US12319996B2
A cutting tool includes a substrate and a hard layer, wherein the hard layer includes a first unit layer and a second unit layer being alternately layered in the hard layer, a thickness of the first unit layer is 2 to 100 nm, a thickness of the second unit layer is 2 to 100 nm, the first unit layer is composed of TiaAlbBcN, the second unit layer is composed TidAleBfN, an atomic ratio a satisfy 0.25≤a<0.45, an atomic ratio b satisfy 0.55≤b<0.75, an atomic ratio c satisfy 0
US12319979B2
A method for recovering at least cobalt of valuable metals, cobalt and nickel, from an acidic solution obtained by subjecting waste containing positive electrode materials for lithium ion secondary batteries to a wet process, the acidic solution comprising cobalt ions, nickel ions and impurities, the method including: a first extraction step for Co recovery, the first extraction step being for extracting cobalt ions by solvent extraction from the acidic solution and stripping the cobalt ions; and a second extraction step for Co recovery, the second extraction step being for extracting cobalt ions by solvent extraction from a stripped solution obtained in the first extraction step for Co recovery and stripping the cobalt ions, wherein the first extraction step for Co recovery includes: a solvent extraction process for extracting cobalt ions in the acidic solution into a solvent; a scrubbing process for scrubbing the solvent that has extracted the cobalt ions; and a stripping process for stripping the cobalt ions in the solvent after the scrubbing into a solution.
US12319975B2
A modular direct reduction system for producing direct reduced iron (DRI) includes a reformer system which receives a flow of feed gas and which discharges a flow of reducing gas, the reformer system including a plurality of separate reformer modules connected together and wherein each reformer module includes a reformer vessel including an internal chamber, a reactor tube extending through the internal chamber of the reformer vessel and containing a catalyst configured to react with the feed gas received by the reactor tube to form the reducing gas, and a burner to burn a fuel gas to heat the reactor tube, and a furnace system connected to the reformer system and including a furnace having a first inlet which receives an iron ore, a second inlet which receives the reducing gas from the reformer system to form the DRI, and an outlet which discharges the DRI.
US12319974B2
The present invention relates to the use of reactive colourless and metal-free protein cross-linking agents for the cross-linking (tanning) of protein-containing substrates, said agents are environmentally friendly and give an improved fixation yield, a long-term cross-linking (tanning) stability and good washing off properties. The present invention further relates to processes for the cross-linking (tanning) of protein-containing substrates thereby creating an environmentally friendly process which minimizes the use of chemicals and further improves the quality and efficiency of the tanning and dyeing process.
US12319962B2
Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.
US12319960B2
A method for sequencing a nucleic acid molecule includes providing a sequencing cell having a nanopore in a membrane that resides over a well, a first electrode at a bottom of the well, a second electrode in a chamber above the membrane, and an electrolyte in the well and the chamber. The first electrode is configured to facilitate non-Faradaic conduction of ionic current and forms a capacitance with ions in the electrolyte. A first voltage signal is applied across the first and second electrodes, thereby creating a force that moves a nucleic acid molecule in the sequence cell through the nanopore. The first voltage signal increases to compensate for changes in the capacitance at the first electrode during application of the first voltage signal. The method further includes determining signal values measured during the first voltage signal, which correspond to one or more nucleotides in the nucleic acid molecule.
US12319958B2
Methods of treating disease include measuring a CCR2 profile of a patent, selecting a CCR2 antagonist based on the CCR2 profile of the patient, and administering the CCR2 antagonist to the patient. Methods for stratifying one or more patients for pain medication based on a CCR2 profile include measuring a CCR2 profile of one or more patients and partitioning the one or more patients into predetermined groups or subgroups based on the CCR2 profile of the one or more patients. Kits for performing the methods are also described.
US12319955B2
The present disclosure relates to materials and methods for spatial detection of nucleic acid in a tissue sample or a portion thereof. In particular, provided herein are materials and methods for detecting RNA so as to obtain spatial information about the localization, distribution or expression of genes in a tissue sample. In some embodiments, the materials and methods provided herein enable detection of gene expression in a single cell.
US12319953B2
Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.
US12319952B2
The invention belongs to the field of bioengineering and food technology, and discloses a method for enzymatic resolution of chiral substances, including the following steps: (1) preparing an enzyme solution with a lipase concentration of 1-3000 U/mL, and adding a soluble salt, a hydrophilic solvent and a hydrophobic solvent to the enzyme solution to form a three-liquid phase system; the hydrophobic solvent contains esters or amide compounds composed of racemic chiral compounds; (2) subjecting the three-liquid phase system to enzyme-catalyzed reaction under stirring condition; after the reaction is completed, standing or centrifuging the three-liquid phase system to divide it into three layers, which are a upper liquid layer, a middle liquid layer and a lower liquid layer from top to bottom. The optically pure chiral product after hydrolysis is mainly rich in the middle liquid layer or the lower liquid layer, while the upper liquid layer product is another ester or amide product containing an optically pure chiral product. The method has the advantages of low energy consumption, high raw material utilization rate, and mild reaction conditions, and solves the problems of low chiral resolution efficiency, poor chiral selectivity, low recovery rate, and difficulty in industrialization in the existing enzymatic method.
US12319948B2
Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same.
US12319943B2
Provided is a mutant protease with improved stability under acidic condition. A mutant protease that consists of the amino acid sequence as shown in SEQ ID NO:2 or an amino acid sequence having an identity of at least 90% thereto, in which the amino acid residue at a position corresponding to position 303 in the amino acid sequence as shown in SEQ ID NO:2 is substituted with another amino acid residue.
US12319941B2
The present disclosure discloses a thermophilic recombinant type II pullulanase and the application thereof, and belongs to the technical field of genetic engineering. The present disclosure obtains a thermophilic recombinant type II pullulanase by heterologously expressing type II pullulanase in Escherichia coli. Its optimum pH is 6.6, it has better pH tolerance under the conditions of pH 5.8-8.0, and its optimum temperature is 95° C. After incubating at 95° C. for 10 h, the remaining enzyme activity is greater than 50%. It can exhibit higher specific enzyme activity under strong reducing conditions. For example, adding DTT to the culture environment can increase the specific enzyme activity of Sumo-PulPy by 237.2%. The present disclosure also provides the combined truncation mutant Δ28N+Δ791C of type II pullulanase Sumo-PulPy. The specific enzyme activity of the enzyme mutant is 32.18±0.92 U/mg, which is 5.99 times as high as that of the wild-type enzyme, thereby having important industrial application value and potential.
US12319937B2
The present invention relates to a composition for culturing organoids and a method for culturing organoids by using the same. Since the present invention includes a compound, which can replace an essential protein component in a conventional medium, consistent stability during organoid culturing can be maintained and culturing can be performed at low cost.
US12319932B2
Provided herein are nucleic acids useful as guide nucleic acids (gNAs), e.g., guide ribonucleic acids (gRNAs), in a CRISPR system wherein the guide nucleic acids contain one or more modifications to one or more nucleotides, use of such guide nucleic acids in modifying cells, and other uses wherein CRISPR Cas proteins are utilized.
US12319925B2
Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
US12319922B2
The present disclosure provides compositions and methods for altering gibberellin (GA) content in corn or other cereal plants. Methods and compositions are also provided for altering the expression of genes related to gibberellin biosynthesis through suppression, mutagenesis and/or editing of specific subtypes of GA20 or GA3 oxidase genes. Modified plant cells and plants having a suppression element or mutation reducing the expression or activity of a GA oxidase gene are further provided comprising reduced gibberellin levels and improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types.
US12319910B2
Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.
US12319909B2
This invention relates to the isolation, concentration and/or purification of ribonucleic acid (RNA) in aqueous two-phase phase systems. In some embodiments, the present invention provides sample preparation methods, compositions and kit components for the isolation, concentration and/or purification of RNA from fluid mixtures comprising biological materials.
US12319908B1
A system and method for controlling active ion transporters, such as sodium-potassium (Na/K) pumps to actively transports 3 Na+ and 2 K+ ions by consuming one ATP. The system and method provide an oscillating electric field that is effective in running the active ion-transport at their physiological running mode by consuming one ATP molecule to actively transport ion and to synthesize one ATP for each pumping cycle. The ATP molecule that is synthesized compensates for the ATP molecule that is consumed in actively transporting ions, resulting in a net-consumption of ATP that is significantly reduced, theoretically to zero.
US12319905B2
It was difficult to create a thin bio sample embedded in an embedding material without using an expensive microtome. The present invention provides a medical device having a space for assisting in the embedding of a bio sample in an embedding material, the medical device being provided with a cover part and a base part having a recessed section in which the space is created by covering the cover part, wherein the base part is provided with a flow passage having an inlet section that is in fluid communication with the space, and the flow passage is configured such that when a force is applied to the medical device so that the volume of the space decreases, the embedding material flows out while preventing a positional misalignment of the bio sample inside the embedding material.
US12319904B2
Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.
US12319900B2
A gassing unit for bubble-free introduction of process gas into a liquid in a reactor, wherein the gassing unit includes at least: first and second spaced apart gas receiving chambers, the two gas receiving chambers connected to one another via at least two two-dimensional, gas-conducting diffusion membranes including hollow fibers spaced apart from one another and at least partially fixed to one another; a gas supply receptacle on at least one gas receiving chamber; a shaft receptacle on at least one gas receiving chamber; wherein the gassing unit for gassing the liquid in the reactor is supplied with process gas via the gas supply receptacle, is set into a rotational movement via the receptacle for the shaft and forms a convection flow within the reactor via rotational movement of the gassing unit in the liquid. Further included is a method for gassing a process liquid, a gas-liquid reactor including a gassing unit, and the use of a gassing unit for supplying biological cultures with process gases.
US12319899B1
In accordance with embodiments of the invention, a beverage additive is provided. The beverage additive includes β myrcene, β caryophyllene, a Pinene, 5 limonene, and α humulene. In one embodiment, the β myrcene is 3303000 ppm, the β caryophyllene is 1799000 ppm, the α Pinene is 574000 ppm, the 5 limonene is 505000 ppm, and the α humulene is 35000 ppm. A method for infusing a liquor is provided. The method includes the steps of steam distilling a hemp biomass for period of time to extract essential oils, providing a liquor, and adding the extracted essential as a beverage additive oils to said liquor.
US12319897B2
The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface.
US12319895B2
The present invention relates to compositions such as cleaning compositions comprising a mix of enzymes. The invention further relates, use of compositions comprising such enzymes in cleaning processes.
US12319891B2
A method for releasing an aldehyde or ketone of formula (2) by allowing a hydrolase to act on a compound of formula (1) is disclosed. The compound of formula (1) is used as a flavor or fragrance precursor. In formulas (1) and (2), each of R1, R2 and R3 independently represents a hydrogen atom, an alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, an alkenyl group which may have a substituent, an aryl group which may have a substituent, or an aralkyl group which may have a substituent; R1 and R2 or R1 and R3 may form a ring; Ar represents an aryl group which may have a substituent:
US12319886B2
A method of lubricating a fluid production pump may include mixing a polarized lubricant with water to produce a diluted lubricant. The method may additionally include creating a flowpath within the fluid production pump. An initial volume of the diluted lubricant may be circulated within the flowpath to allow the diluted lubricant to react with components of the fluid production pump and form a protective barrier on the components of the fluid production pump. The method may further comprise repeatedly introducing a periodic volume of diluted lubricant into the fluid production pump according to a predefined lubrication schedule.
US12319878B2
A process is provided for upgrading low value lipid feedstocks for refinery processing. The process includes (a) treating a lipid feedstock comprising at least one fatty acid with a metal oxide catalyst on an oxide support under treating conditions to produce a treated stream, wherein the treating conditions include a temperature in a range of from 400° C. to 700° C.; a pressure in a range of from 0 to 10 MPa; and a liquid hourly space velocity in a range of from 0.1 to 10 h−1; and (b) fractionating the treated stream to obtain a gaseous fraction and a liquid fraction comprising a bio-oil; wherein the bio-oil has a lower content of oxygen and impurities as compared to the lipid feedstock.
US12319875B2
A thermo-catalytic process for the depolymerizing waste plastic material and producing a pyrolytic oil, uses two agitated vessel depolymerization reactors, two condensation units, and a char handling section.
US12319874B2
A corbel for a coke oven, including a gunblock section having a longitudinal through-bore arranged therein, the gunblock section having at least one substantially vertical though-bore in communication with the longitudinal through-bore. The gunblock section may be integral with a base. The gunblock section may also include a substantially vertical-angular channel open to a first end of the gunblock section and also open to a first side of the gunblock section.
US12319868B2
Disclosed herein is a method of servicing a wellbore penetrating a subterranean formation with a thixotropic cement composition. The thixotropic cement composition comprises a cementitious material, maltodextrin, and an aqueous fluid, has a 10-minute gel strength of from about 30 lbf/100 ft2 to about 300 lbf/100 ft2, and can be used to reduce lost circulation in the wellbore. By incorporating maltodextrin into the thixotropic cement composition as disclosed herein, the thixotropic cement composition can have a similar 10-minute gel strength and an increased thickening time when compared to a reference composition.
US12319867B2
In general, in one aspect, embodiments relate to a bulk dry cement that includes a dry blend of, a cement, a solid particle, and a solid resin accelerator, where the solid resin accelerator includes a liquid resin accelerator disposed and dried on the solid particle so as to be included in the bulk dry cement.
US12319848B2
The teachings herein are directed at solid polymeric adhesive compositions for adhering metal components, methods for compounding the polymeric adhesive compositions, articles including a component having the polymeric adhesive composition, methods for producing articles including curing a solid adhesive, and articles including the cured adhesive. Preferred solid polymeric adhesive compositions include a plurality of one or more epoxy resins and one or more polysulfones. In one preferred aspect, the teachings are directed at a stator ring (e.g., for a hybrid motor) including the polymeric adhesive composition for adhering components to a ring.
US12319845B2
An aqueous adhesive for rubber includes rubber latex and an ammonium-salt-based vulcanization acceleration aid. An amount of the ammonium-salt-based vulcanization acceleration aid contained in the aqueous adhesive is preferably not less than 0.01% by weight and not greater than 5.0% by weight in terms of solid content. An aqueous adhesive for a ball includes rubber latex as a main component. A content of an inorganic filler in the aqueous adhesive is not greater than 0.1% by weight in terms of solid content. A ball 2 includes a hollow core 4 obtained by crosslinking a rubber composition that contains a vulcanizing agent. The core 4 is formed of two hemispherical half cores. The two half cores are adhered to each other by using the aqueous adhesive for a ball.
US12319841B2
A slurry composition for a chemical mechanical polishing (CMP) process, the slurry composition including a first organic polishing booster including a quaternary amine group; a second organic polishing booster including an amino acid; and a carrier; wherein inorganic polishing particles are not included in the slurry composition or included in an amount of less than 0.01% by weight.
US12319839B2
A coating composition for an optical article containing a photochromic compound and two or more (meth)acrylates, the two or more (meth)acrylates containing a non-cyclic difunctional methacrylate having a molecular weight of 500 or more and a non-cyclic tri- or higher functional (meth)acrylate.
US12319829B2
An organic electronic material including a charge transporting polymer having a structure that is represented by Formula (1) and that is branched in three or more directions (in the formula, Rf's are each independently a fluoroalkyl group, a and b are 0 or 1, and a and b are not both 0 at the same time).
US12319815B2
A resin composition including (A) a glycidyloxy group-containing organopolysiloxane in an amount of 100 parts by weight, (B) a neutral salt in an amount of 0.001 parts by weight or more and 1 part by weight or less, (C) a β-dicarbonyl compound in an amount of 0.5 parts by weight or more and 10 parts by weight or less, and (D) a solvent in an amount of 20 parts by weight or more and 300 parts by weight or less is provided. In a multi-liquid curable resin composition including a first liquid and a second liquid, the first liquid is the resin composition, and the second liquid contains (E) an organoaluminum compound and/or organotitanium compound.
US12319810B2
The present invention relates to a composition comprising components a), b) and c). The component a) is a block copolymer or a blend of block copolymers. The component b) is a low Tg additive selected from the group consisting of an oligo random oligo random copolymer b-1), an oligo diblock copolymer b-2), an oligo diblock copolymer b-3) and a mixture of at least two of these. The component c) is a is a spin casting organic solvent. The invention also pertains to the use of said compositions in directed self-assembly. The invention further pertains to the novel oligo diblock copolymer b-2) which is an oligo diblock copolymer of block A-b) and block B-b), wherein block A-b) is a random copolymer of repeat units having structures (III), and (IV and block B-b) is a random copolymer of repeat units having structures (V), and (VI).
US12319809B2
In the present disclosure, there are provided a vinyl alcohol-based copolymer including a first repeating unit derived from an olefin, a second repeating unit containing a hydroxyl group, and a third repeating unit containing a cyanoalkyloxy group formed by a reaction of the repeating unit containing a hydroxyl group and an unsaturated nitrile-based compound, wherein the third repeating unit is included in an amount of 2 mol % or more and less than 10 mol % with respect to 100 mol % of a total amount of the second repeating unit and the third repeating unit; a method for preparing the same; and a gas barrier film including the same. The vinyl alcohol-based copolymer has excellent moisture stability, thereby exhibiting excellent gas barrier properties even in a humid environment.
US12319808B2
Disclosed is a thermoplastic resin composition including a base resin having a diene-based rubber graft copolymer and a vinyl cyanide-aromatic vinyl-based copolymer, an olefin-based copolymer having a crystalline unit, and a metallic pigment.
US12319800B2
Methods of preparing reinforced anion exchange membranes are provided, as well as produced membranes and corresponding devices utilizing the membranes. Methods comprise compounding a halide-functionalized polymer (selected to react with amines to yield anion-conducting quaternary amine groups) with thermoplastic polymer(s) (selected to support and/or reinforce the membrane), and with copolymer(s) (selected to enhance the compounding of the polymers)—by heating, mixing and cooling—to form blend pellets, extruding the blend pellets to form a blend film, cross-linking polymer(s), and functionalizing the blend film to prepare the anion exchange membrane. Functionalization comprises a quaternization step comprising reacting halogen groups of the first polymer with tertiary amines to produce the quaternary amine groups with ion-exchange functionality. Reinforced anion exchange membranes are provided, which are produced by the disclosed methods, functionalized to yield a membrane for fuel cell(s), electrolyzer(s), reversible electrochemical device(s), desalination unit(s), etc.
US12319785B2
Provided is a method for producing an aromatic polyether, comprising reacting 4,4′-dichlorobenzophenone and hydroquinone in the presence of a potassium carbonate satisfying at least one of the following conditions (A) and (B): (A) the potassium carbonate has a bulk density of 1.2 g/ml or less; and (B) an average particle diameter D (μm) and a specific surface area S (m2/g) of the potassium carbonate satisfy D/S≤600.
US12319782B2
A phase difference film formed of a resin containing a polymer having crystallizability, wherein: a coefficient of variation CV(Re) of an in-plane retardation of the phase difference film at a measurement wavelength of 590 nm is 1.0% or less.
US12319771B2
The present invention relates to a catalyst composition including an imidazolinium ion-based catalyst and an aluminum-based cocatalyst, and a method for preparing an isobutene-isoprene copolymer using the same.
US12319770B2
Fluorided silica-coated alumina activator-supports have a bulk density from 0.15 to 0.37 g/mL, a total pore volume from 0.85 to 2 mL/g, a BET surface area from 200 to 500 m2/g, an average pore diameter from 10 to 25 nm, and from 80 to 99% of pore volume in pores with diameters of greater than 6 nm. Methods of making the fluorided silica-coated alumina activator-supports and using the fluorided silica-coated aluminas in catalyst compositions and olefin polymerization processes also are described. Representative ethylene-based polymers produced using the compositions and processes have a melt index of 0.1 to 10 g/10 min and a density of 0.91 to 0.96 g/cm3, and contain from 70 to 270 ppm solid oxide and from 2 to 18 ppm fluorine.
