The invention belongs to the technical field of steelmaking continuous casting, and relates to a control method for typical middle cracks and center segregation during pipeline steel slab continuous casting. The control method comprises the steps that a roll gap of a casting machine is subjected to offline calibration and online detection, and it is guaranteed that precision is +/-0.2 mm; steel grade grouping is carried out, and matching of steel grades and thermophysical parameters is enhanced; the degree of superheat is strictly controlled, the proportion of equiaxed grains is increased, and developed columnar grains are avoided; a pulling rate and a secondary cooling process are adjusted, and basic roll gap control in the casting slab solidification process is optimized; and the soft press quantity is optimized, two or three segments of press are selected to the greatest extent according to the continuous casting process, and a large press quantity difference is avoided in press distribution between different sector segments. The control method has the beneficial effects that the internal quality of the casting slab is improved, and the product competitiveness is enhanced.