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发明公开
CN101282969A 双环芳基－磺酸[1,3,4]－噻二唑－2－基－酰胺、它们的制备方法以及它们作为药物的用途 无效 - 撤回

双环芳基－磺酸[1,3,4]－噻二唑－2－基－酰胺、它们的制备方法以及它们作为药物的用途
摘要：
本发明涉及显示出PPARδ、α和γ激动剂活性的式1的双环芳基－磺酸[1，3，4]噻二唑－2－基－酰胺及其生理学上可接受的盐和生理学功能衍生物，其中各基团如所定义的那样，并且涉及其生理学上可接受的盐和它们的制备方法。这些化合物适于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用紊乱以及其中涉及抗胰岛素性的紊乱、中枢和外周神经系统的脱髓鞘性疾病和其它神经变性紊乱。
摘要（英）：

The invention relates to Bicyclic aryl-sulfonic acid [1 ,3, 4]thiadiazol-2-yl-amides of the formula (1) and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta, -alpha and -gamma agonist activity, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

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