US12319769B2
What is provided is a RAFT polymerization reaction solution containing a RAFT agent represented by a specific chemical formula, water, and a water-soluble inorganic base, in which the RAFT polymerization reaction solution may further contain a polymerization initiator as an optional component, the RAFT agent has an acid group, the acid group forms a salt, and a molar ratio represented by M3/(M1+M2) is 1.0 to 10, in which the number of moles of the acid group forming the salt is indicated as M1, the number of moles of an acid group of the polymerization initiator, which may form a salt, is indicated as M2, and the number of moles of the water-soluble inorganic base is indicated as M3.
US12319761B2
The present invention relates to an olefin-based polymer satisfying requirements: (1) a melt index (MI, 190° C., 2.16 kg load conditions) ranging from 1.0 to 10.0 g/10 min; (2) a density (d) ranging from 0.875 to 0.895 g/cc; (3) 0.5 J/g≤dH(100)≤3.0 J/g and 1.0 J/g≤dH(90)≤6.0 J/g as measured by successive self-nucleation/annealing (SSA) using a differential scanning calorimeter (DSC); (4) 15≤T(90)−T(50)≤30 and 50° C.≤T(50)≤75° C. as measured by SSA using a DSC; and (5) a melting point (Tm) of 55° C.≤Tm≤80° C. as measured using a DSC. The olefin-based polymer according to the present invention is a low-density olefin-based polymer and has a highly crystalline region introduced therein, thereby exhibiting high mechanical stiffness.
US12319757B2
The invention pertains to a method of making fluoropolymer dispersions using certain polyfunctional perfluoropolyether derivatives including a plurality of ionisable groups selected from the group consisting of —SO.sub.3X.sub.a, —PO.sub.3X.sub.a and —COOX.sub.a, whereas X.sub.a is H, an ammonium group or a monovalent metal, and whereas said groups are comprised as pendant groups in the perfluoropolyether chain, and to fluoropolymer dispersions therefrom.
US12319756B2
A process for propylene preliminary polymerization in liquid phase that occurs in a continuous preliminary polymerization reactor may include feeding a propylene monomer and a Ziegler-Natta catalyst system having (a) a pro-catalyst having an internal electron donor comprising a substituted phenylene aromatic diester, (b) a catalyst activator and optionally (c) an external donor, into the continuous preliminary polymerization reactor, wherein the feeding is carried out without pre-contact of the pro-catalyst with the catalyst activator, and also without pre-contact of the catalyst activator with the propylene monomer before entering the continuous preliminary polymerization reactor.
US12319752B2
Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.
US12319751B2
The present invention provides an antibody specific to IgE antibody-producing B cells or an antibody binding fragment thereof. More specifically, the present invention provides an isolated monoclonal antibody or an antigen binding fragment thereof that binds to a peptide having a sequence consisting of an amino acid sequence set forth in SEQ ID NO: 1 or 18, and (1) binds to IgE antibody on a B cell surface and/or (2) binds to IgE antibody heated at 56° C.
US12319749B2
Disclosed are an antibody or a functional fragment thereof binding to 3′-sialyl lactose and comprising a heavy chain variable region which is optionally substituted with 3 or less amino acids and which comprises a CDR sequence consisting of an amino acid sequence ARKNGGLDYAMDY (SEQ ID NO: 3), a polynucleotide encoding the antibody or the functional fragment thereof, an expression vector comprising the polynucleotide, and a test drug for a disease and a pharmaceutical composition comprising the antibody or the functional fragment thereof.
US12319744B2
An antibody, preferably a blocking antibody, and most preferably a monoclonal antibody (mAb), specific for human endothelial cell protein C receptor (EPCR) such as mAbs JRK 1494 or JRK 1535 is used to reduce or attenuate joint swelling, macrophage infiltration, iron deposition and/or blood vessel formation and to treat arthropathy in a hemophilic subject.
US12319740B2
Provided herein are methods for the production of tissue resident memory-like T cells by the combination of hypoxia and TGFβ. Further provided herein are methods of using the tissue resident memory T cells as adoptive cell therapy.
US12319736B2
A pharmaceutical composition and a therapeutic method wherein an antibody-drug conjugate and an immune checkpoint inhibitor are administered in combination, and the antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to the antibody via a thioether bond; and a pharmaceutical composition and a therapeutic method for use in treatment of a disease that can be ameliorated through an antitumor immunity-activating effect wherein the antibody-drug conjugate is included.
US12319733B2
Method of detecting phosphorylation at Threonine 166 of a Rubicon protein to identify a subject having a disease associated with Leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease and compounds and methods for treating the same.
US12319728B2
The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
US12319725B2
The present disclosure discloses IL-2 mutants and uses thereof. More specifically, the disclosure provides IL-2 mutants and corresponding fusion proteins, conjugates, nucleic acid fragments, vectors, host cells, methods for preparing the mutants or fusion proteins, IL-2 mutants or fusion proteins prepared according to the methods, pharmaceutical compositions, pharmaceutical uses, methods for treating diseases, and methods for preferentially stimulating regulatory T cells. Compared to wild-type IL-2, the IL-2 mutants of the present disclosure have higher Tm values and improved stability; alternatively, the IL-2 mutants of the present disclosure have an increased yield or changed binding activity to the IL-2Rβγ complexes compared to wild-type IL-2.
US12319718B2
The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)n motif-REP]m or Formula 2: [(A)n motif-REP]m-(A)n motif, and having a serine residue content rate of less than 5.5%.
[In Formula 1 and Formula 2, the (A)n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A)n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300. The plurality of (A)n motifs may be the same amino acid sequence or different amino acid sequences. A plurality of REPs may be the same amino acid sequence or different amino acid sequences.]
US12319713B2
3,4-thiazolo steroids are provided herein. Also provided herein are methods of making and using the same for the inhibition of cell proliferation or the killing of cells.
US12319712B2
Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.
US12319702B2
Substituted benzoxazole and benzofuran chemical entities of Formula (I): wherein, V, W, X, Y, Z, and m have any of the values described herein and compositions comprising such chemical entities; processes for making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; and the treatment of one or more disorders, including neurological, cognitive, immunological, and inflammatory disorders, as well as other conditions and diseases involving PDE7 or cyclic nucleotide signaling.
US12319701B2
Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
US12319700B2
The invention relates to a process for preparing a monohydrate potassium salt of a 5 thienopyridone derivative. It also relates to a monohydrate potassium salt of a thienopyridone derivative and its use in medicine, in particular for treating or preventing metabolic disorders, such as NASH.
US12319698B2
The present invention is directed to compounds having the Formulae (Ia), (Ib), (Ic), or (Id); or the Formulae (II), (IIa), (IIb), or (IIc); or the Formulae (III), (IIIa), (IIIb), (IIIc), (IIId), or (IIIe), and pharmaceutically acceptable salts, solvates, clathrates and prodrugs of any Formula thereof, compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
US12319694B2
Heterocyclic nitrogen-containing purine derivatives and their use in the medicinal applications and compositions containing these derivatives is disclosed. A new generation of compounds possessing selective antineurodegenerative properties on neuronal cells and tissues and that can be particularly used in the treatment and prophylaxis of neurodegenerative disease, particularly in the treatment and prophylaxis of Parkinson's disease is also disclosed.
US12319693B2
Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
US12319692B2
The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
US12319685B2
Disclosed herein are small molecule pyrin-domain targeted NLRP3 inflammasome inhibitors.
US12319684B2
Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment of diseases including heart failure, chronic kidney disease, hypertension, and metabolic disorders such as insulin resistance/diabetes and obesity. The compounds disclosed herein are highly specific for the apelin receptor versus the angiotensin II receptor (ATI).
US12319683B2
The purpose of the present invention is to provide compounds having an M3 PAM action. Examples of the present invention include azabenzimidazole compounds represented, for example, by formula [I], and pharmacologically acceptable salts thereof. These compounds have M3 PAM activity. In addition, because these compounds have M3 PAM activity, these compounds are useful as agents for the prevention or treatment of voiding and/or storage disorders in underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, and neurogenic bladder.
US12319681B2
The present specification discloses tripartite androgen receptor eliminators (AREs), pharmaceutical compositions and medicaments comprising such AREs, methods and uses for such AREs and compositions and medicaments, and methods and uses for AREs and compositions and medicaments for treating an androgen receptor signaling-mediated condition, disease or disorder.
US12319677B2
The present invention relates to a process for the synthesis of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine in two hydrated crystalline forms and in one anhydrous crystalline form. The present invention further relates to methyl (Z)-4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)-N-cyanopiperidine-1-carbimidothioate which is an intermediate in this process.
US12319658B2
The present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type 2 diabetes mellitus.
US12319650B2
The disclosure relates to a cleaning process of a vinyl aromatic compounds distillation unit wherein the vinyl aromatic compounds distillation unit comprises one or more distillation columns, the process comprises a step of cleaning one or more distillation columns followed by a step of passivation of at least one distillation column wherein a flux comprising a passivation mixture is passed through at least one distillation column under passivation conditions comprising a temperature of at least 90° C., wherein the passivation mixture comprises a component A being one or more polymerisation inhibitors; and a component B selected from steam and/or one or more hydrocarbons devoid of vinyl group. The disclosure also relates to the process of purification and of production of one or more vinyl aromatic compounds that include the said cleaning process.
US12319648B2
The present invention relates to the use of a compound of Formula (I), wherein R1, R2 and n are as defined herein as a herbicide. The invention further relates to agrochemically acceptable salts, to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.
US12319646B2
The disclosure pertains to a urea production process wherein carbamate in a medium pressure (MP) urea solution is decomposed in a tube bundle of a high pressure (HP) carbamate condenser and resulting gas is condensed in indirect heat exchange with urea solution to be heated and wherein a high pressure (HP) stripper is preferably operated with relatively low stripping efficiency.
US12319644B2
The present invention belongs to the field of biomedicine, which discloses a class of lipid compounds containing carbamate bond and applications thereof. The lipid compounds have the following structures: wherein the definitions of the various groups are described in the specification. The lipid nanoparticulate carriers prepared from the compounds described in the present invention exhibit excellent biocompatibility and safety as well as unexpected improvements in transfection efficiency, making them suitable for biomedical industrialization.
US12319643B2
Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
US12319636B2
A composition including 2-chloro-3,3,3-trifluoropropene (1233xf), one or more of 2,3-dichloro-1,1,1-trifluoropropane (243db), 1,2-dichloro-3,3,3-trifluoropropene (1223xd), 2,3-dichloro-3,3-difluoropropene (1232xf), 2,2,3-trichloro-1,1,1-trifluoro-propane (233ab), 2,3,3-trichloro-1,1,1-trifluoro-propane (233da), 3,3,3-trifluoropropyne, 1-chloro-3,3,3-trifluoropropyne, 3,3,3-trifluoro-1-propene (1243zf), 1-chloro-3,3,3-trifluoro-1-propene (1233zd), 1-chloro-2,3,3,3-tetrafluoro-1-propene (1224yd), or 2-bromo-3,3,3-trifluoropropene and optionally 1233xf oligomers are disclosed.
US12319631B2
A fertilizer composition and method to produced based on milk which comes from ruminant animals like cows and goats and adding a coal dust component. The previous or past milk-based fertilizers have had poor efficacy obtained due to the high fat content of these milk sources due to using too much milk, or rather too much fat in the milk, since the bacteria in the composition will spoil and result in a foul odor, poor growth, and poor crop yield. This fertilizer composition contains a nutrient ingredient, which is the de-fatted milk, as a liquid or dry product, and are utilized between 10 percent weight and 95 percent weight plus uses the coal dust as a less expensive stabilizer and chelator as well as other minerals for Nitrogen-Phosphorus-Potassium utilization.
US12319626B2
Compositions and methods are provided for a system in which liquid carbon dioxide, or a mixture of liquid and gaseous carbon dioxide, is converted to solid carbon dioxide by exiting an orifice at a sufficient pressure drop, e.g., for delivery of carbon dioxide to a concrete mixture in a mixer.
US12319625B1
Systems and methods for forming laser induced periodic surface structures (LIPSS) on a ceramic substrate via an ultrashort pulse variable wavelength laser are disclosed. The LIPSS may comprise channels, protrusions, or other microstructures. LIPSS may be selectively formed on the ceramic substrate to allow for the adjustment of one or more properties of the ceramic material. Pre-processing and post-processing may be utilized to further adjust or change the properties and microstructure of the ceramic material. Post-processing, such as a heat treatment, may be utilized to join two or more ceramic substrates comprising LIPSS to adjust or change properties of a joined part comprising the two or more ceramic substrates.
US12319623B2
Methods of flash sintering have been developed in which particle are initially coated with thin layers by atomic layer deposition (ALD). Examples are provided in which 8 mol % yttria-stabilized zirconia (8YSZ) particles are coated with small quantities of Al2O3 by particle atomic layer deposition (ALD). Sintered materials that result from the process have been characterized. Sintered materials having unique characteristics are also described.
US12319621B2
Provided is at least one of a zirconia sintered body and a method for producing the same. The zirconia sintered body can be used in a wide range of applications compared with ceramic joined bodies of the related art that include transparent zirconia. A zirconia sintered body includes a transparent zirconia portion and an opaque zirconia portion, wherein the zirconia sintered body has a biaxial flexural strength of greater than or equal to 300 MPa.
US12319619B2
A composition configured to be mixed with cement, and associated systems and methods are disclosed herein. In some embodiments, the composition includes at least 10% by weight lime particles, and at least 35% by weight pozzolan particles. Properties of the composition can include a magnesium oxide concentration of at least 0.5%, and an iron oxide concentration of at least 0.5-2.0%, an aluminum oxide concentration of 2-8%, a silicon dioxide concentration of 20-40%, a potassium oxide concentration of 20,000-30,000 ppm, and a sodium oxide concentration of 10,000-20,000 ppm. In some embodiments, the lime-based cement extender composition, or product, is combined with cement to produce a cement blend for use in the mining industry as mine backfill.
US12319614B2
An article of fire rated glass and method of producing the same prepared by selecting a sheet of clear float annealed glass of at least 19 millimeters in thickness and providing the edge of the sheet substantially free of imperfections. The glass sheet is then specially tempered at a temperature of at least 575 degrees Celsius for a period of at least 750 seconds, followed by a cooling step.
US12319611B2
The present disclosure provides a glass substrate to which water repellency that is not lost by a heat treatment is imparted. Provided is a water-repellent-film-attached glass article including a glass substrate and a water-repellent film on the glass substrate. The water-repellent film includes cerium oxide, a contact angle of water on a surface of the water-repellent film is 75° or greater, and the contact angle is 75° or greater after the glass article is exposed to a thermal treatment at 760° C. for 4 minutes.
US12319608B2
Provided is a glass fiber, which achieves both of a low spinning temperature, and a low dielectric constant and a low dielectric loss tangent. The glass fiber includes as a glass composition, in terms of mass %, 40% to 80% of SiO2, 0% to 20% of Al2O3, and 10% to 30% of B2O3, includes at least one kind selected from MgO, CaO, SrO, BaO, Li2O, Na2O, K2O, ZrO2, Fe2O3, SnO2, F, and Cl, has a total content of MoO3, Cr2O3, Pt, and Rh of from 0.01 ppm to 500 ppm, and has a value of TiO2 (mass %)×MoO3 (ppm) of 3,100 or less.
US12319606B2
A method for the production of glass ribbon portions is provided that includes: transporting a glass ribbon at a velocity v1, wherein the velocity v1 is dependent on the predetermined glass thickness (d1), with the application of a tensile stress parallel to the edges of the glass ribbon, in a plane E1, and cooling the glass ribbon at a cooling rate that is dependent on the predetermined glass thickness (d1), inserting a score on the surface of the glass ribbon in at least one edge area by scoring the glass surface with a scoring tool, wherein the score has an angle a to the transport direction of the glass ribbon, deflecting the glass ribbon in a plane E2 to generate a bending stress and separating a glass ribbon portion with the formation of edges by breaking the glass ribbon on the extension of the score running transversely to the glass ribbon.
US12319600B2
Various aspects of the present disclosure are directed to sewage treatment plants and methods of operating sewage treatment plants. In one example embodiment, the sewage treatment plant includes a clarifier having an aeration region with a vent opening to blow in oxygenous gas for mixing water to be clarified and a settling region with an outlet. The sewage treatment plant further includes a wall system that delimits the at least one aeration region from the at least one settling region by the wall system. The wall system has a channel system which has at least one first opening leading to the aeration region in the region of the water level and a sludge removal device of the channel system in the region of a lower wall of the clarifier for transporting solids-rich water from the settling region into the aeration region.
US12319598B2
A flow electrode capacitive deionization system and a method for recovering phosphorus in phosphogypsum leachate and synchronous performing brine desalination belong to the technical field of wastewater treatment and recycling. The flow electrode capacitive deionization system includes a phosphorus recovery electrodeionization module and a desalination electrodeionization module. A first flow electrode solution reservoir, a phosphorus recovery electrodeionization module cathode flow electrode chamber, and a desalination electrodeionization module anode flow electrode chamber are interconnected in a circulation. A second flow electrode solution reservoir, a phosphorus recovery electrodeionization module anode flow electrode chamber, and a desalination electrodeionization module cathode flow electrode chamber are interconnected in a circulation. Two independent flow electrode solution circulation loops are formed. The phosphogypsum leachate enters the phosphorus recovery electrodeionization module and phosphorus is enriched into a flow electrode solution. A phosphorus-rich solution is reacted with a ferrous solution under an oxygen-free condition to generate vivianite [Fe3(PO4)2·8H2O].
US12319595B2
A fully stand-alone modular system which integrates tandems of photo-anodes and photovoltaic cells in a photo-electrochemical cell configuration.
Such a system consists of devices capable of using only solar energy, in particular by utilizing the visible spectrum, so as to decontaminate the wastewater from emerging pollutants, with the simultaneous production of hydrogen as an added value to the decontamination process, by means of photocatalytic processes.
US12319594B2
Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS.
US12319584B2
A carbon dioxide fixation method includes a step of preparing a calcium-containing substance containing calcium, a step of preparing a calcium extraction substance for extracting calcium ions from the calcium-containing substance by a reaction with the calcium-containing substance to produce a calcium-containing intermediate, a step of producing a gel including the calcium-containing intermediate, by mixing the calcium-containing substance and the calcium extraction substance, a step of supplying a basic substance and carbon dioxide to the gel including the calcium-containing intermediate to precipitate calcium carbonate which is slightly soluble, and a step of removing the precipitated calcium carbonate.
US12319581B2
A method of fabricating a silicon carbide material is provided. The method includes the following steps. A first annealing process is performed on a wafer or on an ingot that forms the wafer after wafer slicing. The conditions of the first annealing process include: a heating rate of 10° C./minute to 30° C./minute, an annealing temperature of 2000° C. or less, and a constant temperature annealing time of 2 minutes or more and 4 hours or less for performing the first annealing process. After performing the first annealing process, an average resistivity of the wafer or the ingot is greater than 1010 Ω·cm.
US12319573B2
A method for producing hydrogen by thermochemical splitting of water includes injecting one or more feed streams of water into a reaction chamber. The method further includes using a molten salt heated by a subterranean heat source to carry out the thermochemical splitting of water to form hydrogen and oxygen in the reaction chamber. The formed products are subsequently removed from the reaction chamber. Hydrogen formed in the reaction chamber may be used in a downstream process to generate hydrocarbons.
