The invention discloses a cylinder block flow resistance measurement system which includes: a water storage tank, a cylinder block water inlet pipe, a cylinder block water outlet pipe assembly, a pressure sensor, and a recorder. One end of the cylinder block water inlet pipe is communicated with the water storage tank through a water inlet pipe, and the water inlet pipe is provided with a controllable flow pump; one end of the cylinder block water outlet pipe assembly is communicated with the water storage tank through a water outlet pipe, and the water outlet pipe is provided with a flow sensor; the pressure sensor is respectively arranged at each cylinder block water inlet pipe of the cylinder block water inlet pipe and at each cylinder block water outlet pipe of the cylinder block water outlet pipe assembly; and the recorder is respectively connected to the output end of each pressure sensor. The cylinder block flow resistance measurement system uses the cylinder block water inlet pipe and the cylinder block water outlet pipe, which are arranged respectively at the cooling water inlet channel and at the cooling water outlet channel of the cylinder block, to accurately measure the water inlet/outlet pressure of the cooling water inlet channel of the cylinder block, to stabilize the water inlet flow and the water outlet flow, and to be capable of accurately measuring the water inlet/outlet pressure of the cooling water inlet channel of the cylinder block.