The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The preparation method comprises the steps that: (1) cyclopropyl methyl ketone, dimethyl sulfate, dimethyl sulfide and sodium hydroxide take epoxidation reaction to obtain 2-cyclopropyl-2-methyl ethylene oxide; (2) the 2-cyclopropyl-2-methyl ethylene oxide is catalyzed and re-ranged by anhydrous zinc chloride at the room temperature to obtain 2-cyclopropyl propionaldehyde; (3) the 2-cyclopropyl propionaldehyde is oxidized by 50 percent oxydol at the room temperature to obtain 2-cyclopropyl monoprop; (4) the 2-cyclopropyl monoprop and thionyl chloride take reaction to obtain 2-cyclopropyl propionyl chloride; (5) the 2-cyclopropyl propionyl chloride takes reaction with chlorobenzene and anhydrous aluminum trichloride to obtain the 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone with the content being 98.0 percent to 98.7 percent, and the total yield is 80.0 percent to 83.1 percent. The preparation method has the advantages that the steps are simple, raw materials are cheap and are easy to obtain, easy-self-ignition compounds are not used, organic solvents are not used in the steps (2) and (3), three wastes are few, and the preparation method is suitable for industrialization.