US12319570B2
Porous aluminum nitride (AlN) provides a greater surface area and higher permeability, which is especially desirable for advanced functional application. Porous or bulk aluminum nitride is very difficult to manufacture due mainly to its high melting point (e.g., 2200 degrees Celsius). A new processing method synthesizes porous aluminum nitride through a complete transformation from porous aluminum using a remarkably low nitriding or sintering temperature. The manufactured porous aluminum nitride foam can be used for such applications as filters, separators, heat sinks, ballistic armor, electronic packaging, light- and field-emission devices, and highly wear-resistant composites when infiltrated with metal such as aluminum, titanium, or copper.
US12319565B2
The disclosed invention is a MEMS environmental sensor and preparation method thereof. A transfer cavity is produced in the middle of a transfer substrate of a MEMS environmental sensor, and a transfer medium is located inside the transfer cavity. The surface area of an input port is larger than the surface area of an output port. An elastic transfer membrane is provided on the surface of the input port, and an elastic pressure membrane is provided on the surface of the output port. A load bearing cavity is provided in a load bearing substrate, a magnetic sensing element is positioned inside the load bearing cavity, and the load bearing cavity partially overlaps with the output port. The surface area of the input port of the transfer cavity is larger than the surface area of the output port, and on the basis of Pascal's principle, differences in the volume of the transmission cavity are used to transform a small displacement in a region of large volume into a large displacement in a region of small volume. In addition, because the output port and the end of the output port at least partially overlap, and a magnetic sensing element is arranged in the load bearing cavity, a change in displacement is produced, producing a change in a magnetic field, that is converted into a change in electrical resistance, which provides high-sensitivity and low-power detection.
US12319550B2
A pry bar includes a member having a first end, a second end, and an intermediate portion, a prying member arranged at the second end; and a retractable end guard moveably mounted at the second end. The retractable end guard is selectively configurable between a first position in which the retractable end guard covers the prying member and a second position in which the prying member is exposed.
US12319549B1
Disclosed is a multifunctional stable winch hook guide rail system. The system includes: a storage buckle; a guiding groove, where the guiding groove is formed on a front face of the storage buckle, a movable opening is formed on a back face of an inner wall of the guiding groove, and a winch hook is arranged inside the guiding groove; a hanging opening, where the hanging opening is located at a top of the winch hook at a position close to one end thereof, a side of an inner wall of the hanging opening is fixedly connected to a connector, an outer surface of the connector, through an insertion pin, is rotatably connected to a movable buckle. The winch hook can be easily tightened and securely locked in the guiding groove. The winch hook has a uniform and clean appearance and is used for rescue and heavy-duty towing tasks.
US12319541B2
An elevator system includes an elevator car within an elevator hoistway; a camera; and an image analysis system in communication with the camera; the camera providing a reference image to the image analysis system; the camera providing a current image to the image analysis system; the image analysis system comparing the current image to the reference image to detect a difference between the current image to the reference image; the image analysis system initiating a maintenance notification in response to the comparing.
US12319540B2
A method and arrangement for aligning elevator guide rails includes measuring the position of two opposite guide rails in respect of the direction between guide rails (DGB) direction and the back to front wall direction (BTF) direction with a plumb line and a measurement device arranged at each guide rail. Each measurement device includes a guide shoe supported on at least two guide surfaces of the guide rail, a measurement frame connected to the guide shoe, and a sensor for sensing the position of the plumb line in respect of the measurement frame. The twist of the guide rails is measured with a wire extending between the two measurement devices and an edge sensor arranged in connection with at least one of the two measurement devices.
US12319538B2
A method for dispatching an elevator car that includes determining a first duration for each of a plurality of first elevator cars to travel from a current location to a first location, and dispatching at least one of the first elevator cars to the first location when the first duration of the at least one first elevator car is less than a threshold duration. The method includes determining a second duration for an occupant to travel from the first location to a second location, and each of a plurality of second elevator cars to travel from the current location to the second location, when the first duration for the first elevator cars exceeds the threshold duration. The method includes dispatching at least one of the second elevator cars to the second location when the second duration of the at least one second elevator car is less than the threshold duration.
US12319537B2
A sheet conveying apparatus includes a tray having a plurality of sheets, a feeder to successively convey sheets stacked on the tray, a controller, and a double-feed sensor to detect double feed when the feeder conveys a plurality of sheets in an overlapping manner. When a double-feed length, which corresponds to a length, in a conveyance direction of the sheet, of a region in which the double feed has been detected by the double-feed sensor, is larger than a predetermined distance, the controller determines that the double feed has occurred. When the double-feed length is smaller than the predetermined distance and a sheet size is smaller than a predetermined size, the controller determines that the double feed has occurred. When the double-feed length is smaller than the predetermined distance and the sheet size is larger than the predetermined size, the controller determines that the double feed has not occurred.
US12319531B2
Sorting module for bags checking machines, of the type that are installed before the bag can enter the checking machine comprising driving means that activate the module, and in that comprises: a pressure roller (102) that puts pressure on the bags (1) as they pass through under said roller (102), which has an ascending and a descending motion, a first input roller (101) connected to conveyance means (4) of the checking machine and to the pressure roller (102), and at least one automatic or manually-operated diverter element (103) positioned bellow pressure roller (102), which has at least two positions, a first upward position that blocks the passing of the bags towards the conveyance means (4) and guides the bags towards another predetermined destination, and a second downward position that defines a passage (105) formed by the conveyance means (4), said diverter element (103) blocks the passing of the bags (1) towards the other predetermined destination and guides the bags (1) towards the passage (105).
US12319526B2
A horizontal forming device, in particular for horizontal flow pack machines, comprises at least one, in particular roller-free, forming unit (12a12d), in particular a forming shoulder, which is configured for forming a packaging material web (14a), in particular a paper web, into a packaging material tube (16a), the forming unit (12a-12d) comprising at least one folding edge (72a-72d) around which the packaging material web (14a) is deflectable, and comprises at least one form-guiding unit (18a-18d), in particular a further forming shoulder, which is configured for further guiding the packaging material tube (16a) transversely to a run-in direction (20a20d) of the packaging material web (14a) at the forming unit (12a-12d) while maintaining an, in particular homogeneous, material tension generated by the forming unit (12a12d),
wherein the horizontal forming device comprises at least one support surface (22a), in particular a work plate, on which products (24a) that are to be packaged can be transported, the forming unit (12a-12d) and the form-guiding unit (18a-18d) being arranged on sides (26a-26d, 28a-28d) of the support surface (22a) that face away from each other, wherein the form-guiding unit (18a-18d) comprises at least one form-guiding contour (86a-86d), which is configured to support the guided packaging material tube (16a) in order to implement a maintaining of the homogeneous material tension.
US12319525B2
A sheet feeding device includes a sheet tray, an extended bottom plate, a casing, and a support. The sheet tray includes a bottom plate and feeds a sheet placed on the bottom plate, toward an image forming apparatus. The extended bottom plate extends outward from the sheet feeding device and is coupled to an upstream end of the bottom plate of the sheet tray in a sheet conveyance direction in which the sheet is conveyed. The casing is attached to a side face of the sheet feeding device to cover the extended bottom plate. The support is disposed between an inner wall face of the casing and the extended bottom plate to support a weight load of the extended bottom plate.
US12319521B2
A computing system including a processing circuit in communication with a robot and a camera having a field of view. The processing circuit obtains image information based on the objects in the field of view and a loading environment, the loading environment which includes loading areas, an object queue, and a buffer zone. The computing system is configured to use the obtained image information in motion planning operations for the retrieval and placement of objects from the object queue into the loading environment. Pallets provided within the loading environment (i.e., within the loading areas) are dedicated to receiving objects having corresponding object type identifiers. The computer system further uses the image information to determine the fill status of pallets existing within the loading environment, and whether new pallets need to be brought into the loading environment and/or swapped out with existing pallets to account for future planning and placement operations.
US12319516B2
A selectably configurable modular labware transport system including a labware bulk overhead transport system module forming an overhead transport path. The labware bulk overhead transport system module has a labware support, with at least a movable part of the labware support being configured to support labware thereon, and move longitudinally defining the overhead transport path. The labware support has more than one labware holding stations for holding a labware piece, each of the labware holding stations having a different location along the labware support and overhead transport path. The labware bulk overhead transport system module is communicably couplable to another labware bulk overhead transport system module that forms another different overhead transport path, and effects undisrupted transport of the labware throughout the overhead transport path with the labware bulk overhead transport system module both coupled to and uncoupled from the other labware bulk overhead transport system module.
US12319513B2
A bulk feeder includes a feeder main body, a track member provided to be vibratable with respect to the feeder main body and formed with a conveyance path through which multiple components are conveyed and a supply region that communicates with the conveyance path and opens upward to collect the multiple components, an excitation device configured to apply vibration to the track member so that the multiple components are conveyed along the conveyance path, a shutter provided above the track member to close an opening of the supply region, and a driving device configured to open or close the shutter to separate the shutter from the track member when the shutter shifts from a closed state to an open state.
US12319511B2
A device attaches and detaches at least one of rollers in a belt conveyor in which an endless belt is wound around the rollers between a front plate and a rear plate of the belt conveyor. The device includes a guide and a roller holder. The guide has a base end and extends along a longitudinal direction of the detachable roller and includes a guide groove. The roller holder holds the detachable roller and includes an engagement portion, another engagement portion, and a guided portion. The engagement portion detachably engages with the front plate. The other engagement portion detachably engages with the rear plate. The guided portion slides along the guide groove toward the rear side or the front side of the device to engage or disengage the engagement portion with or from the front plate and engage or disengage the other engagement portion with or from the rear plate.
US12319505B2
A selective access device for a picking/deposit station in an automated warehouse defines an area which is accessible after having formed a passage having a front edge, a rear edge and two side edges opposite one another; the device is provided with a first cover engaging the area and includes a roller shutter, which is operated to open, so as to define the front edge of the passage, and with a second cover, which engages the area above the first cover, is defined by a plurality of doors beside one other along a first straight axis and is operated to open so as to define the side edges of the passage; the doors can slide to open and close along respective second axes orthogonal to the first axis, so as to also define the rear edge of the passage when the second cover is open.
US12319504B2
The technical field of intelligent warehousing is related, and an intelligent warehousing system, a processing terminal, a warehouse robot, and an intelligent warehousing method are disclosed. Where the intelligent warehousing system (100) includes: a warehouse robot (10) and a material fetching device (20); the warehouse robot includes a first warehouse robot (11) and/or a second warehouse robot (12); the first warehouse robot is configured to receive a first scheduling instruction, and handle a material box to a first target position according to the first scheduling instruction; the second warehouse robot is configured to receive a second scheduling instruction, and handle a portable shelf to a second target position according to the second scheduling instruction; and the material fetching device is configured to receive a material fetching instruction, and fetch a material from the material box and/or the portable shelf according to the material fetching instruction.
US12319501B2
A container handling vehicle for picking up storage containers from a three-dimensional grid of an underlying storage system includes a first set of wheels for moving the vehicle along an X direction on a rail system of the grid; and a second set of wheels for moving the vehicle along a Y direction on the rail system of the grid. The Y direction is perpendicular to the X direction. The container handling vehicle includes a vehicle body having a vehicle body footprint defined by horizontal peripheries in the X and Y directions of the vehicle body. The vehicle body includes a first section and a second section. The first section has a first footprint and the second section has a second footprint. The first and second footprints are defined by horizontal peripheries in the X and Y directions of the first and second sections, respectively. The container handling vehicle includes a lifting device for lifting storage containers from the storage system; and a lifting device motor arranged to drive the lifting device when lifting storage containers from the storage system. The first section and the second section are arranged side-by-side such that a total area of the first and second footprints equals a total area of the vehicle body footprint, and a centre point of the first footprint is arranged off centre relative a centre point of the vehicle body footprint. The first section defines a storage container receiving space which is configured to accommodate a storage container. The first section accommodates the lifting device for lifting a storage container from the storage system. The lifting device motor is accommodated in the second section.
US12319493B2
A collapsible container that includes a base, a first side panel hingedly attached to the base, a second side panel hingedly attached to the base, a first end panel hingedly attached to the base, with the first end panel including a door, and a second end panel hingedly attached to the base. The collapsible container can further include a top cover. The collapsible container is configured to be positioned in a collapsed position and an assembled position. In an assembled position, the collapsible container is configured to hold items during a domestic or international move.
US12319492B2
Provided is a foldable container automatic folding system including: a transfer unit on which the foldable container is mounted and which transfers the foldable containers; an introduction unit in which fasteners fastened to the foldable container are disassembled at a position where the transfer unit starts a folding operation; an operation unit which includes foldable container folding device that are disposed adjacent to the introduction unit and each located at front and rear surfaces of the foldable container to fold and unfold the foldable container; a locking unit which is disposed adjacent to the operation unit, stacks the foldable containers that are folded after the folding operation is completed by the operation unit, and performs a locking operation to make the folded foldable containers into one bundle unit; and a discharge unit in which a plurality of foldable containers wait to be transported and stored.
US12319486B2
A cushioning material includes cushioning sheets stacked on top of another and configured to reduce an external force acting on an electrical device. The cushioning sheets include a first cushioning sheet that is positioned to intersect a direction of the external force acting on the electrical device and a second cushioning sheet that has a higher strength in the direction of the external force acting on the electrical device than the first cushioning sheet and is positioned to intersect the direction of the external force acting on the electrical device.
US12319484B2
The present invention relates to a one-touch-removable container packaging film, and a container comprising same and, more specifically, to a one-touch-removable container packaging film, and a container comprising same, the packaging film: being naturally removable from the container when a container lid is rotatably separated from a container body in order to open contents sealed in the container, so as to be forcibly removed from the container according to the opening of the container contents without the need to consciously remove the packaging film in order to recycle the used container, and thus inconvenient actions such as removal of the packaging film during disposal of the container can be fundamentally eliminated; being forcibly removable according to the opening of the container contents so that the packaging film is necessarily removed from the container after the container is used even if the packaging film is not intended to be removed; and being easily removable with only a one-touch rotational operation of the lid so that the separation and discharge of the packaging film can be conveniently induced.
US12319474B2
A plastic container having a body member and a bottom insert member which are separately molded. The body member is formed with an open top having attached hinge lid and open bottom having a contoured flange engagement surface in its bottom interior wall. The bottom insert member has a pair of annular registration flange elements registerable within the body bottom flange engagement surfaces with a plurality of annular sealing flanges there between with interlocking the bottom insert in sealing relation therewith.
US12319472B2
A fishhook carrying device has a resilient prismatic block, of which two adjacent faces are cut into by at least one set of spaced grooves extending along a longest dimension thereof. Two opposite parallel grooveless faces thereof abut two rigid exterior walls, which, along with a connecting bottom wall, form a unitary box structure. Rigid exterior walls of either side of the box structure maintain the prismatic block in a compressed form such that interior walls of each groove are pressed against each other in a first resting condition. When a flange is inserted into a pressed groove, the interior walls of the groove resiliently separate and thereafter abut the flange, frictionally holding the flange in place. The interior groove walls return to the first resting condition upon removal of the flange from the device.
US12319471B2
A gripping attachment (10) is disclosed which facilitates the handling of a medication bottle (12). The medication bottle includes a container (14) having a cylindrical wall (16) extending parallel to a longitudinal axis. The container is closed at one end by a base wall (18) and has an opposed open end. The container receives a cap (20) on the open end to enclose the container. The gripping attachment comprises a sleeve portion (22) having a sleeve wall (24) defining an internal, cylindrical surface configured to removably attach to the container wall. The gripping attachment further comprises a leverage component connected to the sleeve portion to facilitate gripping the sleeve portion.
US12319470B2
A stackable crate has a horizontally oriented bottom panel and four vertically oriented side panels that are separately attached at their edges to form the stackable crate. Two straight-line channels, with widths at their tops being greater than at their bottoms, form ribs within the crate. When the channels and ribs of a first crate are aligned with the channels of a second stackable crate, the first crate nests within the second crate even when non-uniform material in the second crate is stored within it, without spilling the material or toppling the stack. When the channels and ribs of the first crate are not aligned with the channels of the second crate, the first crate does not nest within the second crate but instead rests on the tops of the ribs of the first crate.
US12319465B2
The invention relates to a packaging tray (1), produced from a thermoformed plastics sheet, with a base (10), sidewalls (11, 12) and a sealing edge (13) which is formed peripherally on the upper side of the sidewalls (11, 12) and onto which a sealing film (2) can be placed and can be bonded to the sealing edge (13), in which the sealing edge (13) is formed with a contact surface, which is provided for supporting the sealing film, with a profiling in the form of projections (133) in each case forming part of the contact surface and with depressions (134) which run between adjacent projections (133) and interrupt the contact surface, wherein the depressions (134) in each case define a receiving volume.
US12319461B2
A roll-packing machine (100) is provided with a belt drive mechanism having a closed-loop belt (110). Further, the roll-packing machine (100) is provided with a feed mechanism (130, 140) configured to feed a mattress (10) to the belt (110). The belt drive mechanism is configured to form an inner loop (115) of the belt, to receive the mattress (10) in the inner loop (115), and to roll the mattress (10) by advancing the belt (110) while the mattress (10) is received in the inner loop (115). The inner loop (115) of the belt may thus act as a rolling chamber for the mattress (10).
US12319457B2
An automatic packaging machine for paper bags contains: a support platform, a rotation table, a stacking device, a displacement device, a packaging device, and a paper delivery device. The support platform includes multiple paper bags delivered thereon. The rotation table is configured to rotate the multiple paper bags at two opposite angles. The stacking device is configured to stack the multiple paper bags. The displacement device is mounted below the stacking device and is configured to deliver the multiple paper bags. The packaging device is connected on the displacement device and includes an entering platform, a press plate, and a glue sprayer. An inlet of the entering platform accommodates the press plate, and the glue sprayer is fixed on a predetermined position of the entering platform. The paper feeder is connected with the packaging device and is configured to deliver multiple packing papers onto the entering platform.
US12319455B2
Filling apparatus (10) and method for automatically filling containers (100) for smoking articles with a desired metered quantity of incoherent material (M) of the fibrous type. The apparatus (10) comprises a first and a second filling station (A2, A4) each having one or more delivery devices (22) and being configured to deliver respectively a first and a second quantity of incoherent material (M) into each container (100), wherein the second filling station (A4) is disposed downstream of said first filling station (A2) along a working line.
US12319446B2
A flying vehicle that is compact and portable and can be carried over the roof rack of a passenger car. The flying vehicle includes an upper chassis and a lower chassis removably mounted to the upper chassis. The lower chassis is positioned below the upper chassis. Eight rotors, a battery pack, and a control unit are mounted to the upper chassis. A seat for the rider is mounted to the lower chassis directly below the battery pack. Such a position of the seat allows a rider to egress from the vehicle safely without requiring the vehicle to land and turn off the rotors.
US12319425B2
An apparatus is provided for an aircraft propulsion system. This apparatus includes an acoustic panel and a mount. The acoustic panel includes a perforated face skin, a back skin, a perforated intermediate layer, a first cellular core and a second cellular core. The first cellular core includes a first section and a second section. The first section is between and is connected to the perforated face skin and the perforated intermediate layer. The second section is between and is connected to the perforated face skin and the back skin. The second cellular core is between and is connected to the perforated intermediate layer and the back skin. The mount is attached to the back skin along the second section.
US12319420B2
A propulsion assembly comprising a fan casing and a nacelle which comprises an air inlet which is connected to the front end of the fan casing, an intermediate portion which is positioned around the fan casing and a rear portion which cooperates with the rear end of the fan casing. The intermediate portion comprises at least one aerodynamic panel which extends from a front edge which is attached to the air inlet as far as a rear edge which is attached to the rear portion and at least one intermediate radial support comprising an internal edge which is connected to the fan casing and an external edge which is connected to the aerodynamic panel, this panel comprising a front edge which is connected to the air inlet by a first connection system. Also an aircraft with such a propulsion assembly.
