the shaped thermosetting mineral wool at a temperature for long enough to enable the constituents of the binder to be condensed and an insoluble binder to be formed.
US12187640B2
[Problem] To provide glass having a colored layer. [Solution] Glass having a colored layer.
US12187638B2
A chemically toughened glass article is provided that has a thickness (t) of equal to or less than 0.4 mm, a first surface, a second surface, and a compressive stress region that is defined by a compressive stress (CS) of at least 100 MPa and at least one edge connecting the first surface and the second surface. The at least one edge has at least one chamfer with a chamfer width (A) and a chamfer height (B). The chamfer has a ratio of chamfer width/chamfer height (A/B) of between 1.5-20 and the chamfer has a ratio of chamfer width/glass thickness (A/t) of at least 0.5.
US12187637B2
An apparatus and a method for continuously manufacturing tempered glass are provided. The tempered glass is continuously manufactured by transferring the raw glass in one direction, spraying a boiled potassium nitrate solution to the raw glass to reinforce the raw glass, and recovering and reusing the potassium nitrate solution from the raw glass. This invention can reduce the time to manufacture tempered glass since you can manufacture tempered glass consecutively, and the cost of purchasing potassium nitrate solutions can be reduced, which has an economic advantage. Since the raw glass is preheated, strengthened and annealed by divided sections of preheating, strengthening and annealing section in one furnace, it is less likely that impurities will be attached to the raw glass due to low external exposure during each process movement, thus preventing deterioration of quality.
US12187633B2
To solve problems of frequent occurrence and great harm of membrane fouling during MBR wastewater treatment process, the invention proposes a membrane fouling intelligent early warning method to realize online and accurate early warning of membrane fouling. This early warning method achieves accurate prediction of water permeability by constructing soft-computing model based on recurrent fuzzy neural network. The intelligent early warning of membrane fouling is achieved by the comprehensive evaluation method, which solves the problem that membrane fouling is difficult to be early warning in the MBR wastewater treatment process, improves the pretreatment ability of membrane fouling, reduces the damage caused by membrane fouling, ensures the safe operation of MBR wastewater treatment process, and promotes efficient and stable operation of MBR wastewater treatment plant.
US12187620B2
The invention is directed to kits, compositions, tools and methods comprising a cyclic industrial process to form biocement. In particular, the invention is directed to materials and methods for decomposing calcium carbonate into calcium oxide and carbon dioxide at an elevated temperature, reacting calcium oxide with ammonium chloride to form calcium chloride, water, and ammonia gas; and reacting ammonia gas and carbon dioxide at high pressure to form urea and water, which are then utilized to form biocement. This cyclic process can be achieved by combining industrial processes with the resulting product as biocement. The process may involve retention of calcium carbonate currently utilized in the manufacture of Portland Cement.
US12187618B2
A silica particle dispersion liquid includes a silica particle that satisfies (i) to (iii) below: (i) an average particle diameter d is 5 to 300 nm; (ii) an occlusion amount of a basic substance per 1 g of the particle is 2 mg or more; and (iii) a Sears number Y exceeds 12.0.
US12187612B2
Hydrogen generation assemblies and methods are disclosed. In one embodiment, the method includes receiving a feed stream in a fuel processing assembly, and heating, via one or more burners, a hydrogen generating region of the fuel processing assembly to at least a minimum hydrogen-producing temperature. The method additionally includes generating an output stream in the heated hydrogen generating region of the fuel processing assembly from the received feed stream, and generating a product hydrogen stream and a byproduct stream in a purification region of the fuel processing assembly from the output stream. The method further includes separating at least a portion of the carbon dioxide gas from the byproduct stream to generate a fuel stream having a carbon dioxide concentration less than the byproduct stream, and feeding the fuel stream to the one or more burners.
US12187611B2
In a process for the separation of a mixture containing hydrogen and carbon monoxide to produce gaseous hydrogen, the mixture is cooled down to a temperature below −180° C. and then separated at a temperature below −100° C. to produce a gas enriched in hydrogen and a fluid enriched in carbon monoxide, at least a part of the gas enriched in hydrogen is sent to a pressure swing adsorption separation apparatus operating at a temperature above 0° C. to produce a gas rich in hydrogen at a pressure of at least 20 bars, and at least a part of the gas rich in hydrogen is cooled in the heat exchanger down to a temperature below −100° C., reduced in pressure in a turbine down to a pressure of at least 8 bars and reheated in the heat exchanger to constitute a product rich in hydrogen at a pressure of at least 8 bars.
US12187607B2
A method of manufacturing a semiconductor substrate according to an embodiment includes a first step of forming a groove having a bottom surface and a side surface on which scallops are formed by performing a process including isotropic etching on a main surface of a substrate, a second step of performing at least one of a hydrophilic treatment on the side surface of the groove and a degassing treatment on the groove, and a third step of removing the scallops formed on the side surface of the groove and planarizing the side surface by performing anisotropic wet etching in a state where the bottom surface of the recess is present.
US12187599B2
Described embodiments include a microelectromechanical system (MEMS) array comprising a first MEMS device that includes a first movable electrostatic plate elastically connected to a first structure, the first movable electrostatic plate having a first mass, a first fixed electrostatic plate, and a first drive circuit having a first drive output coupled to the first fixed electrostatic plate. There is a second MEMS device that includes a second movable electrostatic plate elastically connected to a second structure, the second movable electrostatic plate having a second mass that is different than the first mass, a second fixed electrostatic plate, and a second drive circuit having a second drive output coupled to the second fixed electrostatic plate.
US12187598B2
An actuator device includes a support part, a first movable part, and a second movable part. The second movable part includes a pair of first connection portions positioned on both sides of the first movable part on a first axis and connected to a pair of first connecting parts, a pair of second connection portions positioned on both sides of the first movable part on a second axis and connected to a pair of second connecting parts. An outer edge of the second connection portions includes a protrusion portion protruding in a second axis direction. The outer edge of the protrusion portion includes a linear portion extending in a first axis direction and a pair of curved portions positioned on both ends of the linear portion.
US12187596B2
A beer dispensing faucet is configured to be attached to a shank connector. The shank connector has a connecting member and an internal passageway having an outlet opening positioned within the connecting member. The dispensing faucet has a housing defining a central conduit having an inlet opening and an outlet opening. The housing defines a valve seat in the central conduit and further has an aperture in communication with the central conduit. The inlet opening is dimensioned to correspond in size to the outlet opening of the internal passageway and further configured to be positioned in confronting relation to the outlet opening of the internal passageway. The housing has a connecting member configured to cooperate and connect to the connecting member of the shank connector. A valve stem is positioned in the aperture. The valve stem has a first position wherein the valve stem is engaged with valve seat to define a closed faucet position. The valve stem has a second position away from the valve seat to define an open faucet position.
US12187595B2
A fluid line monitoring and control assembly for detecting foaming and terminating flow in a beverage line includes a valve and a flow meter, which are insertable in-line with a conduit connecting a storage vessel to a dispensing tap, such that the valve is positioned proximate to the storage vessel. The valve can close the conduit to prevent flow of a beverage therethrough. The flow meter quantifies flow and can detect at least one parameter indicative of each of a liquid state and a foam state of the beverage and generates first and second signals, corresponding thereto. A controller receives the first signal and the second signal from the flow meter. Foam in line programming code positioned on the controller enables the controller to selectively actuate the valve to close the conduit upon receipt of the second signal. The valve limits flow of the beverage in the foam state past the valve.
US12187594B2
Athletes in an athletic organization are provided access to a network of beverage dispensers associated with the organization. User profiles for each of the athletes are actively synchronized on the beverage dispensers within the network in response to changes to any of the user profiles. The user profiles are centrally maintained on a profile database and each profile includes performance parameters and personal parameters. Different users are given different levels of access to the user profiles. Each athlete is given access to view their entire profile and make modifications to personal parameters in their profile. Likewise, trainers or other training staff of the athletic organization are given access to view personal parameters of athlete's profiles and access to make modifications to performance parameters. Upon receiving a selection of an athlete's profile, a dispenser in the network is configured according to the personal and performance parameters stored in their profile.
US12187592B2
An apparatus for capping containers includes, at least one capping head which is moveable between a position for picking up a cap and a position for applying the cap at a neck of a container, the grip element defining a receptacle for the cap and component for the removable retention of the cap within the receptacle; A second motor component is provided to actuate the movement of the grip element in an axial direction. The apparatus also includes a control and actuation unit functionally connected to the first and second motor components and is configured to receive in input a number of data items; The control and actuation unit is configured to actuate the first and second motor components as a function of the variation of the value over time of the number of data items.
US12187585B2
A crane vessel for hoisting of an offshore wind turbine or a component thereof, includes a hull having a deck. A crane configured for hoisting of an offshore wind turbine or a component thereof includes a vertical crane structure having a crane structure base fixed to the hull, the crane structure extending from the hull over a height thereof to a top along a vertical axis of the crane structure, a boom, and a slew bearing allowing to revolve the boom, about a slew axis. A main hoisting system includes at least one main hoisting winch, an associated main hoisting cable and a load connector, the main hoisting cable extending from the main hoisting winch to a main hoist cable guide on the boom and then to the load connector. The crane further includes a dynamic behaviour adjustment system that is configured to adjust the dynamic behaviour of the vessel by moving and/or arranging an adjustment mass that is distinct from the offshore wind turbine or component thereof into or in at least one dynamic behaviour adjustment position along the height of the vertical crane structure.
US12187581B2
Provided is a guide rail device for an elevator, which includes a plurality of fixing bodies. Among the plurality of fixing bodies, a fixing body that is the closest to a fishplate is referred to as a first fixing body, and a fixing body that is the second closest to the fishplate is referred to as a second fixing body. Further, a distance between a position of the first fixing body and a position of the second fixing body in a vertical direction is referred to as a rail fixing distance. In this case, a distance from the position of the first fixing body to a position of the fishplate in the vertical direction is one-third or less of the rail fixing distance.
US12187580B2
A method remotely recovers at least one peripheral device of a people conveyor system. The method includes controlling at least one network element, into which the at least one peripheral device is connected, to control power supply of the at least one peripheral device to remotely recover the at least one peripheral device. The invention relates also to a remote monitoring unit and a remote monitoring system for remotely recovering at least one peripheral device of a people conveyor system.
US12187574B2
A system of where internal friction otherwise known to be back pressure or resistance is eliminated and iterations of power transfers allows for a greater use of the effort put into the use of the device embodied within the 2 powered system, as presented here as to teach others how we, as in the use of shared and sustained power, may be able to reduce the consumption of power and where certain artifacts are taken to power stages within a hose. To aid in lessening the power needed when a material is compressed into a hose forcing a pump implemented in the duty range to produce such pressure is unduly burdened. To achieve equilibrium within the material delivery system by inducing movement and in doing so making the jerking action of energy transfer across unequal pressures to be relieved. The coordination of these simple components to the delivery that may be generated from this specification are to be considered the use of any of the parts as they are each unique to a developed system to deliver pressured materials through a hose. Operators of said equipment generated through this method may indulge in ease of operation within a lowered power range. This is a SAFETY METHOD.
US12187572B2
A binding device binds a material strip reel on which a contact material strip is wound. The binding device includes a frame, a tape supply unit installed on the frame for supplying an adhesive tape, a first damper and a second damper mounted on the frame for clamping the adhesive tape, and a first roller and a second roller installed on the frame. The first roller and the second roller push and paste the adhesive tape between the first damper and the second damper onto a pair of opposite sides of the material strip reel.
US12187566B2
A controller, upon occurrence of a sheet jam in a downstream conveyor, discharges a sheet in an upstream conveyor from a discharge port by controlling an operation of a switchback roller depending on an operation status of the switchback roller at a time of the occurrence of the sheet jam and then stops sheet conveyance by a conveyor.
US12187564B2
Systems for processing material, taping stations to apply tape to one or more rolls of material, and methods of processing material are disclosed. A system for processing material includes a winding station and a taping station. The winding station includes a winder to wrap material around a mandrel to produce one or more rolls of material. The taping station is arranged downstream of the winding station to receive the one or more rolls of material therefrom and apply tape to the one or more rolls of material.
US12187552B2
A linear motor conveyor system having a moving element comprising a first and a second magnetic element on opposite sides; a first track comprising a first linear motor configured to generate a dynamic magnetic field which acts on the first magnetic element to provide a first dynamic lateral force and a first dynamic longitudinal force; a second track with a transfer region positioned adjacent to the first track, the second track configured to generate a magnetic field that acts on the second magnetic element to provide a second lateral force; and a controller to control the first linear motor such that the first dynamic lateral force is configured to bias the moving element toward the first linear motor until the moving element reaches a switch point in the transfer region, after which the dynamic lateral forces are selectively adjusted to bias the moving element toward the first or second track.
US12187550B2
A transfer operation of moving the slider between one fixed linear module and a movable linear module while locating the movable linear module in the facing range facing the one fixed linear module is performed. At this time, it is judged whether or not the coordinate axis of the one fixed linear module and the coordinate axis of the movable linear module are continuous If it is judged before the transfer operation that the coordinate axes are not continuous, the transfer operation is performed after the coordinate axes are made continuous in the direction by changing the coordinate axis. Thus, it is possible to suppress the occurrence of a situation where the transfer operation of moving the slider between the fixed linear module and the movable linear module cannot be performed due to the discontinuity of the coordinate axes respectively set for the fixed and movable linear modules.
US12187549B2
A parts supply apparatus includes multiple parts containers configured to accommodate multiple parts, and a stage. The multiple parts containers are attached to the stage, and the multiple parts are scattered on the stage from the multiple parts containers.
US12187547B2
A method for controlling the material flow of goods to be conveyed in a conveyor system of a real warehouse by a virtual three-dimensional model, for which purpose the conveyor system of the real warehouse is virtualized in a central computer, for which purpose a virtual three-dimensional model of the real conveyor system having the dimensions of the individual conveyor components and the movement parameters thereof, including the actuator properties and the identity, shape and position of the goods to be conveyed, is stored, and the conveyor system of the real warehouse is centrally controlled from the virtual model, images of the goods to be conveyed in the real conveyor system are cyclically captured by sensors, and the virtual model is cyclically compared with the reality on the basis of the recorded images.
US12187544B2
A system for instrument conveyance may include a shuttle device including an internal compartment for containing instruments; at least one handling unit configured to dispense instruments, where the handling unit includes: an opening mechanism configured to open the shuttle device to expose the internal compartment of the shuttle device, and a loading mechanism configured to load instruments into the internal compartment of the shuttle device; at least one head unit configured to obtain input from a user in connection with a transaction involving instruments; and a transportation system disposed between the at least one handling unit and the at least one head unit, where the transportation system is configured to transport the shuttle device between the at least one handling unit and the at least one head unit.
US12187535B2
A storage system for storing product items includes a grid structure and a number of first storage bins configured to be stored in vertical stacks in the grid structure. Each first storage bin is configured to contain at least one product item. A vehicle is arranged to move horizontally at the top level of the grid structure, and further arranged to pick up, carry, and place the first storage bins at desired locations within the grid structure. The storage system further includes a robot device that includes a movable arm with a picking mechanism in one end thereof. The robot device is configured to move a storage item between a first location and a second location by means of its picking mechanism. The first location is the location of a first storage bin stored in the storage grid.
US12187534B2
An apparatus for supporting a bag, particularly a heavy-duty bag, in an open-position on a support-surface. The apparatus includes a support-frame, a frame-backing, at least one fastener, and in some embodiments, at least one clip. The apparatus may be mounted to any support-surface. The apparatus is particularly useful for supporting a heavy-duty bag on any surface in a warehouse.
US12187526B2
A container has a side wall thickness profile sufficient for withstanding loads such as a top load, a package including the container and a lid, and methods and systems related to the container, are disclosed.
US12187514B2
A direct-to-consumer heat shrunk bundled product made up of a plurality of paper product rolls each individually packaged by a first package material and arranged relative to one another so as to form a bundle, the bundle being packaged by a second package material, wherein a substantial portion of the inner surface of the second package material is in contact with the first package material of the plurality of paper product rolls and is nonstick relative to the first package material. The bundle includes fused end seals so that the bundle does not include open gussets that might otherwise catch on machinery during sorting and shipping. The packaging material and/or wrapper may include laser energy absorbing material or adhesive.
US12187505B2
An apparatus and method utilizes a forming machine which includes a mandrel and forming plate each shaped to conform the paperboard and/or corrugated material blank passing through the mandrel into the desired configuration for a leak-proof tray. The blank includes a layer of a suitable paperboard and/or corrugated material, and a layer of leak-proof plastic or paper material disposed over one side of the corrugated material. The corrugated material includes cutouts at each corner of the blank that enable the sides and ends of the blank to be folded relative to one another. The paper material continuously overlaps the surface of the corrugated layer and these cutouts to provide a continuous leak-proof barrier layer within the formed tray and at the corners of the blank when folded to form the tray, as the paper material is folded over itself to form a bellows corner in the tray.
US12187498B2
Disclosed is an airtight container including a main body with an opening, and a cover, the airtight container including: an edge portion to press a sealing edge formed at an upper end of the main body; a locking clamp including an engaging portion to engage with an engaging-portion holder extended from the sealing edge or formed in a lateral wall; and a hinge provided between the edge portion and the locking clamp and including a material to be folded and unfolded with respect to the edge portion so that the engaging portion can be locked to and released from the engaging-portion holder. Thus, there is provided an airtight container with a soft hinge and a double injection-moulding structure, which is improved in durability because the hinge is prevented from damage even though it is used for a long time.
US12187496B2
A plastic cap is able to be applied to a container having a screw formed with a vent. The plastic cap has an outer ring for sealing at least the outer surface of the mouth of the container, and an inner ring for sealing the inner surface of the container mouth. In a closed state, sealability is maintained by a seal point on the inner surface of the outer ring. In an unsealing step, a seal point on the outer surface of the inner ring is shifted into a pressure-contacted state on the inner surface of the container mouth, where there is no risk of sink marks caused by molding strain, before a seal by the outer ring is released. Thus, reliable sealability can be exhibited even when the cap is applied to a container having inferior dimensional accuracy.
US12187495B2
The invention relates to a closing cap (11) and a method for producing a closing cap for a container (10) for receiving cosmetic creams, liquids or pasty substances, such as in particular mascara, the closing cap (11) being designed as a material hybrid and having a connective area for establishing a connection realized as a screw connection, bayonet connection or the like between the closing cap (11) and the container (10), the connective area being formed on an inner side (15) of a base body (12) made of metal, plastic or ceramics. The connective area has a plastic material as a contacting material in merely a portion for forming a physical contact between the closing cap (11) and the container (10) and the remaining portions are made of the same material as the base body (12).
US12187493B2
A package (10) is provided and comprise a frame (15) formed from a plastics material and a wall (20) formed from a paper or paper-based material.
US12187484B2
Provided is a multi-compartment tray having at least two compartments that are connected at the time of sale and then able to be split into separate, detached compartments by a user. The compartments are conjoined by a 3-dimensional wave-shaped perforation region. Each perforation wave includes a crest and a trough and perforation tabs are formed on at least some of the crests and troughs and form the point of interconnection between the compartments. In use, a user can apply leverage to the offset planes resulting in bending/snapping of the compartments relative to one another and causing the perforation break, thereby separating the compartments.
US12187483B2
A container with separable laminated layers includes an outer layer body, an inner layer body separably laminated on an inner surface of the outer layer body and capable of undergoing volume reduction and shape change, and an ambient air inlet continuously extending between the outer layer body and the inner layer body. The container with separable laminated layers has a bottle shape including a tubular mouth, a shoulder continuous with the mouth, a trunk continuous with the shoulder, and a bottom continuous with the trunk. The trunk includes a squeeze area that is continuous with the shoulder via a circumferential step portion or a circumferential rib portion. The step portion or the rib portion is provided with a recess that is concave toward an inner side of the container.
US12187480B2
A system and method are provided for packaging and sterilizing analyte sensors. The packaging system provides a structure for securing the analyte sensors in a fixed position and fixed orientation within the package.
US12187476B2
A packing machine for packing articles into a packing box comprises a packing box conveyor for conveying packing boxes with the bottom side supported on the packing box conveyor and an open top side directed upward; and an article conveyor for conveying articles, which is arranged adjacent and alongside the packing box conveyor. A pick-and-place arrangement picks articles from the article conveyor to place the articles in a parallel orientation into a packing box that is conveyed on the packing box conveyor, wherein the parallel orientation is an orientation of an article within the packing box which is parallel to an orientation of an article conveyed on the article conveyor. A transverse packing arrangement of the packing machine comprises a cassette and is configured to present an open side of the cassette sideward for collecting articles from the article conveyor into the cassette in a stacked relationship of the articles in the parallel orientation, and subsequently provides the collected articles in a transverse orientation from the cassette into a packing box, wherein the transverse orientation is an orientation of an article which is transverse to an orientation of an article conveyed on the article conveyor.
US12187467B2
The embodiments is an unmanned aerial vehicle. The unmanned aerial vehicle includes: an airframe; and a fixed-wing assembly and a rotor assembly, both replaceably connected to the airframe. The fixed-wing assembly is connected to the airframe to form a vertical take-off and landing fixed-wing unmanned aerial vehicle and the rotor assembly is connected to the airframe to form a multi-rotor unmanned aerial vehicle, thereby implementing an unmanned aerial vehicle that can switch between the vertical take-off and landing fixed-wing unmanned aerial vehicle and the multi-rotor unmanned aerial vehicle.
US12187466B2
Material transfer interfaces for space vehicles, and associated systems and methods, are disclosed. A representative system includes a coupling mechanism including a support structure, a latch-arm base movably connected to the support structure, and a latch arm pivotably connected to the latch-arm base. Another representative system includes a service valve portion, a coupling portion configured to receive the service valve portion, and a coupling mechanism for coupling the service valve portion to the coupling portion. The coupling mechanism can include latch arms positioned to pivot between a position in which the latch arms are pivoted outwardly and a position in which the latch arms are pivoted inwardly to capture the service valve portion. The latch arm can be carried by a latch-arm base that translates relative to a support structure of the coupling portion. Material transfer interfaces can include self-aligning ports having faces that engage each other with cup-and-cone structures.
US12187465B2
A module separation mechanism, in particular for rockets, includes a cylindrical first body, a cylindrical second body, and a ring connecting the two bodies, The ring comprises at least one tension lock together with a cover. The first body comprises at least one radially mounted actuator that is adapted to eject the tension lock together with the cover from the ring in a manner to disengage the ring. The first body further comprises at least one ejecting member adapted to eject the second body from the first body. The outer surface of the ring together with the cover is faced with the outer surface of the first body and the second body.
US12187464B2
A mass propelled device is described. The mass propelled device includes an evaporation chamber. The evaporation chamber has at least one transparent substrate configured to receive light on a first surface and a plurality of nanostructures disposed on a second surface opposite the first surface. The plurality of nanostructures excite electrons in response to light being provided to the first surface. The mass propelled device also includes propellent storage to store propellent and a propellent delivery system to provide propellent from the propellent storage component to the evaporation chamber. The evaporation chamber is configured to heat the propellent using electrons. The mass propelled device also includes at least one nozzle configured to exhaust heated propellent from the evaporation chamber in order to produce thrust.
