A vehicle panel structure according to technology disclosed herein includes: a panel member employed in a vehicle; a joining member configured including an angled wall that is disposed on one plate thickness direction side of a joined-to wall of the panel member, and that is angled with respect to the joined-to wall, and a joining wall that is disposed facing the one plate thickness direction side of the joined-to wall, and that is coupled to the angled wall through a bent portion; and a spot weld that configures a join portion where the joining wall is joined to the joined-to wall, and that is set at a portion of the join portion where an extension line running along an axial direction of the angled wall intersects.