US12319414B2
A seat rail system for an interior space of a vehicle includes a seat rail having a plurality of attachment sockets arranged in a row along a longitudinal extension of the seat rail. Each attachment socket has an at least partly spheroid concave bearing surface. Two coupling openings are embedded in each concave bearing surface; an attachment stud having an at least partly spheroid or cylindroid convex bearing surface with a curvature corresponding to a curvature of the concave bearing surface of the attachment sockets. A coupling pin is arranged on or in the convex bearing surface and configured to enter one of the attachment openings to couple the attachment stud to the seat rail. A locking pin is configured to enter the respective other attachment opening through a through hole in the attachment stud and thereby lock the attachment stud to the seat rail.
US12319411B1
A drone deployable modular system for remote solar energy generation utilizes remote-controlled multi-rotor drones configured to deliver and maintain modular heliostat units for assembly into heliostat fields in remote locations. The drone deployable modular heliostat unit may include a frame that supports at least one deployable, mirrored surface controlled by a heliostat driver. In one embodiment, the deployable, mirrored surface is a MYLAR film tensioned over a mirror frame portion supported and controlled by the heliostat driver to orient a working face of the mirrored surface in various positions. The drone deployable modular heliostat unit may include a deployable stand arrangement and/or an anchor system. The modular heliostat units may be configured to be deployed in heliostat fields in a generally peripheral arrangement to provide reflected solar energy to a centrally located concentrating solar collector/energy utilization system.
US12319408B2
A fairing arrangement for an aircraft high-lift mechanism, the high-lift mechanism including a flap arranged at an aircraft wing trailing edge and a mounting and guiding mechanism for the flap. The fairing arrangement includes a flap side fairing unit and a wing side fairing unit. The flap side fairing unit includes a flap side fairing covering an aft part of the mounting and guiding mechanism and a flap side fairing mount mounting the flap side fairing to the flap. The wing side fairing unit includes a wing side fairing covering a forward part of the mounting and guiding mechanism and a wing side fairing mount mounting the wing side fairing to the wing. The wing side fairing mount is configured to connect the wing side fairing movably to the wing such that the wing side fairing is rotatable around an axis directed at least partially in a vertical direction.
US12319403B2
A system configuration significantly reduces the number of interconnections needed between an electromechanical actuator (EMA) and an EMA controller (EMAC) while maintaining redundancy and other safety aspects needed by the target application. This allows simplification of communication interfaces between multiple sensors in the EMA and EMAC and unification of the interface to multiple sensors inside the EMAC, leading to cost and weight reduction that can be significant for many aerospace products and applications, including unmanned vehicle (e.g., UAM/UAV) applications.
US12319397B2
A thruster system for improved steering and maneuverability of a marine vessel when operating at relatively low, or wakeless speeds, such as in the vicinity of docks, swimmers or other obstacles, or when trailering, beaching or mooring. The thruster system has a modularized design adapted to independently control separate motor/propeller units located at various positions on the vessel's hull. Each propeller of the modular thruster motor system has its own relatively small, electric motor and mounting bracket, permitting each motor to be separately mounted to a location on the hull of the marine vessel apart from other thruster motors. The thruster system is further enhanced by an electrical control system for controlling each modular thruster motor system of the thruster system. In some embodiments, a charging system is provided that permits each electrical control system to be separately charged from the marine vessel's main battery.
US12319388B2
A Load Lifter Assembly is configured to allow for lifting, moving and releasing a barge lid via a material hander such as a crane without need for manual intervention between the load lifter assembly and the barge lid.
US12319380B2
A handlebar arrangement for a vehicle is provided, having a fork bridge, an ignition steering lock and a retention member or holder to which the ignition steering lock is fastened. The retention member is fixed on the fork bridge by fasteners, wherein elastic decoupling elements for shock and/or vibration decoupling are arranged between the fork bridge and the retention member.
US12319379B2
Various systems and methods associated with protecting a rider of an electric bicycle from hazards while riding their bicycle are described. In some embodiments, the systems and methods enhance the safety of the rider in response current detected conditions surrounding the rider, such as conditions associated with the route or path traveled by the rider, other vehicles within the route or path traveled by the rider, potential hazards within the route or path traveled by the rider, environmental conditions through which the rider is traveling, and so on.
US12319362B2
The disclosed art includes: a machine body; an operator's seat mounted on the machine body and including a seat part and a backrest part; a manipulator base disposed on a lateral side of the operator's seat; and a housing body for housing a printed material therein, and the housing body is disposed forward of the backrest part and on the opposite side of the manipulator base from the operator's seat.
US12319348B2
In an embodiment a vehicle body structure includes a front pillar tube positioned inside of each of a pair of front pillars in a vehicle and a center pillar tube positioned inside of each of pair of center pillars of the vehicle, wherein the front pillar tube and the center pillar tube cross each other.
US12319347B2
Method of manufacturing a metal structural component (E) for a vehicle, comprising the steps of a) providing a planar blank (B); b) cutting out the blank (B) to create an opening (A) having a first portion (Q) and wherein the first portion (Q) of the opening A) has a second length (lt) in a first transverse direction (T); c) welding a patch (P) to the blank (B) so as to cover the opening (A), the patch (P) being made of the metal having greater ductility than the material of the blank (B); d) stamping the assembly formed by the blank (B) and the patch (P) to obtain the component (E).
US12319342B2
A vehicle maneuvering scenario can be identified based on data from vehicle sensors including at least one of (a) a location of the vehicle, or (b) data indicating that a first steering wheel rotation in a first direction and a second steering wheel rotation in a second direction each exceed a rotation threshold. A steering ratio can be determined based on the vehicle maneuvering scenario. Vehicle steering can then be actuated according to the steering ratio.
US12319330B2
Disclosed herein is a component storage device for workpieces which are mounted in stacking columns on or at pawls one above the other or next to one another characterized in that the stacking columns are arranged on a movable trolley. Also disclosed is a system for presenting workpieces with the component storage device characterized in that a coordinate system is assigned to the carriage. Further disclosed is a stacking column for storing workpieces on or at pawls one above the other or next to one another, the pawls being provided in or at a frame characterized in that the frame comprises at least two parts which are connected to one another in an articulated manner.
US12319319B2
Generally, the disclosed systems and methods utilize multi-task machine-learned models for object intention determination in autonomous driving applications. For example, a computing system can receive sensor data obtained relative to an autonomous vehicle and map data associated with a surrounding geographic environment of the autonomous vehicle. The sensor data and map data can be provided as input to a machine-learned intent model. The computing system can receive a jointly determined prediction from the machine-learned intent model for multiple outputs including at least one detection output indicative of one or more objects detected within the surrounding environment of the autonomous vehicle, a first corresponding forecasting output descriptive of a trajectory indicative of an expected path of the one or more objects towards a goal location, and/or a second corresponding forecasting output descriptive of a discrete behavior intention determined from a predefined group of possible behavior intentions.
US12319315B2
Aspects and implementations of the present disclosure relate to autonomous vehicle (AV) trajectories computed using a box-based probabilistic overlap model. An example method includes: receiving, by a data processing system of an AV, data descriptive of an agent state of an object relative to the AV; computing an initial overlap region between a first box representative of the AV and a second box representative of the agent state; updating dimensions of the second box; and computing an updated overlap region by interpolating the initial overlap region based on the updated dimensions of the second box.
US12319314B2
A vehicle integrated-control device generates internal commands that supplement insufficient external commands in an environment where external commands are insufficient and that integrally controls each actuator to improve the operational feeling of the driver and occupant ride comfort. The vehicle integrated-control device integrally controls actuators mounted in a vehicle to control the vehicle using six control axes which are front-rear, left-right, up-down, roll, pitch, and yaw control axes, and comprises a command value acquisition unit that acquires an external command corresponding to at least one and not more than six control axes for realizing a desired driving operation; a command value supplementation unit that, based on the external command, generates an internal command corresponding to a control axis other than the control axes corresponding to the external command; and an operation amount control distribution unit that controls the plurality of actuators based on the external command and the internal command.
US12319307B2
Provided are a method and apparatus for providing a driver interface. The method of providing a driver interface may include, based on a state of a vehicle, determining a main interface configured to display information regarding a vehicle operation service, and generating the determined main interface, wherein the generating of the main interface may include determining a before-starting-work interface as the main interface, in response to the state of the vehicle being switched to a moving-to-workplace state, determining a moving-to-workplace interface as the main interface, and in response to the state of the vehicle being switched to a standby-for-dispatch state, determining a standby-for-dispatch interface as the main interface.
US12319304B2
A vehicle includes: an in-vehicle sensor that detects an environment around the vehicle; an autonomous driving unit that executes automated valet parking based on the detection result from the in-vehicle sensor; a detection unit that detects dirt or a raindrop attached to the in-vehicle sensor before the automated valet parking is started by the autonomous driving unit; and an informing unit that outputs information that suggests removing the dirt or the raindrop on the in-vehicle sensor in response to the detection unit detecting the dirt or the raindrop attached to the in-vehicle sensor.
US12319295B2
The system comprises input means for receiving user data from associated user monitoring means that each monitor at least one respective attribute of the user of the vehicle. The user data is indicative of the plurality of respective attributes. A plurality of inference modules each receive user data from the user monitoring means, and each determine a respective inference of a cognitive state of the user based on the received user data. Each inference module is arranged to output user state data indicative of the determined inference of the cognitive state of the user. An inference fusion module receives the user state data from each of the plurality of inference modules to determine an inference of an aggregated cognitive state of the user and to output cognitive state data indicative of the aggregated cognitive state for controlling the vehicle functions.
US12319294B2
Methods and a system for estimating a coefficient of friction of a surface being traveled upon by a vehicle is disclosed. The methods and systems may be active when wheel slip is not present and while wheel slip is present. The coefficient of friction for the surface being traveled upon may be estimated as a function of time since a most recent wheel slip event.
US12319292B2
Example intelligent vehicle control methods and apparatus are described. In one example method, an intelligent vehicle control system obtains a driving mode, a driving style model, and a target speed of an intelligent vehicle at a current moment, then determines a speed control instruction based on the driving mode and the driving style model. The intelligent vehicle control system sends the speed control instruction to an execution system of the intelligent vehicle.
US12319288B2
An autonomous driving apparatus for generating an intersection path reflecting a driving record may include: a path generating device that generates information on a first path for driving of an autonomous vehicle at an intersection; a path comparison operating device that generates offset information between the generated information on the first path and information on a second path along which the autonomous vehicle is driving; a comparison operation evaluating device that determines whether to store the information on the second path based on the generated offset information; and a comparison operation storage that stores the information on the second path and the offset information based on the determination of whether to store the information on the second path.
US12319286B2
A network computer system can monitor a plurality of mobile computing devices to determine a current location of a corresponding freight operator of a plurality of freight operators. The network computer system can record the current location of each of the plurality of freight operators in a data store of the set of memory resources. Additionally, the network computer system can repeatedly query the data store to determine when at least two freight operators of the plurality of freight operators that satisfy a set of drafting conditions. The set of drafting conditions including a proximity condition as between the at least two freight operators and a candidate commencement location in response to the determination, the network computer system can implement a drafting arrangement between the at least two freight operators.
US12319271B2
Among other things, techniques are described for receiving, from at least one sensor of a vehicle, sensor data associated with a surface along a path to be traveled by a vehicle; using a surface classifier to determine a classification of the surface based on the sensor data; determining, based on the classification of the surface, drivability properties of the surface; planning, based on the drivability properties of the surface, a behavior of the vehicle when driving near the surface or on the surface; and controlling the vehicle based on the planned behavior.
US12319269B2
The present disclosure relates to a hybrid electric vehicle in which powertrain noise may be controlled to improve the voice command recognition performance of the vehicle control system and also improve the driver's experience with the audio guidance system, and a method for supporting audio input/output function for the same. A method of supporting audio input/output for a hybrid electric vehicle may include: determining a first condition for audio input/output function and a second condition for inside noise level; and performing a noise reduction control by inducing an engine-off state based on a current drive mode and further based on the first and the second conditions being satisfied.
US12319258B2
A positive pressure chock system has a first arm with a first wheel chock and a second arm with a second wheel chock. The first wheel chock is attached at a bottom end of the first arm and the second wheel chock is positioned at a bottom end of the second arm. The first arm and the second arm are attached at a hinge point such that the first wheel chock and the second wheel chock are movable between an open position where the first wheel chock and the second wheel chock move away from each other and a closed position in which the first wheel chock is biased towards the second wheel chock.
US12319248B2
A piston actuation device for the supply of a pressure medium in a pressure medium circuit of a brake system of a motor vehicle. A piston actuation device includes a piston actuable by a spindle drive to execute a back-and-forth translation movement in the direction of a piston guidance axis. The spindle drive has a spindle nut and a spindle that cooperates with the spindle nut via a screw drive. The screw drive converts a rotation movement of the spindle nut into a translation movement of the spindle in the direction of a spindle movement axis. To transmit the translation movement to the piston, the piston and the spindle are connected to each other in an axially fixed manner. The axially fixed connection between the piston and the spindle includes an articulated joint, which allows for a concentricity deviation between the piston guidance axis and the spindle movement axis.
US12319240B2
A movable transversal roof rack according to the invention, enabling loading and unloading a cargo away from a vehicle roof consisting of two support elements, one support element to be placed on a front part of the vehicle roof, and another support element to be placed on a rear part of the vehicle roof, wherein each support element comprises a support, a first arm and a second arm adapted for the mutual insertion in such a way that the support element in its folded position forms the compact longitudinal body of substantially square, rectangular, or elliptical cross-section.
US12319234B2
An accessory support includes a support frame for attachment to a vehicle, upper and lower support rails coupled to the support frame, and an accessory engaged with both support rails. The accessory, for example a stair, a platform, a storage device, or the like, is repositionable along the support rails.
US12319232B2
An access control system (53) for a vehicle (10) having at least one access system associated with a closure (19) of the vehicle (10), the access control system (53) comprising one or more controllers (22), the access control system configured to receive a first signal (34) from an associated user device (12), the first signal (34) being indicative that the user device (12) is beyond a threshold distance from the vehicle (10); receive a second signal (30) indicative of a user request to change a lock mode of the access control system (53); operate in a lock mode selected from a plurality of lock modes in dependence on receipt of the second signal (30); and generate a control signal to activate the at least one access system (51) into a lock state in dependence on the selected lock mode and in response to the first signal (34) indicating that the proximity of the user device (12) to the vehicle (10) exceeds the threshold distance.
US12319228B2
An automobile antitheft device is equipped with a seat frame installed between upper rails that are slidably supported by lower rails provided on a floor of a vehicle interior respectively, a seat cushion that is supported by the upper rails, that is configured to be able to rise and fall with respect to the upper rails, and that slides forward while falling when a cockpit is locked, and a seat back that is turnably supported by a back side of the seat cushion and that inclines forward when the cockpit is locked. A gap between a lower surface of the seat cushion and the seat frame is set as a gap that does not allow a connector provided below the seat cushion in front of the seat frame to be accessed from behind, when the cockpit is locked.
US12319226B2
A belt retractor unit with a housing, a rotatably mounted belt reel, a blocking unit for blocking the belt reel, wherein the blocking unit has an electrically controllable actuator unit, a control apparatus for controlling the actuator unit, which has a sensor apparatus for measuring at least one horizontal acceleration value and a switching apparatus for controlling the actuator unit in dependence on at least the at least one horizontal acceleration value, wherein the belt retractor unit has a first emergency state, in which the magnitude of the horizontal acceleration value is above a first limit value and in which the belt reel is blocked, and an unblocking state in which the magnitude of the horizontal acceleration value is below the first limit value.
US12319224B2
An integral ignition structure and a compressed-gas-type fuel gas generator are provided. The integral ignition structure comprises an ignition box, an igniter, and an end cover, wherein the ignition box is open at one end, and has a closed end and an open end opposite to each other; the igniter is provided at the closed end; and the end cover is provided at the open end, and is arranged to form, together with the ignition box, an ignition chamber, wherein at least one flow-through hole for communicating with the ignition chamber is formed in the end cover, an ignition composition is provided in the ignition chamber, the igniter is configured to ignite the ignition composition and generate an inflation gas, and the end cover is further configured to be plastically deformed under effect of a pressure of the inflation gas, so as to increase a volume of the ignition chamber.
US12319222B2
An assembly includes a dash and a deployable panel supported by the dash. The deployable panel is moveable relative to the dash from an undeployed position to a deployed position. The deployable panel has a proximal end at the dash in the deployed position and a distal end spaced above the dash in the deployed position. An airbag is supported by the dash and is inflatable to an inflated position. The airbag abuts the deployable panel when the deployable panel is in the deployed position and the airbag is in the inflated position. A tether extends from the airbag to the deployable panel in the undeployed position.
US12319221B2
A pillar structure includes a tether clip including a clip body having a panel anchor part and a trim anchor portion. The tether clip further includes: a head anchor part configured to be combined with the trim anchor portion, and a tether connecting the clip body and the head anchor part. The pillar structure further includes: a pillar panel connected with the panel anchor part; and a pillar trim including a tether clip bracket of which a head anchor part insertion hole and a trim anchor portion coupling hole are formed thereto.
US12319220B2
A vehicle seat comprises an outer frame of a seatback frame for forming a framework of a seatback, a frame bracket coupled to one side of the outer frame, a module bracket fastened to the frame bracket at fastening points and configured to support an airbag module, and a pan frame coupled to the rear side of the outer frame. The pan frame includes a protrusion section protruding from an upper portion of the pan frame on the one side such that the fastening points are located below the protrusion section, and at least part of the airbag module is positioned frontward of the protrusion section.
US12319213B2
A cross-member arrangement for a bumper assembly on a motor vehicle includes a first deformation element mounting and a second deformation element mounting, a forward cross-member profile, which is connected to each of the two deformation element mountings, a rear cross-member profile, which is connected to each of the two deformation element mountings. A bumper assembly for a battery-powered motor vehicle includes one deformation element for bracing the bumper assembly against a front end of the motor vehicle arranged on each side of a central longitudinal axis of the motor vehicle.
US12319210B2
Even when a power supply relay cannot be turned off and when power supply to a microcomputer is normally cut off, fixing of the power supply relay is detected. An electronic control device 100 according to an aspect of the present invention includes a relay drive circuit 13 that controls on and off of a power supply relay 12 according to information about the on and off of power supply, an electronic circuit (first power supply system block 110, microcomputer 102) that operates at a first power supply voltage (V1) supplied from a battery 10 through the power supply relay 12, and a monitoring unit (second power supply system block 120) that monitors the first power supply voltage when the power supply is turned off, and holds a monitoring result, the first power supply voltage reflecting presence or absence of fixing of the power supply relay.
US12319205B2
A device for a motor vehicle may have a base support with an opening and a movable closure element for opening or closing the opening. The device may also have a sensor unit with a housing unit holding this sensor unit, which is movably arranged in the base support. The device may also have a link mechanism. The housing unit may be movable via the link mechanism in the base support between a first position and a second position in which the housing unit with the sensor unit projects at least partially out of the opening. The link mechanism may be designed as a multi-link mechanism and having at least three links. A first link and a second link are each articulated between the housing unit and the base support and a third link is articulated between the housing unit and the closure element.
US12319203B2
The vehicle-mounted device-fixing structure includes a vehicle-mounted device, a first bracket that is fixed to the vehicle-mounted device, and a second bracket that is fixed to the vehicle-mounted device. The first bracket has a first fastening member that is fastened to a first fastening surface provided on a vehicle. The second bracket has a second fastening member that is fastened to a second fastening surface provided on the vehicle. The first fastening member includes a first contact surface that contacts the first fastening surface, and the second fastening member includes a second contact surface that contacts the second fastening surface. An angle formed between the first contact surface and the second contact surface is an obtuse angle.
