The invention discloses a circuit and a method for achieving a high-efficiency voltage multiplier, wherein, the high positive-negative supplying voltage for the inside of a chip is generated from an outside low positive-negative supplying voltage and an earth potential. The critical voltage decreasing loss is eliminated by increasing the voltage of an internal node through a multi-phase control signal, thereby improving the pressurizing efficiency of a prior field-effect transistor circuit arranged with diodes. The next class MOS transistor substrate is eccentrically pressured through the voltage signal of the last class, thereby releasing the stress of a grid oxide layer of the MOS transistor produced by the treble-well technique. The method is called leapfrogging substrate voltage tracking method, which can appear MOS transistors with different classes in a same substrate effect, that is, the MOS transistors with a relatively high class have the same effect with that of the MOS transistors with a relatively low class.