The invention discloses a preparing method of a GH4169 alloy large-scale special-shaped cross section annular blank. The preparing method comprises the steps that a GH4169 alloy bar is heated to be 1100+/-10 DEG C in a certain heating mode, and is then subjected to upsetting, punching and rolling to become a rectangular cross section annular blank; then, the rectangular cross section annular blank is expanded into a primary special-shaped cross section annular blank at the pressure of 34 to 36MN; next, the primary special-shaped cross section annular blank is expanded into a secondary special-shaped cross section annular blank at the pressure of 32 to 35MN; then, the upper end of the secondary special-shaped cross section annular blank higher than a loose tooling is subjected to free upsetting to be flush with the loose tooling at the pressure of 20 to 26MN, and the final special-shaped cross section annular blank is obtained. The method has the advantages that the forming pressure required by the blank manufacturing can be effectively reduced, meanwhile, the flow direction of process excess materials can be effectively controlled, and the forming dimension of an intermediate blank is ensured. The method is applicable to the preparation of the intermediate blank of a large-scale special-shaped cross section annular blank element.