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发明公开
CN101747414A TNF-α结合肽和TNFR1封闭肽及其在治疗TNF相关疾病中的应用 失效 - 权利终止

TNF-α结合肽和TNFR1封闭肽及其在治疗TNF相关疾病中的应用
摘要：
本发明涉及一条TNFR1封闭肽及其与人IgG1Fc段基因重组后形成的TNFR1-Fc融合蛋白。该TNFR1封闭肽为12线肽；本发明还涉及一条TNF结合环肽和一条TNFR1封闭环肽，二者均为环9肽(即C7C)；该TNFR1封闭肽、TNFR1-Fc融合蛋白、TNF结合环肽和TNFR1封闭环肽等无论在体内还是在体外均能竞争性抑制TNF-α与TNFR1结合，从而拮抗TNF-α的生物学功能，并分别在佐剂性关节炎大鼠模型、高脂高糖诱导的肥胖和胰岛素抵抗大鼠模型及TNBS诱导的实验性溃疡性结肠炎大鼠模型中取得较好的疗效。
摘要（英）：

The invention relates to a tumor necrosis factor receptor 1(TNFR1) blocking peptide and a TNFR1-Fc fusion protein formed by recombining the TNFR1 blocking peptide and a gene of an IgG1Fc segment. The TNFR1 blocking peptide is a 12-mer linear peptide. The invention also relates to a TNF binding cyclic peptide and a TNFR1 blocking cyclic peptide which are both cyclic 9 peptides (i.e. C7C), the TNFR1 blocking peptide, the TNFR1-Fc fusion protein, the TNF binding cyclic peptide, the TNFR1 blocking cyclic peptide and the like can competently inhibit the binding between the TNF-alpha and the TNFR1 no matter in vivo or vitro, thereby antagonizing the biological function of the TNF-alpha. And the TNFR1 blocking peptide, the TNFR1-Fc fusion protein, the TNF binding cyclic peptide, the TNFR1 blocking cyclic peptide and the like can obtain better treatment effects respectively on a rat model of adjuvant arthritis, a rat model of high fat and high glucose induced obesity and insulin-resistance and a rat model of trinitro-benzene-sulfonic acid (TNBS) induced experimental ulcerative colitis.

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