US12187462B2
A control system includes a target spacecraft and a swarm of chaser spacecraft. Each chaser spacecraft is controlled to follow a corresponding computed trajectory. The system also includes at least one computing device that executes a nested genetic algorithm. The nested genetic algorithm includes multiple guidance genetic algorithms and an outer genetic algorithm. Characteristically, each chaser spacecraft has an associated guidance genetic algorithm that determines a computed trajectory for the chaser spacecraft associated therewith. Advantageously, the outer genetic algorithm checks for collisions and is configured to alter one or more computed trajectories to avoid collisions.
US12187460B2
A part of a spacecraft, for instance an upper stage, is configured to re-enter into the atmosphere and to be reused for several missions. The part is equipped with a reusable kit comprising non-ablative heat shields, for example constructed with an outer surface formed of Ceramic Matrix Composites, such as Ultra High Temperature Ceramic Matrix Composites, and optionally at least one decelerator and/or at least one parachute and/or parafoil system.
US12187458B2
A method, apparatus, and system for testing a fuel tank for an aircraft. Electrical power is sent to an optical data concentrator for the fuel tank for the aircraft from a power supply such that the optical data concentrator sends optical signals to optical sensors inside the fuel tank through optical fibers connecting the optical data concentrator to the optical sensors. The electrical power is sent during a phase of manufacturing of the aircraft. Test data is received from the optical data concentrator by a computer system. The test data is based on optical response signals received from the optical sensors. A determination of states for the optical sensors is made by the computer system using the test data. A graphical indication of the states determined for the optical sensors inside the fuel tank is displayed by the computer system in a graphical user interface on a display system.
US12187453B2
An aircraft (41) including a fuselage (14) having a skin (15) and extending along a longitudinal axis (39) from a front end to a rear end (17) of the aircraft, and an engine (30) including an air intake (31) forming an opening in the skin (15) and an exhaust (32) forming another opening in the skin (15). The engine is in a rear fuselage section, in which the exhaust (32) is situated ahead of the air intake (31) along the longitudinal direction (39).
US12187444B1
The power plant can have a structure; an output shaft connectable to a load, the output shaft rotatable about an axis relative the structure; a thermal engine secured to the structure, the thermal engine having a thermal engine shaft; an electric motor having a stator and a rotor shaft, the stator secured to the structure; an epicyclic gearing having a sun gear coaxial to a ring gear, a plurality of planet gears meshed between the sun gear and the ring gear, and a carrier coaxial to the sun gear and to the ring gear, the sun gear, carrier, and ring gear being rotatable relative the casing structure, the output shaft and the rotor shaft both coupled to the carrier, and the thermal engine shaft coupled to sun gear and the carrier; and an overrunning clutch operable to prevent the rotation of the ring gear in one angular direction.
US12187429B2
The present disclosure provides an insert that includes a locking mechanism that may either be formed integrally to the component or attached separately to the insert body. The top of the locking mechanism is offset from the first surface by an offset distance to enable the insert to be coupled to a recess of a component such as an aircraft component. An aperture formed in a top surface of the first portion is configured to allow additional elements to be coupled to the aircraft component. The coupling of the insert to the aircraft component is further promoted by a compression mechanism that forces the locking mechanism to couple to an overhang portion of the top layer after the force applied to the insert once it is positioned in the recess is removed, such that the top surface of the insert is co-planar with an outermost surface of the aircraft component.
US12187426B2
A wing for an aircraft is disclosed having a fixed wing, a foldable wing tip portion mounted to the fixed wing via a hinge rotatable about a hinge axis between an extended position and a folded position, and an actuation mechanism for moving the foldable wing tip portion. The actuation mechanism includes a drive arm mounted to the fixed wing in a manner rotatably driven about a drive axis, and the drive arm is configured to effect movement of the foldable wing tip portion between the extended position and the folded position upon rotation of the drive arm about the drive axis.
US12187423B2
Systems, devices, and methods including one or more rib mounting flanges, where each rib mounting flange comprises: a spar opening configured to receive a main spar of a wing panel; one or more holes for receiving cross-bracing cables; and one or more holes for receiving cross-bracing cables; and one or more holes for connecting the rib mounting flange to an adjacent rib mounting flange.
US12187421B2
Systems, devices, and methods for an aircraft having a fuselage; a wing extending from both sides of the fuselage; a first pair of motors disposed at a first end of the wing; and a second pair of motors disposed at a second end of the wing; where each motor is angled to provide a component of thrust by a propeller attached thereto that for a desired aircraft movement applies a resulting torque additive to the resulting torque created by rotating the propellers.
US12187417B2
A landing gear system includes a landing gear assembly coupled to a body of a vehicle and configured for reciprocating motion between a retracted position and an extended position. A fail-secure uplock assembly is reciprocal between a locked state and an unlocked state. A first electromagnet and a first permanent magnet are mounted to the body, and a second electromagnet and a second permanent magnet are mounted to a component of the landing gear assembly. The first and second electromagnets generate magnetic fields with reversible polarities. When the landing gear assembly is in the retracted position, the first permanent magnet is attracted to the second permanent magnet. The first electromagnet is attracted to the second electromagnet when the uplock assembly is in the locked state and is repelled by the second electromagnet when the uplock assembly is in the unlocked state.
US12187412B2
An insulation attachment system for an aircraft includes a first insulation blanket including a first tab at an aft end of the first insulation blanket and a second insulation blanket including a second tab at an aft end of the second insulation blanket. The system also includes a third insulation blanket and a first attachment component disposed on an outboard forward portion of the second insulation blanket and clasping a first frame member of the aircraft such that the first tab and the second insulation blanket are attached to the first frame member. The system also includes a second attachment component disposed on an outboard forward portion of the third insulation blanket and clasping a second frame member of the aircraft that is aft of the first frame member such that the second tab and the third insulation blanket are attached to the second frame member.
US12187409B2
A vertical take-off and landing (VTOL) aircraft provides transportation to users of a network system. The network system may include multiple aircraft or other types of vehicles to provide multi-model transportation. An aircraft may include a fuselage, a truss coupled to the fuselage, and multiple distributed electric propellers coupled to the truss. The distributed electric propellers may be positioned on at least two different planes. The fuselage may include a cabin having one or more seats for the passengers arranged in a configuration that has a compact footprint, provides legroom, provides visibility to surroundings of the aircraft, or facilitates convenient ingress or egress of passengers. The aircraft may open a port cabin door and starboard cabin door for simultaneous ingress or egress of passengers.
US12187405B1
Devices, systems, and methods are directed to controlling lifting gas in a volume defined by an inflatable structure of an aircraft. For example, controlling lifting gas in the volume of the inflatable structure may account for variations in ambient and tactical conditions experienced by the aircraft over the course of flight, as may be useful for lifting the aircraft to a target altitude and/or carrying out a particular mission. Additionally, or alternatively, controlling lifting gas in the volume of the inflatable structure may facilitate lifting the aircraft using lifting gas generated by reacting stable materials with one another at a launch site in the field. As an example, aluminum may react with water to form a lifting gas including hydrogen and steam. As the steam condenses to water in the inflatable structure, a valve may expel water from the inflatable structure to assist in maintaining buoyancy of the aircraft.
US12187399B2
A propulsion device for a marine vessel includes an engine and a forward/reverse shifting mechanism. The direction of a propulsive force generated by the propulsion device is changed according to a shift position of the forward/reverse shifting mechanism. The shift position is changeable between a forward position and a reverse position via a neutral position. In response to a command signal based on an operation of a joystick or an operator, the shift position of the forward/reverse shifting mechanism and the engine are controlled. When the shift position of the forward/reverse shifting mechanism is changed from the neutral position to a position corresponding to a direction opposite to a travelling direction of the marine vessel, which is determined based on the speed of the marine vessel, a correction control is performed to increase an output of the engine based on the speed of the marine vessel.
US12187396B2
A vessel operation system includes an outboard motor or other propulsion apparatus disposed on a hull, a trolling motor mounted externally to the hull, a joystick or other first operator, and a controller. The joystick is operated by a vessel operator in order to indicate at least one of a magnitude and a direction of a thrust that the outboard motor is to apply to the hull. In a state in which the trolling motor is generating a first thrust, the controller controls the outboard motor so as to generate a second thrust in accordance with a command indicated by the joystick. Additionally, the controller controls the trolling motor so that the first thrust changes.
US12187390B2
The disclosure includes systems, assemblies, sub-assemblies and methods for removably and securely attaching a hydrofoil to a board used in water sports. At least some of the systems include toolless removable attachment. In various embodiments, the attachment a hydrofoil adaptor mechanically attached to a trench frame by one or more toolless locking assemblies.
US12187385B1
A foam release apparatus for use in conjunction with a vessel air lubrication system has a chamber intersected by and in fluid communication with the air lubrication system return pipe and one or more sloped release channels formed within the lower portion of the chamber opposite the return pipe chamber inlet, each release channel terminating in a respective release slot formed in the vessel hull so as to fluidly communicate between the chamber and the water boundary layer beneath the hull via the release channels and release slots.
US12187383B2
A drive device includes a motor, an output part outputting torque to the outside, a gear part transmitting torque of the motor to the output part, and a housing having an internal space. The gear part includes at least one gear shaft extending in an axial direction, to which at least one gear is fixed, and a gear case accommodating the gear. The gear case includes a wall part facing an outer circumferential surface of the accommodated gear in a radial direction and extending in a circumferential direction and an opening adjacent to the wall part in the circumferential direction and penetrating in the radial direction. The opening faces the housing in the radial direction, and in a rotation direction of the gear, the wall part includes a front end disposed on a front side of the opening and adjacent to the opening. The front end contacts the housing.
US12187377B2
Brake mounts for bicycles are described herein. The brake mounts are for coupling a brake caliper to a bicycle. An example brake mount includes a bracket having a first side and a second side opposite the first side. The bracket has bores to receive fasteners to couple the brake caliper to the bracket. The brake mount includes a sleeve extending from the first side of the bracket. An opening extends through the sleeve and the bracket. The opening is to receive an axle of a hub assembly of the bicycle. The sleeve is to extend into an axle opening in a frame of the bicycle. A distal end of the sleeve is threaded. The brake mount also includes a nut to be threadably coupled to the distal end of the sleeve when the sleeve is inserted into the axle opening in the frame e.
US12187376B2
An electric powered personal mobility vehicle that includes at least one front wheel and an electric motor that provides rotational force to a wheel of the vehicle. The electric motor is supported by the vehicle and is powered by a rechargeable battery that is also supported by the vehicle. The vehicle can also include swivel caster wheels each configured to rotate about a wheel axis.
US12187360B2
A steering control device and a steering control method are disclosed. Particularly, a steering control device according to the disclosure comprises: a command current calculation unit for calculating a first command current on the basis of detected steering wheel steering information; a resistance calculation unit for calculating internal resistance on the basis of a detected internal temperature; a supply current estimation unit for estimating the supply current of a battery on the basis of an input supply voltage of the battery, the first command current and the internal resistance; and a command current applying unit for comparing the supply current and a preset reference current and, if the supply current is greater than the reference current, changing the first command current to a second command current and applying the second command current to a steering motor.
US12187359B2
A device for preventing a reverse input includes a first housing, a second housing coupled with the first housing to define an internal space along with the first housing, an output shaft including an output disk disposed in the internal space and having one or more concave curved surfaces on an outer circumference surface of the output disk and an output shaft body configured to protrude from the output disk, an input shaft including an input disk having one or more concave grooves on an outer circumference surface thereof and an input shaft body disposed on a same rotation axis as a rotation axis of the output shaft body to protrude from the input disk, and one or more moving pins disposed on the concave grooves, respectively, to come into contact with the concave curved surfaces, respectively.
US12187351B2
A power operated tailgate for a vehicle includes a major gate having a hinge about which the major gate is configured to be coupled to the vehicle for movement between open and closed positions, a minor gate configured to be coupled to the major gate for movement between open and closed positions with respect to the major gate, and a minor gate drive unit configured to drive movement of the minor gate with respect to the major gate. The minor gate is disposed at least partially within an outer profile of the major gate and supported by the major gate for movement therewith.
US12187348B2
A system for preventing rust and corrosion on vehicle drain holes utilizes a sealing gasket with a bottom opening. The gasket is configured to cover the vehicle drain hole. An exterior guard member has an upper shield component and a lower water and debris collection chamber having chamber drain holes. The guard member is configured to cover the sealing gasket, such that moisture and debris from the vehicle drain hole flows through the bottom opening of the gasket, into the collection chamber, and out through the chamber drain holes, thus eliminating water and other foreign debris from the area and thus providing a significant measure of protection to the drain holes in preventing rust and corrosion.
US12187347B2
An embodiment floor body for a vehicle includes a floor panel including an upper surface and an integrated frame coupled to the upper surface of the floor panel, the integrated frame including a pair of side sill upper portions extending in a front/rear direction of the vehicle to be spaced apart from each other in a right/left direction of the vehicle and a cross member extending in the right/left direction of the vehicle to connect the side sill upper portions on either side, wherein the pair of side sill upper portions and the cross member are integrally molded.
US12187345B1
A structural assembly for a vehicle that includes a cast main body, a left apron, a right apron, a left mounting feature, a right mounting feature, a left strut cap, and a right strut cap. The left apron is fixed to a left upper rail and defines a first opening extending therethrough. The right apron is fixed to a right upper rail and defines a second opening extending therethrough. The left mounting feature extends at least partially around a first periphery of the first opening. The right mounting feature extends at least partially around a second periphery of the second opening. The left strut cap is secured to the left mounting feature such that the left strut cap covers the first opening. The right strut cap is secured to the right mounting feature such that the right strut cap covers the second opening.
US12187339B2
A vehicle (10) comprising: a vehicle body (12) defining a longitudinal axis “L”; a suspension system (40) mounted to the vehicle body (12) and connected to a drive wheel (32A, 32B) defining a drive wheel axis “A”, the suspension system (40) being configured to allow displacement of the drive wheel axis “A” relative to the vehicle body (12) with a component of the displacement occurring in a direction parallel to the longitudinal axis “L” of the vehicle body (12); a sensor (110) for providing an output indicative of a level of displacement provided by the suspension system (40); and a torque control device (120) for automatically varying torque supplied to the drive wheel (32A, 32B) in dependence upon the output of the sensor (110).
US12187328B2
A guide-type anti-climbing energy-absorbing device based on hydraulic shearing includes an energy-absorbing tube, an anti-climbing portion, a first connecting portion, a plurality of partition plates, and two guide plates. The anti-climbing portion and the first connecting portion are respectively provided at two ends of the energy-absorbing tube. The partition plates are sequentially arranged inside the energy-absorbing tube along an axial direction to divide the interior of the energy-absorbing tube into a plurality of first energy-absorbing cavities, each filled with a first honeycomb body. The two guide plates are symmetrically arranged in the energy-absorbing tube along a vertical direction of the energy-absorbing tube. Each guide plate is arranged obliquely and includes a connecting end connected to the anti-climbing portion and a free end passing through the partition plates in sequence to extend outside the first connecting portion.
US12187327B2
A fuel control system obtains a measured amount of fuel consumed by an engine and one or more corresponding operating parameters of the engine and determines a fuel consumption modeled amount based at least in part on a fuel consumption model of the engine and the one or more operating parameters. The fuel consumption model associates different amounts of fuel that, when supplied to the engine, generate corresponding designated outputs of the engine. The system also determines one or more differentials between the measured amount of fuel and the modeled amount and, responsive to the one or more of the differentials exceeding a threshold value, the system identifies one or more components of the powered system that contribute or cause the one or more differentials and/or changes an amount of fuel supplied to the engine according to the fuel consumption model to obtain a desired output of the engine.
US12187323B2
To correct an axis deviation of a sensor. An aiming device, which calculates correction amounts of detection results of two or more sensors using the detection results of the sensors, includes: a sensor coordinate conversion unit that converts sensor data detected by the sensor from a coordinate system unique to the sensor into a predetermined unified coordinate system; a target selection unit that selects predetermined features from the sensor data detected by each of the sensors; a function fitting unit that defines functions each approximating an array state of the selected features for the respective sensors; a fitting result comparison unit that compares the functions each approximating the array state of the features detected by each of the sensors; and a correction value calculation unit that calculates a correction amount for converting coordinates of the features detected by the sensors from a result of the comparison of the functions.
US12187316B2
The present technology pertains to determining whether traffic signal cameras of an AV are miscalibrated. One technique for determining if a given traffic signal camera is miscalibrated includes obtaining an image from a traffic signal camera, marking the location of a traffic signal in the image with a bounding box, and determining if the light sources of the traffic signal are within the bounding box. If not, an alternate reason check is performed to determine whether an alternate reason exists for why the light source of the traffic signal is not within the bounding box. If no such reason exists, then the traffic signal camera may be miscalibrated. An additional calibration check may be performed using images from two traffic signal cameras of the AV each having four common light sources, and performing a homographic computation using the location of the light sources in the images.
US12187313B2
There is provided a method for operating a vehicle having an automated driving system (ADS) and a fallback stop feature. The method includes obtaining sensor data and localization data including information about a surrounding environment of the vehicle, and determining a plurality of candidate paths for a prediction time horizon within a drivable area in the surrounding environment of the vehicle based on the sensor data and the localization data. Further, the method includes determining an expected trajectory of a target vehicle located in the surrounding environment of the vehicle for the prediction time horizon based on the obtained sensor data and localization data, and determining, for each candidate path, an overlap cost parameter for an overlap between the target vehicle's expected trajectory and a set of stop positions of the vehicle based on predicted executions of the fallback stop feature within the prediction time horizon.
US12187312B2
Aspects of the disclosed technology provide solutions for measuring divergence between recorded real-world scene data, and a simulated environment. A process of the disclosed technology can include steps for generating, based on real-world autonomous vehicle (AV) scene data, a computer-generated simulation of a real-world scenario, determining, an occlusion region in which at least one surrounding object obstructs a field of view of the AV, and determining, based on the occlusion region, a portion of the object of interest that is visible to the AV. In some aspects, the process can further include steps for determining a divergence value indicating a difference between the portion of the object of interest that is visible to the AV within the simulation of the real-world scenario to an actual portion of the object of interest that is visible to the AV within the real-world scenario. Systems and machine-readable media are also provided.
US12187304B2
The present invention relates to a method for operating a driver model for controlling a vehicle. The driver model comprises a vehicle module (203) which determines an accelerator pedal position to be set on the vehicle. In addition, the vehicle module (203) determines a required power as a component of a total power, which total power can be generated by a drive system of the vehicle, wherein the required power corresponds to a power that is necessary for moving the vehicle at a required speed and/or a required acceleration (311) along a predefined road course. The method according to the invention further provides for a value (313) of a permissible pedal position to be assigned to the required power and for the value (313) of the permissible pedal position to be transmitted to the driver model in order to control the vehicle.
US12187302B2
Methods and systems for tuning vehicle drivability are provided. The vehicle system includes, in one example, a vehicle control unit (VCU) that is designed to electronically communicate with a human machine interface (HMI). In the system, the VCU is designed to, in reaction to receiving an acceleration or deceleration request from the HMI, send a virtual acceleration or deceleration command to a transmission control unit (TCU), where the virtual acceleration or deceleration command correlates to the acceleration or deceleration request and the correlation is user adjustable via a user interface (UI) of the VCU.
US12187298B2
Method for monitoring operation of a technical object, wherein a) a first orientation of the first acceleration sensor in the form of a position vector is determined, b) the mathematical model for operation of the object is generated and trained, c) the first acceleration sensor is disassembled and a three-axis replacement acceleration sensor is assembled with a new orientation on the object, d) acceleration values are detected, e) respective indicator values are calculated from the temporal course of the detected acceleration values of the replacement acceleration sensor, f) a replacement vector is determined from the indicator values and a differential vector between the replacement vector and the position vector of the first acceleration sensor determined in step b) is determined, and g) the model during operation of the object for the position vector in the orientation of the replacement vector is applied by taking into account the differential vector.
US12187294B2
A magnetic torque sensing device having a torque transferring member with a magnetoelastically active region. The magnetoelastically active region has oppositely polarized magnetically conditioned regions with initial directions of magnetization that are perpendicular to the sensitive directions of magnetic field sensor pairs placed proximate to the magnetically active region. Magnetic field sensors are specially positioned in relation to the torque-transferring member to accurately measure torque while providing improved RSU performance and reducing the detrimental effects of compassing. The torque sensing devices are incorporated on vehicle drive train components, including differential components, transfer case components, transmission components, and others, including on power transmission shafts, half-shafts, and wheels, and output signals representing characteristics of the vehicle are processed in algorithms to provide useful output information for controlling actions of the vehicle.
US12187293B1
Techniques for determining a modified lateral motion boundary of a vehicle in an environment are discussed herein. Techniques may include determining a lateral motion boundary for a vehicle in an environment, based partly on data associated with the environment and/or the vehicle, where representations of objects in the environment may be projected onto the lateral motion boundary. The lateral motion boundary may be modified based on such projections to determine a modified lateral motion boundary. The modified lateral motion boundary may include an open lateral boundary, configured by closing off portions of the lateral motion boundary corresponding to the projections, allowing a vehicle to move laterally to traverse the environment and avoid the objects.
US12187288B1
Techniques for determining behavior profiles and unique identities for objects observed in an environment surrounding an autonomous vehicle are described. The behavior profiles may be generated and associated with unique identifiers that are stored and used by a fleet of vehicles for planning and navigating in traffic environments. The behavior profiles may be used to control operation of the vehicle and increase safety of the vehicle by identifying potentially risky or erratic objects and navigating through the environment accordingly. The behavior profiles may be stored at a central database and propagated across a fleet to increase observations used to build profiles and thereby increase profile confidence.
US12187287B1
Techniques for determining behavior profiles and unique identities for objects observed in an environment of an autonomous vehicle are described. The behavior profiles may be used to control operation of the vehicle and increase safety of the vehicle by identifying potentially risky or erratic behaviors and navigating through the environment accordingly. The behavior profiles may be stored locally for a short-term period of time to ensure rapid access to profiles when the object is observed and readily identified.
US12187283B2
Disclosed is an apparatus for assisting driving of a vehicle including a camera installed in the vehicle to have a front field of view of the vehicle and obtain image data, and a controller to process the image data. The controller is configured to identify objects surrounding the vehicle and lanes defining a road on which the vehicle travels based on the processing of the image data, identify a lane in which the vehicle travels based on relative positions of the surrounding objects, and control the vehicle to change the lane based on a distance from the road on which the vehicle is traveling to an additional lane for entering an exit road.
US12187282B2
A vehicle includes a chassis, a driveline coupled to the chassis, and a control system. The control system is configured to monitor a condition of at least one of the vehicle, an area around the vehicle, or an operator of the vehicle; and control operation of the driveline based on the condition. Controlling the operation of the driveline includes at least one of limiting a speed at which the driveline drives the vehicle or shutting down the driveline and isolating a component of the driveline.
