The invention provides a sodium prasterone sulfate sustained-release tablet and a preparation method thereof. The sodium prasterone sulfate sustained-release tablet comprises, by weight, 10% to 90% of sodium prasterone sulfate, 5% to 75% of framework matierals, 0.1% to 80% of filler and 0.1% to 5% of lubricant. The sodium prasterone sulfate sustained-release tablet in the embodiment only needs to be taken once a day and is good in patient compliance. The stable blood concentration can be provided, the limited concentration can be kept for a long time, and thus, the toxic and side effects of the medicine are reduced, and the safety of the medicine is improved.