The invention discloses methicillin-resistant staphylococcus aureus (MRSA) recombinant multivalent subunit genetic engineering vaccine and a method for preparing the same. The recombinant multivalent subunit genetic engineering vaccine is prepared by recombining, fussing and expressing the active and functional fragments of two antigen molecules of ClfA and IsdB and the specific enterotoxin C mutant for the MRSA to construct recombinant multivalent genetic engineering antigen protein under the assistance of aluminum adjuvant. The recombinant multivalent subunit genetic engineering vaccine is constructed with a unique method and prepared with simple process, is easy to be amplified and has good repeatability and high protein purity. The experiment on the animal shows that the recombinant multivalent subunit genetic engineering vaccine can effectively stimulate the body to produce higher humoral immune response and have good immune protection function.