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发明授权
CN103483439B αO-超家族芋螺毒素肽、其药物组合物及用途 有权

αO-超家族芋螺毒素肽、其药物组合物及用途
摘要：
本发明属于生物化学和分子生物学领域，涉及一种αO-超家族芋螺毒素肽、其药物组合物、其制备方法及用途。本发明还涉及所述芋螺毒素肽的前肽、其核酸构建体、其表达载体和转化的细胞、以及其融合蛋白。本发明还涉及一种阻断乙酰胆碱受体的方法、以及所述芋螺毒素肽的制药用途。本发明的αO-新超家族芋螺毒素肽能够特异地阻断乙酰胆碱受体（nAChRs）（例如α9α10 nAChR），以及NMDA受体（例如NR2C NMDAR)，并且具有治疗神经痛、成瘾的活性、以及癌症化疗、乳腺癌、肺癌、伤口愈合、癫痫、局部缺血等的活性，具有在制备镇痛药物、治疗成瘾的药物以及神经科学工具药等方面的良好应用前景。
摘要（英）：

The present invention pertains to fields of biochemistry and molecular biology, relates to an ±O-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof. The present invention further relates to a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The new ±O-superfamily conotoxin peptide of the present invention is capable of specifically blocking acetylcholine receptor (nAChRs) (e.g., ±9±10 nAChR), and NMDA receptor (e.g., NR2C NMDAR), and has activity for treatment of neuralgia, addiction, and activity for treatment of chemotherapy of cancers, breast cancer, lung cancer, wound healing, epilepsia, ischemia, and thus is promising in the manufacture of analgesic, a medicament for treatment of addiction, and a tool drug for neuroscience.

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