US12319200B2
To allow an easily producible lighting device that manages with few components and enables an efficient, desired light distribution in an interior space, the provided method and device includes a light guide with a longitudinal transport section and at least one transverse transport section. The longitudinal transport section has at least one light entry surface, arranged transversely with respect to the longitudinal extension of the longitudinal transport section, for coupling light into the longitudinal transport section, and a light exit section along the longitudinal extension. The transverse transport section has a flat design, and is connected to the longitudinal transport section at least one first narrow side. The transverse transport section also has secondary deflection elements at which the coupled-in light is deflected in such a way that the light exits at the opposite broad sides.
US12319188B2
A vehicle entrance structure includes a body panel disposed in a rear part on a peripheral region of an entrance of a vehicle body, and configured to be exposed when a vehicle door is open. The body panel includes an assist surface having a predetermined area to support a hand of a user boarding or getting off of the vehicle. The assist surface is disposed at a higher level than a seat surface of an in-vehicle seat disposed beside the entrance.
US12319180B2
An apparatus includes a frame configured to interface with a seatback of a vehicle seat, a lumbar mat configured to provide lumbar support for the vehicle seat, and a flexible element coupling the frame to the lumbar mat. Another apparatus includes a lumbar mat configured to interface to a seatback of a vehicle seat, a flexible printed circuit board (PCB) affixed to a rear side of the lumbar mat, and a cover arranged rearward of the lumbar mat and flexible PCB and configured to enclose circuitry of the flexible PCB.
US12319177B2
A recliner for a vehicle seat includes a first gear having a collar part extending from a center of one surface, a second gear configured to eccentrically engage with the first gear while being internally in contact with the first gear, a ring member coupled to surround the collar part, a socket coupled to surround the ring member, and a pair of wedge cams disposed between the ring member and the second gear and configured to restrain or release the ring member and the second gear.
US12319174B2
In an arrangement which includes: a seat support body slidably supported on a fixed rail fixed to a floor; a power supply device supplying power to an electrical component on a seat side; and a drive device driving the seat support body in a front-and-rear direction and having a motor and a transmission member disposed so as to pass longitudinally through an interior of the fixed rail, the power supply device includes: a housing housing an electric wire for power supply; and a slider linked to the seat support body and slidable within the fixed rail. The electric wire is drawn out from the housing, retained by the slider and slidable within the fixed rail. The slider has an interference-avoiding portion for avoiding interference with the transmission member disposed so as to pass longitudinally through the interior of the fixed rail. Accordingly, the transmission member of the drive device and the slider for retaining the electric wire, which slides within the fixed rail, can be arranged in proximity to each other within the fixed rail while avoiding interference therebetween, thus enabling simplification and a reduction in the size of a rail structure.
US12319169B2
A method of preventing output limit of a battery of a vehicle for improving output decrease due to output limit of the battery configured to supply power to a motor for driving the vehicle, includes monitoring a temperature and a state of charge (SOC) value of the battery configured to supply power to a motor configured for driving the vehicle while driving, determining a level of a possibility of occurrence of the output limit of the battery based on a level determination map configured based on the temperature and the SOC value of the battery, and selectively performing control for raising the temperature of the battery according to the determined level of the possibility of occurrence of the output limit of the battery.
US12319164B2
A power feeding management system includes a management apparatus and a plurality of on-vehicle apparatuses. The management apparatus communicates with the on-vehicle apparatuses of first and second vehicles to assist the first and second vehicles with first inter-vehicle power feeding to the first vehicle from the second vehicle. The management apparatus decides a price on the power-receiver side of the first inter-vehicle power feeding on the basis of a common power price and an amount of fed power in the first inter-vehicle power feeding. The management apparatus decides a return on the power-sender side of the first inter-vehicle power feeding on the basis of the amount of fed power in the first inter-vehicle power feeding and a power price for external charging carried out by the second vehicle before the first inter-vehicle power feeding.
US12319162B2
An electric vehicle pre-charging circuit is provided. In one or more embodiments, the electric vehicle pre-charging circuit can comprise a first contactor located on a positive bus between a load and a battery. In various embodiments, the electric vehicle pre-charging circuit can comprise a second contactor located on a negative bus between the load and the battery. In further embodiments, the electric vehicle pre-charging circuit can comprise an on-board charger connected to the positive bus and the negative bus on a battery-side of the positive bus and a battery-side of the negative bus, wherein a phase wire connects the on-board charger to the positive bus on a load-side of the positive bus, and wherein a neutral wire connects the on-board charger to the negative bus on a load-side of the negative bus.
US12319160B1
An electrified military vehicle system includes a first military vehicle and the second military vehicle. The first military vehicle includes a prime mover configured to drive the first military vehicle and a first mechanical coupling interface positioned at a rear end of the first military vehicle. The second military vehicle includes an axle, a second mechanical coupling interface positioned at a front end of the second military vehicle where the second mechanical coupling interface is configured to engage with the first mechanical coupling interface to selectively couple the second military vehicle to the first military vehicle, an energy storage system, and a generator coupled to the axle and electrically coupled to the energy storage system. The generator is configured to generate electric power while the axle rotates as the second military vehicle is towed by the first military vehicle to charge the energy storage system.
US12319159B2
A charging device includes: a relay cable having one end connected to a charging connector; a battery charged by a direct current supplied from the charging connector; a battery cable having one end connected to the battery; a charging connection portion connected to the other end of the relay cable; a battery connection portion connected to the other end of the battery cable; a relay that switches the direct current to be supplied or not relative to the battery; and a housing arranged between the battery and the charging connector so as to house the relay. The charging connection portion is arranged on the housing adjacent to the charging connector, and the battery connection portion is arranged on the housing adjacent to the battery.
US12319158B2
An energy conversion arrangement configured to convert chemical energy into electrical energy. The energy conversion arrangement comprises plural cell groups 30, 32, 34, 36, each cell group being configured to convert chemical energy into electrical energy. The energy conversion arrangement also comprises at least one measurement arrangement 38, 40, 42, 44, 46 configured to make measurements at each of the plural cell groups 30, 32, 34, 36. Each energy conversion arrangement is configured to determine a condition of at least one of: each of the plural cell groups; and the energy conversion arrangement. The condition is determined in dependence on the measurements made at each cell group and a model of each cell group.
US12319151B2
Presented are smart vehicle systems and control logic for battery thermal event detection and severity assessment, methods for making/using such systems, and vehicles equipped with such systems. A method of operating a vehicle includes a resident or remote vehicle controller detecting a thermal event in at least one battery cell in the vehicle's battery system and, upon detection, monitoring the vehicle's surrounding area to detect target objects near the vehicle. Responsive to detecting any target objects near the vehicle, the controller aggregates target object data, including a total number of detected target objects and respective proximities of the detected target objects to the vehicle. Using this target object data, a situational severity level is estimated for the thermal event; the controller determines if the severity level exceeds a maximum allowable severity level. If so, the controller responsively commands a vehicle subsystem to execute a control operation to mitigate the event.
US12319147B2
Pulsed control of electric motors, and more particularly, to selectively adjusting one or more of a pulsing frequency, an amplitude of the pulses and/or a duty cycle of the pulses for reducing Noise, Vibration and Harshness (NVH) while maintaining high levels of operating efficiency.
US12319141B2
A steering wheel includes a control unit that executes an acceleration control or a deceleration control of a vehicle based on results of detections by a first contact detecting portion, a second contact detecting portion, a first operation detecting portion, and a second operation detecting portion. The control unit does not execute the acceleration control or the deceleration control based on an operation of a first operating portion when the first operating portion is operated in a state in which the first contact detecting portion is not detecting contact by a driver with a first gripping portion, and does not execute the acceleration control or the deceleration control based on an operation of a second operating portion when the second operating portion is operated in a state in which the second contact detecting portion is not detecting contact by the driver with a second gripping portion.
US12319129B2
A vehicle trim element having at least one functional component and at least one aerator of the vehicle compartment. The aerator includes at least one duct for conveying a gas flow defining an opening for diffusing the gas flow, the conveying duct extending in a main direction. The aerator is arranged to diffuse a gas flow in the passenger compartment of the vehicle in a diffusion direction in which the gas flow is diffused and which is variable by Coanda effect, between a first diffusion direction and a second diffusion direction that is different from the first diffusion direction. The opening for diffusing the gas flow extends around the periphery of at least one portion of the functional component.
US12319128B2
A vehicular heat management system includes: a heat pump type refrigerant circulation line including a compressor, a high-pressure side indoor heat exchanger, a heat pump mode variable expansion valve, an outdoor heat exchanger, an air conditioner mode variable expansion valve, and a low-pressure side indoor heat exchanger; a cooling water circulation line configured to circulate cooling water between a radiator and a specific cooling target; and a refrigerant-cooling water chiller configured to allow the refrigerant in the refrigerant circulation line transferred from the outdoor heat exchanger to the low-pressure side indoor heat exchanger to exchange heat with the cooling water in the cooling water circulation line circulated through the specific cooling target.
US12319127B2
A heat pump arrangement and a method of operating a heat pump arrangement. The heat pump arrangement has a refrigerant circuit and a coolant circuit, wherein the coolant circuit is configured for indirect battery heating. The refrigerant circuit includes a compressor, a heating condenser, a 3/2-way expansion valve, an external heat exchanger, at least one evaporator with an associated expansion element as well as a 3/2-way expansion valve arranged in parallel to the evaporator, and a battery chiller. The coolant circuit includes a coolant cooler and a battery heat exchanger with an associated coolant pump and at least one drive train cooler with an associated coolant pump arranged in parallel to the battery heat exchanger.
US12319121B2
A quality determination apparatus includes a state detector and a main processing unit. The state detector detects a state index. The state index is an index indicating a state of a target article contained in a storage space where an internal environment is controlled. The main processing unit performs a determination operation. The determination operation is an operation of determining whether a sign condition indicating a sign of degradation of the target article is met based on the state index detected by the state detector.
US12319113B2
An environmental control system for thermally conditioning air within an enclosed space is provided. The system includes a refrigerant circuit having a compressor, an indoor heat exchanger, an expansion device, and an outdoor heat exchanger. The system also includes an exhaust flowpath having a first inlet for receiving an exhaust flow of thermally conditioned air from the enclosed space and an outlet for discharging the exhaust flow to an external environment. A heat transfer section of the outdoor heat exchanger is located in the exhaust flowpath The exhaust flowpath is configured to direct the exhaust flow of thermally conditioned air through the heat transfer section of the outdoor heat exchanger.
US12319110B2
A suspension assembly for a vehicle suspension system may include a lower control arm, an upper control arm, a damper, and a drop link. The lower control arm may be operably coupled to a chassis of a vehicle via a first bushing assembly and a second bushing assembly. The first and second bushing assemblies may each pivot about an axis substantially parallel to a longitudinal centerline of the vehicle. The upper control arm may be operably coupled to the chassis. The damper may be operably coupled to the lower control arm to dampen pivoting motion of the upper and lower control arms relative to the chassis. The drop link may operably couple the lower control arm and an anti-roll bar that includes a disconnect assembly to translate a roll motion into a force exerted on the lower control arm in a direction substantially parallel to the axis.
US12319109B2
A stabilizer bar includes a housing configured to be fixed to a first side-bar, a hydraulic power unit and a clutch piston disposed within the housing, and a clutch ring configured to be fixed to a second side-bar. The hydraulic power unit is configured to selectively move the clutch piston from a first connected position to a second disconnected position.
US12319103B2
In a pneumatic tire, a tread average thickness A in a tire width direction region of a center land portion where a center cover layer is disposed, a tread average thickness B in a tire width direction region of the center land portion where the center cover layer is not disposed, and a tread average thickness C in tire width direction regions where second land portions located further on an outer side than the center land portion in a tire width direction and adjacent to the center land portion are defined and formed satisfy a relationship A
US12319102B2
An air valve connector includes a head and a switching assembly. The head has a first insertion hole, a second insertion hole, a communicating passage, and an inlet hole. The first insertion hole is provided with a first airtight portion disposed between the communicating passage and the inlet hole, and a second airtight portion disposed between the inlet hole and the first port. The switching assembly includes a plunger movably disposed in the first insertion hole to alternately abut against the first airtight portion or the second airtight portion.
US12319097B2
A system for monitoring tire tread on a vehicle may include front wheels, rear wheels, a sensor network to determine rolling radius data associated with the front wheels and the rear wheels, processing circuitry which may include a memory unit and may be configured to receive the rolling radius data from the sensor network, and a user interface which may display information to an operator of the vehicle. The processing circuitry may be further configured to determine a rolling radius of the front wheels and the rear wheels, determine a difference in the rolling radius between the front wheels and the rear wheels, compare the difference in the rolling radius to a predetermined threshold value, and generate a notification via the user interface to indicate that a tire rotation may be recommended responsive to the difference in the rolling radius exceeding the predetermined threshold value.
US12319093B2
In a pneumatic tire, a plurality of first land portions are arrayed adjacent to each other in a tire circumferential direction, and a plurality of second land portions are arrayed adjacent to each other in the tire circumferential direction. Moreover, the first land portions and the second land portions are each arrayed in a staggered manner along a tire equatorial plane. Additionally, the first land portions and the second land portions each include a plurality of through grooves that extend through the land portions and open to a pair of inclined main grooves, and a plurality of blocks defined by the through grooves. The blocks include an innermost center block that is defined as a block closest to the tire equatorial plane. In addition, an edge portion of the innermost center block includes a notch portion that opens to a connection portion of the inclined main grooves.
US12319089B2
A vehicle system includes an axle arrangement operably coupling a wheel assembly with a frame. The frame defines a fore-aft axis and a transverse axis extending generally transverse to the fore-aft axis. The axle arrangement includes first and second axle elements adapted for operative connection between the frame and the wheel assembly for extension and retraction along the transverse axis. The first axle element can be operably coupled with the frame and the second axle element can be integrated with the wheel assembly. One or more sensors can be configured to generate vehicle dat. A computing system can be configured to receive an input related to an adjustment to the position of the second axle element relative to the fore-aft axis and generate an adjustment model based at least partially on the input and the vehicle data.
US12319088B2
An example article of furniture includes a number of furniture legs having mechanically coupled thereto a respective furniture caster having a rolling component. The furniture casters are movable between (i) an extended position in which their rolling components at least partially extend below bottom surfaces of the furniture legs and (ii) a retracted position in which their rolling components are positioned entirely above the bottom surfaces of the furniture legs. Push-pull cables are mechanically coupled to the furniture casters, and at least one actuator is mechanically coupled to the push-pull cables. When actuated, the actuator applies a pushing force to the push-pull cables, thereby causing the furniture casters to transition from the retracted position to the extended position. When the actuator is not actuated, the pushing force is removed from the push-pull cables, thereby causing the furniture casters to transition from the extended position to the retracted position.
US12319086B2
A chalk reel is provided that includes a handgrip on housing supporting a chalk line extending from a nozzle of the housing that extends from the chalk reel to mark a straight line. The chalk reel may further include a rotatable handle that rotates to extend or retract (“pay out”) the chalk line. A hook is secured to the end of the chalk line to facilitate extension of the chalk line and prevent retraction of the chalk line end into the housing nozzle. The chalk reel may further include a transmission system with gearing and a selector to lock the gearing at locations around the handle rotation. The chalk reel may also include a large removable cap to facilitate refilling the chalk or other marking material.
US12319076B2
In a medium conveyed in a first direction, a first slit has a square shape including first, second, third, and fourth sides. A second slit is positioned downstream from the first slit in the first direction and has a square shape including fifth, sixth, seventh, and eighth sides. The first, second, fifth, and sixth sides are parallel to the first direction. The third, fourth, seventh, and eighth sides are parallel to a second direction orthogonal to the first direction. The third and seventh sides are positioned upstream from the fourth and eighth sides in the first direction, respectively. A first print label spans across the first and second sides. A second print label spans across the fifth and sixth sides. A mark has an upstream edge in the first direction positioned downstream from the fourth side and a downstream edge in the first direction positioned upstream from the seventh side.
US12319072B2
A recording apparatus to record an image on a sheet includes a roller pair and a switching unit. The roller pair sandwiches the sheet between the roller pair to convey the sheet. The switching unit switches between a first state in which the roller pair sandwiches the sheet and a second state in which rollers of the roller pair are separated from each other. The switching unit includes a first movable member that is moved in a first direction so that the first state is switched to the second state, and includes a second movable member that is moved in a second direction different from the first direction so that the first state is switched to the second state.
US12319062B2
A printhead module includes a monolithic substrate having longitudinal ink supply channels defined through a thickness of the substrate and extending parallel with each other along a length of the substrate; rows of print chips mounted on a front face of the substrate, each row of print chips receiving ink only from a respective one of the ink supply channels; and first PCBs mounted on the front face, each PCB extending alongside a respective one of the rows of print chips and supply power thereto. The rows of print chips and the first PCBs are mounted alternately across the front face of the substrate.
US12319050B2
The invention relates to a method of aligning a plurality of printed motifs on a sheet (3) in a converting machine (10). An actual position (Pa_1) at a first sensor is defined as an initial reference position (P_ref1) for the sheet, and at least one displacement error (Δd2) is calculated and compared to a first threshold (T1). If the displacement error is lower than the first threshold, then the angular position (α) of a printing cylinder (42) in the second flexographic printing unit (16b) is adjusted. However, if the error is higher than the first threshold, then at least part of the of the displacement error (Δd_2) is corrected by modifying the speed (V) of a vacuum transfer unit located between the first printing unit and the second printing unit.
US12319033B2
There is provided a composite structure, comprising a protective structure comprising a plurality of ballistic layers arranged as a stack; and an ancillary structure adjacent to the protective structure adapted to at least partly absorb a force acting on the protective structure. The ancillary structure comprises at least one first layer comprising an aerogel arranged to at least partly absorb a force acting on the protective structure. A part of each ballistic layer is moveable relative to at least one adjacent ballistic layer and wherein a part of each ballistic layer is connected to at least one adjacent ballistic layer so as to restrict relative movement of a part of each of the adjacent ballistic layers.
US12319030B2
Various embodiments for a laminate glass article and related methods are provided. The laminated glass article includes a first and second glass layers with an interlayer positioned therebetween, comprising: a polymer core layer comprising a high modulus polymer (e.g. polyethylene terephthalate, polycarbonate, polyacrylate, and polyimide); a first low modulus material layer (e.g. first TPU or first PVB or first EVA) configured between the first layer and the polymer core layer; and a second low modulus material layer (e.g. second TPU or second PVB or second EVA) configured between the second layer and the polymer core layer.
US12319023B2
A slitter device includes an upper rotary shaft and a lower rotary shaft that are supported so as to be able to rotate. An upper slitter head that is supported by the upper rotary shaft so as to be able to rotate therewith. A lower slitter head that is supported by the lower rotary shaft so as to be able to rotate therewith and that is disposed on one side of the upper slitter head in the axial direction of the lower rotary shaft. An upper movement device that can move the upper slitter head in the axial direction of the upper rotary shaft. A lower movement device can move the lower slitter head in the axial direction of the lower rotary shaft. A control device that controls movement of the upper movement device and the lower movement device.
US12319022B2
A method for producing a screen body for a screen used in a screw press, which screen body comprises one or more openings on a screen surface, In order to achieve a particularly long service life, it is provided that the screen body is formed by a sintering process and/or an additive manufacturing process, in particular a 3D printing process. Further embodiments include a screen, in particular for a screw press, having a screen body which has openings on a screen surface.
US12319002B2
Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a plurality of containers configured to receive a plurality of additively manufactured object having excess material thereon. The system can include a rotor having a central shaft and a plurality of arms, each arm having a first end and a second end opposite the first end. The first end of each arm can be coupled to the central shaft and a second end of each arm can be coupled to a respective container of the plurality of containers. The system can also include an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects. The system can further include at least one heat source carried on the rotor to heat the excess material to decrease a viscosity thereof.
