The invention discloses a manufacturing method of a 12Cr13 pipe blank for a nuclear power plant reactor control rod drive mechanism. The manufacturing method aims at solving the problems that production cost is high, the rod inclusion level is low, and it is difficult to meet the standard requirement for the mechanical performance of a nuclear power drive rod. According to the technical scheme, by the adoption of an existing device, the electric arc finance+LF+VOD/VHD process, the electric slag furnace remelting and smelting process, the rolling material forming process and the quenching and tempering heat treatment process are adopted, the chemical components meet the standard requirements, and all the elements are reasonable in matching; the smelting process is good in deoxidization effect, so that the inclusion level is lowered; the rolling ratio in the machining process is controlled, and the grain size is ensured; and high strength, good ductility and toughness and appropriate hardness are obtained through reasonable quenching and tempering thermal treatment. The manufacturing method has the beneficial effects that by means of the existing device, the novel process is adopted for manufacturing the long high-quantity 12Cr13 pipe blank with low cost, and the performance of the 12Cr13 pipe blank meets the standard requirement of a nuclear power plant reactor control rod drive mechanism drive rod.