US12187281B2
Techniques are provided for operating a vehicle in a first vehicle mode; operating at least one component of the vehicle in a first component mode; detecting a first change in operation of the vehicle from the first vehicle mode to a second vehicle mode different from the first vehicle mode; based on the detected the first change in the operation of the vehicle, predicting a second change in operation of the vehicle; in response to predicting the second change in operation of the vehicle, operating the at least one component in a second component mode different from the first component mode prior to the predicted second change in operation of the vehicle.
US12187276B2
An obstacle trajectory prediction method and apparatus are provided. In some embodiments, a global interaction feature under joint action of a vehicle and obstacles is determined according to historical status information and current status information of the vehicle, historical status information and current status information of the obstacles, and a future motion trajectory planned by the vehicle; an individual interaction feature of a to-be-predicted obstacle is determined according to the global interaction feature and current status information of the to-be-predicted obstacle; and a future motion trajectory of the to-be-predicted obstacle is predicted through the individual interaction feature and information about an environment around the vehicle.
US12187259B2
A braking system with redundant trailer communication is provided. In one embodiment, a braking control system for a tractor-trailer comprises a primary brake controller in a tractor configured to communicate with a trailer brake controller in a trailer via a first communication channel, and a redundant brake controller in the tractor configured to communicate with the trailer brake controller via a second communication channel. The primary brake controller is further configured to serve as a master brake controller for the trailer and communicate with an automated driving computer in the tractor. The redundant brake controller is further configured to take over as the master brake controller in response to determining that the primary brake controller can no longer serve as the master brake controller.
US12187257B2
A control device for a two-stage solenoid valve, including an activation unit which outputs a current flowing through a solenoid coil of the solenoid valve as a switching signal. The solenoid valve is switchable from its de-energized switching state into its energized switching state by increasing a current intensity of the switching signal from zero to a switching current intensity. The solenoid valve is switchable from its energized switching state into its de-energized switching state by designing the activation unit to set the current intensity of the switching signal during a switching time interval to at least one current intensity value between zero and the switching current intensity, reduce it to zero after the switching time interval and during the switching time interval, increase it at least twice, each for a predefined pulse time interval, to a predefined current pulse value between zero and the switching current intensity.
US12187256B2
Disclosed are an apparatus for controlling an electromechanical brake system and a method thereof. An apparatus for controlling an electromechanical brake system of the present invention includes: a brake pedal detector unit configured to detect a stepping amount of a driver; a braking module configured to brake the vehicle; a memory configured to store a slope variable braking diagram set according to a characteristic value of the vehicle; and a processor configured to calculate a braking request value based on the stepping amount input from the brake pedal detector unit, and output a control command determined by a brake distribution ratio between front and rear wheels according to the braking request value to the braking module based on the slope variable braking diagram stored in the memory.
US12187254B2
A controller and method for controlling trailer service braking on a tractor-trailer vehicle are provided. The controller receives a signal from a trailer hand control apparatus, disposed in the cab of the tractor, that is manually activated by a driver. The signal received by the controller includes a differential signal obtained from two sensors having values that change in opposite directions based on movement of the trailer hand control apparatus. Based on the signal, the controller outputs a control signal that is output to a valve controller which controls the application of the trailer service brakes.
US12187253B2
A pedal sensor is provided with a carrier that can be mounted to a motor vehicle. A housing is formed at the carrier, and a pedal arm is mounted on the carrier so as to be pivotable. A mechanism to transmit movements of the pedal arm relative to the carrier is arranged in the housing, and a sensor for measuring the movements is provided. A damping element is fixed to the carrier in a groove in such a way that any contact between the pedal arm and the carrier is dampened. The damping element is securely held on the carrier. This is achieved by the damping element being secured on both sides against slipping out of the groove.
US12187246B2
A method of controlling an electric booster including a reaction disk, a boosting body and a pedal push rod connected to a pedal and configured to come into contact with the reaction disk, the electric booster being subjected to braking control according to a braking map, includes: a first braking control step of controlling and generating a reaction force at normal times in accordance with a pedal effort by compressing and expanding a fluid while moving the pedal push rod; and a second braking control step of controlling and generating the reaction force in accordance with the pedal effort only in a condition in which the reaction disk and the pedal push rod are in contact with each other by detecting a size of an air gap between the reaction disk and the pedal push rod.
US12187241B2
A wiper heating device for selectively heating a wiper blade and wiper blade holder to melt snow and ice that has built up on each includes a wiper assembly comprising a wiper blade, a blade holder, and an arm. A blade heating element is embedded within and extends throughout the wiper blade, the blade heating element selectively heating the wiper blade. A holder heating element is embedded within and extends throughout the blade holder, the holder heating element selectively heating the blade holder. Each of the blade heating element and the holder heating element are electrically powered by a battery.
US12187240B2
In a cross-sectional structure of an existing blade rubber having a non-hollow cross-section, only elasticity of a material of the blade rubber is used for pressure to wipe a windshield. Therefore, it is difficult for the blade rubber to flexibly follow change of a surface shape of the windshield, and sufficient wiping performance is not obtainable. A blade rubber to be attached to a frame of a vehicle wiper and to wipe the windshield according to the present invention includes a wing portion extending in a lateral direction to fix the blade rubber to the frame, a neck portion perpendicularly coupled to the wing portion, a deformation portion elastically deformable and coupled to a lower side of the neck portion, and a contact portion provided on a side of the deformation portion opposite to a side provided with the neck portion, and configured to abut on the windshield. The deformation portion internally includes a cavity portion having a heart-shaped cross-section. The neck portion is coupled to an upper intersection of two curved portions surrounded by an outside of the deformation portion and the heart-shaped cavity. The contact portion is coupled to a lower intersection.
US12187225B2
A vehicle includes: a brake mechanism configured to brake a wheel in accordance with a pressure of a brake fluid; a hydraulic circuit configured to adjust the pressure of the brake fluid and transfer the brake fluid to the brake mechanism; and a controller. The controller includes one or more processors to execute: a torque adjustment process of giving an offset to increase a required driving torque determined based on an operation amount of accelerator of the vehicle in a case where it is determined that the vehicle is in a stolen state; and a brake fluid pressure adjustment process of applying control to the hydraulic circuit to pressurize the brake fluid so as to compensate for an increase in the required driving torque due to the offset.
US12187216B1
A knee airbag includes a front panel, a rear panel coupled to the front panel to define an inflation chamber, and an intermediate panel between the front panel and the rear panel and within the inflation chamber. The intermediate panel is connected to the front panel and the rear panel at various locations between a proximal end and a distal end of the intermediate panel to control an inflated configuration of the knee airbag. The knee airbag has a two-layer construction only including the front panel and the rear panel in a depth direction, a three-layer construction including the front panel, the rear panel, and the intermediate panel in the depth direction, and a transition construction including the front panel, the rear panel, and an air permeable portion in the depth direction. The knee airbag includes the two-layer construction in at least first and second two-layer areas that extend at least substantially along first and second lateral sides of the knee airbag. The knee airbag includes the three-layer construction in a laterally central area between the first and second lateral sides.
US12187214B2
A ROPS frame for a work vehicle includes: a first pipe having an end; a second pipe having an end facing the end of the first pipe; a plate-shaped first joint coupled to the end of the first pipe and oriented orthogonally to a longitudinal direction of the pipes; a plate-shaped second joint coupled to the end of the second pipe and oriented orthogonally to the longitudinal direction of the pipes, the second joint being placed on the first joint; and a bolt extending through the first and second joints and fastening the first and second joints to each other.
US12187200B2
The motor vehicle camera assembly includes a first housing part, a second housing part, and an attaching mechanism for attaching the first and second housing parts together defining an inner space for receiving at least an electronics carrier. The attaching mechanism is configured such that, when the first and second housing parts are attached to each other, the first housing part contacts at least one portion of a first surface of the electronics carrier and the second housing part contacts at least one portion of a second surface of the electronics carrier. The first housing part may be coupled to the second housing part with the electronics carrier being tightly sandwiched there between.
US12187197B2
The present disclosure relates to a vehicle display device and a control method thereof, the vehicle display device comprising: a display unit; and a control unit that activates a navigation mode for guiding to a destination, and controls the display unit to display a virtual item indicating a driving direction that needs to be changed at a specific display angle when the driving direction needs to be changed within a preset distance on the basis of road information provided in the navigation mode while a vehicle is driving to the destination, wherein the control unit performs a control such that the display angle of the item changes on the basis of the angle of the driving direction that needs to be changed.
US12187196B2
Infant observation mirror assembly with temperature display for attachment to a top portion of a rear vehicle seat includes a main panel having opposed front and rear surfaces and a mirror embedded in the front surface thereof. The mirror assembly further includes a temperature display section defined on the front surface of the main panel. A positioning base is coupled to the rear surface of the main panel. The main panel is pivotably attached to the positioning base for allowing rotation about a horizontal axis and a vertical axis. A mounting harness attaches to the positioning base. The mounting harness removably attaches to the top portion of the rear vehicle seat to hold the mirror assembly in a selected lateral and vertical position on the rear vehicle seat.
US12187194B2
A synthetic-image formation unit forms a vehicle-inside view point image showing a periphery of a vehicle in such a way as to transparently pass through a portion or an entirety of the vehicle and taken from a vehicle-inside view point inside a vehicle room. The synthetic-image formation unit further forms an interior-added image including an image of an interior member viewed from the vehicle-inside view point using pre-stored data for drawing an image of the interior member. A display control unit temporarily displays the interior-added image and displays animation which gradually raises a transparency of the image of the interior member, before displaying the vehicle-inside view point image, when changing over a display screen of the display to the vehicle-inside view point image in response to a user's manipulation on the vehicle.
US12187189B2
A vehicle roof rack is provided, including: a main body and a light assembly. The main body includes a plurality of rod members and a plurality of connecting portions, and the plurality of connecting portions are detachably connected with the plurality of rod members to form a frame. At least one of the plurality of rod members includes at least one recession. The light assembly includes at least one light-emitting member and at least one power supply unit electrically connected with the at least one light-emitting member. The at least one light-emitting member is received within the at least one recession, and light emitted from the at least one light-emitting member is projected outward through an opening of the at least one recession.
US12187180B2
A leaning vehicle or a straddled vehicle, including a vehicle body, a light source unit, a light using device, an optical fiber cable, an electrical power supply unit, a plurality of electrical units, and an electrical cable. The vehicle body includes a seat and a body cover. The optical fiber cable has a supported portion disposed along, and supported by, a trunk portion of the electrical cable, and an upstream portion connecting the light source unit and the supported portion without being supported by the trunk portion. The supported portion and the upstream portion are partially disposed within an in-body covered region, which is at least one of a region closer to a vehicle center than an outermost surface of the body cover is, or a region positioned further in a downward direction than an uppermost portion of the seat is, both being invisible from an outside of the vehicle.
US12187169B2
A seat for a vehicle with a new structure integrates a walk-in mechanism, a mechanism for a relaxation posture change function, and a mechanism for a seatback full-flat folding function into one mechanism. The seat selectively performs one function of a walk-in function, a relaxation posture change function, and a seatback full-flat folding function through the one integrated mechanism.
US12187150B2
A method of intelligently allocating power to one or more devices connected to a power delivery system includes detecting an event related to an allocation of power between the one or more connected devices. The method further includes maximizing an initial non-power delivery (non-PD) power provided to at least one of the connected devices based on an available shared capacity (ASC) associated with at least one connected device and also includes allocating power to the at least one connected device using PD protocols.
US12187144B2
The present invention relates to the connection of a charging circuit for charging an electrical energy accumulator by means of a single-phase or multi-phase electrical alternating voltage. To this end, a filter means for suppressing interfering signals is provided at an input before a switchover between a single-phase or multi-phase charging process. In this way, the properties, in particular the capacitive properties, of the filter means are not influenced by the circuit configuration at the switchover between single-phase or multi-phase charging.
US12187136B2
A method for determining an optimized torque distribution to the wheels of a road vehicle comprising the steps of determining a table of distribution of the torque between a front axle and a rear axle; determining a second table and a third table of distribution of the torque between a right wheel and a left wheel of the rear axle and of the front axle, respectively; detecting the current longitudinal dynamics; using the first, the second and the third table to determine a current value of the first, of the second and of the third distribution factor, respectively, based on the current longitudinal speed and on the current longitudinal acceleration of the road vehicle.
US12187135B2
A driving force control method controls front wheel driving force and rear wheel driving force by a front wheel motor connected to a front wheel of a vehicle and a rear wheel motor connected to a rear wheel, respectively. The driving force control method includes: executing a cooperative process of lifting up or lifting down a vehicle body by cooperation of adjustment of at least one of the front wheel driving force and the rear wheel driving force and application of friction braking force to at least one of the front wheel and the rear wheel.
US12187129B2
A straddled vehicle, including a frame structure, a rear arm, a driving wheel rotatably supported by the rear arm, a power source unit, and a drive unit including a gear box, a drive motor and a control unit. The drive motor is arranged with an off-set toward a first direction from a center of the straddled vehicle, without overlapping the power source unit in a side view. The control unit is further in a second direction than the drive motor, and overlaps the drive motor, but does not overlap the power source unit, in the side view. The gear box is further in the second direction than the drive motor, and overlaps the drive motor in the side view. The gear box is also further in the first direction than the control unit, and overlaps with the control unit, but does not overlap the power source unit, in the side view.
US12187121B2
A vehicle control system includes a steering operation element configured to receive a steering operation of a vehicle by a driver, a grip detector configured to detect a gripping state of the steering operation element by the driver of the vehicle, and a display processor configured to cause a display device to display a notification image indicating at least the gripping state. The notification image includes a first graphic deformable based on a circle within an entire image area. The display processor causes the display device to display the notification image including the first graphic deformed to expand a location corresponding to a part where the driver is gripping the steering operation element.
US12187120B2
Provided are a control system and method using an in-vehicle gesture input, and more particularly, a system for receiving an occupant's gesture and controlling the execution of vehicle functions. The control system using an in-vehicle gesture input includes an input unit configured to receive a user's gesture, a memory configured to store a control program using an in-vehicle gesture input therein, and a processor configured to execute the control program. The processor transmits a command for executing a function corresponding to a gesture according to a usage pattern.
US12187114B2
A shutter device includes a frame, an opening-closing portion, and a protrusion. The frame is disposed between a first heat exchanger and a second heat exchanger and defines an inner space through which air introduced from a grill opening of a vehicle flows in an airflow direction. Each of the first heat exchanger and a second heat exchanger has a core and a remaining portion other than the core. The opening-closing portion is configured to selectively open and close the inner space of the frame. The protrusion protrudes, in a direction parallel to the airflow direction, from the frame toward the remaining portion of at least one of the first heat exchanger or the second heat exchanger.
US12187110B2
A body structure for an electrically operated vehicle, having an installation space for a traction battery, which space is open toward the vehicle bottom in the vertical vehicle direction, is closed toward the vehicle top by a floor pan part that forms the vehicle floor, and is delimited on both sides in the transverse vehicle direction by a rocker panel that delimits a side-door opening toward the vehicle bottom, wherein a rear body longitudinal member that transitions into the respective rocker panel toward the front of the vehicle in the longitudinal vehicle direction extends on each vehicle side in the rear-end region, and wherein the relevant rear corner of the traction battery is enclosed by an interior corner region, in particular right-angled interior corner region, that stretches between the rocker panel and the front battery cross member.
US12187106B2
An open roof construction for a vehicle comprises a frame and a panel capable of at least partly opening and closing an opening in a fixed roof. A drive motor in the vicinity of the rear edge of the opening and in the vicinity of a longitudinal center line of the opening comprises elongate drive members extending from its output shaft oppositely along the rear edge. An operating mechanism is movably connected between the frame near the rear edge and the rear edge of the panel. The operating mechanism includes two height-adjusting members on the frame, one on each lateral side of the drive motor and guided for a movement in lateral direction initiated by the drive members. Two height-adjustable members are immovably fixed to the panel and cooperate with the height-adjusting members which move along with the drive members so as to cause the height adjustment.
US12187103B1
A rib tail-end connector of an automobile sunshade comprises a connector, wherein the connector is bendable; one surface of the connector is provided with a butting convex part which is used for butting with the ribs; the butting convex part comprises an insertion part and a installation part, wherein the insertion part is used for insertion of the rib, and an elastic member is installed inside the installation part.
US12187100B2
An information processing device that controls a vehicle including a plurality of heating devices. The information processing device executes acquiring an air conditioning request transmitted from a user terminal, and selecting a heating device to be operated, among the heating devices in which an operation is specified by the air conditioning request, based on a remaining battery amount of the vehicle.
US12187096B2
The invention concerns a control device (1) for a heating and/or ventilation and/or air conditioning installation of a motor vehicle, the installation comprising an air treatment unit (9) comprising air outlets intended to open into a zone (ZG, ZD) of the passenger compartment of the vehicle, including at least first and second air outlets, and at least first (21) and second (23, 25) members for mixing the air flow. According to the invention, the device (1) comprises a user interface (5) comprising at least first (51) and second (53) control members, and a control circuit (7) for receiving, from each control member (51, 53), an input signal with its own temperature setpoint, and for delivering separate control signals for controlling the first and second mixing members (21, 23, 25).
US12187088B2
Disclosed is an automatic vehicle suspension tuning system. The system has a control module to receive user input, an ECU with a processor and a memory, one or more road condition sensors, and one or more controllable suspension system components. The ECU controls the adjustments of the controllable suspension system component in response to user input to the control module as well as input from the road condition sensors during operation of the vehicle. A method of tuning a controllable suspension system component is also disclosed.
US12187076B2
A pneumatic vehicle tire, in particular utility vehicle tire, having a tread which has a directional profiling with shoulder-side and middle profile ribs running in a circumferential direction, wherein at least one of the middle profile ribs (1), which is in particular a profile rib running along the tire equator, is traversed in an axial direction by sipes (4) with a width (b1) of 0.5 mm to 1.2 mm, each of which has a central portion (4a), in which the sipe (4) runs with an undulation in the direction of extent thereof, and two lateral portions (4b). The sipes (4) extend, in plan view, in an arc shape and symmetrically with respect to the centerline of the profile rib (1), and, in the lateral portions (4b) and in the central portion (4a), have a uniform undulation running in the radial direction, on which the undulation present in the extent direction of the sipes (4) is superposed only in the central portion (4a) of the sipe (4).
US12187075B2
A tire comprises a tread portion having a tread surface and buttress surfaces. The buttress surfaces have inclinations such that the tread edges shift axially outwards as the tread portion is worn off. The tread rubber includes a radially outermost first rubber layer and a radially inner second rubber layer. The loss tangent δ2 of the second rubber layer is larger than the loss tangent δ1 of the first rubber layer. One of or each of the buttress surfaces is provided with an outer lateral groove. The outer lateral groove is located axially outside the tread edge when the tire is new, and when the tread portion is worn off and the tread edge shifts axially outward, the outer lateral groove is at least partially located axially inward of the tread edge.
US12187072B2
A hub device is provided, including: a hub shell, defining an axial direction, including a room and a projection, the room having an opening open in the axial direction, an inner wall of the room being integrally connected with the projection, the room further including an annular toothed portion, the projection projecting radially within the room; and a ratchet ring, including an outer toothed portion and an engaging slot corresponding to the projection, the ratchet ring being disposing in the room, the outer toothed portion being engaged with the annular toothed portion so that the ratchet ring is rotatable with the hub shell, the engaging slot being disposed on the ratchet ring, the projection being engaged radially within the engaging slot and abutted radially against the hub shell.
US12187067B1
System of flip-book binding components, and preferable adaptation tool, for creating a plurality of different size thicknesses of flip book bindings, comprising a threaded screw having an initial length and having a screw head end and an initial threaded tip end, the screw comprising at least one designated intermediate break area to facilitate optional modification of the screw to a different threaded length with a different resulting threaded tip end, the system further comprising a threaded cap nut adapted for threaded receipt and retention of one of the initial threaded tip end and the optional resulting threaded tip end to enable binding of a plurality of given flip book size thicknesses.
US12187065B2
A security device (1) comprising an optically transparent layer (3) including a repeating first array of separate optical focussing elements (3) (e.g. having translational symmetry) wherein a pitch distance between repeated elements in the first array is a first pitch value (A). The device also includes a repeating second array of separate image elements (6) (e.g. having translational symmetry) collectively defining an image viewable through the first part. The device is structured such that a pitch distance between repeated or successive elements in the second array is a second pitch value (B) wherein the ratio (A/B) of the first pitch value and the second pitch value has a value, A/B=n±Δ, that differs from a positive integer value, n, according to an absolute difference, Δ, not exceeding 0.01 and not less than 0.001.
US12187058B2
A printing apparatus includes a printing head; an airflow generating unit; a first flow path that includes a one-side end coupled to the airflow generating unit and an another-side end coupled to a first discharge port and through which the airflow passes; and a peeling unit configured to partially peel the label from the base sheet. When, the label partially peeled from the base sheet by the peeling unit, at least a portion of a peeled portion peeled from the base sheet is at a position not overlapping with the peeling unit in plan view and a non-peeled portion not peeled from the base sheet is in a state of overlapping with the peeling unit in plan view, the first discharge port is disposed at such a position that the airflow outputted from the first discharge port hits the back surface of the peeled portion.
US12187055B2
Disclosed is a substrate treating apparatus. The inventive concept includes a support unit having a plate that supports a calibration board, on which a plurality of alignment marks are displayed, a first vision unit configured such that a relative location with respect to the plate is changeable, and that photographs the calibration board, and a second vision unit that photographs the calibration board in a scheme that is different from that of the first vision unit.
US12187051B2
An image forming apparatus includes an image forming portion that forms an image on a medium, a casing that houses the image forming portion, a power operating portion for use in switching on and off the main power source of the image forming apparatus, and a touch operation portion for use in inputting operations on the image forming apparatus. Assuming that a direction in which the casing faces a user when the touch operation portion is used is a front-to-back direction, the power operating portion is disposed at a one side in a lateral direction crossing the front-to-back direction at a front of the casing in the front-to-back direction, and the touch operation portion is disposed at an other side at the front of the casing in the front-to-back direction.
US12187050B2
A printing apparatus includes: a motor; a printing mechanism; a print processor; a connector; a substrate that transmits a signal received via the connector to the print processor, the print processor and the connector being mounted on the substrate; a plurality of metal plates that separate the substrate from the motor. The metal plates surround the substrate. The cable is coupled to the connector via a through-hole. The through-hole is covered with a metal cover.
US12187048B2
A liquid ejecting device includes a flow path member, an actuator, a pump, and a controller. The flow path member includes a flow path configured to direct flow of a pseudoplastic liquid through the flow path member. The actuator is configured to cause droplets to be ejected. The pump is configured to cause the liquid to flow sequentially through a supply reservoir, a plurality of supply manifolds, a plurality of supply flow paths, and a plurality of pressure chambers. The controller is configured to adjust a flow rate of the liquid to a prescribed target flow rate. The flow path has a flow path shape in which an average viscosity of the liquid in the plurality of supply flow paths is less than or equal to half an average viscosity of the liquid in the plurality of supply manifolds when the flow rate is equal to the target flow rate.