US12319001B2
A method of manufacturing a tower structure includes printing and depositing, via a printhead assembly of an additive printing system, one or more printed layers of a wall of the tower structure. The method also includes unwinding at least one continuous roll of a reinforcement material to form at least one continuous reinforcement ring member layer, the reinforcement material comprising a pultruded polymer material. Further, the method includes placing the at least one continuous reinforcement ring member layer atop the one or more printed layers of the wall of the tower structure. Moreover, the method includes printing and depositing, via the printhead assembly of the additive printing system, one or more additional printed layers of the wall of the tower structure atop the at least one continuous reinforcement ring member layer.
US12318998B2
A three-dimensional (3D) printer nozzle. The 3D printer nozzle includes a nozzle body that is adapted to be deformed to allow for cross-sectional profile control during printing of a 3D printed object.
US12318997B2
A nozzle assembly for a printer head of a 3D printer includes at least two conduit portions, with each conduit portion including an interfacing surface having a recessed channel that is non-linear. The recessed channels cooperate with one another to define a serpentine path, in response to the interfacing surfaces of the associated conduit portions being engaged to one another. The serpentine path extends from a feed opening to a discharge opening for moving a filament therethrough. The nozzle assembly further includes a heating element connected to the conduit portions for transferring heat to the filament disposed in the serpentine path to fully melt the filament without caramelizing or burning the filament.
US12318995B2
The present teachings contemplate additive manufacturing of articles, such as articles made by layer-by-layer deposition of one or more reformable resin polymeric feed material. In particular the invention relates to a feed material system for preparing an article by additive manufacturing, comprising one or more preform elements of a feed material (i) formed of a reformable resin polymeric material including a polymer backbone having a plurality of repeat units each having ether linkages (e.g. derived from an epoxy containing reactant), and optionally one or more pendant hydroxyl moieties; and (ii) which is capable of transforming from a generally non-tacky first state to a second state in which the material is softened, upon application of heat, relative to the first state and is at least partially tacky in the second state to permit it to adhesively bond to a surface upon which it is deposited for forming a layer on the surface, to a third state in which the material is harder than when in the second state but remains able to further soften upon application of heat, wherein the resulting adhesive bond is substantially devoid of any cross-linking between the layer and the surface, and wherein the one or more elements of the feed material are in a form adapted to be dispensed by an additive manufacturing apparatus.
US12318981B2
A conveyance apparatus for conveying a mold into an injection molding machine includes a frame configured to form a supporting plane for supporting the mold, and an actuator configured to move the mold along the supporting plane between a first position inside the injection molding machine and a second position different from the first position, wherein the improvement to the conveyance apparatus includes the actuator being located below the supporting plane in a vertical direction; and a linking unit configured to link the mold and the actuator, wherein the linking unit is connectable to a side surface of the mold, wherein, in a state where the mold is at the second position, at least a part of the actuator is closer to the injection molding machine than the side surface of the mold in a conveying direction where the actuator moves the mold.
US12318978B2
A method for producing a vehicle interior decorative part comprises providing a substrate film, forming a composite layer by applying a decorative ply to a first side of the substrate film, micro-perforating the decorative ply in one or more regions, inserting the composite layer made of substrate film and micro-perforated decorative ply into a cavity of an injection mold wherein, when plastics material is injected into the cavity, the decorative ply of the composite layer is back-injected and a second side of the substrate film opposite the first side is pressed against a wall of the cavity, closing the cavity and injecting plastics material into the cavity to form the decorative part substrate, the decorative ply being back-injected and the decorative ply being applied to a surface of the substrate facing the decorative ply during substrate formation in the cavity, and opening the cavity and removing the decorative part.
US12318975B2
A method of molding a resin molded product, including: a first molding step of injecting a first resin molding material into a first molding die to form a first resin product, wherein a fixing protrusion is formed on at least one of an inner and an outer wall part of the first resin product, and has a shape in which a width increases in a direction extending from the gap; and, a second molding step of positioning the first resin product in a second molding die, and injecting a second resin molding material at least into the gap of the first resin product to form a second resin product, wherein the fixing protrusion is embedded into a fixing recess disposed on the second molding die, thereby limiting movement of the fixing protrusion in a direction towards the gap.
US12318971B2
Disclosed is a mold for partially shortening the circumference of a tube billet and a using method of the mold. The mold comprises an upper mold, a lower mold and a mold core used for being inserted into a tube cavity of the tube billet, wherein the upper mold is provided with an upper mold cavity, the lower mold is provided with a lower mold cavity, and the upper mold cavity and the lower mold cavity are matched to form a mold cavity. After the mold core is placed in the mold cavity, a tube billet deformation cavity is formed in the mold cavity; and the upper mold cavity and/or the lower mold cavity are/is in the shape of a flaring, the two sides of the flaring are arc-shaped, and included angles are formed between the two sides of the flaring and the moving direction of a movable mold.
US12318970B2
A high-efficiency mold temperature control system includes a dielectric heating module, a cooling module, and a flow control module. The dielectric heating module includes a heating circuit, a dielectric heater, a high-frequency power supply, a high-temperature heat medium storage tank, and a heat circulation pump. The cooling module includes a cooling circuit, a heat exchanger, a low-temperature heat medium storage tank, and a cold circulation pump. The flow control module includes multiple thermal switch valves and multiple cooling switch valves to control a high-temperature heat medium to the heating circuit or control a low-temperature heat medium to the cooling circuit. Through the design of the dielectric heating module, the high-temperature heat medium can be rapidly heated and the overall heating efficiency can be enhanced, thereby rapidly heating or cooling a mold and controlling the rapid heating and cooling of the mold.
US12318964B2
A preform tooling arrangement includes a base plate comprising a male die surface and a stripper plate comprising a female die surface. A plurality of perforations are disposed in the base plate and/or the stripper plate. The stripper plate is moveable with respect to the base plate. The preform tooling arrangement is configured to receive a fibrous preform between the male die surface and the female die surface. The preform tooling arrangement is a dual-purpose fixture configured to accommodate z-needling and densification, all while the fibrous preform remains in the same fixture (i.e., the preform tooling arrangement). The perforations are configured to receive one or more textile needles for through thickness reinforcement of the fibrous preform.
US12318958B2
A high speed food article slicing machine with a slicing station, a moveable frame supporting a food article feed mechanism frame, a food article gate, and a safety guard system for detecting an intrusion into the machine. Food articles are loaded onto a lift tray and raised to a staging position where food articles are in contact with a food article gate. The lift tray is located inline with the food article feed paths such that lateral shifting of food articles into the feed paths is not needed. Food article grippers, individually driven along feed paths by an overhead conveyor, move food articles over the food article gate towards the slicing station. The food article gate functions to assist in removal of food article end portions. The slicing machines utilizes a horizontally radiating laser intrusion detector to shut down systems when an unwanted intrusion is sensed.
US12318955B2
A handle assembly for a hair removal device, including a handle with a connection portion for supporting a hair removal head and an elongated grip portion, at least a first accessory component that is disassemblable from the grip portion, and a holding mechanism, a first portion of the holding mechanism being engageable with a second portion of the holding mechanism to resist disassembly of the first accessory component from the grip portion. A recycling process for the same.
US12318954B2
A razor cartridge comprising a frame, wherein the frame comprises a leading longitudinal member and a trailing longitudinal member and at least one transverse frame member defining a cartridge plane, disposed in between, and joining, the leading longitudinal member and the trailing longitudinal member, in a transverse direction of the razor cartridge. The at least one transverse frame member comprises a plurality of cutting member guides defining a plurality of cutting member support slots, each cutting member support slot configured to accommodate a longitudinal cutting member, and a plurality of longitudinal cutting members, wherein each cutting member is disposed in a respective cutting member support slot.
US12318953B2
A folding knife is provided with a power storage device that can be charged and recharged by a charge component that wirelessly receives power from a remote source. In some embodiments, the folding knife can have a device that consumes energy such as a light, a camera, a microphone, an audio speaker, etc. The power storage device and the charge component can be positioned in a scale of the handle where the substantially planar shapes of the scale, the power storage device, and the charge component are oriented in a common direction. In some embodiments, the cavities, recesses, and channels in the first scale that house these components and linking wires are strategically positioned to leave a reinforcing area that provides strength and stiffness to the handle. Various features are also described herein that improve safety of the charging system.
US12318943B2
A control device includes a processor that calculates one or more predetermined command values for one or more robots to undergo synchronous control in predetermined control cycles, an output unit that outputs the one or more predetermined command values in each of the predetermined control cycles, and a generator that generates an output signal for a virtual robot. The virtual robot is virtually defined in relation to the synchronous control. The processor calculates the one or more predetermined command values using the output signal for the virtual robot generated by the generator.
US12318942B2
This robot programming device creates an operational program for a robot that moves while pressing a gripped object, which is gripped by the robot, against a fixed object. The robot programming device includes a model arrangement unit which arranges, in a three-dimensional virtual space, a robot model of the robot, a gripped object model of the gripped object, and a fixed object model of the fixed object, a reference line designation unit which designates a reference line indicating a range, of the outer circumference of the gripped object model, to be pressed against the fixed object, a transfer start point designation unit which designates a transfer start point for transferring the reference line onto the fixed object model, and an operational path creation unit which creates an operational path by transferring the reference line onto the fixed object by using the transfer start point as the start point.
US12318938B2
Multi-target libraries, projects, and activities for robotic process automation (RPA) are disclosed. Some embodiments multiple target platforms can be handled in the same project. The target platform(s) can be specified at the automation and/or activity level in order to provide the supported functionality for each. This may also allow previously built automations to be applied to new target frameworks without starting from scratch.
US12318936B2
A method for determining a torque for an operation of a robot that includes multiple components, using a model of the robot. Two components of the robot being movable using an actuator relative to one another at a connection point. The model maps parameters for the connection points onto a torque for the respective actuator. The method includes: providing values for the parameters including: a position or an angle a velocity, and an acceleration of the respective actuator; determining a value for the rigid body partial torque, the friction partial torque, and the machine learning partial torque, based on the values of the parameters and the model; determining a value of the torque of the respective actuator based on the values of the partial torques, and providing the value of the torque for the respective actuator for use during the operation, control or regulating of the robot.
US12318925B2
A robot includes a robot hand, a robot arm, a force sensor, and a control device. The control device performs admittance control to determine a position of the robot hand in accordance with a force detected by the force sensor, and provides, to the robot arm, an instruction to move the robot hand to the determined position. Further, the control device records, as teaching data, the instruction provided to the robot arm.
US12318923B2
A system for assisting an operator in exerting efforts comprises a garment that can be worn by the operator, which is to engage, when worn, the mutually mobile parts of a joint of the operator. The system defines at least one axis of rotation that is to assume a position corresponding to the joint of the operator. A device is carried by the garment and designed to operate so as to compensate the resistive moments that act on the joint during the effort exerted by the operator. A compensation device is provided equipped with a rotational assembly, which has a neutral position and is able to determine a pre-set plot of the assisting torque that is a function of the angle of rotation of the joint. The compensation device may include a tension regulation device to regulate a moment obtained about the joint of the operator.
US12318912B2
A method of inspecting a balcony identifies an area of the balcony where there is no access to pass a crawler robot from the outside of the balcony into the interior space of the balcony, drills a hole into the interior space of the balcony, passes the crawler robot that includes a humidity sensor through the hole into the interior space of the balcony. The method, by the processor of an electronic device, receives humidity measurements of the interior space of the balcony from the humidity sensor, compares the humidity measurements with a threshold value, determines that at least one of the humidity sensor measurements exceeds the humidity threshold value; and generates a notification indicating the humidity in the interior space of the balcony exceeds the humidity threshold value based on the determination. The method removes the crawler robot from the interior space of the balcony and seals the hole.
US12318905B2
An apparatus for supplying a power tool with electrical energy is provided. The apparatus can be used, for example, to connect the power tool to an energy network so that it can perform the function of a mains adapter. The apparatus includes a first component for converting an AC voltage into a DC voltage, as well as a second component which is configured to convert the DC voltage generated by the first component into a device DC voltage. In a second aspect, the invention relates to a system which includes a apparatus and a power tool, wherein the power tool can be supplied with electrical energy using the apparatus. A use of the apparatus for supplying a power tool with electrical energy. Advantageously, particularly high power densities can be achieved with the invention and powers of more than 1700 watts can be provided.
US12318899B2
A powered fastener driver includes a housing, a cylinder within the housing, the cylinder containing a pressurized gas, a piston within the cylinder and movable from a top-dead-center position to a bottom-dead-center position, a driver blade movably coupled to the piston, a lifter, a drive unit configured to provide torque to the lifter, and a sensor. The driver blade has a plurality of teeth defining a predetermined number of edges. The sensor is configured to detect an edge of one or more of the plurality of teeth and a controller in communication with the drive unit and the sensor. The controller is configured to count a number of edges detected by the sensor, compare the number of detected edges to the predetermined number of edges, and stop the drive unit when the number of detected edges is less than the predetermined number of edges.
US12318894B1
A ratchet-type tensioning device comprises a base, wherein the base is provided with a accommodating area for accommodating a webbing, and the accommodating area is provided with a winding and winding and unwinding mechanism which is used for winding and unwinding the webbing; the winding and winding and unwinding mechanism comprises a ratchet wheel with gear teeth, and the accommodating area is further provided with an operating mechanism, and the winding and winding and unwinding mechanism can be selectively locked or unlocked by the operating mechanism.
US12318889B2
A radial grinding tool for a machining center utilizing through-spindle coolant is disclosed and includes a main body having a central longitudinal axis, a spindle extending along the central longitudinal axis, a disc-shaped wheel member located at an end of the spindle and including a working surface at a periphery of the wheel member, and a passageway extending through the main body configured to accommodate a flow of coolant. The tool includes an impeller attached at a lower side of the wheel member and having a plurality of blades that are configured to impart a force against the coolant to reshape the flow of coolant into a generally flat stream and redirect and drive the coolant radially outward from the central longitudinal axis to the working surface.
US12318876B2
A control unit is configured to performs a first control of controlling a movement unit so that a fitted part of a screw member and a fitting part of a rotating body are axially aligned with each other; a second control of controlling the movement unit to press the fitting part against the fitted part; a third control of, while maintaining a state in which the fitting part is pressed against the fitted part, controlling a rotation-driving unit to rotate the rotating body to a first rotation direction side by a first predetermined angle; a fourth control of, while maintaining the state in which the fitting part is pressed against the fitted part, controlling the rotation-driving unit to rotate the rotating body to a second rotation direction side by a second predetermined angle, which is smaller than the first predetermined angle, the fourth control performed after the third control.
US12318875B2
In order to improve the estimation of the arc voltage for use in a welding process, a welding line is modeled using a welding line model in the form of a transfer system with an order greater than one for estimating the arc voltage, and the estimated value of the arc voltage is determined as the difference between the measurement voltage at the measurement point and the determined line voltage drop.
US12318864B2
A method for welding a flexible film (10) to a carrier component (20) having the following steps: 1) pressing the film (10) on the carrier component (20) by a volumetric flow of a fluid, and 2) laser welding the film (10) on the carrier component (20).
US12318863B2
In an ultrasonic joining apparatus according to the present disclosure, an ultrasonic joining apparatus control board controls an operation of a lead set unit and a tension adjustment unit including a dancer roller to perform joining tension control processing. The joining tension control processing includes steps of: making a lead wire housing mechanism perform a rewinding driving of rewinding a lead wire in a lead cassette when the dancer roller reaches a lower limit adjustment position in a tension adjustment range; and making the lead wire housing mechanism perform a delivery driving of sending out the lead wire from the lead cassette when the dancer roller reaches an upper limit adjustment position in the tension adjustment range.
US12318855B2
A method for creating an electric heating source, including a body equipped with one or more housings containing mineral-insulated heating cables. The housings communicate with one or more reservoirs which accept a purely metallic solder material in solid, powder or sheet form. The device is heated in a vacuum degassing plateau, followed by a casting plateau during which the solder melts and fills the housing around the heating cables, resulting in full metal contact between the cables and the body, providing a more uniform temperature and a shorter response time to heating or cooling. Also, a heating source obtained in this manner, including an infrared faired source or an immersion heater for the heating of a liquid bath of molten metal.
US12318841B2
Embodiments can relate to an improved hydroflux, additive or electroless plating assisted densification cold sintering process to densify powdered metals at lower compaction pressures and lower temperatures (e.g., 520 MPa and 140° C.). The process can involve inducing dissolution precipitation mechanisms at powder interfaces by introducing a transport phase (formed by the introduction of water during the process to suppress melting temperatures) that is not an aqueous solution. Particle interfaces in the cold sinter fuse together by the presence of the additional transport phase, thereby reducing the temperatures and pressures needed for compaction. Some embodiments involve the use of elements to form a eutectic at the desired low temperature, thereby stabilizing certain crystal structure shapes of isometric crystal systems, inducing rapid densification, and facilitating pore smoothing. Embodiments of the process can be used to generate a green compact via sintering that exhibits improved green strength.
US12318829B2
Apparatus (10) for forming a spirally wound conduit (14) from a flat strip (2) comprising: a forming device (6) comprising a bending section (7) configured to spiralling bend the strip (2) and a joining section (8) configured to join opposite longitudinal sides (2A,2B) of the strip (2) each other; a feeding device (11) of the strip (2) along a feeding direction (F) parallel to the longitudinal edges (9) of the strip (2); a cutting device (1) arranged upstream the forming device (6) comprising a cutting head (3) for cutting the strip (2) and moving means configured to move said cutting head (3) along a plurality of moving axes (X,Y,Z) orthogonal to each other; a control unit (18) configured to command said moving means according to diameter (D) of the conduit (14) to be realized and to the width (B) of the strip (2) so that said cutting head (3) realizes on the strip (2) a plurality of arrays (12) of holes (13) each one tilted with respect to one of the longitudinal edges (9) of the strip (2) by an angle (α) function of the width (B) of the strip (2) and of the diameter (D) of the spiral conduit (14) to be realized. The present invention relates also to a air conduit (14), a perforated strip (2′) and a coil (19) of a perforated strip (2′) comprising a plurality of said arrays (12) of holes (13) wherein said holes (13) comprise at least two different shapes.
US12318827B2
Provided are: an upper work roll, radial bearings and a thrust bearing provided on a work side and a drive side of the upper work roll and supporting the upper work roll. Shift cylinders are provided on the work side of the upper work roll and apply forces in both a work side direction and a drive side direction to the thrust bearing. Shift cylinders are also provided on the drive side of the upper work roll and apply forces in both the work side direction and the drive side direction to the radial bearing 790B. The shift cylinders each apply a force in the same direction to the radial bearing and the thrust bearing when the upper work roll does not shift in an axial direction at least during rolling.
US12318826B2
A cold-rolled steel strip manufacturing facility includes: a joining device configured to join a trailing end of a preceding steel strip and a leading end of a following steel strip to form a joined steel strip; a looper configured to store the joined steel strip; a heating device configured to heat a joint portion between the preceding steel strip and the following steel strip over an entire width direction; and a cold rolling mill configured to cold-roll the joined steel strip for which the joint portion was heated by the heating device, wherein the heating device is switchable between an output state and a non-output state, and during a period in which the joint portion passes through the heating device, is switched to the output state.
US12318820B2
A cleaning apparatus for use with a water source, the cleaning apparatus including a handheld cleaning device that includes a transducer therein that is capable of stimulating water located inside a body of the handheld cleaning device, such that bubbles created by the excitation of the water via the transducer can be used to provide a cleaning effect, for example to clean the surface of a soiled object by way of bubbles bursting at, on or near the surface of the object.
