The invention relates to a manufacturing method for a blind hole workpiece, in particular to a manufacturing method for a large-caliber deep blind hole workpiece blank. The manufacturing method is characterized in that firstly, a steel ingot (billet steel) is manufactured into a blind hole blank, and the blind hole blank is extruded into a part blank of the required specification on an extrusion machine. Compared with a method that a steel ingot is manufactured into round steel in a forging manner and then cutting and forming are conducted on the round steel, by the adoption of the manufacturing method that modification and forming of materials are completed at a time, the utilization rate of the materials can be increased, the weight of the steel ingot can be reduced, the quality of products can be improved, manufacturing cost can be lowered, and production efficiency can be improved. The method can be applied to manufacturing of large-caliber deep blind hole workpiece blanks of materials of carbon steel, alloy steel, copper, aluminum, titanium and the like, and especially, the problem about manufacturing of the large-caliber deep blind hole workpiece blanks high in performance is solved effectively.