The invention provides a bisphenol or dual amine containing a benzocyclobutene structure unit, preparation and application thereof. Specifically, the preparation method consists of: taking 4-halogenated benzocyclobutene as the raw material, carrying out acylation reaction to obtain 4-acyl substituted benzocyclobutene, and reacting the latter with substituted phenol or aniline to obtain a compound shown as formula I, wherein all the groups are defined as the specification. The method provided by the invention has the characteristics of simple process, convenient operation and excellent yield, and is suitable for large-scale industrial production, and the obtained product has a curable group and can be used for preparation of novel high performance organic thermosetting materials. (formula I).