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发明公开
CN101910162A 环状的吡啶基-N-[1,3,4]-噻二唑-2-基-苯磺酰胺、它们的制备方法及它们用作药物的用途 无效 - 撤回

环状的吡啶基-N-[1,3,4]-噻二唑-2-基-苯磺酰胺、它们的制备方法及它们用作药物的用途
摘要：
本发明涉及显示PPARδ或PPARδ和PPARγ激动剂活性的环状的N-[1，3，4]-噻二唑-2-基-苯磺酰胺及其生理上可接受的盐和生理学功能衍生物。所描述的是式I化合物和其生理上可接受的盐以及它们的制备方法，其中所述基团如本文定义。这些化合物适用于治疗和/或预防脂肪酸代谢和葡萄糖利用障碍以及其中涉及胰岛素抵抗的障碍、中枢和外周神经系统的脱髓鞘性疾病和其它神经退行性障碍。
摘要（英）：

The invention relates to cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist activity. What is described are compounds of the Formula (I), in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

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