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发明公开
CN106188293A 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 无效 - 撤回

抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途
摘要：
本发明涉及抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途。具体地，本发明涉及一种抗c-Met抗体，c-Met的抗原结合片段，包含所述抗c-Met抗体CDR区的嵌合抗体、人源化抗体，及其抗体-细胞毒性药物偶联物或其可药用盐或溶剂化合物，以及包含人源化抗c-Met抗体和抗原结合片段及其抗体-细胞毒性药物偶联物或其可药用盐或溶剂化合物的药物组合物，以及其作为抗癌药物的用途，尤其在制备用于治疗c-Met介导的疾病或病症的药物中的用途。
摘要（英）：

The invention relates to an anti-c-Met antibody, an anti-c-Met antibody-cytotoxic medicine conjugate, and a medicinal use of the antibody and the conjugate, and concretely relates to an anti-c-Met antibody, a c-Met antigen binding fragment, a chimeric antibody and a humanized antibody respectively including the CDR region of the anti-c-Met antibody, an antibody-cytotoxic medicine conjugate or a medicinal salt or a solvate of the anti-c-Met antibody, a medicinal composition including the humanization anti-c-Met antibody and the antigen binding fragment and the antibody-cytotoxic medicine conjugate or the medicinal salt or the solvate of the anti-c-Met antibody, a use of the anti-c-Met antibody as an anticancer medicine, and especially a use of the anti-c-Met antibody in the preparation of medicines for treating c-Met mediated diseases or illnesses.

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