US12187046B2
A memory stores manufacturing information including at least the number of refills, an electronic signature of the manufacturing information, and a first error-detecting code of the manufacturing information. The number of refills is the number of times that, after consumption of a liquid contained in the cartridge, the cartridge is refilled with the liquid.
US12187034B2
A printing platform includes a printing engine with one or more printheads arranged such that the ink drops are jetted vertically upwards against the action of gravity; and a substrate transportation system where the normal to the surface in contact with the substrate is parallel and with opposite direction to the travelling direction of the jetted ink drops. It is necessary to counteract the weight of the substrate during the printing process to avoid it from falling under the action of gravity. This is achieved through any of a mechanical element that interferes with the falling of the substrate and that keeps it in place; or a system that generates adhesion forces between the element that transmits the motion to the substrate, typically a conveyor belt, and the substrate through the action of electrostatic forces, an air pressure differential between both faces of the substrate, or any other suitable mechanism.
US12187028B2
A printing device includes: a platen unit; and a main body unit. The platen unit includes a platen roller configured to convey a printing medium. The main body unit includes: a printing head; and an attachment-detachment portion which the platen unit is attachable to and detachable from. The printing head is configured to nip the printing medium in cooperation with the platen roller to perform printing on the printing medium. When the platen unit is attached to the attachment-detachment portion, the main body unit and the platen unit are assembled as a single unit. When the platen unit is detached from the attachment-detachment portion, the main body unit and the platen unit are separated as separate units.
US12187027B2
A system and method for performing quality control in a digital printing system (DPS) is provided. The DPS includes an impression station for transferring an ink image from a surface of an intermediate transfer member to a substrate. The impression station includes an impression cylinder housing one or more grippers operable to grasp and hold a leading edge of the substrate as it passes through the DPS, for conveying the substrate along the impression cylinder during the transfer of the ink image. An imaging device is operable, during advancement of the substrate on the impression cylinder, to capture a digital image including a region of interest (ROI) that is associated with at least a portion of the grippers and at least a portion of the substrate. A controller is configured, based on the digital image, to indicate an error in a position of the substrate relative to the grippers.
US12187021B2
The invention provides a method for delaminating a composite by immersing the composite into a delamination solution; wherein the composite comprises a metal substrate and a coating applied on one side or both sides of the metal substrate, wherein the coating comprises a polymeric binder; and wherein the polymeric binder comprises an aqueous copolymer. The use of delamination solution comprising a weak base allows for complete delamination of the composite in a highly efficient and extremely fast manner. Furthermore, the delamination method disclosed herein circumvents complex separation processes, contamination and corrosion of the metal substrate and enables an excellent materials recovery. An application of the method for delaminating an electrode for a battery is disclosed herein.
US12187020B2
A method for making an accessory cladding element for use in architecture and design. The method provides preparing an elastically deformable support element, including a first outer surface, in particular a decorated surface, a second outer surface and a plurality of spacer elements placed between the two surfaces. An impermeable and removable layer is applied on the first outer surface to protect at least a part thereof. Then a fluid cement mixture is prepared and introduced into the support element to obtain a cement-based composite structure in a deformable state. The excess fluid cement mixture is removed from the support element. The cement-based composite structure in the deformable state is positioned in a forming device which gives it the desired shape. The composite structure is solidified and after the removable layer is removed.
US12187019B2
Due to the increased glazed area of modern vehicles, especially the large panoramic glass roofs, we have seen a substantial growth in the use of anti-reflective coatings. Unfortunately, these types of coatings accentuate fingerprints and smudges. The invention provides an automotive glazing which is substantially resistant to fingerprints, and a method of manufacture thereof through the application of an anti-fingerprint coating based on low surface energy silanes.
US12186998B2
A plugged stringer on a surface of a part, and a method and assembly for production of the plugged stringer. The plug has opposite first and second axial end faces. The plug also has a radially outer margin defined by a radially outer bottom face, radially outer first and second opposite side faces, and a radially outer top face. The plugged stringer also includes a covering overlaying the radially outer top face and the first and second opposite side faces of the plug and extending away from the plug along an axis to form a stringer having first and second segments delineated by the plug. The radially outer margin of the plug is at least partly covered by an adhesive. The radially outer bottom face is adhered to the surface of the part, and the covering is adhered to the radially outer first and second opposite side faces and the radially outer top face. The first and second segments of the stringer respectively define first and second fluid passages separated by the plug. The first fluid passage is fluidly isolated from the second fluid passage by the plug.
US12186997B2
A method for manufacturing a composite structure having first and second structural members includes the steps of: (A) placing a plate in a forming mold having a first molding member, and a second molding member with an injection hole; (B) moving the first molding member toward the second molding member to stamp and deform the plate; (C) injecting a molten substrate onto the plate via the injection hole to stamp and deform again the plate so as to form the first structural member; (D) removing an assembly of the first structural member and a solidified substrate from the first molding member; and (E) removing an excess part of the solidified substrate to form the second structural member.
US12186988B2
Method and kits for handling an aqueous waste solution or dispersion obtained upon removing a water-miscible support material from a three-dimensional object during additive manufacturing of the object, and additive manufacturing processes utilizing same are provided. The methods and kits utilize a super absorbent polymeric material to convert the liquid waste solution to a solid or semi-solid composition.
US12186986B2
A method is disclosed for 3D printing thermally curable polymeric inks and their composites for scaffolds or devices. In this method, an extrusion based direct ink writing printing technology was used. The method includes an in-situ curing process and print layer height adjustment steps after each print layer to compensate for shrinkage during a thermal treatment step.
US12186984B2
An enclosure for a three-dimensional printing system comprises a plurality of walls and a glass panel. The walls define an inner chamber for receiving the three-dimensional printing system and an opening that provides access to the inner chamber from outside the walls. The glass panel is shiftable between a closed position in which the panel blocks access to the inner chamber and an open position in which the panel allows access to the inner chamber via the opening.
US12186982B2
A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.
US12186974B2
Provided are methods and systems for manufacturing and using heat-shrink elastomeric. An example method of manufacturing a heat-shrink elastomeric element comprises providing a thermoplastic elastomeric element having a first shape; modifying the thermoplastic elastomeric element to produce a thermoset elastomeric element having the first shape; heating the thermoset elastomeric element to a temperature of at least the glass transition temperature of the thermoset elastomeric element; adjusting the first shape of the thermoset elastomeric element to produce a second shape with at least one dimension greater than that of the first shape; and cooling the thermoset elastomeric element to a temperature below that of the glass transition temperature of the thermoset elastomeric element to produce the heat-shrink elastomeric element.
US12186973B2
A method is provided for manufacturing flooring planks including a plastic base and an image plastic layer. The method includes a feeding step of feeding a plastic layer into oppositely rolling rollers; and a rolling step of hot rolling an embossing on the plastic layer. A feeding tension of the plastic layer is adjusted according to a longitudinal deviation between the embossing and the pattern in the rolling step. A device includes a first feeding device, an oppositely rolling rollers control device, a detecting device, and a tension controller disposed on the first feeding device. The method, the device and the long plastic layer with the embossing in register with the pattern processed use the method, implement the embossing rolled on the plastic layer in register with the pattern on the plastic layer and have high production efficiency, low cost and less energy consumption.
US12186972B2
Provided is a roll mold that has a plurality of linear grooves arranged side by side on its outer peripheral surface and in which an optical step between adjacent linear grooves is sufficiently small. A roll mold comprising, on an outer peripheral surface thereof, n linear grooves extending in a roll axial direction or a direction inclined with respect to the roll axial direction and arranged side by side, where n is 800 or more, wherein the n linear grooves are arranged in a manner that a gradual decrease and a gradual increase in groove depth are repeated, and the number of points at which a transition from the decrease to the increase in groove depth occurs is m or less, where m is selected from 2 to 8.
US12186967B1
A multi-cavity mold (1) for a thermoforming machine used in high-volume, continuous thermoforming of thin-gauge plastic products (2) from a preheated thin-gauge thermoplastic sheet (3) comprising an upper tool (11) and a lower tool (12) arranged in a cooperating manner; the lower tool (12) comprising cavities (8) in which cavity molds (8′) are placed and base plates (91) from which supporting blocks (92) extend perpendicularly over a predetermined total height (a), situated between adjacent cavities (8), each supporting block (92) comprising two zones, a first substantially rectangular shaped zone (92a) and a second substantially isosceles trapezoid shaped zone (92b) in a vertical cross section through a y-z plane and two vertical channels (81) to alter, during forming of the products (2), a thickness of a peripheral flange (B), to decrease from a medium thickness (t) to a lesser thickness (t1).
US12186966B2
A method of forming a vacuum insulated structure includes providing a structural envelope an insulating cavity defined within the structural envelope. An expanding device is attached to opposing outer walls of the structural envelope and the interior cavity is expanded by pulling the opposing outer walls away from one another to define an expanded state. An insulating material is disposed within the insulating cavity to occupy substantially all of the insulating cavity in the expanded state. Gas is expressed from the insulating cavity to collapse the structural envelope to a final state and a final interior volume that is less than the expanded interior volume. The final state of the structural envelope defines a densified state of the insulating material within the insulating cavity. The vacuum port is then closed to hermetically seal the insulating cavity.
US12186958B2
A machine including a mold which delimits an overmolding cavity, for receiving a hollow portion of a bi-material part, cooling means along the overmolding cavity, a core positionable inside the hollow portion and containing heating means for bringing the core to a heating temperature higher than 150° C., and an injector injecting an overmolding material, formed by the core and the hollow portion, for forming an inner portion of the bi-material part. In order to obtain the overmolded inner portion even if the hollow portion has poor heat resistance, the cooling means maintain the overmolding cavity at a cooling temperature lower than 110° C. while the core is brought to the heating temperature, while the overmolding material has been injected by the injector into the overmolding cavity.
US12186952B2
An injection mould and an injection moulding method are provided. The injection mould includes: a base plate, configured to place a package chip to be injection-moulded, the package chip including a substrate and at least one chip fixed on a surface of the substrate by a flip chip process, the substrate having a through hole, a glue injection channel being formed in the base plate and configured to inject a moulding compound, and the glue injection channel being connected with the through hole on the substrate. The above-mentioned injection mould can improve the reliability of the package chip after injection moulding.
US12186950B2
Method for viewing and selecting production resources, in particular peripheral devices, for the injection molding industry, which are organized in at least one work cell for producing an injection-molded part and connected to one another via a network. Following a manual storage request on a control device, in particular a work cell controller, or on a production resource, in particular a processing machine, all connected production resources are queried and defined data, such as the respective settings, as well as program sequences, formulations and other configurations, are read out from these and, together with the internal settings, in particular those of the processing machine, combined to form a mold data record for this injection-molded part. A listing of production resources for the injection-molded part producible on this processing machine can be automatically generated from the mold data record and displayed at an output location, preferably of the processing machine.
US12186944B2
A method of manufacturing a toy using a model frame in liquid includes: filling a water tank; dissolving calcium chloride, a powder component, into the water filled in the water tank; wherein the amount of calcium chloride is determined in anticipation of the degree of gelation by chemical action with sodium alginate, filling a liquid paint to the model frame; wherein the liquid paint is comprised water 96 wt. %, CNC 0.99 wt. %, sodium alginate 3 wt. %, luminous material 0.01 wt. % or water 91 wt. %, CNC 1 wt. %, sodium alginate 3 wt. %, shiny material 5 wt. % or water 96 wt. %, CNC 0.99 wt. %, sodium alginate 3 wt. %, color conversion material 0.01 wt. %; immersing the model frame filled with the liquid paint in the water tank; solidifying and shrinking the liquid paint filled in the model frame immersed in the water tank; and shaking the model frame.
US12186943B2
Provided herein are methods of forming and optimizing cured features on a surface including controlling the surface upon which the cured features are applied. Additionally, a system for forming and processing the topographical features on the membrane is also described, along with mechanical features at specific system stations. More particularly, provided herein are methods of forming and optimizing topographical features applied to a membrane surface by controlling the membrane surface and by controlling the direction and magnitude of pressure applied to the membrane (substrate), as well as initially partially curing the topographical features, followed by fully curing of the topographical features to form the membrane having topographical spacing features formed thereon.
US12186938B2
The invention provides methods and compositions for treating wash water from concrete production with carbon dioxide. The treated wash water can be reused as mix water in fresh batches of concrete.
US12186930B2
A chainsaw includes a chain tension mechanism. The chain tension mechanism includes: an adjustment dial made of resin and rotatable about an axis in a right-left direction; a rotation transmission member made of metal and rotatable about an axis in the right-left direction; a feed screw member made of metal and rotatable about an axis in a front-rear direction; and a slide member coupled to a guide bar. The slide member is screwed to the feed screw member. A first gear of the adjustment dial is meshed with a second gear of the rotation transmission member, and a first bevel gear of the rotation transmission member is meshed with a second bevel gear of the feed screw member.
US12186923B2
The present disclosure relates to an autonomous driving robot that can move without user intervention. The autonomous driving mobile robot able includes a PC that receives vision data from a vision device, sets a route, generates operation commands, and thereby controls a motor drive board and a power supply board, in which the PC is configured with a state determination module and a trajectory generation module and a state determination module determines whether the robot is at a location less than or equal to a first threshold distance from a destination is performed after determining a position and direction of the robot. When the robot is located at the location less than or equal to the first threshold distance from the destination, the trajectory generation module generates a stationary trajectory where the speed of the robot decreases and becomes zero as the robot approaches the destination.
US12186921B2
A robotic system for forming a moldable workpiece is provided. The robotic system includes a robot, an end effector, an adjustment module, and a control module. The robot is configured to pass the workpiece through a machine. The end effector is configured to be attached to the robot and configured to grasp and release the workpiece. The end effector is adjustable to a plurality of different configurations. The adjustment module is configured to determine a change in the workpiece from (a) a first form of the workpiece prior to the passing of the workpiece through the machine to (b) a second form of the workpiece after passing of the workpiece through the machine. The control module is configured to adjust a present configuration of the end effector to a second configuration based on the change in the workpiece from (a) the first form to (b) the second form.
US12186918B2
A robot control system and a method for updating camera calibration is presented. The method comprises the robot control system performing a first camera calibration to determine camera calibration information, and outputting a first movement command based on the camera calibration information for a robot operation. The method further comprises outputting, after the first camera calibration, a second movement command to move a calibration pattern within a camera field of view, receiving one or more calibration images, and adding the one or more calibration images to a captured image set. The method further comprises performing a second camera calibration based on calibration images in the captured image set to determine updated camera calibration information, determining whether a deviation between the camera calibration information and the updated camera calibration information exceeds a defined threshold, and outputting a notification signal if the deviation exceeds the defined threshold.
US12186915B2
A device and a method for controlling one or more robots. The method includes: for each robot of the one or more robots, determining a labeled Markov decision process for each skill of one or more skills which the robot is able to implement, each labeled Markov decision process having a labeling function which indicates for each state of the labeled Markov decision process, whether one or more control conditions of a plurality of predetermined control conditions is/are satisfied; providing a control mission defined by a mission specification, the mission specification having a time sequence over a subset of the plurality of predetermined control conditions; and controlling the one or more robots to execute the control mission in such a way that the control conditions of states of the one or more robots contained in the mission specification are satisfied.
US12186905B2
Embodiments of the present disclosure provide a slip simulation apparatus, a controlled robot, a game handle, a virtual game console, and a control system. The slip simulation apparatus includes a base; at least one motor arranged on the base; a slip simulation controller, configured to: receive slip data, and generate a rotating speed control signal used for controlling the at least one motor; and at least one synchronous wheel, at least one synchronous belt, and at least one limit apparatus associated with the motor, the synchronous wheel being sleeved on the synchronous belt and the limit apparatus, the motor being drivingly connected to the at least one synchronous wheel to drive, according to the rotating speed control signal, the at least one synchronous wheel and the at least one synchronous belt to rotate.
US12186902B2
An external gear includes a body, external teeth, a diaphragm, and a strain gauge. The diaphragm extends in a direction intersecting with an axial direction on another side in of the body the axial direction. The strain gauge is on at least one of a surface on one side of the diaphragm in the axial direction and a surface on another side of the diaphragm in the axial direction. The strain gauge is only in a region that is about a half or less of a radial length from one end of the diaphragm in the axial direction to the other end of the diaphragm in the axial direction with a radial midpoint between the one end of the diaphragm in the axial direction and the other end of the diaphragm in the axial direction as a center in a section passing through the central axis.
US12186896B2
A robot includes: an arm; a shaft supported at a tip of the arm so as to be movable in a direction of a predetermined axis; a power transmitting unit fixed to the arm and connected to a power supply; and a power receiving unit and a battery that are fixed to the shaft. In a state in which the shaft is positioned at a predetermined position in the direction of the axis, the power receiving unit is close to the power transmitting unit to wirelessly receive power transmitted from the power transmitting unit, and the battery stores the power received by the power receiving unit and uses the power as a power source of a device attached to the shaft.
US12186892B2
A gripper jaw to grip an object, the jaw having a gripping surface with a recess therein, the jaw including: a tactile sensor with a sensor surface and a sensor thickness integrated in the recess in a z-direction, wherein the sensor includes: a base arranged lowermost in the recess, a sensor array arranged on the base with a plurality of taxels being sensitive elements arranged over an area of the base, the taxels configured to detect externally applied forces along the z-direction, wherein each taxel is reversibly deformable, and an elastic layer arranged above and overlapping the array, the layer acting as a mechanical low-pass filter and, in an unloaded state, having a layer thickness, wherein an outwardly facing surface of the layer forms a partial area of the sensor surface, wherein the sensor integrated in the recess projects with the sensor surface beyond the gripping surface in the z-direction.
US12186891B2
The present technology relates to an information processing device, an information processing method, a program, and a robot capable of estimate a value outside a detection range of a sensor. A control device of a first aspect of the present technology is a device that acquires detection results of a sensor unit composed of a plurality of sensors including a first sensor having a predetermined detection range, and a second sensor having a range in a detection range thereof in which detection by the first sensor is not possible and estimates a detected value of the first sensor outside the predetermined detection range on the basis of detection results of the second sensor. The present technology can be applied to a device that controls a robot having a hand part capable of gripping an object.
US12186880B2
An oscillating power tool includes an outer housing, and an inner housing positioned within the outer housing. A motor and a drive mechanism are supported by the inner housing. The drive mechanism includes an output shaft that is rotational in an oscillating manner and that defines an output axis. A damping element is positioned between the inner housing and the outer housing through which the inner housing is mounted to the outer housing, thereby attenuating vibration transmitted to the outer housing from the inner housing. An over-travel limit member is positioned between the inner housing and the outer housing. In response to relative movement between the inner housing and the outer housing while the power tool is in use, the limit member is configured to prevent direct contact between the inner housing and the outer housing, inhibiting vibration produced by the motor and/or drive mechanism from bypassing the damping element.
US12186872B2
A rotary-to-linear lifter for fastener driving tools is provided that has independently movable lifter pins that lift a driver with driver protrusions during a lift stroke. The lifter includes a central lifter shaft that rotates during a lift stroke, a solenoid that actuates, a plurality of lifter pins, and a lifter base. When the solenoid actuates, the lifter pins protrude from the top of the lifter base, and when not actuated, the lifter pins retract inside the lifter base. Each lifter pin has a set of forward and rearward springs that allow for longitudinal pin movements along the lifter's axis of rotation. If there is interference during a lift stroke, individual lifter pin(s) become blocked, and mostly remain inside the lifter base, until the lifter rotates the affected pin away from the interference. Then that lifter pin will again protrude from the lifter base, ready to engage the driver protrusions.
US12186867B2
To cut or score straight lines along sheet materials such as drywall panels, insulation boards, and timber sheets, it is commonly known to use a guide rail. Guide rail attachment means include screws, clamps, and/or adhesive pads. These securing means are time consuming to implement, and can cause damage to a main face of the sheet material. The present invention provides a guide rail securing device for releasably securing a guide rail 100 to a sheet material 200, comprising a guide rail attachment mechanism, and at least one penetrating element 20 to secure the guide rail securing device to the sheet material 200 by penetrating an edge of the sheet material 200. In this way, once the guide rail securing device is securely attached to the guide rail, a user may instantly connect the guide rail to the sheet material by penetrating an edge of the sheet material with the penetrating element.
US12186866B2
An electric tool system includes an electric tool and an inspection device. The electric tool includes: a tightening unit configured to tighten a workpiece onto an attaching target by driving force of a drive source; and a sensor configured to measure a tightening torque provided by the tightening unit. The inspection device includes a measuring unit configured to measure tightening force applied from the tightening unit. The electric tool system further includes an association processor configured to associate a first torque measured value with a second torque measured value. The first torque measured value corresponds to a measurement result by the sensor. The second torque measured value corresponds to a measurement result by the measuring unit.
US12186853B2
A hydraulic arrangement (HA) for an apparatus (AV) for deblocking optical workpieces (L), from associated block pieces (B), includes a nozzle arrangement (DA) for delivery of high pressure jets of pressure means for deblocking the workpiece from the associated block piece at a first pressure and for cleaning the blocked workpiece and/or block piece at least one second pressure which is different from the first pressure. Furthermore, there is a pump device (PE) which applies pressure in a defined manner to the pressure means and conveys it under pressure to the nozzle arrangement. The pump device has at least one high pressure pump (HP1, HP2) which is drivable by an associated rotary drive (SM1, SM2), the speed of which is modifiable in order to adjust the first pressure or the second pressure.
US12186833B2
The invention relates to an apparatus 100 for 3D shaping of a workpiece 101 by material ablation with a laser beam 102. The apparatus 100 comprises a machining unit 103, which is configured to provide a pressurized fluid jet 104 onto the workpiece 101 and to couple the laser beam 102 into the fluid jet 104 towards the workpiece 101. Further, the apparatus 100 includes a motion controller 105 configured to set an x-y-z-position of the workpiece 101 relative to the machining unit 103. It also includes a measuring unit 107 configured to measure a z-position of the point of incidence 108 of the pressurized fluid jet 104 on the workpiece 101 in the z-direction.
US12186832B2
The present invention generally describes apparatuses and methods used to perform an annealing process on desired regions of a substrate. In one embodiment, pulses of electromagnetic energy are delivered to a substrate using a flash lamp or laser apparatus. The pulses may be from about 1 nsec to about 10 msec long, and each pulse has less energy than that required to melt the substrate material. The interval between pulses is generally long enough to allow the energy imparted by each pulse to dissipate completely. Thus, each pulse completes a micro-anneal cycle. The pulses may be delivered to the entire substrate at once, or to portions of the substrate at a time. Further embodiments provide an apparatus for powering a radiation assembly, and apparatuses for detecting the effect of pulses on a substrate.
US12186819B2
An apparatus that may be attached between a five gallon bucket and a power saw so that debris generated by the power saw is collected in the five gallon bucket. The power saw may be one of a plurality of compatible power saws. The apparatus including a debris conduct, a duct and a skirt disposed about an upstream edge of the duct.
