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发明授权
CN106278941B 九种PTP1B抑制剂及其合成和应用 有权

九种PTP1B抑制剂及其合成和应用
摘要：
本发明涉及九种新型PTP1B抑制剂的化学全合成方法以及在治疗2型糖尿病药物中的应用，所述PTP1B抑制剂以下述九种化合物中的一种或二种以上为活性成份，九种化合物结构式如下：该化合物通过抑制PTP1B的活性，增强胰岛素受体敏感性，对胰岛素抵抗类2型糖尿病具有良好的治疗作用。
摘要（英）：

The invention relates to a chemical total synthesis method of nine novel PTP1B inhibitors and application of the nine novel PTP1B inhibitors in medicine for treating type 2 diabetes. According to the PTP1B inhibitors, one or two or more of nine compounds serve as active ingredients, and the structural formulas of the nine compounds are shown in the specification. By means of the compounds, the sensitivity of insulin receptors can be enhanced by inhibiting the activity of PTP1B, and a good treatment effect is achieved for insulin resistance type 2 diabetes.

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