The invention discloses a preparation method of a grape pomace essence and fruit and vegetable powder combined blending agent, which relates to the technical field of food processing. The preparation method comprises steps of firstly, extracting nutrition ingredients in grape pomace through a microwave vacuum extracting technology, and simultaneously drying fruits and vegetables through microwave vacuum drying, and then grinding the dried fruits and vegetables; then, dissolving the obtained materials in extracting water, flavoring and pelleting; and finally, carrying spray-drying, rotationally roasting in three sections in a vacuum environment at low temperature to obtain a finished product. The prepared blending agent disclosed by the invention not only realizes reasonable utilization of residual dregs in a wine brewing process and reserves nutrition ingredients in the grape dregs, but also contains nutrition ingredients of fruits and vegetables; so that the prepared blending agent is green and healthy, high in nutrition value and convenient to eat.