US12186817B2
A sliding cutting machine (1) includes: at least one slide bar (51) having an elongated shape; a slide base (17) slidably mounted on the at least one slide bar (51); and a cutting-machine main body (10) mounted on the slide base (17) such that it is movable in an up-down direction relative to the slide base (17). The cutting-machine main body (10) includes: an output shaft (27) that extends in an axial direction orthogonal to an extension direction of the at least one slide bar (51) and on which a cutting tool (11) is mounted; and an electric motor (21) disposed between the cutting tool (11) and the at least one slide bar (51), as viewed along the extension direction of the at least one slide bar (51), while the output shaft (27) is rotating and the cutting tool (11) is vertical.
US12186809B2
A compositionally graded alloy construction for separating a low oxygen content corrosive environment from a high oxygen content oxidizing environment includes a wall having a wall thickness and a first surface segment for contacting the low oxygen content corrosive environment, and a second surface segment for contacting the high oxygen content oxidizing environment. The alloy comprises, in weight percent: 0 to 5 Al; 5 to 30 Cr; 0 to 20 Co; 0 to 70 Fe; 0 to 2 Nb; 0 to 2 Ta; 0 to 3 Ti; 0 to 1 Si; 0 to 1 V; 0 to 2 Mn; 0 to 5 Cu; 0 to 30 Mo; 0 to 30 W; 0 to 0.1 P; 0 to 1 Zr; 0 to 1 Hf; 0 to 0.1 Y; 0.05 to 0.5 C; 0 to 0.1 N; and balance Ni.
US12186802B2
There is provided casting equipment including a control device that acquires, regarding multiple processes in the casting equipment, specific data regarding casting molds in each frame, and that associates the specific data for the respective processes with the casting molds, separately for the casting molds in each frame; and a display device provided, with respect to a first process among the multiple processes and a second process later than the first process, on equipment for executing the second process. The control device displays, on the display device, the specific data for the first process associated with the casting molds that are to be processed in the second process.
US12186800B2
A system and method of creating molten metal droplets is disclosed. The system may be used for 3D printing. The system relies on a change in momentum of the droplet relative to the tip of the metal microwire to cause the droplet to separate from the tip of the metal microwire. The change in momentum can be created by using an oscillating printhead. In other embodiments, a mass strikes the printhead to cause the droplet to separate from the metal microwire. The metal microwire may be heated using a heat source, such as a laser, an induction coil or a plasma arc.
US12186792B2
According to the present disclosure, a hot stamping forming method for forming components having various strength according to parts through cooling control for each position includes: setting a required strength for each product part for a sheet supplied into a multi-point forming mold device to which a plurality of forming modules are coupled; adjusting an arrangement of the plurality of forming modules according to the set required strength; and performing cooling control for each part by controlling an amount of cooling air or mist sprayed to the sheet by the air jet nozzle in order to achieve a required cooling speed for each strength part of the supplied sheet, wherein components having various shapes are formable with respect to the supplied sheet in a single mold.
US12186789B2
The invention concerns a method and a plant for producing flat rolled products, in order to obtain strips having a multiple crown transverse profile that subsequently have to be divided in a longitudinal direction into strips of a smaller width; the method provides a rolling step carried out in a rolling mill comprising roughing stands and finishing stands equipped with respective work rolls, in order to supply a strip of a determinate width.
US12186788B2
A furnace for heating metal strips, and to a device and a method for producing metal strips by continuous casting and rolling. The device includes a casting machine, a furnace through which a metal strip can be transported in a conveying direction, a first external cutting apparatus and a second external cutting apparatus, the first external cutting apparatus being upstream of the furnace and the second external cutting apparatus being downstream of the furnace, in the conveying direction of the metal strip, and at least one rolling mill. A first internal cutting apparatus and a second internal cutting apparatus are provided inside the furnace. A segment of the metal strip between said internal cutting apparatuses can be separated by actuating the latter.
US12186785B2
Provided is a method of preventing a sudden increase in the number of particles detected on wafer surfaces even when cleaning of a wafer is performed repeatedly using a single-wafer processing wafer cleaning apparatus. The method uses a single-wafer processing wafer cleaning apparatus including a rotatable stage; chemical solution supply nozzles; pure water supply nozzles; a chemical solution supply line for supplying chemical solutions to the chemical solution supply nozzles; a pure water supply line for supplying pure water to the pure water supply nozzles; and a waste liquid line. The method includes a pipe cleaning step of introducing pure water containing micro-nano bubbles into the pure water supply line, and cleaning the pipe of the pure water supply line.
US12186780B2
Multi-function sorting system for use in a sorting operation includes a server, a sortation engine, and first and second function sorting systems. First function sorting system for sorting articles includes first function vehicles traversing a first function platform for transporting and depositing first function articles into first sort receptacles. Second function sorting system for sorting articles includes second function vehicles traversing a second function platform spaced apart from the first function platform for transporting and depositing second function articles into second sort receptacles. The second function platform is arranged above the first function platform in a vertical stacked configuration.
US12186779B2
A radiation detection system that includes a radiation detector, a photo multiplier tube, and a pulse height analyzer. The radiation detector is configured to emit light when exposed to radiation. The photo multiplier tube is configured to convert the light to an electrical signal. The pulse height analyzer is configured to output at least one value associated with an amount of radiation detected based on at least in part on the electrical signal.
US12186778B2
A laser line is provided for providing separation of hazelnut from items thereof, which are not compliant to standard, in hazelnut processing facility. The laser line comprises at least one first detection module having at least one first detection unit for use in visual picking of hazelnut on said laser line, and at least one second detection unit provided at the continuation of said first detection unit and which provides keeping of the items, which are not suitable to standard and which are not kept by the first detection unit, by means of visual detection, and at least one second detection module provided at the continuation of said first detection module and which can provide keeping of the items, which are not suitable to standard and which exist in hazelnut, by detecting said items by means of laser scanning.
US12186776B2
A method for producing a carrier layer with a hydrophilic polymeric nanocoating wherein a polymeric carrier layer is produced with filaments of polymer material(s). The hydrophilic polymer nanocoating is applied with a low pressure plasma polymerization process using organic precursor monomers deposited onto the polymeric carrier layer and/or composite membrane. Additionally, a carrier layer includes a polymeric hydrophilic nanocoating.
US12186765B2
The invention relates to a device (10) for providing mist to a surrounding environment, the device (10) comprising a housing unit (12) having an inlet opening (18), an outlet opening (20), and a chamber (22) extending between the inlet opening (18) and the outlet opening (20) along a central axis (24); a nozzle unit (14) including at least one orifice (26); wherein the nozzle unit (14) is arranged in the chamber (22), the nozzle unit (14) being slidable along the central axis (24) between a closing position, in which the nozzle unit (14) closes the outlet opening (20), and an opening position, in which the at least one orifice (26) connects the chamber (22) to the surrounding environment in fluid communication; wherein the nozzle unit (14) transfers from the closing position to the opening position if a fluid pressure at the inlet opening (18) exceeds a predefined threshold; wherein the nozzle unit (14) comprises a deflector part (28) for deflecting fluid in the opening position and for closing the outlet opening (20) in the closing position, wherein the at least one orifice (26) is arranged offset to the central axis (24) between the inlet opening (18) and the deflector part (28); wherein the at least one orifice (26) is configured to guide fluid flowing through the at least one orifice (26) and to lead the fluid towards the deflector part (28). The invention provides an improved device (10) for providing mist to a surrounding environment, which reduces the required amount of fluid and increases the efficiency of the fluid distribution.
US12186764B2
Disclosed herein are adhesive splitter systems and methods for using the same. The adhesive splitter systems comprise a multi-nozzle adapter configured to dispense multiple streams of adhesive onto a substrate. The splitter system can also include an attached adhesive dispenser for providing adhesive to the multi-nozzle adapter.
US12186760B2
Provided is a food waste disposer. The food waste disposer according to a concept of the disclosure includes: a housing; a grinding device positioned inside the housing and configured to grind food waste; and a storage device positioned below the grinding device and storing the grinded food waste, wherein the grinding device includes: a grinding case configured to grind the food waste, and including an outlet opening to transfer the food waste to the storage device; and a valve assembly positioned below the grinding case and opening and closing the outlet, the valve assembly being separable from the housing together with the grinding case.
US12186756B2
A reaction processor includes: a vessel installation unit for installing a reaction processing vessel provided with a channel formed in a substrate; a high temperature heater and a medium temperature heater for adjusting the temperature of the channel of the reaction processing vessel; a vessel alignment mechanism for adjusting the position of the reaction processing vessel 10; and a housing that has a housing main unit and a cover portion capable of being opened and closed with respect to the housing main unit and that houses the vessel installation unit, the high temperature heater, the medium temperature heater, and the vessel alignment mechanism. In conjunction with the state of the cover portion being changed from an open state to a closed state, the vessel alignment mechanism aligns the reaction processing vessel such that the reaction processing vessel can be heated by the high temperature heater and the medium temperature heater.
US12186750B2
Provided are devices for carrying out reactions, which in some embodiments can include a plurality of first, second, third, and fourth reservoirs disposed on first and second surfaces, wherein the first and second surfaces are configured to move relative in to each other between first, second, third, fourth, and fifth positions to expose the first, second, third, and fourth reservoirs to each other or isolate the first, second, third, and fourth reservoirs from each other, as desired. In some embodiments, the devices include one or more detection windows that are substantially transparent to light in the ultraviolet (UV)/visible spectrum to allow assaying the extent to which a reaction has proceeded and/or to determine an optimal degree thereof. Also provided are methods for using the disclosed devices for performing reactions including but not limited to conjugation reactions as well as to optimize the same.
US12186749B2
The invention relates to a device and method for in situ temperature-induced antigen retrieval of samples wherein all steps are performed under a pressure higher than the atmospheric pressure on a sample immobilized on a sample support which can be further subjected to staining and imaging on the same sample support, optionally by cycle multiplexing that enables imaging of various molecular targets through multi-molecular read-outs on the same sample in a rapid, highly sensitive and reliable manner.
US12186744B2
A microfluidic cartridge having a detection chamber for detecting biomolecules in a sample solution. A CMOS-based microchip having a sensor area is arranged in the detection chamber and a contact area that is fluid-tightly separated from the detection chamber. The sensor area of the microchip including an array of functionalized test sites for electrochemically detecting biomolecules in the sample solution, and each test site in the sensor area is furnished with its own sigma-delta modulator for the analog-to-digital conversion of electrical signals produced at the test sites upon electrochemical detection.
US12186741B1
A method for destroying pathogens is disclosed. The method includes forming anionic polymer encapsulants (CAPs) including ingredients in a plasma reaction chamber (PRC). The ingredients include at least one of: a) one or more essential oils; and b) an energy amplifying liquid. The method includes creating plasma discharges in the plasma reaction chamber, in response to a pulsed electromagnetic energy field, and forming cold plasma by discharging dielectric barrier plasma discharges from the plasma reaction chamber into a fluid medium having pathogens dispersed therein.
US12186739B2
A process prepares an oxygen carrier for a chemical looping process including providing a material A having a first transition metal and/or an oxide of the first transition metal. The first transition metal is selected from chemical element groups 6-11 of the Periodic System. Material A is subjected to a reaction with H2 to reduce the first transition metal and/or oxide to form a reduced material B. Material B is treated with a salt solution of a second transition metal selected to have a standard reduction potential larger than the first transition metal. A portion of the first transition metal in the reduced material B is replaced by the second transition metal. A molar ratio of the first transition metal with respect to the second transition metal in material B ranges between 2:1 and 100:1. An oxygen carrier is obtained with the method and is regenerated using steam.
US12186738B2
A catalyst system comprising a combination of a tin-based moisture-cure catalyst, a titanium(IV) compound that is titanium dioxide or a titanium alkoxide, and zinc oxide. A catalyst masterbatch comprising the catalyst system and a carrier resin. A moisture-curable prepolymer formulation comprising the catalyst masterbatch and a (hydrolyzable silyl group)-functional polyolefin prepolymer. Methods of making and using same. Cured polymer products made therefrom. Articles containing or made from same.
US12186734B2
A polymer/activated carbon composite made up of a branched polyethylenimine and magnetic cores involving Fe3O4 disposed activated carbon. The magnetic cores have activated carbonyl groups on the surface. A process for removing organic dyes, such as methyl red, as well as heavy metal ions from a polluted aqueous solution or an industrial wastewater utilizing the composite is introduced. A method of synthesizing the polymer/activated carbon composites is also specified.
US12186725B2
The disclosure pertains to a high pressure carbamate condensation apparatus for a urea plant, a urea plant, and a urea production method. The apparatus comprises a first U-shaped tube bundle arranged around a second U-shaped tube bundle.
US12186723B2
The present invention relates to a method for preparing solid microcapsules comprising the following steps: a) preparation of a composition C1, which is either a composition C1a, comprising a single hydrophobic solid particle, or a composition C1b comprising a plurality of hydrophobic solid particles dispersed in a hydrophilic phase, b) addition under stirring of the composition C1 in a polymeric composition C2 at a temperature Tb, whereby an emulsion (E1) is obtained; c) addition, under stirring, of the emulsion (E1) in a composition C3 at a temperature Tc, whereby a double emulsion (E2) is obtained; d) applying a shear to the emulsion (E2), whereby a double emulsion (E3) is obtained; and e) the polymerization of the composition C2, whereby solid microcapsules dispersed in the composition C3 are obtained.
US12186705B2
A subsea desalination template includes subsea desalination module zones and module fluid couplings. A desalinated water outlet is in fluid connection with the module fluid coupling in the subsea desalination module zone. Subsea desalination modules with reverse osmosis cartridges are in fluid connection with a subsea template fluid coupling, a seawater inlet section, and a concentrated seawater outlet section. A transport pump assembly for desalinated water in a pump module is in fluid connection with the subsea desalination template and the desalination modules. A seawater circulation pump is in fluid connection with a seawater side of the at least one reverse osmosis cartridge. A desalinated water pipeline conveys fluid from the desalinated water transport pump assembly to a location above sea level.
US12186702B2
Examples of apparatuses for harvesting water are described herein. The apparatuses include a wall having a hydrophilic contacting surface and a hydrophobic collecting surface. A plurality of pores defining an inner volume extend between the contacting surface and the collecting surface and provide a fluid flow communication between the contacting surface and the collecting surface. As air is directed across or towards the wall, water condenses on the contacting surface, seeps into the pores and passes through the wall to the collecting surface for collection.
US12186701B1
A method for removing hydrogen sulfide (H2S) from a H2S-containing gas composition, including charging an aqueous media to a reactor under continuous agitation, dispersing particles of a composite in the aqueous media to form a composite mixture, continuously agitating the composite mixture, introducing the H2S-containing gas composition to the reactor containing the composite mixture under continuous agitation and passing the H2S-containing gas composition through the composite mixture, and adsorbing and removing H2S from the gas composition by the composite mixture to form a purified gas composition. The composite contains a CuMnAl layered triple oxide (LTO) and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The ZIF-67 nanoparticles are dispersed between layers of the CuMnAl LTO.
US12186700B2
The integrated device for adsorptive purification and catalytic regeneration of VOCs is provided and includes a filtration adsorption coupling filter, a catalytic combustion regeneration box and a housing, where the housing includes a filter inner cavity and a combustion inner cavity that are communicated in sequence. The VOC exhaust gas is adsorbed and filtered by the filtration adsorption coupling filter. Moreover, under an operating condition of desorption regeneration, the catalytic combustion regeneration box is utilized to perform thermal desorption and regeneration on the filtration adsorption coupling filter, and catalytically combust and purify the VOC exhaust gas obtained by thermal desorption.
US12186696B2
The present invention relates to a modular filter element comprising a first elongate hollow body, a second elongate hollow body and connection means for connecting the first elongate hollow body to the second elongate hollow body, wherein the connection means comprises a connection member that extends into a lower wall of the first elongate hollow body and into the upper wall of the second elongate hollow body to provide a gas-tight seal between the first elongate hollow body and the second elongate hollow body.
US12186693B2
A filter support for a filter is adjustable to modify the size and/or shape of the filter. The filter support may include one or more wedges engaging a wall of the filter, and a connector connecting the one or more wedges to one another. The connector allows selective adjustment of the filter support.
US12186688B2
A dewatering screen includes a frame, a deck mounted upon the frame, and the deck having a plurality of apertures therein. The frame is mounted on a base with a vibration generator for imparting vibration to the deck. A delivery device delivers wet particulate material to be dewatered onto the deck, and there is at least one dividing wall extending across a portion of the deck, the dividing wall(s) separating the deck into a material dewatering region and one or more water drainage regions. The delivery device delivers wet particulate material to be dewatered onto the material dewatering region of the deck.
US12186677B2
An information provision device in an information provision system includes, as its functions: a score control circuit that increases or decreases a provision timing score on the occurrence of a predetermined action; a timing determination circuit that determines the coming of the time to provide quiz information if the provision timing score exceeds a predetermined threshold; a priority control circuit that determines or changes, based on the situation of, e.g., a sport game on each occurrence of an action, priority associated with text information from which quiz information is generated; a quiz information generation circuit that generates appropriate quiz information based on the situation of, e.g., the sport game at the time determined; and a quiz information provision circuit that provides the generated quiz information to a user.
US12186674B2
A dice scanner for assisting in electronic gaming is disclosed which comprises a flat scanner with a scanning surface and a processor. The scanning surface is adapted for the rolling of one or more thrown dice and the flat scanner is configured for acquiring images of the scanning surface and the dice rolling or resting on that scanning surface in real time. The processor is configured for receiving one or more acquired images of the scanning surface and deriving therefrom data relating to the dice. The dice scanner also comprises a video acquisition system and/or an audio acquisition system which are arranged relative to the scanning surface such that at least a user face and/or at least a user voice can be recorded while gaming.
US12186673B2
A game apparatus including a plurality of first and second player game pieces, each having a first portion that is a chess piece, such that the plurality of first and second player game pieces include all the pieces for a first and second player, respectively for a game of chess. Each of the plurality of first and second player game pieces has a second portion fixed to a corresponding first portion. Each second portion has a recess so that a cube can be inserted into the recess so the cube cannot be seen from a front of the second portion. The game apparatus may further include a base; a grid; and a first and/or second plurality of insert pieces. The grid and the base form a chessboard pattern of a plurality of grid spaces. Each of the insert pieces fits within a space of the plurality of grid spaces.
US12186670B2
Systems and methods for maintaining contests including non-fungible tokens (NFTs), determining that an outcome of a contest indicates a tie, and establishing a placeholder are disclosed. The NFTs can be associated with attributes and stored on a blockchain. The system can receive a request and selections of NFTs for entering a contest. Each NFT can be associated with a player profile and satisfy a selection rule. The system can generate a fantasy sports lineup including NFTs and modifying a restriction condition for each NFT. The system can determine that an outcome of a contest indicates a tie and calculating edition number totals to determine a winner of the tie. The system can determine that an NFT has been transferred to a player profile. The system can modify a first lineup to include a placeholder in lieu of an NFT.
US12186660B2
A virtual character control method includes: displaying a virtual environment interface; receiving a skill cast operation and a movement control operation, the skill cast operation being used for casting a directional skill in a first direction, and the movement control operation being used for controlling a main control virtual character to move in a second direction, the first direction and the second direction being independent of each other; and controlling the main control virtual character to cast the directional skill in the second direction. When the directional skill is cast, the second direction is determined according to the received movement control operation, and the main control virtual character is controlled to cast the directional skill in the second direction.
US12186653B2
The present disclosure relates to the field of game technologies, and in particular, to an information processing method, apparatus, medium, and electronic device in a mobile terminal. The method includes: in response to a first touch operation acting on a first attack control, controlling a first game character to perform a first attack operation corresponding to the first attack control according to a preset automatic target selection rule; and in response to a second touch operation acting on the first attack control, displaying a target selection control containing at least one game character identification, determining a target game character identification from the at least one game character identification according to a third touch operation acting on the target selection control, and controlling the first game character to perform the first attack operation against a target game character corresponding to the target game character identification.
US12186647B2
A face guard is disclosed herein. The face guard is configured for a human user having a face with a mouth and nose. The face guard includes a mouthpiece configured for retention in the mouth of the human user. The face guard also includes a face mask coupled to the mouthpiece, wherein the face mask configured to cover the mouth and nose of the human user.
US12186628B2
A reformer includes a base having a longitudinal direction, a carriage coupled to the base and moveable relative to the base in the longitudinal direction, and an actuator coupled to the carriage and the base such that the actuator is arranged to exert a force between the carriage and the base. The force moves the carriage relative to the base in the longitudinal direction or resists movement of the carriage relative to the base in the longitudinal direction.
US12186625B2
A golf tracking system including a tag coupled to a golf club. The tag includes a plurality of sensors, each which output a signal based on a detected movement of the golf club, a microcontroller that compares each of the plurality of sensor outputs to stored reference sensor output values, and a transceiver that transmits data corresponding to the sensor outputs to a device remote from the tag based on the comparison performed by the microcontroller. The location-aware device then processes the information received from the tag to determine whether a shot should be registered.
US12186615B2
An exercise device is providing, including: a frame, including a weighting seat, two first movable pulley assemblies and two second movable pulley assemblies; a first operation assembly, disposed on the frame, including two first connecting members connected to opposing ends of the first cable and a first cable curving back around the two first movable pulley assemblies and the weighting seat; a second operation assembly, including two second connecting members and two second cables each being connected to the frame and curving back around one first movable pulley assembly and one second movable pulley assembly, each second connecting members being connected to one second cable; a third operation assembly, including two third connecting members and two third cables each being connected to the frame and curving back around one second movable pulley assembly, each third connecting members being connected to one third cable.
US12186613B2
Provided herein are embodiments of a barbell spotting apparatus having all the benefits of a free-floating, unconstrained barbell in both the horizontal and vertical axes with the safety of a dedicated spotting mechanism, while addressing safety, noise, and space concerns raised by typical barbell apparatus. The embodiments herein permit a loaded barbell to be positioned in line with the axis of motion of the lift to be performed at both the beginning and end of the lift.
US12186611B2
A fire sprinkler system, and a method thereof, for building management comprises life safety equipment, sensors positioned proximal to the life safety equipment, and a remote analytics unit communicating directly or indirectly with the sensors via a multi-location network. The life safety equipment include a fluid pump, a fluid pipe section, and a fluid coupling section. The sensors detect a fluid characteristic within a particular equipment of the life safety equipment. The remote analytics unit receives data based on the fluid characteristics detected at the sensors and determines a fault condition associated with one or more equipment based on the fluid characteristic.
US12186610B2
An operation control method suitable for a fire extinguishing system of an extra-high voltage converter station is provided. The method includes: after an upper computer control system receives a sound-light alarm signal, an alarm position signal, and a switch position dividing signal, starting a spray range prediction analysis subsystem for a fixed fire monitor; determining, by the spray range prediction analysis subsystem for the fixed fire monitor based on an external wind direction and an external wind speed, whether a range of a fire monitor effectively covers an entire area of a converter transformer; and if yes, automatically presetting a first fire monitor to which a first compressed air foam generation subsystem belongs and a second fire monitor to which a second compressed air foam generation subsystem belongs; or if no, replacing a fire monitor with a mobile fire-fighting robot to extinguish a fire.
