The invention provides a Tadalafil oral soluble film and a preparation method. The Tadalafil oral soluble film is prepared from a Tadalafil oral soluble film containing specific components through a conventional technology and particularly prepared from Tadalafil, a film-forming material, a plasticizer, an optionally existing corrective, an optionally existing coloring agent and an optionally existing aromatic agent. The Tadalafil oral soluble film is characterized in that the film-forming material is prepared from one or more than two components in polysaccharide, one or more than two components in organic acid and one or more than two components in hydroxyalkyl cellulose. Compared with the prior art, the Tadalafil oral soluble film has the advantages that the preparation technology is simple, no special requirement is needed on production equipment, the preparation stability is high, reproduction is easy, the requirements on storing conditions are low, and packaging, transporting and storing are easy.