The invention belongs to the technical field of vehicles, and provides an anti-collision structure of a four-wheeled vehicle frame. The anti-collision structure of the four-wheeled vehicle frame comprises a front-side anti-collision part and lateral anti-collision parts. The front-side anti-collision part comprises an external front-side anti-collision part and an internal front-side anti-collision part. The external front-side anti-collision part comprises an upper anti-collision portion and a lower anti-collision portion. The lower anti-collision portion is located on the front section of the upper anti-collision portion in a plane position. The lower anti-collision portion is provided with two energy absorption pipes I (6) welded on a front transverse strut beam (11) of a bottom frame. The upper anti-collision portion is provided with two energy absorption pipes II (4) connected with a front bumper by welding. A steering wheel supporting structure of the internal front-side anti-collision part is connected to a vehicle body front transverse strut beam (9) at the front of the frame. The lateral anti-collision parts are arranged on vehicle body frames (19) on two sides of the four-wheeled vehicle frame. The anti-collision structure of the four-wheeled vehicle frame improves the safety of the overall vehicle, and has the characteristics of compact structure, few welding positions, light weight, and high overall structure strength.