The invention discloses a Parkinson's disease resistance safflower carthamus effective part dropping pill and a preparation method thereof, and belongs to the field of preparation of dropping pills. The Parkinson's disease resistance safflower carthamus effective part dropping pill is prepared from a Parkinson's disease resistance safflower carthamus effective part extract and a matrix PEG6000. The preparation method comprises the steps that the matrix is heated to be fused, the Parkinson's disease resistance safflower carthamus effective part extract is added into the fused matrix, and the mixture is stirred to be uniform to obtain fused medicine liquid; the fused medicine liquid is dropped into a condensing agent, shrinkage and forming are performed, and the Parkinson's disease resistance safflower carthamus effective part dropping pill is obtained. The medicine mass ratio, the dropping interval, the dropping speed, condensing agent temperature and the like are optimized during preparation of the dropping pill, the prepared dropping pill is good in roundness and glossiness, good in stability, short in disintegration time and large in dissolving-out amount. The Parkinson's disease resistance safflower carthamus effective part dropping pill can relieve PD symptoms of a PD rat model, effectively achieves the effect of protecting nerve cells, is convenient to take, becomes effective rapidly, is high in bioavailability, and can be used for preventing and treating neurodegenerative diseases such as the Parkinson's disease.