The invention provides a simulation test method of a ventilation on-way frictional resistance coefficient of a curved tunnel and belongs to the technical field of a tunnel ventilation disaster-preventing technology. The simulation test method comprises the following steps of: selecting an appropriate similarity ratio and manufacturing a curved model tunnel and a straight-line model tunnel for rectification section by section; selecting sand paper as an inner surface of the curved model tunnel; connecting the curved model tunnel with the straight-line model tunnel and a rectifying circular tube; connecting the rectifying circular tube with a test fan; mounting static-pressure test tubes on the curved model tunnel at two end points with the length to be detected; inserting a pitot tube into a small test hole of the rectifying circular tube; externally connecting a micro-manometer; providing a test air quantity by the fan; and substituting a measured static pressure difference value and a dynamic pressure value into a formula to calculate the frictional resistance coefficient in the curved model tunnel. By comparing a result obtained by a simulation test with an actual numerical calculation result, the requirement on acceptable precision in engineering is met.