The invention discloses a unidirectional lead core rubber vibration insulation support which comprises an interlayer steel plate, interlayer rubber, outer wrapping rubber, upper seal plate, a cover plate, a lead core, a Teflon sliding plate, a stainless steel plate, an upper support plate, a lower support plate, limiting plates, an upper connecting plate, a lower connecting plate, an anchor bolt, a lateral stainless steel bar and a guide sliding strip. The led core is tightly pressed into a support reserved hole, and the cover plate is arranged on the lead core. The Teflon sliding plate and the stainless steel plate form a support sliding face, and lubrication between the stainless steel plate and the Teflon sliding plate is conducted through silicone grease. The upper seal plate is bonded with the Teflon sliding plate which is provided with the surface coated with epoxy resin and is subjected to surface activation treatment. The limiting plates are arranged on all the side edges of the upper support plate and allow longitudinal sliding but limit transverse moving. By means of the unidirectional lead core rubber vibration insulation support, the problem that a total link bridge length is large or large longitudinal deformation generated under the conventional load action may be restrained when the vibration insulation support is adopted for a large stride bridge is solved, the application range of the vibration insulation support is broadened, and vibration resistance of the overall bridge is improved.