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发明公开
CN106279159A 2-苯基-3-(甲苯磺酰甲基)咪唑并[1,2-a]吡啶类化合物及其合成方法 失效 - 权利终止

2-苯基-3-(甲苯磺酰甲基)咪唑并[1,2-a]吡啶类化合物及其合成方法
摘要：
本发明公开了一种2-苯基-3-(甲苯磺酰甲基)咪唑并[1,2-a]吡啶类化合物及其制备方法，包括下述步骤：在氩气环境下，将2-苯基-咪唑并[1,2-a]吡啶类化合物与对甲苯磺酰甲基异腈加入反应管中，加入三氯化铁，然后加入绿色溶剂，80~120℃下反应18~48小时；反应结束后萃取、色谱分离、干燥既得目标产物。该反应利用廉价金属铁(Ⅲ)作为催化剂，水和聚乙二醇400作为反应溶剂，实现了咪唑并[1,2-a]吡啶化合物与对甲苯磺酰甲基异腈的磺酰甲基化反应，所得化合物的磺酰基可以作为离去基团，实现进一步的官能团化反应，该方法将对咪唑并[1,2-a]吡啶化合物的磺酰甲基化反应的研究和应用具有重要意义。
摘要（英）：

The invention discloses a 2-phenyl-3-(toluenesulfonylmethyl) imidazo[1,2-a] pyridine compound and a preparation method thereof. The preparation method comprises the following steps: adding 2-phenyl-imidazo [1,2-a] pyridine compound and p-tolylsulfonylmethyl isocyanide into a reaction tube in an argon environment, adding ferric trichloride, then adding a green solvent, and reacting for 18 to 48 hours at 80 to 120 DEG C; and after the reaction, extracting, chromatographically separating, and drying to obtain a target product. In the reaction, cheap metal ion (III) is used as a catalyst, water and polyethylene glycol 400 are used as reaction solvents, the sulfonylmethylation reaction of the imidazo [1,2-a] pyridine compound and p-tolylsulfonylmethyl isocyanide is realized, sulfonyl of the obtained compound is used as a leaving group, and the further functional group reaction is realized. The method has important significance on the research and application of the sulfonylmethylation reaction of the imidazo [1,2-a] pyridine compound.

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