Disclosed is a glutamine acyl cyclase inhibitor, and the structure thereof is as shown in formula (I). The glutamine acyl cyclase inhibitor (QC inhibitor) provided in the present invention is designed according to the target enzyme protein activity center crystal structure, shows good selectivity and specificity, and has a higher druggability; and the maternal structure thereof is richer, and same has a good water solubility, a good transmembrane performance, and a higher activity.