The invention discloses a mulberry drink with a protective effect on alcoholic liver injury and a preparation method thereof. The mulberry drink is prepared from the medicinal raw materials such as mulberries, red dates, wolfberry, liquorice, chrysanthemum and radix puerariae. The function evaluation via animal experiments proves that the healthcare drink compounded with mulberries realizes a remarkable liver protection effect on the alcoholic liver injury, and can effectively reduce the content of MDA, AST and ALT in serum, increase the content of GSH and lower the fatty degeneration degree of the liver tissue while avoiding obvious impact on the rat weight; and the sample has an auxiliary protection function on the alcoholic liver injury as well as certain prevention and treatment effect on the alcoholic liver injury.