The present invention relates to amide derivatives and pharmaceutically acceptable salts thereof, preparation method therefor and medicinal application thereof. Specifically, the present invention relates to amide derivatives represented by general formula (I), preparation method therefor, pharmaceutical compositions containing the derivatives, and use thereof as therapeutic agent, especially as inhibitor for microsomal prostaglandin E synthase-1(mPGES-1), and use in preparation of medicines for treating and/or preventing diseases or illness such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.