US12186604B2
An electric vehicle, a battery pack, and a firefighting fluid storage device are disclosed, which relate to the technical field of energy storage devices. The firefighting fluid storage device includes: a box body, where the box body includes an inner cavity and a fluid outlet, the inner cavity is configured to accommodate a firefighting fluid, and the fluid outlet communicates with the inner cavity; and a gas generation component, where the gas generation component is mounted to the box body and configured to release a gas to the inner cavity. When the gas generation component releases the gas, the firefighting fluid moves toward the fluid outlet under the action of the gas.
US12186599B2
A method of assembling a ratcheting strap adjuster comprises inserting a distal end of a rotation assembly through first and second apertures in respective first and second side plates of a frame, with a proximal end of the rotation assembly positioned proximate the first side plate and the distal end positioned proximate the second side plate. A captive member is movably connected to the second side plate proximate the distal end, wherein the captive member is movable between an engaging position and a releasing position, and wherein an engaging portion of the captive member is configured and arranged to selectively engage the distal end of the rotation assembly in the engaging position.
US12186598B2
A personal respiratory protection device comprising an upper panel, a central panel, and a lower panel, the central panel being separated from each of the upper and lower panels by a first and second fold, seam, weld or bond, respectively, such that device is capable of being folded flat for storage along the first and second fold, seam, weld or bond and opened to form a cup-shaped air chamber over the nose and mouth of the wearer when in use, wherein the upper panel has a graspable upper tab, the upper tab being graspable in use to open the device.
US12186596B2
An automatic descent control device includes a line configured to be attached to a load. A line system retracts slack from the line when the line is not loaded and extends the line when the line is loaded. At least one braking system provides a braking force when the line is loaded so as to control extension of the line and a descent rate of the load. The at least one braking system is operable in at least two configurations, a first configuration that the at least one braking system lowers the load at a first descent rate, and a second configuration that the at least one braking system lowers or locks the load at a second descent rate. The load being a constant and the first descent rate is greater than the second descent rate.
US12186595B2
In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.
US12186588B2
A method of generating a treatment plan for treating a patient with radiotherapy, the method includes obtaining a plurality of sample plans, which are generated by use of a knowledge base comprising historical treatment plans and patient data. The method also includes performing a multi-criteria optimization based on the plurality of sample plans to construct a Pareto frontier, where the plurality of sample plans are evaluated with at least two objectives measuring qualities of the plurality of sample plans such that treatment plans on the constructed Pareto frontier are Pareto optimal with respect to the objectives. The method further includes identifying a treatment plan by use of the constructed Pareto frontier.
US12186576B2
An energy concentration apparatus is disclosed. The energy concentration apparatus includes a body part; a loop antenna coil part disposed on the body part; and a cover part coupled to the body part in order to cover the loop antenna coil part. The cover part has a central hole and a micro-slit.
US12186570B2
The present disclosure relates to branched proximal connectors for high density neural interfaces and methods of microfabricating the branched proximal connectors. Particularly, aspects of the present disclosure are directed to a branched connector that includes a main body having a base portion of a supporting structure and a plurality of conductive traces formed on the base portion, and a plurality of plugs extending from the main body. Each plug of the plurality of plugs include an end portion of the supporting structure comprised of the one or more layers of dielectric material, and a subset of conductive traces from the plurality of conductive traces. Each trace from the subset of conductive traces terminates at a bond pad exposed on a surface of the end portion of the supporting structure.
US12186558B2
Presented herein are techniques to control the spread of current beyond, in an apical direction, a predetermined location/point in the cochlea. As a result, the techniques presented herein create a protected apical zone at an apical side of the predetermined location for undisturbed acoustic temporal coding (i.e., an apical region of the cochlea in which the voltage fields from delivered current signals are nulled, minimized, or otherwise controlled in order to eliminate, reduce, or otherwise limit electro-acoustic interactions that could negatively affect remaining low-frequency hair cells).
US12186555B2
A ventilation machine is disclosed that includes a conduit interface configured to be connected to a respiratory system of a human or animal patient, an air flow generator configured to deliver air through the conduit interface into the respiratory system of the patient, a processing unit in communication with the air flow generator and configured to control the airflow generator to deliver air into the respiratory system of the patient according to a breathing scheme, and an induction device for activating a diaphragm of the patient. The induction device is in communication with the processing unit. The processing unit is configured to control the induction device to activate the diaphragm in coordination with the breathing scheme.
US12186550B2
A subcutaneously implantable device is implantable into a body of a patient, and includes a prong and an electrode. The prong has a contact portion at or adjacent to a distal end thereof that is configured to contact an organ. The prong is constructed to apply pressure to the organ with spring action so as to maintain contact between the contact portion and the organ without fixing the contact portion to the organ. The electrode is provided at the contact portion of the prong, is configured to contact the organ, and is electrically coupled or couplable with circuitry that is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ.
US12186530B2
A liquid medicine administration device is configured to reduce the load on the power supply at the start of use and includes: a drive mechanism that advances a plunger that pushes a liquid medicine from a liquid medicine container filled with the liquid medicine toward a distal end opening of the liquid medicine container; and a control unit that controls operation of the drive mechanism, in which the drive mechanism includes a motor that applies, to the plunger, a drive force for advancing the plunger, and an encoder that detects a rotation of the motor, and when driving the drive mechanism, the control unit starts the encoder after starting the motor.
US12186529B2
There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system includes, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive including a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device includes a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.
US12186527B2
A modular arrangement system for arranging medical devices, in particular infusion pumps, and a device having a housing which forms the modular arrangement system. The system has at least two arrangement modules which can be mechanically connected to one another. A first arrangement module has a first housing part with a first coupling structure arranged on at least two diametrically opposed sides. A second arrangement module has a second housing part adapted to be mounted on, below or laterally to the first housing part. The second housing part has a bar rotatably or slidably mounted in the second housing part for locking the two housing parts. The bar is designed in such a way that, by a singular actuation, it engages into the first coupling structure on at least two diametrically opposite sides of the first housing part, preferably simultaneously in an undercutting manner.
US12186525B2
A syringe nest is provided that includes a planar base and a plurality of nesting units extending from and interconnected by the base. Each nesting unit includes a hollow hexagonal body having a first open end and an opposing second open end.
US12186521B2
A device for connection to a medical connector, the device includes a cap body, a coupling cylinder adapted to engage with a male luer connector and a female luer connector, a bulb compartment filled with air, a reagent compartment filled with disinfectant or an antimicrobial reagent, and a passageway connecting the bulb compartment to the reagent compartment. The reagent compartment includes an exterior wall surface, an interior wall surface, an array of resealable pores densely integrated throughout the exterior wall surface and the interior wall surface of the reagent compartment, and a distal tip. The passageway may be positioned in an aperture of the proximal wall of the cap body. The coupling cylinder may include an O-ring.
US12186516B2
The present disclosure relates to a method for producing microneedle arrays in a mold, including a plurality of receptacles that taper from an upper base surface to a lower tip surface, where a first component is fed into at least two receptacles through a feed opening that is spaced apart from the base surface, where the receptacles are filled with an additional component from above the feed opening, where the fillings of at least said two receptacles, which fillings are formed of at least the first component and the additional component, are connected to one another above the base surfaces, and where after the first component and the additional component have solidified, the microneedle array comprising the fillings that have solidified to form needles is removed from the mold.
US12186514B2
An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The invention is well-suited for delivering pharmaceuticals to patients transdermally. In some embodiments, the system includes two separate reservoirs and a mixing area thereby allowing precursors to be mixed immediately before transdermal delivery.
US12186513B2
A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end, a cartridge comprising an interior cavity and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit and a waste conduit. In addition, the cartridge is coupled to the handpiece assembly with the interior cavity of the cartridge being in fluid communication with the fluid delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip, a first opening in fluid communication with the fluid delivery conduit, a second opening in fluid communication with the waste conduit and an abrasive element. The first opening, the second opening and the abrasive element of the tip are generally positioned within the peripheral lip.
US12186512B2
A balm mixture is provided for treating dry eyes. The balm mixture is applied from a container to the skin of the user adjacent their lower eyelid. The balm mixture includes a carrier portion and an active ingredient portion which will cause tears to form in the eye of a user adjacent the application thereof, thereby alleviating a dry eye condition.
US12186508B2
Patient specific medical balloons, assemblies, and systems for forming the same, and devices and methods for treating patients in need of a percutaneous coronary intervention (PCI) are disclosed. The assembly for forming the medical balloon comprises a form for receiving a parison where the form is configured to prepare a patient specific medical balloon matched in geometry to a blood vessel or a lesion for a patient in need of a PCI.
US12186507B2
A method for manufacturing a balloon catheter including preparing a tubular parison (20) made of a resin and a mold (30) that has an inner cavity into which the parison (20) is to be inserted and that has a first groove (41) formed on an inner wall surface forming the inner cavity; inserting the parison (20) into the inner cavity of the mold (30); allowing the resin to enter the first groove (41) by introducing a fluid into a lumen (23) of the parison (20) to expand the parison (20); and removing the parison (20) from the mold (30) before the resin reaches a bottom (41a) of the first groove (41).
US12186502B2
A tool positioning system for use in a medical procedure is provided which includes a medical tool configured to be navigated to a target tool location within a portion of an organ of a patient. The medical tool includes a sheath having a tube defined by a sheath wall, the sheath extending a length in a proximal-distal direction and an inflatable balloon coupled to the sheath and configured to move along the length of the sheath in the proximal-distal direction. When the inflatable balloon is inflated at a target balloon location along the length of the sheath, the inflated balloon is fixed at the target balloon location. The tool positioning system also includes memory configured to store location of the tool in a three dimensional (3D) space and at least one processor configured to generate mapping information for displaying locations of the tool in the 3D space.
US12186501B2
An introducer needle may include a proximal end, a distal tip, and a needle lumen extending therebetween. The introducer needle may include a wall defining the needle lumen, a first notch formed through the wall, and a second notch formed through the wall. A catheter system may include a catheter adapter, a catheter extending distally from the distal end of the catheter adapter, a flash chamber coupled to the introducer needle, and the introducer needle, which may extend through the catheter. The first and second notches and the flash chamber may facilitate pressure-driven blood flow into the catheter for improved flashback and detection of transfixation when the catheter is primed prior to insertion into vasculature of a patient or otherwise.
US12186500B2
An introducer sheath assembly having a handle portion including a distal end and a proximal end, and an introducer sheath extending outwardly from the distal end of the handle portion, the introducer sheath including a device lumen configured to slidably receive a corresponding device, a guidewire lumen configured to slidably receive a corresponding guidewire, and at least one steering cable disposed within at least one steering cable lumens that are disposed radially outwardly from the device lumen, and the handle portion including at least one steering assembly for modifying the tension of at least one of the at least one steering cables.
US12186498B2
A robotic catheter procedure system includes a bedside system that has a percutaneous device, and an actuating mechanism configured to engage and to impart movement to the percutaneous device. The system also includes a workstation coupled to the bedside system. The workstation includes a user interface configured to receive a user input, ma display device configured to display an image, a control system operatively coupled to the user interface and the actuating mechanism. The control system is configured to generate a control signal and the actuating mechanism causes movement of the percutaneous device in response to the control signal. The control system is configured to slow movement of the percutaneous device via the actuating mechanism as an identified point on the percutaneous device approaches a structure requiring a change in direction of the percutaneous device.
US12186497B2
Intravenous cannula devices configured to prevent blood backflow and needle prick injuries include a catheter assembly and a needle guard assembly. The catheter assembly includes a hub having a coaxial recess and a valve member positioned therein. The valve member is cylindrical and includes a distal surface having slits collectively defining prongs configured to open and close upon passage of a needle therethrough. Cannula devices configured to prevent needle stick injuries include a safety release component at a distal end of the needle guard assembly. The safety release component includes moveable locking elements configured to fit within an annular groove defined by a proximal portion of the hub upon movement of a needle through the safety release component. Proximal retraction of the needle through the safety release component causes the moveable locking elements to be displaced from the annular groove, thereby decoupling the catheter assembly from the needle guard assembly.
US12186495B2
A medical multi-lumen tube includes a plurality of inner layer tubes and an outer layer tube covering the plurality of inner layer tubes. The outer layer tube has a first region and a second region placed in the axial direction of the outer layer tube and formed of resins having properties different from each other, and the resin of one of the regions enters the other region, so as to form a wave pattern in a joint part between the first region and the second region.
US12186488B2
There is provided an attachment device for maintaining positive fluid pressure, the attachment device comprising a body having a fluid outlet port and at least two positive pressure fluid inlet ports; wherein each of the at least two positive pressure fluid inlet ports is connectable to a respective fluid source; wherein each of the at least two positive pressure fluid inlet ports is in fluid communication with the fluid outlet port; wherein each of the at least two positive pressure fluid inlet ports comprises an attachment device mechanism for selectively starting and stopping a flow of fluid from the respective fluid source to the fluid outlet port, and wherein the attachment device mechanism comprises a valve moveable between an open valve position and a closed valve position. An attachment device, connector, and method of using an apparatus suitable for a ventilator is also disclosed.
US12186487B2
A method of assessing airway clearance therapy efficacy includes generating a pressure pulse in a respiratory device being used by a patient. The patient's lung impedance is measured during the pressure pulse and the patient's lung condition is assessed based on the patient's lung impedance. The patient's lung condition is then assessed after airway clearance therapy.
US12186485B1
A patient interface cushion and specifically a patient interface cushion with fabric, configured to supply pressurized breathing gas to the nasal and oral airways of a user. The patient interface cushion includes a rigid part, configured to support the elastic part, featuring a first opening and a second opening; The elastic part, configured to provide an attachment surface for the fabric part, featuring a third opening in communication with the second opening and a fourth opening allowing the user's nose and mouth to enter the internal cavity of the elastic part. The fabric part, configured to form a sealing area between the lower lip area and the nasal bridge area, featuring a first surface partially connected to the elastic part, a second surface sealing at least a portion of the user's face, and also having an inner edge and an outer edge.
US12186476B2
Embodiments disclosed herein are directed to the treatment of wounds using negative pressure. Some embodiments disclosed herein provide for a foam pad, which may be suitable for use in abdominal wound sites, and which may be sized in a dimensionally-independent manner. Additional embodiments provide for a wound contact layer, as well as a system for the treatment of abdominal wounds.
US12186467B2
The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.
US12186465B2
A method and apparatus to direct a drug directly at the point needed for a specific duration for dialysis catheters which are made in standard sizes. Disclosed is a combination of a rate and duration-controlled infusion pump and reservoir and a pre-measured infusion catheter with a radiopaque distal tip. Along the length of the infusion catheter there is a luer lock connector and anti-leak valve. The invention is inserted into a dialysis catheter where the preset marking is aligned with the catheter hub and the distal infusion tip rest at or near the end of the dialysis catheter. The infusion unit is then activated, and the drug is delivered at the distal tip of the catheter, at or in the fibrin for maximum effect. The method of use and device saves time and resources as it can be deployed without the need for a surgical suite or heath care team.
US12186450B2
A composition for bone regeneration includes substantially spherical granules. Each of the spherical granules include an outer shell including magnesium phosphate and nano-sized silica and a bioactive core encapsulated by the outer shell. The granules include macro-pores and micro-pores. The macro-pores are intergranular spaces between adjacent granules, and the micro-pores are intragranular nanopores formed on the outer shell of each of the granules. A method of producing the substantially spherical granules, includes providing a mixture of a biological active powder, magnesium phosphate, and an initiator with a colloidal silica solution; rotating the mixture with dual asymmetric centrifugation for a predetermined amount of time; and drying the resulting material.
US12186447B2
This disclosure relates to pectin-based polymer compositions and methods of use thereof to cover, protect, and seal injuries, e.g., surgical wounds, in a mesothelial tissue. The methods include obtaining a bioadhesive pectin-based polymer composition including a complex of high-methoxyl pectin (HMP) and carboxymethylcellulose (CMC) in a ratio from about 10 to 1 to 1 to 10 by weight; applying the composition to an injured mesothelial tissue; and applying pressure for at least one minute to enable the composition to bind to the mesothelial tissue.
US12186446B2
An instrument reprocessor for cleaning, disinfecting, and/or sterilizing a medical instrument is disclosed. To reprocess instruments having one or more channels defined therein, the reprocessor can include one or more flow control systems configured to control a flow of fluid through each channel. A flow control system can include a differential pressure sensor and a proportional valve for controlling the fluid flow in a channel. The reprocessor can also include a fluid circulation pump which can be configured to supply the flow control systems with fluid and a system for controlling the pressure of the fluid supplied to the flow control systems. The reprocessor can also include a system for supplying a metered amount of fluid to the fluid circulation system. The system can include a reservoir having a fluid height sensor to monitor the amount of fluid therein and a pump configured to supply the reservoir with fluid.
US12186437B2
Embodiments of the invention are directed to a self-sanitizing structure that includes a body having a contact surface that can be contacted by a person, along with an energy source formed as an array of addressable energy sources. The energy source generates electromagnetic radiation and direct the electromagnetic radiation through the body to the contact surface. A sensor system is coupled to the contact surface, and a controller is coupled to the energy source and the sensor system. The body scatters the electromagnetic radiation and passes it through the body to the contact surface in a manner that maintains the scattered electromagnetic radiation that reaches the contact surface as sanitizing electromagnetic radiation at or above a minimum irradiance level that neutralizes infectious agents. The sensor system generates touch data in response to the contact surface being touched, and the controller uses the touch data to control the addressable energy sources.
US12186433B2
The present invention concerns modified nucleobases, nucleosides, deoxynucleosides, and/or their derivatives, nanocapsules comprising them, hydrogels and oleogels comprising said nanocapsules or said above-mentioned compounds and their uses, in particular their pharmaceutical uses.
US12186430B2
The present application provides methods and processes for making and using a lyophilized mesenchymal stem cell secretome, as well as methods for treating ocular conditions and/disorders with the reconstituted lyophilized mesenchymal stem cell secretome described herein.
US12186428B2
A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
US12186427B2
The present disclosure provides methods of treating breast cancer including administering aqueous suspensions com-prising solubilized fulvestrant, non-solubilized fulvestrant particles having one or more of an LD Dv(1 0) between about 1.5 and about 2.1 microns, an LD Dv(50) between about 5.5 and about 9.0 microns, and an LD Dv(90) between about 15 and about 35 microns, with the aqueous suspensions further including a surfactant, a polyvinylpyrrolidone, and a sugar alcohol, and a water-soluble excipient. The water-soluble excipient can be an aryl-Ci-6alk-OH, a Ci-6alkyl-OH, a buffering salt, a polysorbate, a polyalkylene glycol, a Ci-i2alkylene glycol, a phosphatidylcholine, or a combination thereof.
US12186424B2
Compositions and methods for inducing pterygium regression from visual axis/central cornea, stabilizing pterygium, treating hyperemia and symptoms in pterygium patients, and treating pterygium recurrence following pterygiectomy are disclosed. The methods include administration of a multikinase inhibitor, an antimetabolite or a combination thereof to patients in need thereof.
US12186420B2
Compositions and methods of use for treatment or improvement of the condition and appearance of skin
Compositions, formulations and methods of use thereof for treating, preventing and improving the condition and aesthetic appearance of skin are described. Compositions, formulations and methods of use thereof for treatment of dermis wounds, aged dermis, diseased dermis or damaged dermis are also described. The present compositions and formulations comprise a peptide with an amino acid sequence of QHREDGS (SEQ ID NO: 1) and methods of use thereof.
US12186415B2
Provided are methods and compositions relating to a dental composition more specifically to prepare the damaged dentin of the tooth prior to repair. The dental compositions include a bioactive glass and a non-aqueous solvent comprising an alcohol, anti-inflammatory and anti-pain reliever.
US12186410B2
Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.
US12186406B2
Materials and methods for treating a patient with hereditary hemochromatosis (HHC), both ex vivo and in vivo, and materials and methods for modulating the expression, function, or activity of a haemochromatosis (HFE) gene in a cell by genome editing.
US12186399B2
The present invention relates to a compound comprising a cisplatin component and a eugenol component. The present invention further relates to a synthesis method of said compound, pharmaceutical compositions comprising the compound and its medical uses. The present invention further relates to a method of treatment of cancer.
US12186390B2
A vaccine delivery method is presented that includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH, physiological salt concentrations and/or physiological temperatures and as a second component one or more antigens. Also included are methods of inducing an immune response in a subject and vaccinating a subject by administering such compositions.
US12186381B2
The invention pertains to the use of VirB10 to immunize a host against an infection by a bacterium having T4SS. The invention provides a vaccine comprising VirB10, a fragment of VirB10, a polynucleotide encoding VirB10 or a polynucleotide encoding a fragment of VirB10 and a pharmaceutically acceptable carrier and/or adjuvant. The invention also provides a method of immunizing a host against an infection caused by a bacterium having T4SS, the method comprising administering to the host a vaccine of the invention. The vaccines and the methods of the invention can be used to immunize against infections caused by bacteria having T4SS in dogs, rabbits, cats, pigs, cattle, sheep, goats, deer, horses, rodents and humans.
US12186376B2
The present invention is related to a method of treating or preventing cancer in a subject comprising administering to a subject having cancer or prone of getting cancer a first agent that depletes the subject's regulatory T cells (Tregs); followed by administering to the subject a second agent comprising a checkpoint inhibitor.
US12186375B2
The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
US12186374B2
The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin glargine or/and a pharmaceutically acceptable salt thereof, wherein the compound (b) and compound (a) are present in a fixed ratio.
US12186368B2
A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
US12186365B2
The present invention relates to a composition for regulating cell division by promoting or inhibiting the activity of FCHo1, and a method for regulating cell division using the same. The FCHo1 activity regulator of the present invention targets FCHo1 which functions as an important factor in cell division, and promotes or inhibits the activity thereof, thereby promoting cell division or inhibiting cell division, and thus can be effectively utilized for the treatment of diseases associated with cell division.
US12186356B2
The present invention relates to a composition for preventing, alleviating, or treating allergic skin diseases comprising, as an active ingredient, an extract of gardenia fruit from which pigment is removed, and since the extract of gardenia fruit from which pigment is removed is more effective for allergic skin diseases compared to an extract of gardenia fruit from which pigment is not removed, the composition can be very advantageously used for allergic skin diseases, in particular, atopic dermatitis.
US12186350B2
An activator suitable for immune response in tumor immunotherapy using an immune checkpoint inhibitor. An agent suitable for potentiating an antitumor effect of an immune checkpoint inhibitor, may contain a probiotic and a prebiotic as active ingredients.
US12186341B1
A phytochemical and nutraceutical composition and method for protection against a wide spectrum of viral and bacterial infections, including Covid-19, and for treatment of established infection and infectious inflammation. The composition includes a novel combination of vitamin, mineral, nutraceutical and phytochemical supplements. The composition of supplements and method may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals and phytochemicals provided, respectively, as immune boosters and antiviral agents along with anti-inflammatory nutraceuticals and phytochemicals.
US12186340B2
Provided herein are pharmaceutical compositions comprising a Fe2+-exchanged fluorinated synthetic smectite and a synthetic semiconducting metal sulfide. The compositions can be used to treat topical conditions and gastrointestinal ailments, and can be incorporated into wound dressings, hydrogels, personal protective equipment, and 3D printed articles. Also provided are methods of synthesizing the Fe2+-exchanged fluorinated synthetic smectite and methods of making the synthetic semiconducting metal sulfide.