US12318813B2
An apparatus for sorting objects includes a feeding device, at least one transfer device and several target containers. The feeding device is configured to convey the objects to the at least one transfer device. The transfer device is configured to transfer the objects to the target containers. The apparatus has a sorting device in which the target containers can be moved such that the target containers can be positioned either at a transfer position assigned to the at least one transfer device or at any one of a plurality of waiting positions. The waiting positions form an at least two-dimensional position grid.
US12318812B2
Disclosed embodiments include a screen deck assembly that can be mounted on a vibratory screening machine. The screen deck assembly includes a plurality of elongated support members that extend in a first direction. A plurality of support rods are mounted to the elongated support members. The support members and support rods form a screen support surface. The support rods extend in a direction that is transverse to the support members.
US12318809B2
Systems and methods for protecting threads of metal pipes while coating the metal pipes with a protective coating are disclosed herein. Innovative metal couplings are used to protect the threads while a protective coating is applied to the metal pipes. The couplings are reusable and result in multiple efficiency improvements over previous methods and systems. Benefits include elimination of plastic caps and reduced waste, improved flowthrough in the powder coating process, more efficient thermo transfer in the thermal chamber, and an increase in the overall capacity of the powder coating operation.
US12318807B2
(a) An aerosol including an active material, a binder, and a gas is made. (b) A film-like flow of the aerosol is formed. (c) An electrically-charged region is formed by corona discharge. (d) The film-like flow passes through the electrically-charged region. (e) The film-like flow is introduced into an electric field after passing through the electrically-charged region. In the electric field, an active material layer is formed by adhering a solid component of the film-like flow onto a surface of a substrate by electrostatic force.
US12318806B2
A method of coating a substrate with a washcoat using a substrate coating apparatus is disclosed. The method comprises locating the substrate below the washcoat showerhead; bringing the partition ring into contact with the face of the substrate to thereby define a central region of the face of the substrate which lies within an interior of the partition ring and a peripheral region of the face of the substrate which lies outside the partition ring; conveying washcoat from the source of the washcoat, along the conduit and through the washcoat showerhead; discharging the washcoat out of the nozzle apertures towards the face of the substrate, the showerhead plate of the washcoat showerhead discharging washcoat onto both the central region and the peripheral region of the face of the substrate.
US12318793B2
An assembly includes a dispenser having a lower body including a bottom from which there extends a lower skirt, wherein the lower skirt there is fitted and an upper body including a neck, a pump adapted to be fixed in the neck, from the neck extends an upper skirt adapted to fit on the lower skirt, the lower body and the upper body defining a cavity in which a liquid pouch can be placed, the assembly comprising a support element comprising a wall-fixing plate to which a fixing base is fixed, the bottom comprising a bottom wall that is arranged around at least a part of the perimeter of the bottom and extends in the opposite direction to the lower skirt, forming an open housing, the bottom being provided with a connection device to the support element.
US12318778B2
A microfluidic chip system for generating droplets is provided by the present disclosure. The microfluidic chip system includes a droplet generation device for generating the droplets, a power generation device for supplying power to the droplet generation device, a collection container for collecting the droplets flowing out of the droplet generation device, a connection device connecting the droplet generation device, the power generation device, and the collection container to each other, and a preparation platform holds together the droplet generation device, the power generation device, and the collection container. A method for preparing the droplets is also provided by the present disclosure.
US12318774B2
A method of manufacturing a laminate microfluidic device is described herein. Also described is the microfluidic device manufactured via the method of the disclosure, as well as use of the device to perform an assay. The laminate device includes a substrate layer, an adhesive layer having a cured adhesive with one or more channels or recesses formed therein, and a top layer.
US12318772B2
An analysis instrument includes a cartridge bay for receiving a sample preparation cartridge. The cartridge bay includes a controllable heater for heating a sample; a first temperature sensor for monitoring the temperature of the controllable heater; and a second temperature sensor for monitoring the temperature of the sample.
US12318771B2
The invention relates to a system for processing liquid and/or solid compounds, comprising a vessel (3) and a holding device (5) for the vessel (3), the holding device (5) comprising a stop (15) against which the vessel (3) rests after being inserted into the holding device (5) and a supply unit (7) opposite the stop (15), the supply unit (7) comprising a closing element (9), which can be set to a first and a second position, wherein in the first position of the closing element (9) the vessel (3) can be inserted into the holding device (5) and in the second position of the closing element (9) the vessel (3) inserted into the holding device (5) is pressed against the stop (15) by the closing element (9).
US12318770B2
The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.
US12318765B2
The present disclosure provides a supercritical fluid gasification system. In some embodiments, the system includes a reactor having a reactor shell including sidewalls that extend between a top reactor cover and a bottom reactor cover, where the sidewalls, the top cover, and the bottom cover enclosing a reactor shell channel. In some embodiments, the reactor includes a thermal shield positioned within the reactor shell channel, the thermal shield having sidewalls that extend between a top thermal shield cover and a bottom thermal shield cover, where the sidewalls, the top thermal shield cover, and the bottom thermal shield cover enclosing a thermal shield channel. In some embodiments, the reactor includes a fluid feed supply conduit in fluid communication with the thermal shield channel, a supercritical fluid conduit in fluid communication with the thermal shield channel, and a product conduit in fluid communication with the thermal shield channel.
US12318762B2
The present disclosure provides SCR catalyst compositions capable of reducing nitrogen oxide (NOx) emissions in engine exhaust. The catalyst compositions include a reducible metal oxide support containing ceria, one or more transition metal oxides as a redox promotor; and an oxide of niobium, tungsten, silicon, molybdenum, or a combination thereof as an acidic promotor. The redox promotor and the acid promotor are both supported on the reducible metal oxide support. Further provided are SCR catalyst articles coated with such compositions, processes for preparing such catalyst compositions and articles, an exhaust gas treatment system including such catalyst articles, and methods for reducing NOx in an exhaust gas stream using such catalyst articles and systems.
US12318759B2
A system and method of applied radial technology chromatography using a plurality of beads is disclosed, with each bead comprising one or more pores therein having a diameter of about 250 Å to about 5000 Å, and each bead having an average radius between about 100 μm to about 250 μm. Also disclosed are processes for selecting beads for use in a radial flow chromatography column, and for purifying an unclarified feed stream using a radial flow chromatography column.
US12318746B2
A mixing device includes a mixing container for receiving mixing material and a mixer cover, wherein a first seal and a second seal is provided between the mixing container and the mixer cover. The first seal and the second seal are so arranged that a first air space is formed between the first seal and the second seal.
US12318742B2
Devices, systems and methods for mixing and/or introducing agrochemicals, comprising a mixer including a mixing chamber in which a liquid is able to flow, and a delivery point located on the mixing chamber for delivering an agrochemical into the mixing chamber, wherein the mixer includes means for generating backpressure in the liquid and the agrochemical in the mixing chamber, and a mixer system including a mixer, an injector, and an agrochemical source, wherein the injector is adapted to receive an agrochemical from the agrochemical source, and a method including the steps of supplying a liquid into a mixing chamber of a mixer or mixer system, delivering an agrochemical into the mixing chamber, and generating backpressure to the liquid flowing through the mixing chamber to effect mixing of the liquid and the delivered agrochemical.
US12318740B2
A method and apparatus for producing chlorine gas whereby a nanobubble generator introduces nanobubbles at a concentration of at least 106 nanobubbles per cm3 into an electrolytic cell comprising a pair of electrodes and a chlorine-containing, electrolyzable liquid, and the electrolytic cell is operated to produce chlorine gas.
US12318730B2
The present invention relates to a catalyst, which comprises * a carrier substrate with a first end a and a second end b, and length L, * a material zone A containing a platinum group metal on a support material with a load of 40 to 150 g/l, relative to the volume of the carrier substrate and * material zone B containing a platinum group metal on a support material with a load of 75 to 200 g/l, relative to the volume of the carrier substrate, wherein material zone B has a greater content of platinum group metal, relative to the volume of the carrier substrate and calculated in g/l, than material zone A, and wherein material zone B has a proportion of pores with a diameter of 0.5 to 50 μm of 20 to 30%.
US12318726B2
A harmless and resourceful treatment method for antibiotic residue includes steps as follows. The antibiotic residue is dried and crushed to obtain a dry powder of antibiotic residue. The dry powder of antibiotic residue is heated to a temperature of 400-800° C. to perform an isothermal pyrolysis treatment under an inert atmosphere. Condensable gas in the volatile substances released during the pyrolysis treatment is collected using a condensing device to obtain a condensable bio-oil product, non-condensable gas in the volatile substances is collected using a gas bag to obtain pyrolysis gas, and the residual substances obtained after the pyrolysis treatment are as a biochar product. The treatment method addresses the issues of incomplete degradation of the antibiotic residue, complex processes, high difficulty in resource utilization, and resource wastage in traditional treatments of the antibiotic residue, thereby achieving the goals of harmlessness and resource utilization of the antibiotic residue.
US12318721B2
A filtration assembly includes a filter housing and a filter element. The filter housing includes a base and a cover including an underside having one or more retainer features. The cover is removably coupled to the base. The filter element is removably installed within the base when the cover is coupled to the base. The filter element includes filter media and an endplate coupled to one end of the filter media. The endplate includes an outer perimeter and one or more engagement features protruding from the outer perimeter. The one or more engagement features engage the one or more retainer features in the cover upon installation of the endplate into the cover, thereby coupling the endplate to the cover.
US12318719B2
A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.
US12318712B2
In one example, an apparatus for filtering a fluid (e.g., a plastic melt having impurities) includes a housing which has at least one inlet for introduction of the fluid and an outlet for delivery of the fluid and a cavity formed in the housing by wall portions of the housing for receiving a sieve support, and a sieve support which is arranged moveably in the cavity of the housing and has a longitudinal axis for receiving at least one filter element for filtering the fluid. The sieve support externally has a plurality of integrally formed raised portions and/or raised portions and/or recesses are formed at wall portions of the housing, that delimit the cavity, such that provided between the wall portion and the sieve support are a plurality of gaps/cavities, by means of which a slight fluid flow is enabled in operation. Another example concerns a valve arrangement.
US12318707B2
An apparatus and process for extracting organic molecular compounds from plant material and concentrating those into a viscous oil, the process supported by a machine architecture that heats, cools, and stirs a cooking mixture of plant material and a consumable solvent oil, the viscous oil suitable for use in sublingual tinctures, food products, and topical salves.
US12318705B1
Methods and systems are described for an animated artificial water surface. A sheet of material having a glossy surface includes a three-dimensional pattern of waves extending along horizontal dimensions of the sheet. The waves have a scale-model height profile. A drive may be coupled to the sheet. The drive may be operable to move at least a portion of the sheet continuously and at a constant speed in one direction relative to the horizontal dimensions of the sheet wherein the waves model an animated water surface.
US12318700B2
A method for providing navigation assistance in a three-dimensional (3D) virtual environment includes a plurality of virtual characters corresponding to a plurality of users, wherein the plurality of virtual characters communicates with each other in the 3D virtual environment and a plurality of virtual cameras corresponding to the plurality of virtual characters. Further, the given virtual camera being movable according to a movement of the corresponding virtual character. Further, providing at least one predefined navigation path in the 3D virtual environment for directing the plurality of virtual characters to move towards at least one virtual area in the 3D virtual environment. Furthermore, providing an indication of scene details in the at least one virtual area. Moreover, capturing a plurality of video streams using the plurality of virtual cameras and sending the plurality of video streams to the plurality of user devices for display thereat.
US12318695B2
An item selected by a user is set as a first owned item. A state change item which changes a state of an operation character from a first state to a second state is associated with the operation character, and the operation character is caused to own a second owned item associated with the state change item. During a game, when a state change condition is satisfied, the state of the operation character is changed from the first state to the second state. When the operation character is in the first state, use item candidates not including the second owned item are presented to the user, and when the operation character is in the second state, use item candidates including the second owned item are presented and a game event is advanced using an item designated by the user.
US12318691B2
System, process and device configurations are provided for user preference customized generation of gaming music. A method can include detecting at least one user preference for gaming music, determining a game state, and generating gaming music based on the at least one user preference and the game state. Customization of audio and gaming music can have a large impact on a gaming experience. Musical preferences may be collected for users to generate dynamic music and to improve gaming system ability to generate a customized experience. Musical preferences can include one or more of genres, specific song titles, indications of preferred types of music, music identified for certain gaming activities, user feedback, and country of origin. Music may be generated based on emotional cues of a game scene. Music may be controlled to be more prominent or less obtrusive to a game state.
US12318690B2
System, process and device configurations are provided for game guides. A method can include detecting user interface selection of a game guide, updating display output and presentation of game guide content. A user interface, processes and device configurations are provided to provide game guidance to assist players of a game find detailed context sensitive game guidance. Game guidance can reduce frustration, increase engagement and keep players in a game. Game guides can present game guide assistance videos that may be presented in addition to game content, such as side-by-side or picture-in-picture to present content to assist a player accomplish tasks of a game and to locate trophies. Game guide elements are provided that include features, such as searching and selection of game guide assistance. Game guide elements can include features for selection of sources and to launch game content. Processes and configurations are also provided for determining game guide content.
US12318688B2
A cloud application-based resource transfer method, apparatus, computer device and storage medium. The method includes: displaying, through a cloud application, a video interface generated after processing through a cloud; displaying, in response to a trigger operation on a target visual element in the video interface used for triggering resource transfer, a resource transfer channel interface generated by the cloud; displaying a target resource transfer channel in the resource transfer channel interface; displaying resource transfer-related information corresponding to the target resource transfer channel and generated by the cloud; and triggering, in response to a resource transfer confirmation operation for the resource transfer-related information, a resource transfer operation that is based on the resource transfer-related information through the target resource transfer channel.
US12318687B2
In an audio device that includes a plurality of input controls, mixing circuitry, a left speaker, and a right speaker, a desired balance, between a first audio signal and a second audio signal, may be determined according to the plurality of input controls. A desired volume, of the first audio signal and the second audio signal, may be determined according to the plurality of input controls. A virtualization, of one or both of the first audio signal and the second audio signal, may be determined according to a head related transfer function. A stereo signal may be generated by combining the first audio signal and the second audio signal according to the desired balance, the desired volume, and the virtualization. A left channel of the stereo signal may be outputted to the left speaker and a right channel of the stereo signal may be outputted to the right speaker.
US12318672B1
Rotating golf tee devices are disclosed. The devices include a central base configured to be positioned on a ground surface. In addition, the devices include a motor that is connected to and located above the central base that rotates an axis perpendicular to the ground surface. The devices further include a plurality of arms extending from and connected, directly or indirectly, to the motor. The devices include a golf tee connected to the distal end of each of the plurality of arms, with the motor being configured to simultaneously rotate the plurality of arms and each connected golf tee.
US12318670B2
A golf club head with a central body component is disclosed herein. The central body component includes a crown portion and a sole portion. The crown portion is composed of a continuous carbon fiber reinforced epoxy material. The sole portion is composed of a chopped carbon fiber reinforced vinyl ester sheet molding compound material. The central body component has a front opening and a rear opening with a hollow interior.
US12318669B2
A golf club head with a central body component is disclosed herein. The central body component includes a crown portion and a sole portion. The crown portion is composed of a continuous carbon fiber reinforced epoxy material. The sole portion is composed of a chopped carbon fiber reinforced vinyl ester sheet molding compound material. The central body component has a front opening and a rear opening with a hollow interior.
US12318668B2
A ball striking device, such as a golf club head, has a face with a striking surface configured for striking a ball where the face has multiple thickness regions. The face has a center region, an upper region, a lower region, a toe region, and a heel region. The upper and lower regions have a ramped thickness extending from a center region to an upper and lower edge of the face. The heel and toe regions have a constant face thickness and have a thickness less than the other regions. Additionally, the club head body has a flange where the face is welded to the club head body. The flange has a thickness that is greater than the thickness of the heel and toe regions of the face.
US12318665B2
Compositions including a resiliency additive and golf ball components made from such compositions having a tailored Coefficient of Restitution are disclosed. The type and concentration of the constituents in the composition, including the resiliency additive, affects the Coefficient of Restitution of components made from the composition and, thus, can be used to produce a golf ball having desirable performance characteristics.
US12318658B1
The present disclosure provides an automatic chassis lifting mechanism for a treadmill, including a chassis, where an upper housing is mounted at an upper end of an upper surface of the chassis, a lower housing is mounted at a position of a lower surface of the chassis corresponding to the upper housing, a running belt is rotationally mounted at the center of the upper surface of the chassis, an automatic lifting mechanism is mounted below the lower housing, the automatic lifting mechanism is rotationally connected to the chassis, and the slope of the treadmill is adjusted by means of the automatic lifting mechanism. The automatic lifting mechanism includes an adjustable lifting frame and a push rod motor, the adjustable lifting frame is rotationally arranged at a position of the bottom of the chassis close to the lower housing.
US12318651B2
A bidirectional rotational resistance assembly is provided. The assembly includes a lever coupled to the one or more discs so that a first torque imparted in a first rotational direction on the lever determines a rate of change of each disc's angular momentum in the first rotational direction in such a way as to oppose a second torque imparted in a second rotational direction on the lever, wherein the first and second rotational directions are opposites.
US12318643B2
A system includes an outrigger assembly configured to be coupled to a chassis of the vehicle. The outrigger assembly includes a pair of outriggers. Each outrigger of the pair of outriggers includes an arm and a support foot. The arm is selectively extendable laterally outward at a fixed angle relative a horizontal.
US12318639B2
A web harness belt includes multiple layers. A first elastomer layer portion and a second elastomer portion each connected to a ballistic material layer of the multiple layers. The first elastomer layer portion and the second elastomer layer portion each including multiple belt configuration slots.
US12318637B2
Various example embodiments of the present disclosure provide systems and methods for the dynamic correction and reduction of thermal variations in skull-induced aberrations during a focused ultrasound therapy procedure. Unlike conventional approaches involving static corrections for skull-induced aberrations, various example embodiments of the present disclosure employ ultrasound detection and a skull thickness estimate from volumetric image data to intermittently and dynamically determine corrections for skull-induced aberrations, such that aberration correction reduction is updated intraoperatively and maintained despite local thermally-induced changes in the speed of sound of the local skull region due to intraoperative intracranial heating. Furthermore, in some example embodiments, a measure dependent on the speed of sound with the skull is intraoperatively determined and compared to a previously determined value of the measure to determine a change in the skull temperature, based on a pre-determined relationship between changes in the measure and changes in skull temperature.
US12318635B2
The present invention relates to means and methods for modifying renal function in a subject, comprising selecting a patient requiring an increment in renal function; emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a period of time from about 1 hours to about 30 days.
US12318629B2
A shield assembly for an intensity modulated brachytherapy (IMBT) system, has: a tubular applicator engageable to a rotating mechanism of the IMBT system, the tubular applicator having a peripheral wall enclosing an internal cavity extending longitudinally along a central axis; a radiation shield extending axially along the central axis and received within the internal cavity, the radiation shield made of an MRI-compatible and radiation attenuating material; and a radionuclide-receiving passage within the internal cavity of the tubular applicator, the radionuclide-receiving passage extending axially and being radially offset from the central axis.
US12318622B2
A system for cosmetically treating a patient's skin or body with one or more EMS coils and/or RF electrodes mounted on a planar holder; a hydrogel containing gel pad, the gel pad being positionable between the holder and the skin tissue; wherein the gel pad being of a material that is biocompatible and conducts RF and/or EMS energy when EMS energy is applied from the one or more EMS coils; a programmable controller to activate the one or more EMS coils; the programmable controller, after the planar holder is applied to the skin tissue, being configured to activate one or more of the plurality of EMS coils to provide treatment in the form of stimulation to the skin tissue.
US12318609B2
An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. A sheath or needle may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via a sheath or needle.
US12318608B2
Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.
