The invention relates to a design method for a launching cylinder preventing a guide missile from rolling in the loading process. The design method for the launching cylinder preventing the guide missile from rolling in the loading process comprises the following steps that the mechanism that the guide missile rolls when the guide missile is loaded into the launching cylinder is analyzed, and thus a mechanical analysis model for rolling occurring in the loading process of the guide missile is established; influence factors influencing rolling of the guide missile in the loading process are obtained from the mechanical analysis model; optimization design is carried out on the launching cylinder through the influence factors; the effect of the launching cylinder for preventing the guide missile from rolling is verified through scale-down tests; optimization design is further carried out on the launching cylinder through verification results. According to the design method for the launching cylinder preventing the guide missile from rolling in the loading process, referable theoretical foundations are provided for engineering practice application, and the launching cylinder designed through the method is capable of effectively preventing the guide missile from rolling in the loading process.