The invention provides an evaluation method of the sand prevention effects of sand prevention layers. A large-size multipoint-pressure-measuring sand production experimental device is used in the evaluation method of the sand prevention effects of the sand prevention layers. The method comprises the steps that firstly, the large-size multipoint-pressure-measuring sand production experimental device is filled with raw materials; secondly, the large-size multipoint-pressure-measuring sand production experimental device is used for measuring permeability and displacement pressure differences of the sand prevention layers different in precision, and produced liquid is collected; thirdly, a full-automatic sand content kit and a Malvin laser particle analyzer of the large-size multipoint-pressure-measuring sand production experimental device are adopted for analyzing the sand content and the sand particle sizes of the produced liquid; fourthly, according to the permeability, the displacement pressure differences, the sand content of the produced liquid, and the sand particle sizes of the produced liquid, the sand prevention effects of the sand prevention layers are evaluated, and sand prevention precision is optimized. The evaluation method of the sand prevention effects of the sand prevention layers can be used for conducting sand prevention precision optimization and sand prevention effect evaluation on the sand prevention layers built in various sand prevention processes, and has the advantages that experimental operation is easy and convenient, and experimental data are accurate.