US12186335B2
This invention relates to methods and compositions for inhibiting the transmission of enveloped viruses, which entails applying a composition containing a high molecular weight hydrophobically-modified polymer to an infectable or ingestible surface that may contain viruses and wherein said anti-viral composition comprises less than about 9% by weight of surfactant having an HLB greater than about 12.
US12186317B2
The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
US12186313B2
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
US12186309B2
The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection. Aspects of the present disclosure also include methods of treating a Baltimore Group IV RNA virus infection in a subject. The present disclosure also provides pharmaceutical compositions related to the same.
US12186304B2
The present disclosure pertains to the field of biomedicine, and specifically relates to a method for treating, suppressing, reducing the severity of, lowering the risk of, or inhibiting the metastasis of cancer in an individual, the method comprising administering to the individual a therapeutically effective amount of an IAP inhibitor, a therapeutically effective amount of a modulator of an immune checkpoint molecule, and optionally a therapeutically effective amount of a tubulin inhibitor. The present disclosure further relates to a pharmaceutical composition or kit comprising an IAP inhibitor, a modulator of an immune checkpoint molecule, and optionally a tubulin inhibitor.
US12186303B2
Provided are a feed additive composition for cattle including N-acetyl-L-tryptophan (NALT) as an active ingredient, and more particularly, a feed additive composition including N-acetyl-L-tryptophan as an active ingredient for reducing temperature stress of cattle, increasing average daily gain of cattle, and increasing feed intake of cattle; a feed including the feed additive composition for cattle; and methods of reducing temperature stress of cattle, increasing average daily gain of cattle, and increasing feed intake of cattle, the methods including feeding the cattle with the feed additive composition or feed for cattle including N-acetyl-L-tryptophan as an active ingredient.
US12186298B2
Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.
US12186297B2
Disclosed herein are “ketone body-HMB” or “KB-HMB” compositions including a combination of: (1) hydroxymethyl butyrate; (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) optionally a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such compositions for producing desired physiological effects, such as fat loss, in a mammal. The compositions beneficially enhance fat loss through ketosis while also reducing or eliminating muscle wasting and/or promoting muscle formation.
US12186293B2
Compositions including a complex of fatty acids (e.g., including one or more C4 to C40 fatty acids, such as a C4 to C20 fatty acid) and one or more amino acids (and particularly one or more amino acids having electrically charged basic side chains, e.g., Arginine, Lysine, etc.) for use as an anti-pathogenic composition. In particular, described herein are compositions of decanoic acid: Arginine in which the decanoic acid and Arginine for a complex having a lamellar supramolecular structure.
US12186292B2
A method of neutralizing or mitigating a drug-induced mitochondrial dysfunction or impairment for an individual, the method including providing to the individual an effective amount of a composition containing glycine or a functional derivative thereof and N-acetylcysteine or a functional derivative thereof. The drug-induced mitochondrial dysfunction or impairment is from at least one drug consumed by the individual selected from the group consisting of an anticonvulsant; a psychotropic other than an antipsychotic drug; an analgesic/anti-inflammatory drug other than acetaminophen; an antibiotic; an anti-arrhythmic drug; a steroid; a beta-blocker; and an immunization.
US12186287B2
Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass % to 6 mass % with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to a total mass of the adhesive layer.
US12186286B2
Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.
US12186284B2
There is provided a composition comprising an organic material and at least a first surfactant which following addition of an aqueous solution to the composition can form a biphasic system, wherein the biphasic system is useful for the treatment of or prevention of hoof infections. Also provided is a biphasic system useful for the treatment of or prevention of hoof infections, wherein the biphasic system comprises the composition and an aqueous phase wherein the composition is dispersed as droplets within the aqueous phase.
US12186273B2
Portable pill dispensers are disclosed herein. The portable pill dispenser may include a container configured to house at least one pill therein, a housing attachable to the container, and a dispensing mechanism disposed within the housing. In one configuration, the dispensing mechanism includes one or more rotating gates disposed about the ramp to control the movement of the at least one pill to the dispensing mechanism.
US12186270B2
Some embodiments disclosed herein relate to a device for transferring precise amounts of fluid from at least one source container to at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container. Some embodiments of the device can include a motor and a controller for automatically actuating a plunger of the syringe to transfer the desired amount of fluid.
US12186260B2
An adjustable chest compression device that can adjust to accommodate a variety of patient sizes. The chest compression device can include adjustable support legs structured to support the chest compression mechanism at a distance from the base member and adjust to accommodate a patient size. Another adjustable chest compression device can include adjustable legs that can adjust to accommodate different patient sizes, as well as perform the chest compressions using the adjustable legs. An extension, such as a back plate and/or leg extension can be added to a chest compression device to make the chest compression device taller and/or wider to accommodate larger patients.
US12186257B1
The present disclosure provides massager, comprising: a base body, a driving mechanism assembled in the base body, and a massage body drivingly connected to the driving mechanism, characterized in that the massage body comprises: a sleeve section is sleeved on the outside of the base body to relatively fix the massage body and the base body; a pressing section is connected to the end of the sleeve section and is drivingly connected to the driving mechanism, and a slap band is formed in the middle part, which is used to perform point-pressure massage on the external massaged area driven by the driving mechanism; the vibration section is used to absorb the power transmitted from the pressing section to massage the external massaged area. The present invention has an integrated design of the massage body, which can be quickly disassembled for deep cleaning of the massage body.
US12186251B2
Implementations of a head and neck cradle comprise an upper platform, a middle platform (or middle portion), and a lower platform. In some implementations, a method of using the head and neck cradle comprises placing the lower platform under a hospital bed mattress such that the upper platform rests adjacent to the end of the mattress and extends away from the hospital bed, and may further comprise placing a patient in a prone position on the hospital bed mattress with the patient's head placed on the upper platform.
US12186246B2
The present invention relates to an indoor and outdoor mobility system 1 forming a mobility device 10 for people with walking disability, the system comprising a base 20 two indoor front wheels 30, which can be attached to the base 20; two outdoor front wheels 40, which can be removably attached to the base 20, wherein the outdoor front wheels 40, when attached to the base 20 comprise a wider track width compared to the indoor wheels 30; indoor back wheels 52 which can be attached to the base 20; and outdoor back wheels 62 which can be removably attached to the base 20, wherein the outdoor back wheels 62, when attached to the base 20 comprise a wider track width compared to the indoor back wheels 30. The invention further comprises a method for the change of a mobility device for people with walking disability from an indoor to an outdoor use.
US12186244B2
A shock absorbing apparatus for mitigating agitations while riding within a vehicle. The apparatus is configured to allow a gurney to be connected thereto and further be connected to the floor of an emergency vehicle. The apparatus includes an airbag system that is deflated/inflated by closing/opening the gurney entrance door of the vehicle.
US12186242B2
A surgical patient support includes a foundation frame, a support top, and a brake system. The foundation frame includes a first column and a second column. The support top is coupled to the first column and the second column for rotation about a top axis extending along the length of the support top. A single-handle unlock for the support top is also provided.
US12186240B2
The present invention provides an inpatient unit of modular design, built of recycled materials and environmentally friendly materials, allowing reconfiguration, redeployment and quick assembly, preventing indoor air from leaking, applicable to epidemic prevention and treating special patients, with high structural strength, lower cost and good environmental benefit.
US12186238B2
A welding lens includes a variable light transmission shutter that automatically darkens in response to light emitted from a source. An intensity of the emitted light is sensed by a photo-sensor located on a front face of the welding lens. Internal circuits located within a housing of the welding lens receive data from the photo-sensor and correspondingly darkens or lightens the variable light transmission shutter based on the intensity of the light. The housing is 50.80 mm in width and 107.95 mm in length to fit in corresponding welding helmets and the housing is made from stainless steel to reflect infrared radiation that would otherwise overheat the internal circuits within the welding lens.
US12186233B2
The present disclosure discloses a non-slip condom, including a sleeve body, where the sleeve body has an open end, a closed end, a male side, and a female side; no less than 5% of a bottom surface of the male side has a primary microstructure capable of increasing a surface area; and an area ratio of a total surface area per unit area of the bottom surface of the male side including the primary microstructure to the unit area is 1.05 to 565.00. The condom provided by the present disclosure can keep fit with a male penis during sexual intercourse to reduce the relative slip between the condom and the penis skin, and is not easy to wrinkle or slip off, thus reducing the mucosal injury and unreality sensation. Moreover, the condom helps to increase the consumers' willingness to use the condom and prevent sexually transmitted diseases (STDs).
US12186230B1
A urination assistance apparatus includes a base, a tube having an upper end and a lower end, a joint assembly, and a urine funnel. The tube is attached to the base at the lower end and attached to the joint assembly at the upper end. The joint assembly connects the urine funnel to the tube.
US12186228B2
A stoma adapter is described that is especially suited to a recessed stoma or a flush stoma. The stoma adapter effectively extends the discharge passage from the stoma, protects peristomal skin, and forms a bridge at the interface between the stoma and an ostomy appliance. The stoma adapter contains a substantially unobstructed discharge passage, at least for effluent flowing in a discharge direction. The stoma adapter includes a seal for sealing against the bowel wall. The stoma adapter has collapsing, expanding, flexible and reinforced designs.
US12186222B2
The orthopedic device includes an articulating frame including a thigh portion including a curved thigh cuff, a calf portion including a curved calf cuff, and a center hinge connecting the thigh portion and the calf portion. A strap includes a calf end segment securely attachable to the calf portion. A suspension segment is adjacent to the calf end segment. A thigh end segment is securely attachable to the thigh portion. A spiraling segment is adjacent to the thigh end segment. An intermediate segment formed of webbing material is between the suspension segment and the spiraling segment. The clip engages the intermediate segment. The clip is engageable with a clip receptacle positioned on the calf portion. During use, the suspension segment lays across the top part of the calf minimizing migration. The intermediate segment facilitates movement of the strap through the clip adjusting the spiraling segment and the suspension segment.
US12186201B2
A spinal cage with a wall extending in a longitudinal direction defining an interior space is disclosed. There is also provided a deployable element in movable relation to the spinal cage.
US12186196B2
The present disclosure generally relates to an elbow arthoplasty prosthesis that includes an ulnar component, a humeral component, one or more articulation liners, and a retention trap. The ulnar component includes a spherical bearing head that can be inserted into the humeral component in a number of orientations. The articulation liners and the retention trap are operatively engaged to the humeral component to retain the ulnar component within a humeral socket. The present disclosure also relates to methods of assembling and implanting the prosthetic device.
US12186195B2
A sacroiliac joint implant system includes a primary implant configured to be received in a sacroiliac joint of a patient and a secondary implant configured to couple with the primary implant. The primary implant includes a body extending from a proximal end to a distal end and a plurality of threads extending from the body. The secondary implant includes a first anchor configured to anchor within a sacrum of the patient and a second anchor configured to anchor within an ilium of the patient.
US12186193B2
The invention relates to medicine and, more particularly to surgery and oral surgery. A titanium matrix based on a tension-free metal warp knit fabric for guided tissue regeneration is made of a warp-knitted mesh fabric formed from titanium threads, the structure of the mesh fabric being in the form of a combined, plain, two-bar metal warp knit fabric formed on the basis of primary and derived weaves and having alternating wales consisting of one and two titanium threads respectively, wherein the titanium threads have a contoured surface. The technical result is: a decrease in the elasticity and an increase in the plasticity of the material, allowing the set dimensions of an implant to be preserved after the removal of all loads on the material; an increase of the adhesion of the matrix to the wound bed; delineation of the growth of the mucous membrane and of the bone tissue; good quality formation of the necessary volume of bone tissue for the subsequent insertion of dental implants; minimal likelihood of biomechanical incompatibility between the warp knit fabric and the mucous membrane, and reduced risk of trauma. 8 d.c., 7 ill. The invention relates to medicine and, more particularly to surgery and oral surgery. A titanium matrix based on a tension-free metal warp knit fabric for guided tissue regeneration is made of a warp-knitted mesh fabric formed from titanium threads, the structure of the mesh fabric being in the form of a combined, plain, two-bar metal warp knit fabric formed on the basis of primary and derived weaves and having alternating wales consisting of one and two titanium threads respectively, wherein the titanium threads have a contoured surface. The technical result is: a decrease in the elasticity and an increase in the plasticity of the material, allowing the set dimensions of an implant to be preserved after the removal of all loads on the material; an increase of the adhesion of the matrix to the wound bed; delineation of the growth of the mucous membrane and of the bone tissue; good quality formation of the necessary volume of bone tissue for the subsequent insertion of dental implants; minimal likelihood of biomechanical incompatibility between the warp knit fabric and the mucous membrane, and reduced risk of trauma. 8 d.c., 7 ill.
US12186186B2
An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.
US12186181B2
Balloon covers for a delivery apparatus for a prosthetic valve are disclosed. As one embodiment, a balloon cover includes first and second shell members that are configured to matingly engage with each other, each of the first and second shell members including a first portion and a second portion, the second portion having a larger width than the first portion. The first portions of the first and second shell members define a first cavity configured to receive a distal end portion of the delivery apparatus and at least a portion of an inflatable balloon mounted on the distal end portion of the delivery apparatus. The second portions of the first and second shell members define a second cavity configured to receive a positioning device mounted on the distal end portion of the delivery apparatus, proximal to a valve mounting portion of the distal end portion of the delivery apparatus.
US12186180B2
The present invention relates to a diffractive ocular implant with correct distance vision and enlarged near vision, which is charaterised, in particular, in that it has a phase-transfer curve as a function of the viewing distance (abbreviated as PTFF-TF) with an absence of discontinuity over a depth of field of at least 1.3D in corneal plane, advantageously greater than 1.45D, the absence of discontinuity being located between intermediate vision and near vision, i.e., between 0.5D and 4D for spatial frequencies from 0 to 100 cycles/mm, for a pupil with a diameter of at least 3 mm.
US12186172B2
A configuration in which an upper auxiliary layer of an absorber includes a super absorbent nonwoven fabric having a surface exposed on an uppermost surface of the absorber and having a Klemm water absorptiveness of 100 mm or more, first super absorbent polymer particles adjacent to a back surface of the super absorbent nonwoven fabric. The main absorption layer of the absorber is a cell absorbing sheet including second super absorbent polymer particles contained in the cells arranged at intervals. A convex bulging upward is formed at each cell in an upper sheet. The first super absorbent polymer particles are fixed to the upper surface of the upper sheet. An adhesion amount of the first super absorbent polymer particles on the upper surface of the upper sheet increases from the top of a convex toward the bottom of a valley between a convex and a convex adjacent each other.
US12186169B2
Aspects of the present disclosure relate to methods for making tampons including primary absorbent members and secondary absorbent members. In some configurations, the tampons may be constructed with a primary absorbent member formed by a primary absorbent pad in a rolled configuration. In some configurations, the tampons may be constructed with a primary absorbent member formed by first and second primary absorbent pads positioned in a crossing configuration.
US12186165B2
A wound treatment apparatus can include a wound dressing configured to be positioned proximate to a wound. Multiple optical fibers positioned at least partly in the wound dressing can include a first optical fiber and a second optical fiber. The wound treatment apparatus can include an emitter and a detector. The emitter can emit first electromagnetic radiation into the first optical fiber so that the first optical fiber passes the first electromagnetic radiation. The detector can generate a signal responsive to second electromagnetic radiation that exits the second optical fiber and contacts the detector.
US12186143B2
A method for excavating tooth material, having the steps of placing (S101) a structure-borne sound sensor on a tooth; excavating (S102) the tooth material by means of a fluid jet; detecting (S103) structure-borne sound signals during excavation by the structure-borne sound sensor; and regulating or controlling (S104) a fluid jet generating device based on the structure-borne sound signals.
US12186139B2
One example method for scene-adaptive image quality in surgical video includes receiving a first video frame from an endoscope, the first video frame generated from a first raw image captured by an image sensor of the endoscope and processed by an image signal processing (“ISP”) pipeline having a plurality of ISP parameters; recognizing, using a trained machine learning (“ML”) model, a first scene type or a first scene feature type based on the first video frame; determining a first set of ISP parameters based on the first scene type or the first scene feature type; applying the first set of ISP parameters to the ISP pipeline; and receiving a second video frame from the endoscope, the second video frame generated from a second raw image captured by the image sensor and processed by the ISP pipeline using the first set of ISP parameters.
US12186135B2
Disclosed are various real-time robotic-assisted dimension measurement systems and techniques based on the collected kinematic data from one or more surgical tools within a robotic surgical system. In some embodiments, the collected kinematic data can include positions and orientations of each joint of the one or more surgical tools which are derived from positions and orientations of a set of arm joints of one or more robotic arms which the one or more surgical tools are attached to. The disclosed dimension measurement systems allow a surgeon to perform real-time length measurements of both straight-lines and curved-lines, as well as area and volume measurements on specified portions of tissues or organs by strategically placing the tips of the one or more surgical tools over the tissues or organs, while viewing the distal ends of the surgical tools in a user display.
US12186133B2
Systems and methods for improving the quality of ultrasound images made up of a combination of multiple sub-images include giving more weight to sub-image information that is more likely to improve a combined image quality. Weighting factor information may be determined from the geometry (e.g., angle or path length) of a location of one or more specific transducer elements relative to a specific point within a region of interest or a region of an image. In some embodiments, any given pixel (or other discrete region of an image) may be formed by combining received echo data in a manner that gives more weight to data that is likely to improve image quality, and/or discounting or ignoring data that is likely to detract from image quality (e.g., by introducing noise or by increasing point spread).
US12186132B2
Ultrasound image devices, systems, and methods are provided. An ultrasound imaging system comprising a processor circuit in communication with an ultrasound probe comprising a transducer array, wherein the processor circuit is configured to receive, from the ultrasound probe, a first image of a patients anatomy; detect, from the first image, a first anatomical landmark at a first location along a scanning trajectory of the patients anatomy; determine, based on the first anatomical landmark, a steering configuration for steering the ultrasound probe towards a second anatomical landmark at a second location along the scanning trajectory; and output, to a display in communication with the processor circuit, an instruction based on the steering configuration to steer the ultrasound probe towards the second anatomical landmark at the second location.
US12186128B2
Methods, systems, and cooptation measurement devices as described herein include an elongate sensor body at the end of a proximal connecting member, and a plurality of sensors in an array across a face of the sensor body, wherein each sensor of the plurality of sensors is configured to detect if a portion of a heart valve is in contact with the sensor.
US12186127B2
A method for tracking an interventional medical device in a patient includes interleaving, by an imaging probe external to the patient, a pulse sequence of imaging beams and tracking beams to obtain an interleaved pulse sequence. The method also includes transmitting, from the imaging probe to the interventional medical device in the patient, the interleaved pulse sequence. The method further includes determining, based on a response to the tracking beams received from a sensor on the interventional medical device, a location of the sensor in the patient.
US12186121B2
A medical image diagnostic apparatus of an embodiment includes processing circuitry. The processing circuitry executes a scan based on a protocol designated by a user. The processing circuitry extracts a candidate protocol to be executed next to the protocol, based on protocol order information in which identification information that indicates each of a plurality of candidate protocols that can be executed starting from a specific protocol, and order information in which each candidate protocol is executed, are correlated with each other. The processing circuitry outputs the extracted candidate protocol.
US12186118B2
A system and method relating to a radiation based imaging are provided. The system may include a radiation source, a detector, a first grid, and a second grid. The detector may include a plurality of detector cells. The first grid may be located between the radiation source and the detector and include a plurality of first radiation transmitting sections. The second grid may be located between the first grid and the detector and include a plurality of second radiation transmitting sections. An extending direction of at least one of the plurality of first radiation transmitting sections may be different from that of at least one of the plurality of second radiation transmitting sections.
US12186113B2
One or more example embodiments provides a method for evaluating an angiographic dual-energy computed tomography dataset recorded using a contrast agent comprising iodine to determine a quantitative calcium score.
US12186111B2
A remote watching system includes a sensor attached to a bed apparatus and configured to acquire biological information about a bed user who uses the bed apparatus, a server configured to receive the biological information from the sensor and output a notification that is based on the biological information, and a mobile terminal configured to receive the notification and display the received notification, wherein the server outputs only a previously set notification or the mobile terminal displays only a previously set notification.
US12186109B2
There is a need for more effective and efficient predictive data analysis, such as more effective and efficient data analysis solutions for performing predictive monitoring of the glucose-insulin endocrine metabolic regulatory system. Certain embodiments utilize systems, methods, and computer program products that perform predictive data analysis by utilizing at least one of glucose surge excursion detections, steady-state glucose-insulin machine learning models, and parameter space refinement machine learning models.
US12186101B2
An insertable physiological monitor injector tool is provided. An elongated handle includes a recess formed along a longitudinal axis and has an opening on a distal end. An insertion tube has a hollow elongated shape that is movably positioned within the elongated handle, in the recess. A stationary arbor is affixed on a proximal end to a proximal end of the elongated handle and extends through the insertion tube when the insertion tube is in a retracted position. A tab is affixed to the insertion tube, wherein the tab can lock the insertion tube in an extended position.
US12186098B2
A medical device includes a sensor to observe a characteristic of an anatomy, and a sensor base coupled to the sensor. The medical device includes a coupling system to couple the sensor base to the anatomy. The coupling system includes a first adhesive member and a second adhesive member. The first adhesive member is coupled to the sensor base and the second adhesive member is to couple to the anatomy. The second adhesive member includes at least one cut-out to direct moisture to an ambient environment surrounding the medical device.
US12186096B2
A substance dispensing apparatus comprises a housing for handheld use and a mouthpiece coupled to the housing. The housing comprises a biometric sensor and a cavity sized to receive a reservoir. The mouthpiece comprises a recess and a capacitive sensor array. The apparatus further comprises a pump coupled to the mouthpiece and couplable to the reservoir and comprises a processor in communication with the biometric sensor, capacitive sensor array, and pump. The processor is configured to cause the pump to automatically dispense a substance from the reservoir to a mouth of an intended user via the mouthpiece in response to determining that: a unique biometric attribute of the intended user is detected by the biometric sensor based on biometric data from the biometric sensor; and a unique dentition of the intended user is positioned within the recess of the mouthpiece based on dentition data from the capacitive sensor array.
US12186089B2
Systems, methods, and apparatus for controlling a device based on the detection of transient oscillatory or pseudo-oscillatory bursts are disclosed. For example, a method can comprise detecting one or more transient oscillatory or pseudo-oscillatory bursts from an ongoing neural signal recording of a subject. The method can also comprise extracting one or more burst features from the one or more transient oscillatory or pseudo-oscillatory bursts detected within a detection period. The method can also comprise predicting a thought generated or conjured by the subject or a change in mental state evoked by the subject by applying at least one of a machine learning algorithm and a feature threshold to the one or more burst features extracted within the detection period. An input command associated with the prediction can be transmitted to the device in order to control the device.
