The invention discloses a method for degrading BCL11B protein, which is characterized by comprising the following steps: (1) obtaining Jurkat cell population capable of realizing inducible expression of a KLF4 gene; (2) expressing the KLF4 gene by adding doxycycline to promote the Jurkat cell; (3) obtaining the Jurkat cell protein and RNA of the expressed KLF4 gene; (4) detecting the SUMO conjugation of BCL11B protein obtained in the step (3) in the Jurkat cell of the expressed KLF4 gene through Western Blot detection; (5) carrying out reverse transcription synthesis on the RNA obtained in the step (3) to obtain cDNA, detecting the expression condition of the BCL11B gene by adopting real-time quantitative PCR (polymerase chain reaction) and determining that the specific protein of the BCL11B gene is degraded. The method disclosed by the invention has the advantages that a new degradation way of specific BCL11B protein is found to partially explain the apoptosis reasons of T-ALL cells to provide theoretical guidance for leukemia treatment on one hand and provide a new train of thought for realizing human T cell transdifferentiation on the other hand.