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发明公开
CN106046121A 一种靶向FAP的抗血管生成肽Z‑GP‑V1及其应用 有权

一种靶向FAP的抗血管生成肽Z‑GP‑V1及其应用
摘要：
本发明属于肿瘤治疗技术领域，具体涉及一种具有抗肿瘤血管生成作用的靶向FAP的合成肽Z‑GP‑V1。该肽分子量为：1270.47 Da，序列为Z‑GPAAATWLPPR；采用Fmoc固相多肽合成法制备而成，可用于抗肿瘤血管生成制剂中。本发明通过利用特异性底物二肽Z‑GP对V1肽进行修饰，获得了新的合成肽Z‑GP‑V1，而新的合成肽对于改善V1肽的靶向性，提高其抗肿瘤血管生成作用，及降低其毒副作用等方面都表现出较好的应用效果，同时也为新的抗肿瘤血管生成治疗方法提供了新的借鉴和参考。
摘要（英）：

The invention belongs to the technical field of tumor treatment, and particularly relates to an anti-tumor angiogenesis synthetic peptide Z-GP-V1 for targeting FAP (familial adenomatous polyposis). The molecular weight of peptide is 1270.47 Da, and the sequence is Z-GPAAATWLPPR; the peptide is prepared by an Fmoc solid-phase multi-peptide synthetic method, and can be applied to an anti-tumor angiogenesis preparation. The anti-tumor angiogenesis synthetic peptide has the advantages that the peptide V1 is modified by a specific primer dipeptide Z-GP, the new synthetic peptide Z-GP-V1 is obtained, the new synthetic peptide has better application effects on improving of targeting property of peptide V1, improving of anti-tumor angiogenesis function, and decreasing of toxic or side effect, and the like, and the new experience and reference can be provided for the new anti-tumor angiogenesis treatment method.

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