US12318606B2
Presented herein are techniques for monitoring the insertion of an intra-cochlear stimulating assembly for the occurrence of one or more insertion stop conditions. The insertion stop conditions are detectable events indicating that movement of the stimulating assembly into a recipient's cochlea should be at least temporarily stopped. The insertion monitoring is based on objectively measured inner ear potentials, such as acoustically-evoked potentials.
US12318603B2
A blood pumping device is described having at least a first pump and a first pump actuator for inducing a blood flow in a body's circulatory system. The pump has one upper chamber having an inlet channel and one lower chamber having an outlet channel. The upper and lower chambers are separated by a movable valve plane provided with a one-way valve. The pump actuator induces movement of the valve plane in an upward and downward direction between the upper and lower chambers in response to control signals from a control unit. When the valve plane moves in an upward direction, the valve opens allowing a flow of blood from the upper to the lower chamber. The lower chamber is provided with a bag-like portion forcing said flow of blood to make a turn of between 110° to 150° before leaving through the outlet channel.
US12318599B2
Methods and devices for bending a needle are provided. A device embodiment can include a needle bending apparatus for imparting a bend in a needle when a needle is received therein. The needle bending apparatus may include a housing having an aperture for receiving a shaft of a needle; and at least one abutment member comprising a needle interfacing surface for supporting a portion of the needle and providing a surface upon which the needle may be bent.
US12318595B2
The disclosure relates to injectors that are configured to inject and deliver medicaments and other fluids from a syringe into a target site.
US12318589B2
Described is a dose tracking mechanism for a drug delivery device, including an RFID device with an electric circuit and a switch operable to open and close the electric circuit to transmit a wireless signal to a receiving device when the electric circuit is closed by the switch. The switch is configured to open and close in response to operation of a dose setting and/or a dose dispensing mechanism of the drug delivery device, and the closing and opening of the electric circuit generates a pulse of the wireless RFID signal. In one embodiment, each pulse corresponds to a unit of a dose of medicament set by the dose setting mechanism or dispensed by the dose dispensing mechanism from a drug container of the drug delivery device, depending on if the dose setting or dose dispensing mechanism is arranged to toggle the switch.
US12318580B2
The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.
US12318577B2
The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include receiving and/or determining one or more user specific dosage parameters.
US12318552B2
Embodiments disclosed herein are directed to a drainage control system including, a tubular body with a tubular body lumen extending from a distal end to a proximal end and a collapsible tube disposed within the tubular body lumen, the collapsible tube including a collapsible tube lumen extending from a distal end to a proximal end of the collapsible tube. The collapsible tube can be attached to the tubular body, such that fluid flow through the tubular body lumen flows through the collapsible tube lumen. The tubular body can include a valve that is actuatable between a first configuration wherein fluid flow is allowed through the tubular body lumen and a second configuration wherein fluid flow is prevented through the tubular body lumen. An airflow source can be coupled to the valve such that pressure from the airflow source actuates the valve.
US12318551B2
An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula. In one embodiment, the cannula includes an inflow section having a sheet formed of a shape memory material embedded within a polymer and having at least one lateral hole or aperture in the inflow section. The at least one lateral hole is defined by a first hole in the sheet and a second hole in the outer polymer layer of the cannula. The first hole and the second hole overlap so that blood can enter the cannula through the holes.
US12318550B2
A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.
US12318547B2
The invention relates to a gas delivery apparatus (1) having an internal gas passage (100), a deformable reservoir (27), a valve device (22), and a control unit (50) with microprocessor (51) controlling the valve device (22) in order to set or adjust the flow rate of gas passing through said valve device (22). A flow rate determination device (60) makes it possible to perform measurements of pressure or flow rate in the internal gas passage (100) and to transmit these measurements to the control unit (50). A pressure sensor (55) performs gas pressure measurements (P55) on the therapeutic gas feeding the deformable reservoir (27) and supplies them to the control unit (50). A breathing mask (10) is in fluidic communication with the internal gas passage (100) in order to be fed with therapeutic gas coming from the deformable reservoir (27).
US12318542B2
A vent arrangement is provided to a mask to discharge exhaled gas from the mask to atmosphere. The vent arrangement is structured to diffuse the exhaust vent flow to produce less air jetting, thereby increasing the comfort of the patient and their bed partner. The vent may include a first wall, a second wall defining an outer perimeter, and a plurality of gas washout vent holes positioned between the first wall and the second wall, the vent holes having an inner edge positioned within the outer perimeter of the second wall.
US12318533B2
In a surgical drain system formed with two or more branches, exudate flow from a patient's wound is directed between two branches with the respective filling and emptying times determined in order to identify the presence of a blockage in the drain.
US12318516B2
A breast pump system comprises at least one wearable milk collection hub connected via an air line to a combined external air pump and control unit. Each milk collection hub comprises: (a) a breast shield made up of a breast flange and a nipple tunnel; (b) a flexible diaphragm that is configured to prevent milk from reaching the external air pump; (c) an outer shell that is configured to removably attach to the breast shield, such that, when attached, the breast shield and outer shell form a vessel for collecting milk; and (d) a diaphragm cap that is configured to be secured over the diaphragm, forms part of the front face of the outer shell, and includes a port connected to the air line.
US12318511B2
Hygienic Hydrophilic coatings, hydrophilic coating formulations and wetting fluids that include an anti-infective agent.
US12318508B2
Compositions for treatment of discogenic pain are discussed herein. In various embodiments, the composition includes PMMA microparticles, Pluronic® surfactant, PBS, and a radio marker. In some embodiments, the PMMA microparticles have a particle size distribution between 25-125 microns and are nonlinearly cross-linked. The composition may be stored at a cooled temperature and upon injection, the composition warms and transitions to a gel state. The composition may also include about 50% PMMA microparticles, about 10% Pluronic®, about 30% PBS, and about 10% of a radio marker.
US12318507B2
Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.
US12318500B2
An apparatus and method for sterilization of an article which has a first open end, a second open end and a lumen extending therebetween. The apparatus comprises a first chamber for receiving the article. The first chamber has an outlet fluidly connectable to a pump for adjusting an internal pressure in the first chamber; and an inlet fluidly connectable to a sterilant source for supplying sterilant to the first chamber. The apparatus includes a second chamber fluidly connectable to the first chamber by a chamber connector fluidly sealable to isolate the first and the second chamber; and an article connector for fluidly connecting the second open end of the article to the second chamber to form a fluid path from the first to the second chamber through the lumen. Also included is an article connector for connecting an open end of an article to be sterilized to a sterilization apparatus.
US12318497B2
UV hard-surface disinfection system that is able to disinfect the hard surfaces in a room, while minimizing missed areas due to shadows by providing multiple UV light towers that can be placed in several areas of a room such that shadowed areas are eliminated and that can be transported by a cart that is low to the ground such that the towers may be loaded and unloaded easily by a single operator. The system is able to be controlled remotely, such that during activation of the system, no operator is present, and to automatically cut power to all towers in the event that a person enters the room.
US12318494B2
Described herein are methods and systems for decontaminating surfaces on aircraft from pathogens using UV lights with wavelengths between about 200 nanometers and about 240 nanometers. These wavelengths are able to effectively decontaminate pathogens while remaining safe to humans. In other words, humans can remain in decontamination zones during operation of these systems. Furthermore, UV transparent apparatuses, such as door handles, allow decontamination of all surfaces of these apparatuses whether these surfaces are directly or indirectly exposed to the UV light. The indirect exposure is provided by the UV lights passing through the apparatus. Therefore, even surfaces without a line of sight to UV light sources are decontaminated. As such, these methods and systems allow to achieve effective decontamination of an apparatus with a complex surface (e,g., a door handle) without requiring many UV light sources positioned around this apparatus.
US12318488B2
The present invention provides methods of preparing solid dosage form, particularly pharmaceutical dosage forms, using extrusion and 3D-printing, as well as the solid dosage form itself, the compositions used to make said items, uses of the solid dosage forms, and containers used in their preparation.
US12318487B2
The present invention relates to solid tablet oral dosage forms of 2,2′-di(pyridin-4-yl)-1H,1′H-5,5′-bibenzo[d]imidazole (which may also be known as 2,2′-di-4-pyridinyl-6,6′-bi-1H-benzimidazole; 5,5′-bis[2-(4-pyridinyl)-1H-benzimidazole]; 2,2′-bis(4-pyridyl)-3H,3′H-5,5′-bibenzimidazole; or 2-pyridin-4-yl-6-(2-pyridin-4-yl-3H-benzimidazol-5-yl)-1H-benzimidazole), referenced herein by the INN name ridinilazole, and pharmaceutically acceptable derivatives, salts, hydrates, solvates, complexes, bioisosteres, metabolites or prodrugs thereof.
US12318483B1
Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.
US12318482B2
An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions that contain the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.
US12318478B2
The present invention is directed to an injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and a DMSO solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 4 weeks and wherein the composition has a pharmacokinetic profile in vivo that makes it suitable to be administered each 4 weeks or even longer periods.
US12318477B2
The present invention relates to aqueous pharmaceutical formulations, methods for their production, and uses thereof. The aqueous pharmaceutical formulations comprise a salt of an optionally substituted dimethyltryptamine compound and water, with a pH from 5 to 6.5, preferably from about 5 to about 6, and a concentration of the optionally substituted dimethyltryptamine compound of about 10 mg/ml or greater as the freebase equivalent. These formulations can comprise an effective dose of an optionally substituted dimethyltryptamine compound for use in psychedelic assisted therapy within a volume of 5 ml or less. Such formulations are surprisingly suitable both for intramuscular injection and nebulised inhalation, being both stable and clinically acceptable, and have potential uses in the treatment of psychiatric or neurological disorders.
US12318473B2
The present invention chiefly aims to provide a novel composition for controlling indigenous bacterial flora in the skin which can enhance or improve the diversity of bacterial species in the indigenous bacterial flora in the skin relative to the condition before treatment. The present invention can include, for example, a composition (e.g., an ointment, a liquid) for controlling the diversity of bacterial species in indigenous bacterial flora in the skin, comprising an effective amount of earthworm lipids extracted from a raw earthworm (Lumbricus rubellus), and a base. The composition of the present invention is useful, for example, as a raw material for skin care products and cosmetics.
US12318463B2
Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
US12318460B2
A dental polymerizable composition includes: a first agent including a (meth)acrylate having an acid group and an organic peroxide, and a second agent including a (meth)acrylate having no acid group, a thiourea derivative, and a glass powder, wherein the glass powder includes aluminum, silicon, and at least one of copper or vanadium.
US12318459B2
The present invention relates to dental, light-curable, one-component composite compositions comprising (A) monomers, (B) fillers, and (C) initiators, the viscosity η20 of which at 20° C. is greater than 400 Pa*s, preferably greater than 800 Pa*s and more preferably greater than 1200 Pa*s, and the viscosity η50 of which at 50° C. is less than 150 Pa*s, preferably less than 120 Pa*s and more preferably less than 90 Pa*s, and wherein the quotient η50/η20 of the viscosity of the composite composition at 50° C. and the viscosity of the composite composition at 20° C. is less than 0.125, preferably less than 0.1. The invention is preferably directed to dental composite compositions selected from the group consisting of dental filling materials, lining materials, luting materials and fissure sealants.
US12318458B2
Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and/or detect cancers associated with increased PSMA expression, have the formula: and include complexes, anions or salts thereof. R1 includes a chelating moiety; a is 0 or 1; n is an integer from 12 to 21; and R2 includes a prostate specific membrane antigen (PSMA)-targeting moiety. Optionally, the chelating moiety is chelated to a metal atom, where the metal atom is a positron or single photon emitting metal isotope, or an alpha, beta, or Auger emitting metal isotope.
US12318446B2
This disclosure provides a system for preventing or reducing side effects in a patent undergoing immunotherapy to remove diseased cells that express a target antigen: for example, by CAR T cell therapy. Side effects can ensue from concurrent depletion of hematopoietic cells bearing the same target antigen. A population of engineered hematopoietic cells is prepared by obtaining healthy hematopoietic cells from the patient or a third party donor, and using them to produce engineered hematopoietic cells. The engineered cells either do not express the target antigen, express it at a lower density, or express it in a modified form. The engineered hematopoietic cells are formulated for administration to the patient, whereupon they reconstitute hematopoietic cell function, thereby preventing or reducing the side effects.
US12318445B2
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.
US12318444B2
The present invention provides mRNA sequences comprising at least one coding region, encoding for at least one epitope of a protein, or of a fragment, variant or derivative thereof, of a virus of the genus rotavirus. Particularly preferred is the protein respectively the protein cleavage product VP8* of rotavirus. The mRNA sequence may be used as a vaccine or generally as a pharmaceutical composition for prophylaxis or treatment of rotavirus infections.
US12318436B2
The invention provides for thermostable spray dried formulations including vaccines and pharmaceutical compositions for inducing or enhancing an immune response and methods of use thereof. The spray dried formulations are a dry powder generally comprising an antigen and/or an adjuvant, a metabolizable oil, and one or more excipients.
US12318431B2
Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
US12318430B2
This disclosure provides a method of preventing, alleviating or treating a condition (i.e., neutropenia) in a subject in need thereof, the condition characterized by compromised white blood cell production in the subject. The method includes administering to the subject a therapeutically effective amount of a protein complex on the same day as a chemotherapy regimen, wherein the protein complex is a modified human granulocyte-colony stimulating factor (hG-CSF) covalently linked to an immunoglobulin Fc region via a non-peptidyl polymer. The non-peptidyl polymer is site-specifically linked to an N-terminus of the immunoglobulin Fc region, and the modified hG-CSF comprises substitutions in at least one of Cys17 and Pro65.
US12318429B2
A peptide according to one aspect of the present invention, and a pharmaceutical composition and a skin external preparation containing same promote the growth of individual hair follicle cells and increase the amount of hair growth-related cytokines, thus having a hair tonic, hair growth, or hair growth-promoting effect, and consequently, the effect of effectively treating, ameliorating, or preventing alopecia.
US12318426B2
Disclosed herein are small molecule GIP/GLP-1 dual receptor agonist compositions, pharmaceutical compositions, the use and preparation thereof.
US12318423B2
The present invention relates to a composition for enhancing exercise capacity and recovery from fatigue containing fermented and aged noni, coconut sugar or muscovado sugar as an active ingredient, and more specifically, to a composition enhancing exercise capacity and recovery from fatigue, which has the effects of enhancing exercise capacity and inhibiting the accumulation of fatigue substances in blood by increasing glycogen storage in tissue and liver function. The present invention provides a food composition for exercise capacity enhancement and anti-fatigue, which is useful in the food industry. The composition of the present invention enables recovery from fatigue or enhancement of athletic ability to be achieved quickly by promoting the reduction of fatigue substances, and may provide sports drink products, functional food products and pharmaceutical composition products that are effective in enhancing recovery from fatigue and exercise capacity.
US12318407B2
The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
US12318406B2
Provided herein are topical formulations containing copper ions and methods of treating radiation dermatitis, damage caused by radiation therapy, or other radiation-induced damage conditions in various areas of the body using such formulations. Methods of treating radiation dermatitis using topical copper ion treatments are provided. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.
US12318398B2
Disclosed is a kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite, or prodrug thereof. Also disclosed are a pharmaceutical composition comprising the kinase inhibitor and uses and methods for inhibiting the activity of one or more tyrosine kinases selected from MST1 and a mutant thereof in a cell or subject and for preventing or treating a disease related to MST1 or a mutant thereof in a subject by using the compound or composition.
US12318397B1
The present disclosure provides a pharmaceutical composition that includes enclomiphene and pregnenolone, and pharmaceutical combinations and uses thereof. The present disclosure also provides a pharmaceutical combination that includes a selective estrogen receptor modulator and testosterone in a form suitable for oral administration, and uses thereof.
US12318395B2
The process comprises combining prepared β-cyclodextrin solution and prepared ethinyl estradiol solution, then removing the solvent by spray-drying for obtaining an ethinyl estradiol β-cyclodextrin complex. The obtainable amorphous ethinyl estradiol β-cyclodextrin complex is suitable for use in pharmaceutical compositions and formulations comprising it.
US12318394B2
In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
US12318389B2
The present application relates to pharmaceutical formulations and dosage forms of an AXL/MER inhibitor, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, including methods of preparation thereof, which are useful in the treatment of AXL/MER mediated diseases such as cancer.
US12318388B2
New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.
US12318368B2
The invention relates to compound shown with formula (I) or a pharmaceutically acceptable derivative thereof for use as a novel inhibitor of BCL-2.
US12318367B2
The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament, and to processes for the preparation of said compositions.
US12318360B2
The present invention relates to a patch comprising a high content of rivastigmine per unit area, which can be continuously administered for a long time. The rivastigmine patch according to the present invention is capable of continuous release of rivastigmine for a long period of time, preferably 3 days, more preferably 4 days or more after attachment, and has excellent physical and chemical stability.
US12318355B2
Disclosed herein are modular container systems having child-resistant containers, tray inserts and tray frames. Also disclosed are methods using the modular container systems and methods of storing substances in containers. The containers have a container base and a container cap and provide for child-resistant containers. A user can releasably remove the container cap from container base with a squeeze and lift sequence. For example, the user squeezes opposite sides of the container base, which releases a locking mechanism and allows for removal of the cap by lifting or pulling the container cap off from the container base. The components of the modular container system are modular and stackable. The modular system allow for organized, efficient, accessible and storage of the child-resistant containers. The modular container system also allows for easy counting, sorting and processing of the containers.
US12318354B2
An electric medicine grinder includes a storing base and a grinding base detachably connected together, and a grinding assembly and an operating module mounted on the grinding base. The grinding assembly includes a driving motor and a breaking tool. The breaking tool is mounted in a storing recess of the storing base. The operating module is electrically connected with the driving motor, and is configured to provide electric power for operation of the driving motor. Medicines can be ground into powder simply by pressing the starting switch, which is time and labor saving. It is useful to reduce the ground medicine remaining in the storing recess and on the breaking tool. A total amount of medicine taken by the patient is not reduced and no ground medicines would be remained in the electric medicine grinder and mix with the subsequent ground medicines to cause adverse effects to the patient.
US12318352B2
The present invention discloses a massager, where an air pressure generating member is provided in an accommodating cavity, where an air pressure generating member is provided with an inner cavity thereon, the inner cavity is provided with a separating body therein to separate the inner cavity to form at least two air pressure generating cavities isolated from each other, openings of the air pressure generating cavities are respectively connected with massage ports, and a driving device is used to drive the separating body to deform or oscillate or displace to increase or decrease a volume of at least one air pressure generating cavity, so that an air pressure difference is formed between two massage ports to perform air stimulation massage on a human body.
US12318348B2
Provided herein is a device comprising a cuirass, which includes a shell, at least one sensor, a pressure creation means for providing at least one of a negative pressure or a positive pressure within the shell, and a controller operably connected to the pressure creation means, wherein the controller is adapted to receive an input signal from the at least one sensor and adapted to provide an output signal to the pressure creation means, and wherein the pressure creation means is adapted to provide a greater or lesser amount of pressure within the shell in response to the output signal. Also provided are methods of use.
US12318344B2
A walking assistance method may include receiving at least one abnormal gait type selected from a plurality of abnormal gait types, and differently controlling a walking assistance apparatus based on the at least one abnormal gait type.
US12318334B2
Systems for positioning a patient are provided. A patient positioning system comprising: an upper support comprising: a mounting plate for a pad; a hinge comprising a curved surface including teeth, the curved surface operable to rotate; a pawl that is in contact with the teeth of the hinge, wherein the pawl is operable to allow rotation of the pad in a first direction due to angles of the teeth; a moveable member extending from the hinge, the moveable member including teeth; and a second pawl that is in contact with the teeth of the moveable member, the second pawl operable to allow movement of the moveable member due to angles of the teeth of the moveable member; and a lower support connected to the upper support via the moveable member.