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发明公开
CN102731277A 二萜类化合物豆荚甲素—己素、其制备方法及其在制备药物中的用途 失效 - 权利终止

二萜类化合物豆荚甲素—己素、其制备方法及其在制备药物中的用途
摘要：
本发明涉及医药技术领域，具体而言，涉及一类从Lobophytum属软珊瑚Lobophytum cristatum Tixier-Durivault中分离得到的6个结构新颖的二萜类化合物豆荚甲素、乙素、丙素、丁素、戊素和己素，其制备方法及其在制备治疗II型糖尿病药物中的应用。本发明的豆荚甲素、乙素、丙素、丁素、戊素和己素的结构式如下所示。该类化合物经过生物活性测试可作为蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制剂和胰岛素增敏剂，它们可用于制备治疗II型糖尿病、肥胖症及其并发症的药物。
摘要（英）：

The present invention relates to the field of medicine technology, and in particular relates to six novel-structured diterpene compounds of Lobophytumin A, Lobophytumin B, Lobophytumin C, Lobophytumin D, Lobophytumin E and Lobophytumin F, which are separated from Lobophytum cristatum Tixier-Durivault of Genus Lobophytum, and a preparation method and application thereof to preparation of medicament for treating type II diabetes mellitus. The structural formulas of the Lobophytumin A, Lobophytumin B, Lobophytumin C, Lobophytumin D, Lobophytumin E and Lobophytumin F are as follows. According to biological activity test, the compounds can be used as a protein tyrosine phosphatase 1B (PTP1B) inhibitor and an insulin sensitizer for preparation of medicaments for treating type II diabetes mellitus, obesity and complications thereof.

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