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发明公开
CN104739780A 一种厄他培南钠药物组合物及其制备方法 无效 - 驳回

一种厄他培南钠药物组合物及其制备方法
摘要：
本发明涉及一种厄他培南钠固态药物组合物及其制备方法，所述药物组合物含有式1所示的厄他培南钠，和式2所示的化合物或其钠盐、水合物或溶剂化物，以及药学上可接受的辅料。本发明提供的厄他培南钠固态药物组合物中式2化合物或其可药用的盐、水合物或溶剂化物所占比例高达80%以上，大大提高了厄他培南钠最终制剂的稳定性。
摘要（英）：

The invention relates to a solid Ertapenem disodium pharmaceutical composition and a preparation method thereof. The pharmaceutical composition contains Ertapenem disodium as shown in formula I and a compound as shown in formula II or a sodium salt, a hydrate or a solvate thereof and pharmaceutically acceptable additives. In the solid Ertapenem disodium pharmaceutical composition provided by the invention, the proportion of the compound as shown in formula II or the sodium salt, the hydrate or the solvate thereof is higher than 80%, and thus the stability of a final Ertapenem disodium preparation is greatly improved.

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