US12186086B2
Methods and systems are provided for automatically diagnosing a patient based on a reduced lead electrocardiogram (ECG), using one or more deep neural networks. In one embodiment, a method for automatically diagnosing a patient using a reduced lead ECG comprises, acquiring reduced lead ECG data, wherein the reduced lead ECG data comprises less than twelve lead signals, determining a type of each of the less than twelve lead signals, selecting a deep neural network based on the type of each of the less than twelve lead signals, and mapping the less than twelve lead signals to a diagnosis using the deep neural network. In this way, reduced lead ECG data may be mapped to a diagnosis using an intelligently selected deep neural network, wherein the deep neural network was trained on reduced lead ECG data comprising a same set of ECG lead types as the acquired reduced lead ECG data.
US12186085B2
In one embodiment, the invention relates to systems, methods, and apparatus relating to the detection of a neuropathy such as a periopertive neuropathy. In one embodiment, a wristband comprising a plurality of anodes and cathodes is used. The wristband can be a component in a electrode array that includes a plurality of reference or recording electrodes. The electrode array can be configured to stimulate and collect responsive signals from an ulnar, a median, radial and posterior tibial nerve. The simulation and signal collection can be performed on a continuous basis for time periods of interest such as a given perioperative time period using a monitoring device.
US12186081B2
A behavioral feedback system is provided to facilitate shaping a subject's behavior during an activity by obtaining user input. The user input is obtained pursuant to user-selection of a behavior-related representation from a set of behavior-related representations, for an activity of a subject, displayed on an electronic device of the user. Each representation corresponds to a different potential behavior of the subject during the activity, and the selected behavior-related representation relates to a user-observed behavior of the subject during the activity. The method further includes determining, by one or more processors, a positive or negative feedback indication associated with the selected behavior-related representation, and generating a feedback signal to send to an electronic device of the subject to indicate to the subject the selected behavior-related representation and the associated positive or negative feedback indication.
US12186080B2
An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.
US12186073B2
The present invention solves the problem of implementation of the divider for determining the golden section of eyebrow in relation to face, which would have an improved construction compared to the dividers known in the art and would be easier to handle, and owing to the smaller number of visible structural elements would also have an innovative, improved design. Divider for determining the golden section of eyebrows according to the invention comprises two arms (1), which are pivotally connected to each other via a serrated gear, with each arm (1) having the longer part (b) and the shorter part (a) whose length ratios are equal to the golden ratio, i.e. 1.618, while the ratio of the distance (c) between the longer parts (b) of the arms and the distance (d) between the shorter parts (a) of the arms are also equal to the golden ratio, i.e. 1.618.
US12186069B2
A sensing system for determining the location and orientation of an object which comprises a magnetic tag. The sensing system comprises selection coils and interrogation coils. The selection coils are arranged to generate a spatially-varying DC magnetic field from which the location of the tag can be determined in use. At least some of the interrogation coils are arranged to generate one or more AC magnetic fields and at least some of the interrogation coils are arranged to receive harmonics, intermodulation products or time dependent variations of the AC magnetic fields, from which the orientation of the tag is determined in use.
US12186068B2
The present disclosure relates to an ear protection system (200) for a medical imaging device. It comprises an ear protection device (210), adapted to be fitted around or in the ears of a patient (P) to be imaged, and at least comprising a first communication interface (211) and at least one sensor device (212) adapted to determine a measurement of noise passing through the ear protection device (210) towards the ears of the patient. The system (200) further comprises a controllable signal emitter (230), adapted to output a proxy signal representing an expected imaging device noise and to be measured by the at least one sensor device (212), and a patient assistance device (220), adapted to assist the patient to fit the ear protection device (210), and at least comprising a second communication interface. During a preparation phase of the patient preceding an imaging phase using the medical imaging device, the ear protection device (210) and the patient assistance device (220) are communicatively connected to each other via the first and second communication interface, and the patient assistance device (220) generates assisting instructions to the patient depending on an evaluation of the proxy signal and the measurement of noise passing through the ear protection device (210) determined by the sensor device (212).
US12186062B2
Systems and methods are disclosed for determining individual-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, individual-specific anatomic data and blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the individual-specific anatomic data and blood flow characteristics for each of the plurality of individuals; relating, based on the executed machine learning algorithm, each individual's individual-specific anatomic data to functional estimates of blood flow characteristics; acquiring, for an individual and individual-specific anatomic data of at least part of the individual's vascular system; and for at least one point in the individual's individual-specific anatomic data, determining a blood flow characteristic of the individual, using relations from the step of relating individual-specific anatomic data to functional estimates of blood flow characteristics.
US12186058B2
A multi-sensor blood loss monitor system is provided. Specifically, the blood loss monitor system can include a weight sensor, a volume sensor within an aspirator canister, and an integration device. Further, the blood loss monitor system can further be connected to a suction head adaptor. The weight sensor can be used to determine how many surgical wipes have been disposed, thereby estimating a volume of blood loss. In addition, the volume sensor can include a fluid level sensor and an optical spectroscopy sensor to determine an amount of blood in the aspirator container. The integration device can combine these data to display a total blood loss, as well as trigger an alarm when a blood loss level is exceeded.
US12186053B2
A computer implemented method, system and device are provided. The method transmits an energizing signal from an external antenna, coupled to a local external device (LED), to an implanted antenna of a passive implanted medical device (PIMD). The energizing signal is transmitted while the external antenna is at first and second positions. The method receives, at the external antenna, first and second energy transfer characteristic (ETC) values associated with the first and second positions, respectively. The method is under control of one or more processors configured with program instructions. The method analyzes the first and second ETC values to determine a difference therebetween. The method provides an energy transfer level (ETL) indicator based on the difference between the first and second ETC values. The ETL indicator provides feedback regarding a degree of energy transfer associated with at least one of the first and second positions.
US12186051B2
A system including a computing device, a software application stored in a memory of the computing device and configured to run on a processor of the computing device, and a module in communication with the computing device, said module including a data communication capability, where the data includes light intensity or wavelength information, a light source configured to provide light capable of penetrating the patient's skin to a subcutaneous level, a light sensor configured to detect the light from the light source reflected and scattered from the patient's skin including from the subcutaneous level at a single point in time or sequentially at multiple points in time, and a power source, where the software application is configured to determine levels or concentrations of a substance in a patient's skin based on a measurement of light intensity or wavelength from the light sensor.
US12186050B2
Computer implemented biometric methods and systems incorporate sensing biophysical phenomena, translating the phenomena into digital data and transmitting the data to a series of servers operating in an open feedback loop to generate a module. A biometric networking system can include a biometric monitoring cloud computing platform with AI/machine learning augmented models are generated to make user assessments, programs and confidence scores to the healthcare provider systems. The AI/machine learning models can be used by the biometric monitoring network to generate health-related AI processes that analyze relationships treatment techniques and outcomes. AI techniques can be used to calculate movement modeling and confidence scoring including support vector machines, neural networks, and decision trees. The biophysical phenomena may include biometric parameters based on data, such as medical history, exertion, sleep, temperature, cardiovascular events, respiratory events, and muscle and blood pH.
US12186047B2
The embodiments described herein can be used in a variety of grasping, cutting, and manipulating operations. In some embodiments, an apparatus includes a shaft, a tool member, and a flexure. The shaft has a distal end portion and a proximal end portion, and defines a longitudinal axis. The distal end portion includes a ground portion. The tool member has an engagement portion and an actuation portion. The engagement portion is disposed distally from the actuation portion, and can exert an engagement force on a target structure. The actuation portion receives an actuation force. The flexure has a first end portion coupled to the ground portion of the shaft, and a second end portion coupled to the tool member. The flexure is configured to deform elastically when the actuation force is exerted on the actuation portion of the tool member such that the tool member rotates relative to the shaft.
US12186045B2
A system comprises a neuromonitoring system configured to generate nerve data regarding a state of a nerve of a patient during a surgical procedure on the patient. The system includes a robotic system configured to receive or generate, for the surgical procedure, location data that identifies a location of the nerve of the patient. The robotic system may cause the neuromonitoring system to be in either an active state or an inactive state based on the location data, where the active state is a state in which the neuromonitoring system provides the nerve data to the robotic system, while the inactive state is a state in which the neuromonitoring system does not provide the nerve data to the robotic system. The robotic system may further generate at least one control signal that implements one or more safeguards for the surgical procedure.
US12186025B2
A C-arm, or a mobile intensifier device, is one example of a medical imaging device that is based on X-ray technology. Because a C-arm device can display high-resolution X-ray images in real time, a physician can monitor progress at any time during an operation, and thus can take appropriate actions based on the displayed images. Monitoring the images, however, is often challenging during certain procedures, for instance during procedures in which attention must be paid to the patient's anatomy as well as a medical imaging device display. In an example, a surgical instrument assembly includes a processor, a surgical instrument configured to operate on an anatomical structure, and a display coupled to the processor and attached to the surgical instrument. The display can be configured to display visual information comprising X-ray images generated by a medical imaging device.
US12186020B2
An ophthalmologic apparatus includes: an objective lens that faces a subject's eye; an alignment light emitting unit that irradiates the subject's eye with alignment light to perform measurement of alignment between the objective lens and the subject's eye; an alignment reflection light receiving unit that receives alignment reflection light, which is a reflection of the alignment light from the subject's eye; an anterior segment camera that receives corneal reflection light; and a holder positioned between the anterior segment camera and the objective lens to hold the anterior segment camera, wherein the holder includes an imaging transmissive portion that transmits the corneal reflection light to the anterior segment camera, a first light-transmissive portion that transmits the alignment light from the alignment light emitting unit, and a second light-transmissive portion that transmits the alignment reflection light from the subject's eye.
US12186019B2
An eyeglasses frame is disclosed that includes a left rim and a right rim. Each of the left rim and the right rim has a medial side and a temporal side. The temporal side of one of the left rim and the right rim has a lens mounting edge and a blind recess that extends from the lens mounting edge. The eyeglasses frame also includes a camera enclosure that is disposed on a posterior segment of the temporal side of one of the left rim and the right rim. The camera enclosure extends from a first end adjacent to the lens mounting edge to a second end disposed posterior of the posterior segment of the one of the left rim and the right rim. The second end of the camera enclosure has an observation aperture, wherein an image viewing axis disposed through the observation aperture is angled medially and upwardly.
US12186017B2
A method comprises capturing at least one image of an eye of a user; processing the at least one image to obtain at least one metric of the eye, wherein the obtained at least one metric comprises at least one of: a sagittal depth of the eye of the user for at least one semi-meridian radial distance outside the cornea, a diameter of the cornea of the eye, a position of a center of the pupil or first Purkinje image of the eye, a radius of curvature of the cornea, or a position of the lids of the eye, and an aperture height between the lids; and determining, based on the at least one metric, at least one parameter of a first contact lens to be worn on the eye with display eyewear or a second contact lens to be worn on the eye without the display eyewear.
US12186015B2
Methods, apparatuses and systems are provided for non-invasive delivery of microwave therapy. Microwave energy may be applied to epidermal, dermal and subdermal tissue of a patient to achieve various therapeutic and/or aesthetic results. In one embodiment, the microwave energy is applied to a target tissue via an energy delivery applicator connected to an energy generator. The energy delivery applicator may comprise one or more antennas, including monopole, dipole, slot and/or waveguide antennas (among others) that are used to direct the microwave energy to the target tissue. The energy delivery applicator may also comprise a cooling element for avoiding thermal destruction to non-target tissue and/or a suction device to localize thermal treatment at specific portions of a skin fold.
US12186011B2
Described here are devices, systems, and methods for applying pulsed or modulated electric fields to tissue. In some variations, a device may comprise a first elongate body comprising a lumen, a second elongate body at least partially positioned within the lumen, and an expandable member rolled about the second elongate body. The expandable member may comprise an inner end coupled to the second elongate body, an outer end coupled to the first elongate body, and an electrode array.
US12186006B2
An energy treatment device includes: a base having electrical conductivity and including a treatment surface for applying a high-frequency current to a treatment target when being supplied with electrical energy. A coating, including a silane coupling agent having a coupling structure, is formed over at least the treatment surface of the base by a bond due to the coupling structure; and an organic layer is disposed between the treatment surface of the base and the coating, and is bonded to the surface of the base. The coupling structure of the coupling agent of the coating is bonded to the organic layer.
US12186002B2
This disclosure relates to surgical devices and methods for repairing bone defects. The defect indicators disclosed herein may be utilized to indicate a precise location of the defect associated with an articular surface of a joint.
US12186000B2
The present disclosure is directed to temporary antimicrobial-eluting cement spacer implants, and assemblies, kits, and methods for forming the same. Particularly preferred disclosures are to modular spacers, assemblies, and kits, as well as methods of manufacturing the same, where the modular nature of the spacer permits the selection of specific desired length spacers, as well as specific selection of antimicrobial compounds and dosages, along with the components and processes for forming the same.
US12185980B2
Bone anchor assemblies and related methods are disclosed herein that can provide for improved fixation of a primary bone anchor. A bone anchor assembly can include a base rotatably received within a rod-receiving member. The base can have a toroid body with a radially-extending portion including at least one auxiliary bone anchor opening that can receive an auxiliary bone anchor to augment fixation of a primary bone anchor of the bone anchor assembly. The base can be rotated relative to the rod-receiving member and the primary bone anchor such that the at least one auxiliary bone anchor opening can be placed in a desired position for supplemental fixation.
US12185975B2
A cannula assembly having a retention member and a method of manufacture of the cannula assembly is provided. The cannula assembly includes a cannula and a sleeve disposed around the cannula from a proximal end to a distal end. The sleeve can include a balloon formed by a stretch blow molding process following local heating once advanced over the cannula. Once formed, the balloon can be conditioned to constrict against the cannula. A conditioning aid can be advanced over the balloon when it is still formable to constrict the balloon against the cannula.
US12185971B2
A surgical knife for introduction through a cannula includes a handle portion with an angled transition to a reduced portion. A blade connected to the reduced portion has a width perpendicular to the longitudinal axis that is equal to or greater than half the effective handle dimension. The blade is connected to the handle so that the outer transverse edge of the blade is outwardly offset from the outer surface of the handle. The blade width is preferably 80% of the effective dimension of the handle. The blade includes a cutting edge that extends across the width of the blade. In use, the knife can be extended through a cannula to make a first incision, retracted and rotated 180°, and then make another incision colinear with the first incision to create a single incision having a length greater than the width of the cannula.
US12185962B2
Described here are methods, systems, and devices, useful for minimally invasive surgical procedures. The methods may include introducing a grasper through an opening into an abdominal cavity, grasping a portion of a left lobe of a liver with the grasper, rotating the grasper towards a control element located outside the abdominal cavity by applying a magnetic field to the grasper across a body wall, and moving the control element over a set of ribs such that the liver bends into a folded configuration.
US12185944B2
An adhesion device incorporates element block assemblies partially disposed within an element support body having an engagement surface. Each element block assembly may include an element activation sheet, an element deployment sheet, a plurality of engagement elements, and an element transition mechanism operatively coupled to the engagement elements. The element transition mechanism is reversible to transition from a neutral configuration wherein the element activation sheet is substantially adjacent to the element deployment sheet, and an expanded configuration wherein the element activation sheet and the element deployment sheet are separated by a transition gap. The element support body, while each element transition mechanism is disposed in the neutral configuration, constrains each engagement element in a deployment state with a substantially straightened configuration perpendicular to the engagement surface and suitable for insertion into (or removal from) a target material. The element support body, while each element transition mechanism is disposed in the expanded configuration, constrains each engagement element in an engagement state eccentrically tensioned as the result of the transition gap into a reactive flexure to capture surrounding target material.
US12185943B2
The present invention provides a suturing device to minimize interference and obstructions during intricate surgeries. The curled suture device is significantly shorter than traditional suturing kits by featuring a needle attached to a specially manufactured thread incorporating a stopping mechanism preceding an angular, semi-rigid portion of thread followed by a curled portion of thread arranged in a corkscrew configuration. The stopping mechanism halts the movement of the thread as the needle and thread intermediate the needle and stopping mechanism is pulled through the suture point, securing the remainder of the thread for access. The semi-rigid portion of thread is thereby utilized in conjunction with its curled portion of thread, allowing for the user's unabated access to the corkscrew configuration to form a ready-made knot, minimizing interference and obstruction during surgery. The thread may be manufactured to form an additional semi-rigid and curled portions of thread upon creation of a knot.
US12185929B2
A suture retention device includes a housing having one or more suture slots. The device also includes a plunger with suture slots. The plunger is slidably disposed in a channel in the housing and when the housing suture slots are aligned with the plunger suture slots, a suture filament may be disposed in the slots. When the plunger is actuated so that the housing suture slots are misaligned with the plunger suture slots, the suture filament is captured between the plunger and the housing preventing movement of the suture filament.
US12185926B2
Techniques for securing an instrument to a surgical robot are provided. In an example, an apparatus can include a first portion, a second portion and a collar. The first portion can attach to an end of an arm of the surgical robot and can include a first rod extending away from the arm. The second portion can hold the surgical instrument and can include a second rod extending away from the surgical instrument. The collar can slidably adjust along an aligned axis of the first and second portions secure interfaces of the portions and to allow engagement and dis-engagement of the interfaces with each other.
US12185923B2
Universal laryngoscope blades and associated methods are disclosed. A universal laryngoscope blade includes a blade body. The blade body includes a first end and a second end. The second end is configured for insertion into a larynx. The universal laryngoscope blade further includes a viewer connected to the blade body. The viewer is configured to function independently from each of a conventional handle and a fiber-illuminated handle. The universal laryngoscope blade further includes a blade fitting disposed at the first end of the blade body. The blade fitting is removably connectable to, one at a time, each of a hook-on fitting of the conventional handle and a hook-on fitting of the fiber-illuminated handle. The hook-on fitting of the conventional handle has at least one physical dimension that is different from at least one physical dimension of the hook-on fitting of the fiber-illuminated handle.
US12185921B2
A flexible high-resolution endoscope apparatus and methods involving a plurality of optical fiber bundles; a plurality of lenses in a one-to-one correspondence with the plurality of optical fiber bundles, each lens of the plurality of lenses comprising a distinct depth of field and a distinct angle of view in relation to another lens of the plurality of lenses; and a plurality of cameras in a one-to-one correspondence with the plurality of optical fiber bundles.
US12185918B2
An operation apparatus for performing an operation by steering an end effector includes a wire which is connected to the end effector to steer the end effector, and a tension compensator which is connected with the wire, wherein in an operating state, the tension compensator changes a shape or position in response to tension of the wire to keep the wire tight, and when the wire is pulled to steer the end effector, the tension compensator is shifted to a lock state in which the shape or position is not changed.
US12185915B2
An actuator system for use in an optical system of an endoscope. The actuator system including: at least one actuator; and a holder for receiving at least one optical element of the optical system, the holder is configured to be flat and extends in a holder plane. The holder including: an outer enclosure; a leaf spring; and an inner platform. Wherein the outer enclosure at least partially surrounds the leaf spring and the leaf spring at least partially surrounds the inner platform, the outer enclosure is elastically coupled to the inner platform via the leaf spring, the inner platform is configured to receive the optical element, and the at least one actuator interacts with the inner platform.
US12185910B2
A method for manufacturing a tip housing for the distal tip of a vision device such as an endoscope is disclosed. The method includes providing a molding tool, introducing in the molding tool a first housing material, introducing in the molding at least one further housing material different from the first housing material, allowing the at least one further housing material to set and form a combined housing component with the first molding material, and removing the combined housing component from the molding tool.
US12185906B2
Systems, devices, methods for capsule endoscopy procedures are disclosed. A system for a capsule endoscopy procedure includes a capsule device configured to capture in-vivo images over time of at least a portion of a gastrointestinal tract (GIT) of a person, a wearable device configured to be secured to the person where the wearable device is configured to receive at least some of the in-vivo images from the capsule device and to communicate at least some of the received images to a communication device at a same location as the wearable device, and a storage medium storing machine-executable instructions configured to execute on a computing system remote from the location of the wearable device. The instructions, when executed, cause the computing system to receive communicated images from the communication device, perform processing of the communicated images received from the communication device, and communicate with at least one healthcare provider device.
US12185897B2
A system includes a power tool and a suction device that is connected to the power tool via a suction hose. The power tool is drivable into a wall or into a substrate by a negative pressure produced by the suction device. A method includes driving the power tool into the wall or into the substrate by using the negative pressure produced by the suction device that is connected to the power tool via the suction hose.
US12185882B1
A disabled person transfer seat with a first vertically oriented bar with a first horizontal pivot, at least two structural support sections each having upper and lower support bars separated vertically with a brace plate covering a majority of the spaces between them, and a seat, which may be removable, positioned for a disabled person to comfortably sit. The at least two structural support sections are serially coupled to the horizontally pivotally coupled to each other between the first horizontal pivot and the seat, which is also pivotally mounted at a distal end of the vertically mounted to the first horizontal pivot. The removable seat includes a frame, a seat and handles, with an open center and gaps to enable drying of a patient. In some embodiments the structural support sections can nest to enable more compact storage.
US12185881B2
A method can include inserting an inflatable body into an opening of a portable toilet; inflating the body by passing air through a valve and into the body, the valve secured to the body and defining a hole in the body; sealably engaging the plug with the opening; and transporting the portable toilet with the portable toilet in a filled condition.
US12185878B2
Food preparation platter system with a juice groove and end notches for food preparation convenience
A system for collecting liquids includes a platter and two or more cutting boards. The platter includes an upper surface, a lower surface, and a platter edge surrounding and joining the upper surface and the lower surface. The platter edge on the upper surface is higher than two or more centers of the upper surface. The platter includes one or more ridges on the lower surface. The one or more ridges is contiguous with the platter edge on the upper surface. Each of the two or more cutting boards include a top surface for receiving food items, a bottom surface resting on the upper surface of the platter, and a board edge surrounding and joining the top surface and the bottom surface. Each cutting board is placed on a center of the upper surface.
US12185875B2
The present disclosure provided a food processor, a cutter set mounting structure and a stirring cup. The cutter set mounting structure includes: a container bottom, a mounting hole being provided in the container bottom; and a cutter holder mounted at the mounting hole and used for allowing a cutter of a food processor to be mounted, and the cutter holder is provided with an anti-disengagement part, an anti-disengagement matching part is arranged at the container bottom, and the anti-disengagement part matches the anti-disengagement matching part to limit the cutter holder from being disengaged from the mounting hole under the action of gravity. In the present disclosure, by means of the matching of the anti-disengagement part and the anti-disengagement matching part, the cutter holder can be prevented from being disengaged from the mounting hole under the action of gravity.
US12185868B2
An automated heating and/or foaming apparatus and a method for heating and/or foaming a liquid are disclosed. The apparatus includes a stage, a liquid sensor, a measuring sensor, and a steam pipe. The stage is configured to support a container holding a consumable liquid. The liquid sensor is configured to recognize a type of the consumable liquid. The measuring sensor is configured to detect a surface level of the consumable liquid. The steam pipe includes a nozzle configured to inject water vapor or compressed gas into the consumable liquid to heat and/or foam the consumable liquid. A position of the nozzle in the consumable liquid relative to the surface level of the consumable liquid is adjusted based on the type and/or volume of the consumable liquid detected by the consumable liquid sensor and/or measuring sensor.
