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发明公开
CN101273036A 具有苯基的苯基－[1,2,4]－噁二唑－5－酮衍生物、它们的制备方法和它们作为药物的用途 无效 - 撤回

具有苯基的苯基－[1,2,4]－噁二唑－5－酮衍生物、它们的制备方法和它们作为药物的用途
摘要：
本发明涉及表现出PPARδ激动剂活性的具有苯基的苯基－1，2，4－噁二唑－5－酮衍生物的所有其立体异构形式和任意比例的混合物以及其生理学上可接受的盐和互变异构形式。本发明描述了式(I)化合物，其中各原子团如所定义的那样，以及它们生理学上可接受的盐和它们的制备方法。这些化合物适合用于治疗和/或预防脂肪酸代谢障碍和葡萄糖利用障碍以及其中涉及胰岛素抵抗的障碍、中枢和外周神经系统的脱髓鞘障碍和其它神经变性障碍。
摘要（英）：

The invention relates to phenyl-[1 ,2,4]-oxadiazol-5-one derivatives with phenyl group in all its stereoisomeric forms and mixtures in any ratio, and its physiologically acceptable salts and tautomeric forms showing PPARdelta agonist activity. What is described are compounds of the formula (I), wherein the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

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